dbPTM

RHG32_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RHG32_HUMAN
UniProt AC	A7KAX9
Protein Name	Rho GTPase-activating protein 32
Gene Name	ARHGAP32
Organism	Homo sapiens (Human).
Sequence Length	2087
Subcellular Localization	Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell projection, dendritic spine . Cytoplasm, cell cortex . Endosome membrane . Golgi apparatus membrane . Endoplasmic reticulum membrane . Membrane . Association to membrane
Protein Description	GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity)..
Protein Sequence	METESESSTLGDDSVFWLESEVIIQVTDCEEEEREEKFRKMKSSVHSEEDDFVPELHRNVHPRERPDWEETLSAMARGADVPEIPGDLTLKTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQGKSWIVKRSYEDFRVLDKHLHLCIYDRRFSQLSELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWMEIDNKGNHLLVHEESSINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQVGLFPGHCVELINQKVPQSVTNSVPKPVSKKHGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKSLLVSSPSTKLLTLEEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKRPQNKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEESLTSLHAVDGDSKLFRPRRPRSSSDALSASFNGEMLGNRCNSYDNLPHDNESEEEGGLLHIPALMSPHSAEDVDLSPPDIGVASLDFDPMSFQCSPPKAESECLESGASFLDSPGYSKDKPSANKKDAETGSSQCQTPGSTASSEPVSPLQEKLSPFFTLDLSPTEDKSSKPSSFTEKVVYAFSPKIGRKLSKSPSMSISEPISVTLPPRVSEVIGTVSNTTAQNASSSTWDKCVEERDATNRSPTQIVKMKTNETVAQEAYESEVQPLDQVAAEEVELPGKEDQSVSSSQSKAVASGQTQTGAVTHDPPQDSVPVSSVSLIPPPPPPKNVARMLALALAESAQQASTQSLKRPGTSQAGYTNYGDIAVATTEDNLSSSYSAVALDKAYFQTDRPAEQFHLQNNAPGNCDHPLPETTATGDPTHSNTTESGEQHHQVDLTGNQPHQAYLSGDPEKARITSVPLDSEKSDDHVSFPEDQSGKNSMPTVSFLDQDQSPPRFYSGDQPPSYLGASVDKLHHPLEFADKSPTPPNLPSDKIYPPSGSPEENTSTATMTYMTTTPATAQMSTKEASWDVAEQPTTADFAAATLQRTHRTNRPLPPPPSQRSAEQPPVVGQVQAATNIGLNNSHKVQGVVPVPERPPEPRAMDDPASAFISDSGAAAAQCPMATAVQPGLPEKVRDGARVPLLHLRAESVPAHPCGFPAPLPPTRMMESKMIAAIHSSSADATSSSNYHSFVTASSTSVDDALPLPLPVPQPKHASQKTVYSSFARPDVTTEPFGPDNCLHFNMTPNCQYRPQSVPPHHNKLEQHQVYGARSEPPASMGLRYNTYVAPGRNASGHHSKPCSRVEYVSSLSSSVRNTCYPEDIPPYPTIRRVQSLHAPPSSMIRSVPISRTEVPPDDEPAYCPRPLYQYKPYQSSQARSDYHVTQLQPYFENGRVHYRYSPYSSSSSSYYSPDGALCDVDAYGTVQLRPLHRLPNRDFAFYNPRLQGKSLYSYAGLAPRPRANVTGYFSPNDHNVVSMPPAADVKHTYTSWDLEDMEKYRMQSIRRESRARQKVKGPVMSQYDNMTPAVQDDLGGIYVIHLRSKSDPGKTGLLSVAEGKESRHAAKAISPEGEDRFYRRHPEAEMDRAHHHGGHGSTQPEKPSLPQKQSSLRSRKLPDMGCSLPEHRAHQEASHRQFCESKNGPPYPQGAGQLDYGSKGIPDTSEPVSYHNSGVKYAASGQESLRLNHKEVRLSKEMERPWVRQPSAPEKHSRDCYKEEEHLTQSIVPPPKPERSHSLKLHHTQNVERDPSVLYQYQPHGKRQSSVTVVSQYDNLEDYHSLPQHQRGVFGGGGMGTYVPPGFPHPQSRTYATALGQGAFLPAELSLQHPETQIHAE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	EKFRKMKSSVHSEED HHHHHHHHHHHCCCC	33.81	23927012
44	Phosphorylation	KFRKMKSSVHSEEDD HHHHHHHHHHCCCCC	20.52	23927012
47	Phosphorylation	KMKSSVHSEEDDFVP HHHHHHHCCCCCCHH	40.29	25849741
89	Phosphorylation	PEIPGDLTLKTCGST CCCCCCEEEEECCCC	30.83	-
95	Phosphorylation	LTLKTCGSTASMKVK EEEEECCCCCEEEEE	23.97	28348404
125	Phosphorylation	AECAHFHYENVEFGS HHCEEEEEECEEECE	14.30	22210691
132	Phosphorylation	YENVEFGSIQLSLSE EECEEECEEEEECCH	16.69	22210691
136	Phosphorylation	EFGSIQLSLSEEQNE EECEEEEECCHHHHH	17.30	22210691
156	Phosphorylation	CESKELVYLVQIACQ CCCHHHHHHEEHHHC	17.49	26074081
193	Phosphorylation	CIYDRRFSQLSELPR EEECCCHHHHHCCCC	28.53	29116813
196	Phosphorylation	DRRFSQLSELPRSDT CCCHHHHHCCCCCCC	29.47	29116813
201	Phosphorylation	QLSELPRSDTLKDSP HHHCCCCCCCCCCCH	32.76	29116813
207	Phosphorylation	RSDTLKDSPESVTQM CCCCCCCCHHHHHHH	29.04	29116813
328	Phosphorylation	QKVPQSVTNSVPKPV CCCCHHHHCCCCCCC	27.33	25599653
514	Phosphorylation	LADYCSITNMHAKNL HHHHHHCCHHHHHCE	15.36	-
537	Phosphorylation	LRSKQIESACFSGTA HCHHHHHHHHHCCCH	31.78	22468782
568	Phosphorylation	NHVDVLFSGRISMAM HHCHHHHHCHHHHHH	24.01	24719451
572	Phosphorylation	VLFSGRISMAMQEGA HHHHCHHHHHHHHHH	10.10	29255136
581	Phosphorylation	AMQEGAASLSRPKSL HHHHHHHHCCCCHHE	26.75	27174698
583	Phosphorylation	QEGAASLSRPKSLLV HHHHHHCCCCHHEEE	44.00	27174698
587	Phosphorylation	ASLSRPKSLLVSSPS HHCCCCHHEEECCCC	29.62	30266825
591	Phosphorylation	RPKSLLVSSPSTKLL CCHHEEECCCCCCEE	36.18	30266825
592	Phosphorylation	PKSLLVSSPSTKLLT CHHEEECCCCCCEEE	18.52	30266825
594	Phosphorylation	SLLVSSPSTKLLTLE HEEECCCCCCEEEHH	39.87	30266825
595	Phosphorylation	LLVSSPSTKLLTLEE EEECCCCCCEEEHHH	29.15	30266825
607	Phosphorylation	LEEAQARTQAQVNSP HHHHHHHHHHHCCCC	31.13	28102081
613	Phosphorylation	RTQAQVNSPIVTENK HHHHHCCCCCEECCC	19.69	25159151
617	Phosphorylation	QVNSPIVTENKYIEV HCCCCCEECCCEEEE	34.26	28796482
621	Phosphorylation	PIVTENKYIEVGEGP CCEECCCEEEECCCC	17.56	28796482
655	Phosphorylation	PQNKMKKSPVGSWRS CCCCCCCCCCCCHHH	21.21	20363803
659	Phosphorylation	MKKSPVGSWRSFFNL CCCCCCCCHHHHHHC	21.39	22617229
662	Phosphorylation	SPVGSWRSFFNLGKS CCCCCHHHHHHCCCC	28.12	26552605
669	Phosphorylation	SFFNLGKSSSVSKRK HHHHCCCCCHHHHHH	26.50	26552605
670	Phosphorylation	FFNLGKSSSVSKRKL HHHCCCCCHHHHHHH	37.94	26552605
671	Phosphorylation	FNLGKSSSVSKRKLQ HHCCCCCHHHHHHHC	37.18	26552605
673	Phosphorylation	LGKSSSVSKRKLQRN CCCCCHHHHHHHCCC	28.79	26552605
674	Acetylation	GKSSSVSKRKLQRNE CCCCHHHHHHHCCCC	51.93	12433347
682	Phosphorylation	RKLQRNESEPSEMKA HHHCCCCCCCHHHHH	59.36	23401153
685	Phosphorylation	QRNESEPSEMKAMAL CCCCCCCHHHHHHHH	46.39	30576142
688	Acetylation	ESEPSEMKAMALKGG CCCCHHHHHHHHHCC	30.84	20167786
700	Phosphorylation	KGGRAEGTLRSAKSE HCCCCCCCCCCCCCH	15.54	25921289
703	Phosphorylation	RAEGTLRSAKSEESL CCCCCCCCCCCHHHC	43.06	23927012
706	Phosphorylation	GTLRSAKSEESLTSL CCCCCCCCHHHCHHE	46.44	29255136
709	Phosphorylation	RSAKSEESLTSLHAV CCCCCHHHCHHEEEC	32.66	29255136
711	Phosphorylation	AKSEESLTSLHAVDG CCCHHHCHHEEECCC	38.22	29255136
712	Phosphorylation	KSEESLTSLHAVDGD CCHHHCHHEEECCCC	24.37	29255136
720	Phosphorylation	LHAVDGDSKLFRPRR EEECCCCCCCCCCCC	36.47	23403867
730	Phosphorylation	FRPRRPRSSSDALSA CCCCCCCCCCCCCHH	36.56	22777824
731	Phosphorylation	RPRRPRSSSDALSAS CCCCCCCCCCCCHHH	33.25	30243723
732	Phosphorylation	PRRPRSSSDALSASF CCCCCCCCCCCHHHC	28.31	30278072
736	Phosphorylation	RSSSDALSASFNGEM CCCCCCCHHHCCCCC	24.48	23090842
738	Phosphorylation	SSDALSASFNGEMLG CCCCCHHHCCCCCCC	18.83	22617229
750	Phosphorylation	MLGNRCNSYDNLPHD CCCCCCCCCCCCCCC	37.17	-
814	Phosphorylation	AESECLESGASFLDS HHHHHHHCCCCHHCC	27.06	28102081
817	Phosphorylation	ECLESGASFLDSPGY HHHHCCCCHHCCCCC	29.84	28102081
821	Phosphorylation	SGASFLDSPGYSKDK CCCCHHCCCCCCCCC	23.52	26657352
824	Phosphorylation	SFLDSPGYSKDKPSA CHHCCCCCCCCCCCC	18.87	22468782
825	Phosphorylation	FLDSPGYSKDKPSAN HHCCCCCCCCCCCCC	40.05	28102081
838	Phosphorylation	ANKKDAETGSSQCQT CCHHCCCCCCCCCCC	44.05	23403867
840	Phosphorylation	KKDAETGSSQCQTPG HHCCCCCCCCCCCCC	25.34	23403867
841	Phosphorylation	KDAETGSSQCQTPGS HCCCCCCCCCCCCCC	36.00	23403867
845	Phosphorylation	TGSSQCQTPGSTASS CCCCCCCCCCCCCCC	36.92	23403867
848	Phosphorylation	SQCQTPGSTASSEPV CCCCCCCCCCCCCCC	23.23	23403867
849	Phosphorylation	QCQTPGSTASSEPVS CCCCCCCCCCCCCCC	36.15	23403867
851	Phosphorylation	QTPGSTASSEPVSPL CCCCCCCCCCCCCHH	35.01	23403867
852	Phosphorylation	TPGSTASSEPVSPLQ CCCCCCCCCCCCHHH	43.38	23927012
856	Phosphorylation	TASSEPVSPLQEKLS CCCCCCCCHHHHHCC	30.52	30278072
863	Phosphorylation	SPLQEKLSPFFTLDL CHHHHHCCCCEEEEC	30.63	23403867
867	Phosphorylation	EKLSPFFTLDLSPTE HHCCCCEEEECCCCC	21.53	26657352
871	Phosphorylation	PFFTLDLSPTEDKSS CCEEEECCCCCCCCC	29.46	28355574
873	Phosphorylation	FTLDLSPTEDKSSKP EEEECCCCCCCCCCC	54.14	28176443
877	Phosphorylation	LSPTEDKSSKPSSFT CCCCCCCCCCCCCCC	56.78	23312004
878	Phosphorylation	SPTEDKSSKPSSFTE CCCCCCCCCCCCCCH	55.09	23312004
881	Phosphorylation	EDKSSKPSSFTEKVV CCCCCCCCCCCHHHH	41.65	23312004
882	Phosphorylation	DKSSKPSSFTEKVVY CCCCCCCCCCHHHHE	44.72	23312004
884	Phosphorylation	SSKPSSFTEKVVYAF CCCCCCCCHHHHEEE	36.52	23312004
889	Phosphorylation	SFTEKVVYAFSPKIG CCCHHHHEEECHHHC	12.62	23927012
892	Phosphorylation	EKVVYAFSPKIGRKL HHHHEEECHHHCCCC	19.67	19664994
902	Phosphorylation	IGRKLSKSPSMSISE HCCCCCCCCCCCCCC	20.87	22777824
904	Phosphorylation	RKLSKSPSMSISEPI CCCCCCCCCCCCCCE	32.05	29496963
906	Phosphorylation	LSKSPSMSISEPISV CCCCCCCCCCCCEEE	27.57	26074081
908	Phosphorylation	KSPSMSISEPISVTL CCCCCCCCCCEEEEC	29.97	26074081
912	Phosphorylation	MSISEPISVTLPPRV CCCCCCEEEECCCCH	21.55	26074081
914	Phosphorylation	ISEPISVTLPPRVSE CCCCEEEECCCCHHH	27.10	26074081
920	Phosphorylation	VTLPPRVSEVIGTVS EECCCCHHHEEEECC	27.68	29083192
925	Phosphorylation	RVSEVIGTVSNTTAQ CHHHEEEECCCCCCC	15.05	29083192
927	Phosphorylation	SEVIGTVSNTTAQNA HHEEEECCCCCCCCC	28.44	29083192
929	Phosphorylation	VIGTVSNTTAQNASS EEEECCCCCCCCCCC	18.92	29083192
930	Phosphorylation	IGTVSNTTAQNASSS EEECCCCCCCCCCCC	30.42	29083192
935	Phosphorylation	NTTAQNASSSTWDKC CCCCCCCCCCCHHHH	32.16	29083192
936	Phosphorylation	TTAQNASSSTWDKCV CCCCCCCCCCHHHHH	29.40	29083192
937	Phosphorylation	TAQNASSSTWDKCVE CCCCCCCCCHHHHHH	30.90	29083192
938	Phosphorylation	AQNASSSTWDKCVEE CCCCCCCCHHHHHHH	39.36	29083192
949	Phosphorylation	CVEERDATNRSPTQI HHHHHCCCCCCCCEE	35.14	28387310
952	Phosphorylation	ERDATNRSPTQIVKM HHCCCCCCCCEEEEC	34.08	30266825
954	Phosphorylation	DATNRSPTQIVKMKT CCCCCCCCEEEECCC	31.97	30266825
961	Phosphorylation	TQIVKMKTNETVAQE CEEEECCCCHHHHHH	34.49	26074081
970	Phosphorylation	ETVAQEAYESEVQPL HHHHHHHHHCCCCCH	21.16	27642862
1069	Phosphorylation	PGTSQAGYTNYGDIA CCCCCCCCCCCCCEE	8.53	-
1085	Phosphorylation	ATTEDNLSSSYSAVA EECCCCCCCCCEEHE	24.40	28348404
1086	Phosphorylation	TTEDNLSSSYSAVAL ECCCCCCCCCEEHEE	36.14	28348404
1087	Phosphorylation	TEDNLSSSYSAVALD CCCCCCCCCEEHEEC	21.52	28348404
1088	Phosphorylation	EDNLSSSYSAVALDK CCCCCCCCEEHEECH	11.55	27259358
1089	Phosphorylation	DNLSSSYSAVALDKA CCCCCCCEEHEECHH	20.43	28348404
1097	Phosphorylation	AVALDKAYFQTDRPA EHEECHHHHCCCCCH	11.27	-
1168	Phosphorylation	PEKARITSVPLDSEK HHHCEEEECCCCCCC	21.26	22985185
1181	Phosphorylation	EKSDDHVSFPEDQSG CCCCCCCCCCCCCCC	31.50	23312004
1194	Phosphorylation	SGKNSMPTVSFLDQD CCCCCCCCEEEECCC	21.82	28102081
1196	Phosphorylation	KNSMPTVSFLDQDQS CCCCCCEEEECCCCC	23.67	28102081
1203	Phosphorylation	SFLDQDQSPPRFYSG EEECCCCCCCCCCCC	45.20	29255136
1208	Phosphorylation	DQSPPRFYSGDQPPS CCCCCCCCCCCCCCH	17.02	28102081
1209	Phosphorylation	QSPPRFYSGDQPPSY CCCCCCCCCCCCCHH	32.93	29802988
1215	Phosphorylation	YSGDQPPSYLGASVD CCCCCCCHHCCCCHH	39.41	24719451
1216	Phosphorylation	SGDQPPSYLGASVDK CCCCCCHHCCCCHHC	18.22	-
1220	Phosphorylation	PPSYLGASVDKLHHP CCHHCCCCHHCCCCC	29.11	29496963
1234	Phosphorylation	PLEFADKSPTPPNLP CCHHCCCCCCCCCCC	34.26	25159151
1236	Phosphorylation	EFADKSPTPPNLPSD HHCCCCCCCCCCCCC	59.47	27134283
1242	Phosphorylation	PTPPNLPSDKIYPPS CCCCCCCCCCCCCCC	55.49	27732954
1249	Phosphorylation	SDKIYPPSGSPEENT CCCCCCCCCCCCCCC	47.61	28348404
1251	Phosphorylation	KIYPPSGSPEENTST CCCCCCCCCCCCCCE	33.21	28348404
1256	Phosphorylation	SGSPEENTSTATMTY CCCCCCCCCEEEEEE	30.63	28348404
1263	Phosphorylation	TSTATMTYMTTTPAT CCEEEEEEEECCCCE	5.01	25332170
1270	Phosphorylation	YMTTTPATAQMSTKE EEECCCCEECCCCCC	20.73	25332170
1311	Phosphorylation	RPLPPPPSQRSAEQP CCCCCCCCCCCCCCC	43.96	-
1314	Phosphorylation	PPPPSQRSAEQPPVV CCCCCCCCCCCCCCC	28.64	-
1401	Phosphorylation	LLHLRAESVPAHPCG EEEEECCCCCCCCCC	32.20	29802988
1435	Phosphorylation	HSSSADATSSSNYHS HHCCCCCCCCCCCCC	29.68	-
1440	Phosphorylation	DATSSSNYHSFVTAS CCCCCCCCCCEEEEC	10.78	-
1445	Phosphorylation	SNYHSFVTASSTSVD CCCCCEEEECCCCCC	20.86	-
1449	Phosphorylation	SFVTASSTSVDDALP CEEEECCCCCCCCCC	30.21	-
1473	Phosphorylation	HASQKTVYSSFARPD CCCCCCCCCCCCCCC	12.11	-
1520	Phosphorylation	KLEQHQVYGARSEPP CCCCCCCCCCCCCCC	9.86	25884760
1523	Asymmetric dimethylarginine	QHQVYGARSEPPASM CCCCCCCCCCCCCCC	36.87	-
1523	Methylation	QHQVYGARSEPPASM CCCCCCCCCCCCCCC	36.87	-
1533	Asymmetric dimethylarginine	PPASMGLRYNTYVAP CCCCCCCEEEEEECC	19.54	-
1533	Methylation	PPASMGLRYNTYVAP CCCCCCCEEEEEECC	19.54	-
1534	Phosphorylation	PASMGLRYNTYVAPG CCCCCCEEEEEECCC	19.52	-
1536	Phosphorylation	SMGLRYNTYVAPGRN CCCCEEEEEECCCCC	15.50	28796482
1537	Phosphorylation	MGLRYNTYVAPGRNA CCCEEEEEECCCCCC	7.32	28796482
1557	Phosphorylation	KPCSRVEYVSSLSSS CCCCCCHHHHHCCHH	11.63	25394399
1559	Phosphorylation	CSRVEYVSSLSSSVR CCCCHHHHHCCHHHC	25.35	21722762
1560	Phosphorylation	SRVEYVSSLSSSVRN CCCHHHHHCCHHHCC	23.40	28857561
1562	Phosphorylation	VEYVSSLSSSVRNTC CHHHHHCCHHHCCCC	23.63	24719451
1563	Phosphorylation	EYVSSLSSSVRNTCY HHHHHCCHHHCCCCC	37.84	28348404
1564	Phosphorylation	YVSSLSSSVRNTCYP HHHHCCHHHCCCCCC	23.01	21815630
1577	Phosphorylation	YPEDIPPYPTIRRVQ CCCCCCCCCCHHHHH	13.98	-
1579	Phosphorylation	EDIPPYPTIRRVQSL CCCCCCCCHHHHHCC	22.67	-
1585	Phosphorylation	PTIRRVQSLHAPPSS CCHHHHHCCCCCCHH	21.18	22617229
1596	Phosphorylation	PPSSMIRSVPISRTE CCHHHCCCCCCCCCC	22.71	26699800
1600	Phosphorylation	MIRSVPISRTEVPPD HCCCCCCCCCCCCCC	27.38	-
1602	Phosphorylation	RSVPISRTEVPPDDE CCCCCCCCCCCCCCC	34.25	22210691
1612	Phosphorylation	PPDDEPAYCPRPLYQ CCCCCCCCCCCCCCC	17.44	27259358
1630	Phosphorylation	YQSSQARSDYHVTQL CCCCCCCCCCEEEEE	45.60	26356563
1632	Phosphorylation	SSQARSDYHVTQLQP CCCCCCCCEEEEEEH	10.23	26356563
1635	Phosphorylation	ARSDYHVTQLQPYFE CCCCCEEEEEEHHEE	15.39	-
1653	Phosphorylation	VHYRYSPYSSSSSSY EEEEECCCCCCCCCC	18.42	-
1660	Phosphorylation	YSSSSSSYYSPDGAL CCCCCCCCCCCCCCC	15.20	-
1673	Phosphorylation	ALCDVDAYGTVQLRP CCCCCCCCCEEEEEE	14.63	27259358
1675	Phosphorylation	CDVDAYGTVQLRPLH CCCCCCCEEEEEECC	7.75	27259358
1692	Phosphorylation	PNRDFAFYNPRLQGK CCCCCCEECCCCCCC	22.34	27642862
1695	Methylation	DFAFYNPRLQGKSLY CCCEECCCCCCCCHH	35.69	-
1699	Ubiquitination	YNPRLQGKSLYSYAG ECCCCCCCCHHHCCC	25.07	-
1700	Phosphorylation	NPRLQGKSLYSYAGL CCCCCCCCHHHCCCC	39.09	27251275
1702	Phosphorylation	RLQGKSLYSYAGLAP CCCCCCHHHCCCCCC	13.51	21609022
1703	Phosphorylation	LQGKSLYSYAGLAPR CCCCCHHHCCCCCCC	17.50	27273156
1704	Phosphorylation	QGKSLYSYAGLAPRP CCCCHHHCCCCCCCC	7.36	21609022
1716	Phosphorylation	PRPRANVTGYFSPND CCCCCCCCEEECCCC	26.43	26356563
1718	Phosphorylation	PRANVTGYFSPNDHN CCCCCCEEECCCCCC	7.48	26356563
1720	Phosphorylation	ANVTGYFSPNDHNVV CCCCEEECCCCCCCC	17.82	-
1739	Phosphorylation	AADVKHTYTSWDLED CCCCCCEEECCCHHH	9.86	27259358
1750	Phosphorylation	DLEDMEKYRMQSIRR CHHHHHHHHHHHHHH	9.67	23882029
1754	Phosphorylation	MEKYRMQSIRRESRA HHHHHHHHHHHHHHH	14.55	24719451
1759	Phosphorylation	MQSIRRESRARQKVK HHHHHHHHHHHHHCC	29.45	23882029
1771	Phosphorylation	KVKGPVMSQYDNMTP HCCCCHHHCCCCCCH	26.31	27642862
1773	Phosphorylation	KGPVMSQYDNMTPAV CCCHHHCCCCCCHHH	11.28	27642862
1777	Phosphorylation	MSQYDNMTPAVQDDL HHCCCCCCHHHHCCC	17.85	27642862
1788	Phosphorylation	QDDLGGIYVIHLRSK HCCCCCEEEEEEEEC	9.16	27259358
1794	Phosphorylation	IYVIHLRSKSDPGKT EEEEEEEECCCCCCC	42.76	23927012
1796	Phosphorylation	VIHLRSKSDPGKTGL EEEEEECCCCCCCCC	50.73	28464451
1801	Phosphorylation	SKSDPGKTGLLSVAE ECCCCCCCCCEEHHC	38.69	23312004
1805	Phosphorylation	PGKTGLLSVAEGKES CCCCCCEEHHCCCCC	25.07	23312004
1810	Ubiquitination	LLSVAEGKESRHAAK CEEHHCCCCCHHHHH	43.98	-
1820	Phosphorylation	RHAAKAISPEGEDRF HHHHHHCCCCCCCCH	23.04	25159151
1828	Phosphorylation	PEGEDRFYRRHPEAE CCCCCCHHHHCCHHH	13.97	-
1854	Phosphorylation	STQPEKPSLPQKQSS CCCCCCCCCCHHHHH	64.84	24275569
1873	Phosphorylation	KLPDMGCSLPEHRAH CCCCCCCCCCHHHHH	41.03	24114839
1884	Phosphorylation	HRAHQEASHRQFCES HHHHHHHHHHHHHHH	20.60	-
1897	Phosphorylation	ESKNGPPYPQGAGQL HHCCCCCCCCCCCCC	16.01	-
1914	Phosphorylation	GSKGIPDTSEPVSYH CCCCCCCCCCCCEEC	29.63	21406692
1915	Phosphorylation	SKGIPDTSEPVSYHN CCCCCCCCCCCEECC	47.48	21406692
1919	Phosphorylation	PDTSEPVSYHNSGVK CCCCCCCEECCCCCE	31.24	21406692
1920	Phosphorylation	DTSEPVSYHNSGVKY CCCCCCEECCCCCEE	12.78	21406692
1923	Phosphorylation	EPVSYHNSGVKYAAS CCCEECCCCCEEECC	31.48	21406692
1927	Phosphorylation	YHNSGVKYAASGQES ECCCCCEEECCCCHH	12.66	-
1930	Phosphorylation	SGVKYAASGQESLRL CCCEEECCCCHHHHC	32.60	25056879
1934	Phosphorylation	YAASGQESLRLNHKE EECCCCHHHHCCCCH	15.76	25056879
1957	Phosphorylation	RPWVRQPSAPEKHSR CCCCCCCCCCCCCCC	48.38	28102081
1986	Phosphorylation	PPPKPERSHSLKLHH CCCCCCCCCCCCEEE	18.76	24719451
1988	Phosphorylation	PKPERSHSLKLHHTQ CCCCCCCCCCEEECC	28.57	23312004
1994	Phosphorylation	HSLKLHHTQNVERDP CCCCEEECCCCCCCC	15.87	23312004
2005	Phosphorylation	ERDPSVLYQYQPHGK CCCCCHHEEECCCCC	11.74	27642862
2007	Phosphorylation	DPSVLYQYQPHGKRQ CCCHHEEECCCCCCC	15.51	27642862
2015	Phosphorylation	QPHGKRQSSVTVVSQ CCCCCCCCEEEEEEE	30.70	26356563
2016	Phosphorylation	PHGKRQSSVTVVSQY CCCCCCCEEEEEEEC	17.30	26356563
2018	Phosphorylation	GKRQSSVTVVSQYDN CCCCCEEEEEEECCC	19.69	26356563
2021	Phosphorylation	QSSVTVVSQYDNLED CCEEEEEEECCCHHH	20.77	26356563
2023	Phosphorylation	SVTVVSQYDNLEDYH EEEEEEECCCHHHHH	10.17	21609022
2029	Phosphorylation	QYDNLEDYHSLPQHQ ECCCHHHHHCCCHHH	5.50	21609022
2031	Phosphorylation	DNLEDYHSLPQHQRG CCHHHHHCCCHHHCC	35.20	26356563
2037	Methylation	HSLPQHQRGVFGGGG HCCCHHHCCCCCCCC	40.91	-
2047	Phosphorylation	FGGGGMGTYVPPGFP CCCCCCCCCCCCCCC	16.68	21945579
2048	Phosphorylation	GGGGMGTYVPPGFPH CCCCCCCCCCCCCCC	12.77	21945579
2058	Phosphorylation	PGFPHPQSRTYATAL CCCCCCCCCCCHHHH	30.92	21945579
2060	Phosphorylation	FPHPQSRTYATALGQ CCCCCCCCCHHHHCC	23.82	-
2061	Phosphorylation	PHPQSRTYATALGQG CCCCCCCCHHHHCCC	10.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RHG32_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RHG32_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RHG32_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NMDE2_HUMAN	GRIN2B	physical	12857875
RHOA_HUMAN	RHOA	physical	12857875
CDC42_HUMAN	CDC42	physical	12857875
GAB2_HUMAN	GAB2	physical	12819203
GAB1_HUMAN	GAB1	physical	12819203
RAC1_HUMAN	RAC1	physical	12819203
CDC42_HUMAN	CDC42	physical	12819203
NCK1_HUMAN	NCK1	physical	12819203
CRK_HUMAN	CRK	physical	12819203
BCAR1_HUMAN	BCAR1	physical	12819203
FYN_HUMAN	FYN	physical	12788081
NTRK1_HUMAN	NTRK1	physical	12446789
CRKL_HUMAN	CRKL	physical	12446789
BCAR1_HUMAN	BCAR1	physical	12446789
CDC42_HUMAN	CDC42	physical	12446789
RHOA_HUMAN	RHOA	physical	12446789
SHC2_HUMAN	SHC2	physical	12446789
SHC3_HUMAN	SHC3	physical	12446789
RHOA_HUMAN	RHOA	physical	12454018
RAC1_HUMAN	RAC1	physical	12454018
SRC_HUMAN	SRC	physical	12454018
CRK_HUMAN	CRK	physical	12454018
PLCG1_HUMAN	PLCG1	physical	12454018
P85A_HUMAN	PIK3R1	physical	12454018
NPHP1_HUMAN	NPHP1	physical	18477472
FZR1_HUMAN	FZR1	physical	23226367
SMUF1_HUMAN	SMURF1	physical	23226367
ABI2_HUMAN	ABI2	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956
RAC1_HUMAN	RAC1	physical	12446789
EGFR_HUMAN	EGFR	physical	12446789
SHC1_HUMAN	SHC1	physical	12446789

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RHG32_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-892 AND SER-1203, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-613; SER-856 ANDSER-871, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1236, AND MASSSPECTROMETRY.	18691976 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1557, AND MASSSPECTROMETRY.	19534553 [Abstract]