dbPTM

IRS4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IRS4_HUMAN
UniProt AC	O14654
Protein Name	Insulin receptor substrate 4
Gene Name	IRS4
Organism	Homo sapiens (Human).
Sequence Length	1257
Subcellular Localization	Cell membrane Peripheral membrane protein Cytoplasmic side .
Protein Description	Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2..
Protein Sequence	MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTATGSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRHSVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMVAENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVKPRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRSTVIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRHLGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGRRSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQEGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGSGGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGSDGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVDRGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPMAPQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYMFMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRGLDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYKIKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYVNVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVIFNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASALAAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGDNQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MASCSFTRDQATRR -CCCCCCCHHHHHHH	19.62	-
62	Phosphorylation	WLSTATGSRSDSESE EECCCCCCCCCCCCC	25.02	22210691
64	Phosphorylation	STATGSRSDSESEEE CCCCCCCCCCCCCCC	47.38	22496350
66	Phosphorylation	ATGSRSDSESEEEDL CCCCCCCCCCCCCCC	44.24	29666759
68	Phosphorylation	GSRSDSESEEEDLPV CCCCCCCCCCCCCCC	55.02	22496350
81	Ubiquitination	PVGEEVCKRGYLRKQ CCCHHHHHHCCHHHC	54.77	32015554
99	Ubiquitination	HRRYFVLKLETADAP CCEEEEEEEEECCCC	38.69	32015554
111	Phosphorylation	DAPARLEYYENARKF CCCHHHHHHHHHHHH	22.22	29978859
112	Phosphorylation	APARLEYYENARKFR CCHHHHHHHHHHHHH	8.04	29978859
202	Ubiquitination	SRLILESKRRRCGTL HHHHHHHHHHHHCCC	40.32	-
208	Phosphorylation	SKRRRCGTLGAQPDG HHHHHHCCCCCCCCC	26.16	22496350
240	Neddylation	DVWQVIVKPRGLGHR HHHHHHCCCCCCCCH	20.20	32015554
240	Ubiquitination	DVWQVIVKPRGLGHR HHHHHHCCCCCCCCH	20.20	22817900
248	Ubiquitination	PRGLGHRKELSGVFR CCCCCCHHHHCCEEE	58.28	-
251	Phosphorylation	LGHRKELSGVFRLCL CCCHHHHCCEEEEEC	33.72	29666759
291	Phosphorylation	RCGHSEQYFFLEVGR HCCCCCEEEEEEECC	7.70	30257219
336	Phosphorylation	RALCADEYRARCRSY HHHHHHHHHHHHHHC	15.32	28509920
342	Phosphorylation	EYRARCRSYSISIGA HHHHHHHHCCCHHHH	27.19	26552605
343	Phosphorylation	YRARCRSYSISIGAH HHHHHHHCCCHHHHH	7.23	26552605
344	Phosphorylation	RARCRSYSISIGAHL HHHHHHCCCHHHHHH	15.88	26552605
346	Phosphorylation	RCRSYSISIGAHLLT HHHHCCCHHHHHHHH	14.72	26552605
353	Phosphorylation	SIGAHLLTLLSARRH HHHHHHHHHHHHHHH	31.82	26552605
356	Phosphorylation	AHLLTLLSARRHLGL HHHHHHHHHHHHHCC	23.89	24719451
375	Phosphorylation	PGGWLRRSRFEQFCH CCCCCHHHHHHHHEE	34.58	22496350
384	Methylation	FEQFCHLRAIGDGED HHHHEEEEEECCCCC	10.65	115480607
398	Methylation	DEMLFTRRFVTPSEP CCEEEEEEECCCCCC	27.59	115480583
401	Phosphorylation	LFTRRFVTPSEPVAH EEEEEECCCCCCCCC	20.56	22496350
403	Phosphorylation	TRRFVTPSEPVAHSR EEEECCCCCCCCCCC	45.20	22496350
409	Phosphorylation	PSEPVAHSRRGRLHL CCCCCCCCCCCCCCC	17.59	22496350
410	Methylation	SEPVAHSRRGRLHLP CCCCCCCCCCCCCCC	34.89	115480575
427	Phosphorylation	RRSRRAVSVPASFFR CCCCCEEECCHHHHH	22.77	29666759
431	Phosphorylation	RAVSVPASFFRRLAP CEEECCHHHHHHHCC	20.88	29978859
439	Phosphorylation	FFRRLAPSPARPRHP HHHHHCCCCCCCCCC	26.11	29666759
442	Methylation	RLAPSPARPRHPAEA HHCCCCCCCCCCCCC	31.97	115480543
444	Methylation	APSPARPRHPAEAPN CCCCCCCCCCCCCCC	42.75	115480551
457	Phosphorylation	PNNGARLSSEVSGSG CCCCCCCCCCCCCCC	20.92	29978859
458	Phosphorylation	NNGARLSSEVSGSGS CCCCCCCCCCCCCCC	46.76	29978859
461	Phosphorylation	ARLSSEVSGSGSGNF CCCCCCCCCCCCCCC	24.16	29978859
463	Phosphorylation	LSSEVSGSGSGNFGE CCCCCCCCCCCCCCC	23.45	29978859
465	Phosphorylation	SEVSGSGSGNFGEEG CCCCCCCCCCCCCCC	32.06	29978859
477	Ubiquitination	EEGNPQGKEDQEGSG CCCCCCCCCCCCCCC	53.52	-
483	Phosphorylation	GKEDQEGSGGDYMPM CCCCCCCCCCCCCCC	38.56	29978859
487	Phosphorylation	QEGSGGDYMPMNNWG CCCCCCCCCCCCCCC	13.34	29978859
495	Phosphorylation	MPMNNWGSGNGRGSG CCCCCCCCCCCCCCC	22.24	26471730
501	Phosphorylation	GSGNGRGSGGGQGSN CCCCCCCCCCCCCCC	32.67	22496350
517	Phosphorylation	QGSSSHSSGGNQCSG CCCCCCCCCCCCCCC	45.34	-
523	Phosphorylation	SSGGNQCSGEGQGSR CCCCCCCCCCCCCCC	30.07	-
552	Phosphorylation	CSRDGQGTAGGHGSG CCCCCCCCCCCCCCC	17.78	29449344
558	Phosphorylation	GTAGGHGSGGGQRPG CCCCCCCCCCCCCCC	28.70	29449344
570	Phosphorylation	RPGGGHGSGGGQGPG CCCCCCCCCCCCCCC	28.70	22496350
582	Phosphorylation	GPGDGHGSGGGKNSG CCCCCCCCCCCCCCC	28.70	26471730
588	Phosphorylation	GSGGGKNSGGGKGSG CCCCCCCCCCCCCCC	42.15	23312004
594	Phosphorylation	NSGGGKGSGSGKGSD CCCCCCCCCCCCCCC	33.02	23312004
596	Phosphorylation	GGGKGSGSGKGSDGD CCCCCCCCCCCCCCC	38.74	23312004
598	Ubiquitination	GKGSGSGKGSDGDGE CCCCCCCCCCCCCCC	57.87	-
618	Ubiquitination	KKRSYFGKLTQSKQQ HHHHHCCCCCCCHHC	38.16	22817900
620	Phosphorylation	RSYFGKLTQSKQQQM HHHCCCCCCCHHCCC	33.99	29978859
622	Phosphorylation	YFGKLTQSKQQQMPP HCCCCCCCHHCCCCC	27.48	29978859
623	Ubiquitination	FGKLTQSKQQQMPPP CCCCCCCHHCCCCCC	42.16	22817900
643	Phosphorylation	PPPPAGGTGGKGKSG CCCCCCCCCCCCCCC	41.67	26471730
646	Ubiquitination	PAGGTGGKGKSGGRF CCCCCCCCCCCCCCE	65.59	21890473
656	Phosphorylation	SGGRFRLYFCVDRGA CCCCEEEEEEEECCC	7.23	30257219
661	Methylation	RLYFCVDRGATKECK EEEEEEECCCCHHHH	19.09	115480559
671	Acetylation	TKECKEAKEVKDAEI CHHHHHHHHHCCCCC	65.22	20167786
671	Ubiquitination	TKECKEAKEVKDAEI CHHHHHHHHHCCCCC	65.22	-
674	Ubiquitination	CKEAKEVKDAEIPEG HHHHHHHCCCCCCCH	52.92	32015554
684	Methylation	EIPEGAARGPHRARA CCCCHHCCCHHHCCC	59.65	115480519
700	Phosphorylation	DEDEDDPYVPMRPGV CCCCCCCCCCCCCCC	24.95	26356563
709	Phosphorylation	PMRPGVATPLVSSSD CCCCCCCCCCCCCCC	18.10	29255136
713	Phosphorylation	GVATPLVSSSDYMPM CCCCCCCCCCCCCCC	31.63	29255136
714	Phosphorylation	VATPLVSSSDYMPMA CCCCCCCCCCCCCCC	21.54	29255136
715	Phosphorylation	ATPLVSSSDYMPMAP CCCCCCCCCCCCCCC	25.84	29255136
717	Phosphorylation	PLVSSSDYMPMAPQN CCCCCCCCCCCCCCC	12.69	29255136
726	Phosphorylation	PMAPQNVSASKKRHS CCCCCCCCCCCCCCC	34.08	29255136
728	Phosphorylation	APQNVSASKKRHSRS CCCCCCCCCCCCCCC	31.07	29255136
729	Ubiquitination	PQNVSASKKRHSRSP CCCCCCCCCCCCCCC	54.25	23503661
730	Ubiquitination	QNVSASKKRHSRSPF CCCCCCCCCCCCCCC	53.50	23503661
733	Phosphorylation	SASKKRHSRSPFEDS CCCCCCCCCCCCCCC	38.19	29449344
735	Phosphorylation	SKKRHSRSPFEDSRG CCCCCCCCCCCCCCC	36.63	29449344
740	Phosphorylation	SRSPFEDSRGYMMMF CCCCCCCCCCCEEEC	22.02	30257219
741	Methylation	RSPFEDSRGYMMMFP CCCCCCCCCCEEECC	53.21	115480591
743	Phosphorylation	PFEDSRGYMMMFPRV CCCCCCCCEEECCCC	4.82	21082442
749	Methylation	GYMMMFPRVSPPPAP CCEEECCCCCCCCCC	30.22	115480527
751	Phosphorylation	MMMFPRVSPPPAPSP EEECCCCCCCCCCCC	32.73	29666759
757	Phosphorylation	VSPPPAPSPPKAPDT CCCCCCCCCCCCCCC	56.81	22496350
764	Phosphorylation	SPPKAPDTNKEDDSK CCCCCCCCCCCCCCC	47.32	22496350
770	Phosphorylation	DTNKEDDSKDNDSES CCCCCCCCCCCCCCC	54.98	26126808
775	Phosphorylation	DDSKDNDSESDYMFM CCCCCCCCCCCCEEE	45.30	29666759
777	Phosphorylation	SKDNDSESDYMFMAP CCCCCCCCCCEEECC	37.68	22496350
779	Phosphorylation	DNDSESDYMFMAPGA CCCCCCCCEEECCCC	11.09	22496350
791	Ubiquitination	PGAGAIPKNPRNPQG CCCCCCCCCCCCCCC	73.75	32015554
803	Ubiquitination	PQGGSSSKSWSSYFS CCCCCCCCCHHHHCC	58.87	22817900
804	Phosphorylation	QGGSSSKSWSSYFSL CCCCCCCCHHHHCCC	33.85	26356563
806	Phosphorylation	GSSSKSWSSYFSLPN CCCCCCHHHHCCCCC	23.42	26356563
807	Phosphorylation	SSSKSWSSYFSLPNP CCCCCHHHHCCCCCC	24.76	26356563
808	Phosphorylation	SSKSWSSYFSLPNPF CCCCHHHHCCCCCCC	7.53	26356563
810	Phosphorylation	KSWSSYFSLPNPFRS CCHHHHCCCCCCCCC	34.38	22496350
817	Phosphorylation	SLPNPFRSSPLGQND CCCCCCCCCCCCCCC	36.37	26356563
818	Phosphorylation	LPNPFRSSPLGQNDN CCCCCCCCCCCCCCC	21.64	26356563
826	Phosphorylation	PLGQNDNSEYVPMLP CCCCCCCCCCCCCCC	32.92	26356563
828	Phosphorylation	GQNDNSEYVPMLPGK CCCCCCCCCCCCCCC	15.07	22496350
835	Neddylation	YVPMLPGKFLGRGLD CCCCCCCCCCCCCCC	35.16	32015554
835	Ubiquitination	YVPMLPGKFLGRGLD CCCCCCCCCCCCCCC	35.16	22817900
839	Methylation	LPGKFLGRGLDKEVS CCCCCCCCCCCCCCC	44.65	115367455
843	Ubiquitination	FLGRGLDKEVSYNWD CCCCCCCCCCCCCCC	66.12	21890473
846	Phosphorylation	RGLDKEVSYNWDPKD CCCCCCCCCCCCHHH	17.53	30257219
847	Phosphorylation	GLDKEVSYNWDPKDA CCCCCCCCCCCHHHC	26.00	30257219
856	Phosphorylation	WDPKDAASKPSGEGS CCHHHCCCCCCCCCC	46.98	19413330
859	Phosphorylation	KDAASKPSGEGSFSK HHCCCCCCCCCCCCC	53.89	22496350
863	Phosphorylation	SKPSGEGSFSKPGDG CCCCCCCCCCCCCCC	23.26	22496350
865	Phosphorylation	PSGEGSFSKPGDGGS CCCCCCCCCCCCCCC	39.37	22496350
866	Ubiquitination	SGEGSFSKPGDGGSP CCCCCCCCCCCCCCC	51.51	-
872	Phosphorylation	SKPGDGGSPSKPSDH CCCCCCCCCCCCCCC	31.37	22496350
874	Phosphorylation	PGDGGSPSKPSDHEP CCCCCCCCCCCCCCC	59.92	22496350
875	Ubiquitination	GDGGSPSKPSDHEPP CCCCCCCCCCCCCCC	52.50	-
877	Phosphorylation	GGSPSKPSDHEPPKN CCCCCCCCCCCCCCC	56.17	22496350
893	Phosphorylation	AKRPNRLSFITKGYK CCCCCCCEEECCCCC	16.03	29978859
896	Phosphorylation	PNRLSFITKGYKIKP CCCCEEECCCCCCCC	19.19	29449344
897	Neddylation	NRLSFITKGYKIKPK CCCEEECCCCCCCCC	56.26	32015554
897	Ubiquitination	NRLSFITKGYKIKPK CCCEEECCCCCCCCC	56.26	22817900
900	Ubiquitination	SFITKGYKIKPKPQK EEECCCCCCCCCCCC	53.58	22817900
902	Ubiquitination	ITKGYKIKPKPQKPT ECCCCCCCCCCCCCC	42.72	22817900
913	Methylation	QKPTHEQREADSSSD CCCCHHHCCCCCCCC	37.78	115480535
917	Phosphorylation	HEQREADSSSDYVNM HHHCCCCCCCCCCCC	38.50	29978859
918	Phosphorylation	EQREADSSSDYVNMD HHCCCCCCCCCCCCC	27.98	26356563
919	Phosphorylation	QREADSSSDYVNMDF HCCCCCCCCCCCCCC	36.59	26356563
921	Phosphorylation	EADSSSDYVNMDFTK CCCCCCCCCCCCCCC	8.82	21082442
927	Phosphorylation	DYVNMDFTKRESNTP CCCCCCCCCCCCCCC	25.57	26356563
928	Ubiquitination	YVNMDFTKRESNTPA CCCCCCCCCCCCCCC	54.91	22817900
931	Phosphorylation	MDFTKRESNTPAPST CCCCCCCCCCCCCCC	50.46	22496350
933	Phosphorylation	FTKRESNTPAPSTQG CCCCCCCCCCCCCCC	30.06	22496350
937	Phosphorylation	ESNTPAPSTQGLPDS CCCCCCCCCCCCCCC	35.15	22496350
938	Phosphorylation	SNTPAPSTQGLPDSW CCCCCCCCCCCCCCC	26.12	22496350
952	Methylation	WGIIAEPRQSAFSNY CCEECCCCCCHHCCC	34.29	115480567
989	Phosphorylation	IPRANPLSLDSARWP CCCCCCCCCCCCCCC	31.24	26471730
1038	Phosphorylation	LADSAIRYDAETGRI HHHHHHEEECCCCCE	17.25	22817900
1046	Phosphorylation	DAETGRIYVVDPFSE ECCCCCEEEECCHHH	7.96	28450419
1052	Phosphorylation	IYVVDPFSECCMDIS EEEECCHHHCEEEEC	34.80	28450419
1059	Phosphorylation	SECCMDISLSPSRCS HHCEEEECCCHHHCC	20.66	23607784
1061	Phosphorylation	CCMDISLSPSRCSEP CEEEECCCHHHCCCC	17.65	28450419
1063	Phosphorylation	MDISLSPSRCSEPPP EEECCCHHHCCCCCH	42.41	24626860
1089	Phosphorylation	RRRPQSRSQSFFAAA HHCCCHHHHHHHHHH	35.11	22496350
1091	Phosphorylation	RPQSRSQSFFAAARA CCCHHHHHHHHHHHH	24.47	29666759
1097	Methylation	QSFFAAARAAVSAFP HHHHHHHHHHHHCCC	20.53	115480599
1105	Phosphorylation	AAVSAFPTDSLERDL HHHHCCCCCCCCCCC	31.59	29978859
1107	Phosphorylation	VSAFPTDSLERDLSP HHCCCCCCCCCCCCC	34.31	19413330
1176	Methylation	AADAEAVRGAQDVAG HHHHHHHCCCCCCCC	41.60	115480615
1185	Phosphorylation	AQDVAGGSNPGAHNP CCCCCCCCCCCCCCC	38.64	26471730
1193	Phosphorylation	NPGAHNPSANLARGD CCCCCCCCCCCCCCC	34.80	26471730
1219	Phosphorylation	APEPPPRSRRVPRPP CCCCCCCCCCCCCCC	30.16	24173317
1231	Phosphorylation	RPPEREDSDNDDDTH CCCCCCCCCCCCCCC	33.29	19413330
1237	Phosphorylation	DSDNDDDTHVRMDFA CCCCCCCCCHHHHHH	29.30	29978859
1252	Phosphorylation	RRDNQFDSPKRGR-- HHCCCCCCCCCCC--	33.34	22496350
1254	Ubiquitination	DNQFDSPKRGR---- CCCCCCCCCCC----	72.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
859	S	Phosphorylation	Kinase	CK1G2	P78368	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IRS4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IRS4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRB2_HUMAN	GRB2	physical	9553137
NISCH_HUMAN	NISCH	physical	11912194
PK3CA_HUMAN	PIK3CA	physical	11912194
HS90A_HUMAN	HSP90AA1	physical	11912194
HSP74_HUMAN	HSPA4	physical	11912194
EGFR_HUMAN	EGFR	physical	16273093
ERBB2_HUMAN	ERBB2	physical	16273093
PPP5_HUMAN	PPP5C	physical	25036637
TEBP_HUMAN	PTGES3	physical	25036637
CYBP_HUMAN	CACYBP	physical	25036637
NISCH_HUMAN	NISCH	physical	25036637
RCN2_HUMAN	RCN2	physical	25036637
RCN1_HUMAN	RCN1	physical	25036637
1433E_HUMAN	YWHAE	physical	25036637
1433B_HUMAN	YWHAB	physical	25036637
WDR6_HUMAN	WDR6	physical	25036637
MAGD1_HUMAN	MAGED1	physical	25036637
P85B_HUMAN	PIK3R2	physical	25036637
1433G_HUMAN	YWHAG	physical	25036637
BIN1_HUMAN	BIN1	physical	25036637
CATB_HUMAN	CTSB	physical	25036637
GBF1_HUMAN	GBF1	physical	25036637
GASP2_HUMAN	GPRASP2	physical	25036637
P4HA1_HUMAN	P4HA1	physical	25036637
P85A_HUMAN	PIK3R1	physical	25036637
P55G_HUMAN	PIK3R3	physical	25036637
TBA1A_HUMAN	TUBA1A	physical	25036637
USP9X_HUMAN	USP9X	physical	25036637
1433F_HUMAN	YWHAH	physical	25036637
RAF1_HUMAN	RAF1	physical	25036637
DNJA2_HUMAN	DNAJA2	physical	25036637
1433T_HUMAN	YWHAQ	physical	25036637
TBB6_HUMAN	TUBB6	physical	25036637
1433Z_HUMAN	YWHAZ	physical	25036637
FKBP5_HUMAN	FKBP5	physical	25036637
TBB4A_HUMAN	TUBB4A	physical	25036637
CALU_HUMAN	CALU	physical	25036637
DNJA3_HUMAN	DNAJA3	physical	25036637
CLPB_HUMAN	CLPB	physical	25036637
P4HA2_HUMAN	P4HA2	physical	25036637
HSPB1_HUMAN	HSPB1	physical	25036637
AKP8L_HUMAN	AKAP8L	physical	25036637
TBL1R_HUMAN	TBL1XR1	physical	25036637
MAGD2_HUMAN	MAGED2	physical	25036637
NECD_HUMAN	NDN	physical	28973533

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IRS4_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-856; SER-859; SER-865;SER-872; SER-874; SER-877; SER-1107; SER-1231 AND THR-1237, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1038, AND MASSSPECTROMETRY.	18083107 [Abstract]
"Tyrosine phosphoproteomics of fibroblast growth factor signaling: arole for insulin receptor substrate-4."; Hinsby A.M., Olsen J.V., Mann M.; J. Biol. Chem. 279:46438-46447(2004). Cited for: PHOSPHORYLATION AT TYR-921, INTERACTION WITH SHC1; GRB2; PHOSPHOLIPASEC-GAMMA AND PHOSPHATIDYLINOSITOL 3-KINASE, AND MASS SPECTROMETRY.	15316024 [Abstract]