| UniProt ID | MB12B_HUMAN | |
|---|---|---|
| UniProt AC | Q9H7P6 | |
| Protein Name | Multivesicular body subunit 12B | |
| Gene Name | MVB12B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 319 | |
| Subcellular Localization |
Endosome . Late endosome membrane Peripheral membrane protein . |
|
| Protein Description | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.. | |
| Protein Sequence | MRSCFCVRRSRDPPPPQPPPPPPQRGTDQSTMPEVKDLSEALPETSMDPITGVGVVASRNRAPTGYDVVAQTADGVDADLWKDGLFKSKVTRYLCFTRSFSKENSHLGNVLVDMKLIDIKDTLPVGFIPIQETVDTQEVAFRKKRLCIKFIPRDSTEAAICDIRIMGRTKQAPPQYTFIGELNSMGIWYRMGRVPRNHDSSQPTTPSQSSAASTPAPNLPRHISLTLPATFRGRNSTRTDYEYQHSNLYAISAMDGVPFMISEKFSCVPESMQPFDLLGITIKSLAEIEKEYEYSFRTEQSAAARLPPSPTRCQQIPQS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 46 | Phosphorylation | SEALPETSMDPITGV HHHCCCCCCCCCCCE | 22817900 | ||
| 47 | Sulfoxidation | EALPETSMDPITGVG HHCCCCCCCCCCCEE | 21406390 | ||
| 64 | Phosphorylation | ASRNRAPTGYDVVAQ EECCCCCCCCCEEEE | 28450419 | ||
| 66 | Phosphorylation | RNRAPTGYDVVAQTA CCCCCCCCCEEEECC | 27282143 | ||
| 72 | Phosphorylation | GYDVVAQTADGVDAD CCCEEEECCCCCCHH | 28450419 | ||
| 91 | Phosphorylation | GLFKSKVTRYLCFTR CCCHHHHHHHHHEEE | 26503514 | ||
| 93 | Phosphorylation | FKSKVTRYLCFTRSF CHHHHHHHHHEEECC | 26503514 | ||
| 99 | Phosphorylation | RYLCFTRSFSKENSH HHHHEEECCCCCCCC | 24719451 | ||
| 101 | Phosphorylation | LCFTRSFSKENSHLG HHEEECCCCCCCCCC | 22817900 | ||
| 102 | Ubiquitination | CFTRSFSKENSHLGN HEEECCCCCCCCCCC | - | ||
| 115 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 115 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 115 | Ubiquitination | GNVLVDMKLIDIKDT CCEEEEEEEEECCCC | 21890473 | ||
| 122 | Phosphorylation | KLIDIKDTLPVGFIP EEEECCCCCCCCEEE | 28450419 | ||
| 149 | Acetylation | RKKRLCIKFIPRDST HCCEEEEEEECCCCC | 25953088 | ||
| 176 | Phosphorylation | TKQAPPQYTFIGELN CCCCCCCEEEEEEEH | - | ||
| 189 | Phosphorylation | LNSMGIWYRMGRVPR EHHCCCEEEECCCCC | - | ||
| 200 | Phosphorylation | RVPRNHDSSQPTTPS CCCCCCCCCCCCCCC | 28450419 | ||
| 201 | Phosphorylation | VPRNHDSSQPTTPSQ CCCCCCCCCCCCCCC | 28787133 | ||
| 204 | Phosphorylation | NHDSSQPTTPSQSSA CCCCCCCCCCCCCCC | 21082442 | ||
| 205 | Phosphorylation | HDSSQPTTPSQSSAA CCCCCCCCCCCCCCC | 21082442 | ||
| 207 | Phosphorylation | SSQPTTPSQSSAAST CCCCCCCCCCCCCCC | 28787133 | ||
| 209 | Phosphorylation | QPTTPSQSSAASTPA CCCCCCCCCCCCCCC | 28464451 | ||
| 210 | Phosphorylation | PTTPSQSSAASTPAP CCCCCCCCCCCCCCC | 28464451 | ||
| 213 | Phosphorylation | PSQSSAASTPAPNLP CCCCCCCCCCCCCCC | 28450419 | ||
| 214 | Phosphorylation | SQSSAASTPAPNLPR CCCCCCCCCCCCCCC | 28450419 | ||
| 224 | Phosphorylation | PNLPRHISLTLPATF CCCCCEEEEEECEEE | 30266825 | ||
| 226 | Phosphorylation | LPRHISLTLPATFRG CCCEEEEEECEEECC | 30266825 | ||
| 230 | Phosphorylation | ISLTLPATFRGRNST EEEEECEEECCCCCC | 29255136 | ||
| 241 | Phosphorylation | RNSTRTDYEYQHSNL CCCCCCCEEEECCCE | 22817900 | ||
| 243 | Phosphorylation | STRTDYEYQHSNLYA CCCCCEEEECCCEEE | 22817900 | ||
| 249 | Phosphorylation | EYQHSNLYAISAMDG EEECCCEEEEECCCC | 22817900 | ||
| 264 | Ubiquitination | VPFMISEKFSCVPES CCEEEECCCCCCCCC | 20654576 | ||
| 264 | Acetylation | VPFMISEKFSCVPES CCEEEECCCCCCCCC | 18530739 | ||
| 290 | Ubiquitination | KSLAEIEKEYEYSFR HHHHHHHHHHCCEEE | 2065457 | ||
| 294 | Phosphorylation | EIEKEYEYSFRTEQS HHHHHHCCEEECCCC | 26074081 | ||
| 295 | Phosphorylation | IEKEYEYSFRTEQSA HHHHHCCEEECCCCH | 26074081 | ||
| 298 | Phosphorylation | EYEYSFRTEQSAAAR HHCCEEECCCCHHHC | 26074081 | ||
| 301 | Phosphorylation | YSFRTEQSAAARLPP CEEECCCCHHHCCCC | 26074081 | ||
| 309 | Phosphorylation | AAARLPPSPTRCQQI HHHCCCCCCCCHHCC | 30266825 | ||
| 311 | Phosphorylation | ARLPPSPTRCQQIPQ HCCCCCCCCHHCCCC | 30266825 | ||
| 319 | Phosphorylation | RCQQIPQS------- CHHCCCCC------- | 26074081 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MB12B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MB12B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MB12B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TS101_HUMAN | TSG101 | physical | 20654576 | |
| VP37A_HUMAN | VPS37A | physical | 20654576 | |
| MB12A_HUMAN | MVB12A | physical | 20654576 | |
| FEM1B_HUMAN | FEM1B | physical | 26186194 | |
| PLCG1_HUMAN | PLCG1 | physical | 26186194 | |
| PLCG1_HUMAN | PLCG1 | physical | 28514442 | |
| FEM1B_HUMAN | FEM1B | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
