RCN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RCN2_HUMAN
• UniProt AC: Q14257
• Protein Name: Reticulocalbin-2
• Gene Name: RCN2
• Organism: Homo sapiens (Human).
• Sequence Length: 317
• Subcellular Localization: Endoplasmic reticulum lumen.
• Protein Description: Not known. Binds calcium..
• Protein Sequence: MRLGPRTAALGLLLLCAAAAGAGKAEELHYPLGERRSDYDREALLGVQEDVDEYVKLGHEEQQKRLQAIIKKIDLDSDGFLTESELSSWIQMSFKHYAMQEAKQQFVEYDKNSDDTVTWDEYNIQMYDRVIDFDENTALDDAEEESFRKLHLKDKKRFEKANQDSGPGLSLEEFIAFEHPEEVDYMTEFVIQEALEEHDKNGDGFVSLEEFLGDYRWDPTANEDPEWILVEKDRFVNDYDKDNDGRLDPQELLPWVVPNNQGIAQEEALHLIDEMDLNGDKKLSEEEILENPDLFLTSEATDYGRQLHDDYFYHDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MRLGPRTAALGLLL -CCCCHHHHHHHHHH	21.29	24719451
30	Phosphorylation	GKAEELHYPLGERRS CCHHHCCCCCCCCCC	16.87	25884760
37	Phosphorylation	YPLGERRSDYDREAL CCCCCCCCCCCHHHH	46.90	29523821
39	Phosphorylation	LGERRSDYDREALLG CCCCCCCCCHHHHHC	20.39	29523821
54	Phosphorylation	VQEDVDEYVKLGHEE CCCCHHHHHHCCHHH	9.83	-
56	Ubiquitination	EDVDEYVKLGHEEQQ CCHHHHHHCCHHHHH	48.09	22817900
56	Ubiquitination	EDVDEYVKLGHEEQQ CCHHHHHHCCHHHHH	48.09	-
64	Ubiquitination	LGHEEQQKRLQAIIK CCHHHHHHHHHHHHH	55.56	22817900
64	2-Hydroxyisobutyrylation	LGHEEQQKRLQAIIK CCHHHHHHHHHHHHH	55.56	-
64	Ubiquitination	LGHEEQQKRLQAIIK CCHHHHHHHHHHHHH	55.56	-
71	Acetylation	KRLQAIIKKIDLDSD HHHHHHHHHCCCCCC	37.25	25953088
71	2-Hydroxyisobutyrylation	KRLQAIIKKIDLDSD HHHHHHHHHCCCCCC	37.25	-
71	Ubiquitination	KRLQAIIKKIDLDSD HHHHHHHHHCCCCCC	37.25	29967540
77	Phosphorylation	IKKIDLDSDGFLTES HHHCCCCCCCCCCHH	47.10	20068231
99	Sulfoxidation	MSFKHYAMQEAKQQF HHHHHHHHHHHHHHH	2.66	30846556
103	Ubiquitination	HYAMQEAKQQFVEYD HHHHHHHHHHHHHCC	43.83	21906983
103	2-Hydroxyisobutyrylation	HYAMQEAKQQFVEYD HHHHHHHHHHHHHCC	43.83	-
103	Ubiquitination	HYAMQEAKQQFVEYD HHHHHHHHHHHHHCC	43.83	-
137	Phosphorylation	VIDFDENTALDDAEE EECCCCCCCCCHHHH	26.92	25849741
146	Phosphorylation	LDDAEEESFRKLHLK CCHHHHHHHHHHHHH	33.36	25159151
149	Ubiquitination	AEEESFRKLHLKDKK HHHHHHHHHHHHHHH	37.94	29967540
156	Ubiquitination	KLHLKDKKRFEKANQ HHHHHHHHHHHHHCC	72.89	24816145
165	Phosphorylation	FEKANQDSGPGLSLE HHHHCCCCCCCCCHH	36.80	24043423
170	Phosphorylation	QDSGPGLSLEEFIAF CCCCCCCCHHHHHHC	39.38	24043423
185	Phosphorylation	EHPEEVDYMTEFVIQ CCHHHCCHHHHHHHH	15.88	24043423
187	Phosphorylation	PEEVDYMTEFVIQEA HHHCCHHHHHHHHHH	21.75	24275569
207	Phosphorylation	KNGDGFVSLEEFLGD CCCCCEECHHHHHCC	28.00	29507054
225	Phosphorylation	DPTANEDPEWILVEK CCCCCCCCCEEEEEC	32.42	32142685
232	Ubiquitination	PEWILVEKDRFVNDY CCEEEEECCCCCCCC	46.88	22817900
241	Ubiquitination	RFVNDYDKDNDGRLD CCCCCCCCCCCCCCC	52.80	24816145
241	2-Hydroxyisobutyrylation	RFVNDYDKDNDGRLD CCCCCCCCCCCCCCC	52.80	-
250	Ubiquitination	NDGRLDPQELLPWVV CCCCCCHHHHCCEEC	54.35	-
250	Ubiquitination	NDGRLDPQELLPWVV CCCCCCHHHHCCEEC	54.35	22817900
259	Ubiquitination	LLPWVVPNNQGIAQE HCCEECCCCCCCCHH	41.67	24816145
281	Ubiquitination	EMDLNGDKKLSEEEI HCCCCCCCCCCHHHH	57.94	23503661
282	Ubiquitination	MDLNGDKKLSEEEIL CCCCCCCCCCHHHHH	63.08	23503661
284	Phosphorylation	LNGDKKLSEEEILEN CCCCCCCCHHHHHHC	52.41	27732954
299	Ubiquitination	PDLFLTSEATDYGRQ CCEEECCCCCHHHHH	50.80	23503661
300	Ubiquitination	DLFLTSEATDYGRQL CEEECCCCCHHHHHC	12.92	23503661
311	Phosphorylation	GRQLHDDYFYHDEL- HHHCCCCCCCCCCC-	16.46	25884760
313	Phosphorylation	QLHDDYFYHDEL--- HCCCCCCCCCCC---	11.35	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RCN2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RCN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RCN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SFXN1_HUMAN	SFXN1	physical	22939629
XPO1_HUMAN	XPO1	physical	21988832
HD_HUMAN	HTT	physical	22863883

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.