SHC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHC2_HUMAN
• UniProt AC: P98077
• Protein Name: SHC-transforming protein 2
• Gene Name: SHC2
• Organism: Homo sapiens (Human).
• Sequence Length: 582
• Protein Description: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity)..
• Protein Sequence: MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAPCPLPALSRCRGAGSRGSRGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSMRSLDFNTRTQVTREAINRLHEAVPGVRGSWKKKAPNKALASVLGKSNLRFAGMSISIHISTDGLSLSVPATRQVIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSIISTVGQAFELRFKQYLHSPPKVALPPERLAGPEESAWGDEEDSLEHNYYNSIPGKEPPLGGLVDSRLALTQPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGLDAPEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSREP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
157	Phosphorylation	GVSYVVRYMGCIEVL CHHHHHHHHHHHHHH	6.05	24719451
166	Phosphorylation	GCIEVLRSMRSLDFN HHHHHHHHHHCCCCC	17.87	24719451
305	Phosphorylation	FELRFKQYLHSPPKV HHHHHHHHHCCCCCC	13.63	-
333	Phosphorylation	AWGDEEDSLEHNYYN CCCCCCCHHHHCCCC	38.65	-
338	Phosphorylation	EDSLEHNYYNSIPGK CCHHHHCCCCCCCCC	13.11	12006576
339	Phosphorylation	DSLEHNYYNSIPGKE CHHHHCCCCCCCCCC	14.04	12006576
341	Phosphorylation	LEHNYYNSIPGKEPP HHHCCCCCCCCCCCC	17.65	-
414	Phosphorylation	PDHEEHLYVNTQGLD CCCCCCEEEECCCCC	8.12	12006576
428	Phosphorylation	DAPEPEDSPKKDLFD CCCCCCCCCCCCCCC	36.64	27251275
467	Phosphorylation	PLEDQWPSPPTRRAP CCCCCCCCCCCCCCC	40.32	27251275
478	O-linked_Glycosylation	RRAPVAPTEEQLRQE CCCCCCCCHHHHHCC	42.28	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SHC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SHC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VGFR2_HUMAN	KDR	physical	10749680
GRB2_HUMAN	GRB2	physical	24430869
EGFR_HUMAN	EGFR	physical	24430869

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.