MB12A_HUMAN - dbPTM
MB12A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MB12A_HUMAN
UniProt AC Q96EY5
Protein Name Multivesicular body subunit 12A
Gene Name MVB12A
Organism Homo sapiens (Human).
Sequence Length 273
Subcellular Localization Cytoplasm. Nucleus. Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Late endosome membrane
Peripheral membrane protein . Colocalizes with F-actin. Some fraction may be nuclear.
Protein Description Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor..
Protein Sequence MDPVPGTDSAPLAGLAWSSASAPPPRGFSAISCTVEGAPASFGKSFAQKSGYFLCLSSLGSLENPQENVVADIQIVVDKSPLPLGFSPVCDPMDSKASVSKKKRMCVKLLPLGATDTAVFDVRLSGKTKTVPGYLRIGDMGGFAIWCKKAKAPRPVPKPRGLSRDMQGLSLDAASQPSKGGLLERTASRLGSRASTLRRNDSIYEASSLYGISAMDGVPFTLHPRFEGKSCSPLAFSAFGDLTIKSLADIEEEYNYGFVVEKTAAARLPPSVS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MDPVPGTDSAPLAG
-CCCCCCCCCCCCCC		23401153
18PhosphorylationPLAGLAWSSASAPPP
CCCCCCCCCCCCCCC		23401153
19PhosphorylationLAGLAWSSASAPPPR
CCCCCCCCCCCCCCC		23401153
21PhosphorylationGLAWSSASAPPPRGF
CCCCCCCCCCCCCCE		23401153
32PhosphorylationPRGFSAISCTVEGAP
CCCEEEEEEEEECCC		28348404
34PhosphorylationGFSAISCTVEGAPAS
CEEEEEEEEECCCCC		24719451
44UbiquitinationGAPASFGKSFAQKSG
CCCCCCCHHHHHHHC		-
80PhosphorylationIQIVVDKSPLPLGFS
EEEEEECCCCCCCCC		25159151
87PhosphorylationSPLPLGFSPVCDPMD
CCCCCCCCCCCCCCC		21815630
98PhosphorylationDPMDSKASVSKKKRM
CCCCCCCCCCCHHCE		-
123MethylationDTAVFDVRLSGKTKT
CEEEEEEEECCCCEE		-
125PhosphorylationAVFDVRLSGKTKTVP
EEEEEEECCCCEEEC		28387310
130PhosphorylationRLSGKTKTVPGYLRI
EECCCCEEECCEEEE		22817900
134 (in isoform 2)Phosphorylation-29116813
163PhosphorylationVPKPRGLSRDMQGLS
CCCCCCCCCCCCCCC		22777824
166SulfoxidationPRGLSRDMQGLSLDA
CCCCCCCCCCCCCCC		21406390
170PhosphorylationSRDMQGLSLDAASQP
CCCCCCCCCCCCCCC		29255136
175PhosphorylationGLSLDAASQPSKGGL
CCCCCCCCCCCCCCH		29255136
178PhosphorylationLDAASQPSKGGLLER
CCCCCCCCCCCHHHH		23403867
179 (in isoform 1)Ubiquitination-21906983
179 (in isoform 3)Ubiquitination-21906983
179UbiquitinationDAASQPSKGGLLERT
CCCCCCCCCCHHHHH		21906983
186PhosphorylationKGGLLERTASRLGSR
CCCHHHHHHHHHHCH		29514088
188PhosphorylationGLLERTASRLGSRAS
CHHHHHHHHHHCHHH		27422710
192PhosphorylationRTASRLGSRASTLRR
HHHHHHHCHHHHHCC		25106551
195PhosphorylationSRLGSRASTLRRNDS
HHHHCHHHHHCCCCC		28348404
196PhosphorylationRLGSRASTLRRNDSI
HHHCHHHHHCCCCCH		26434776
202PhosphorylationSTLRRNDSIYEASSL
HHHCCCCCHHHHHHH		26055452
204PhosphorylationLRRNDSIYEASSLYG
HCCCCCHHHHHHHHC		22617229
207PhosphorylationNDSIYEASSLYGISA
CCCHHHHHHHHCCCC		18005716
208PhosphorylationDSIYEASSLYGISAM
CCHHHHHHHHCCCCC		23898821
210PhosphorylationIYEASSLYGISAMDG
HHHHHHHHCCCCCCC		21082442
213PhosphorylationASSLYGISAMDGVPF
HHHHHCCCCCCCCCE		26356563
221PhosphorylationAMDGVPFTLHPRFEG
CCCCCCEEECCCCCC		26356563
222 (in isoform 2)Ubiquitination-21906983
229UbiquitinationLHPRFEGKSCSPLAF
ECCCCCCCCCCCCEE		-
230PhosphorylationHPRFEGKSCSPLAFS
CCCCCCCCCCCCEEH		29255136
232PhosphorylationRFEGKSCSPLAFSAF
CCCCCCCCCCEEHHH		29255136
237PhosphorylationSCSPLAFSAFGDLTI
CCCCCEEHHHCCEEE		26270265
243PhosphorylationFSAFGDLTIKSLADI
EHHHCCEEEECHHHH		27251275
254PhosphorylationLADIEEEYNYGFVVE
HHHHHHHHCCCEEEE		28796482
256PhosphorylationDIEEEYNYGFVVEKT
HHHHHHCCCEEEEEC		28796482
262UbiquitinationNYGFVVEKTAAARLP
CCCEEEEECHHHCCC		2190698
262 (in isoform 1)Ubiquitination-21906983
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MB12A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MB12A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MB12A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TS101_HUMANTSG101physical
20654576
VP37A_HUMANVPS37Aphysical
20654576
CD2AP_HUMANCD2APphysical
20654576
SH3K1_HUMANSH3KBP1physical
20654576
MB12B_HUMANMVB12Bphysical
20654576
CD2AP_HUMANCD2APphysical
16895919
SH3K1_HUMANSH3KBP1physical
16895919
CEP55_HUMANCEP55physical
17853893
CD2AP_HUMANCD2APphysical
17853893
A4_HUMANAPPphysical
21832049
TS101_HUMANTSG101physical
24284069
VP37B_HUMANVPS37Bphysical
24284069
VP37C_HUMANVPS37Cphysical
24284069
ARFP1_HUMANARFIP1physical
26344197
TS101_HUMANTSG101physical
26344197
VPS28_HUMANVPS28physical
26344197
VP37B_HUMANVPS37Bphysical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MB12A_HUMAN

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Related Literatures of Post-Translational Modification

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