HEM0_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEM0_HUMAN
• UniProt AC: P22557
• Protein Name: 5-aminolevulinate synthase, erythroid-specific, mitochondrial
• Gene Name: ALAS2
• Organism: Homo sapiens (Human).
• Sequence Length: 587
• Subcellular Localization: Mitochondrion matrix .
• Protein Sequence: MVTAAMLLQCCPVLARGPTSLLGKVVKTHQFLFGIGRCPILATQGPNCSQIHLKATKAGGDSPSWAKGHCPFMLSELQDGKSKIVQKAAPEVQEDVKAFKTDLPSSLVSVSLRKPFSGPQEQEQISGKVTHLIQNNMPGNYVFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAWTAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Ubiquitination	AMLLQCCPVLARGPT HHHHHHHHHHHHCCC	31.61	-
13	Ubiquitination	MLLQCCPVLARGPTS HHHHHHHHHHHCCCH	3.99	-
43	Phosphorylation	GRCPILATQGPNCSQ CCCCEEEECCCCCEE	30.52	46161831
54	Acetylation	NCSQIHLKATKAGGD CCEEEEEEEECCCCC	39.59	7677649
109	Phosphorylation	DLPSSLVSVSLRKPF CCCCCCEEEEECCCC	15.98	24719451
111	Phosphorylation	PSSLVSVSLRKPFSG CCCCEEEEECCCCCC	18.23	29496963
166	Ubiquitination	DHTYRVFKTVNRWAD CHHHHHHHHHHHHHH	49.02	-
226	Phosphorylation	HGAGAGGTRNISGTS HCCCCCCCCCCCCCC	21.45	12300667
230	Phosphorylation	AGGTRNISGTSKFHV CCCCCCCCCCCCEEE	39.30	12300677
233	Phosphorylation	TRNISGTSKFHVELE CCCCCCCCCEEEEHH	36.53	12300687
295	Phosphorylation	MIQGIRNSGAAKFVF HHHHHHCCCCCEEEE	21.69	27461979
391	N6-(pyridoxal phosphate)lysine	IISGTLGKAFGCVGG EECCCHHHHHCCHHH	43.59	-
391	Other	IISGTLGKAFGCVGG EECCCHHHHHCCHHH	43.59	-
495	Phosphorylation	KLCDLLLSKHGIYVQ HHHHHHHHHCCEEEE	23.68	37603867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEM0_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEM0_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEM0_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUCB1_HUMAN	SUCLA2	physical	10727444
BANP_HUMAN	BANP	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 300751: Anemia, sideroblastic, X-linked (XLSA)
• 300752: Erythropoietic protoporphyria, X-linked dominant (XLDPT)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00145: Glycine