dbPTM

SHC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SHC3_HUMAN
UniProt AC	Q92529
Protein Name	SHC-transforming protein 3
Gene Name	SHC3
Organism	Homo sapiens (Human).
Sequence Length	594
Subcellular Localization
Protein Description	Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons..
Protein Sequence	MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDGPGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPAMSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	YNRFRNDSVTSVDDL CCCCCCCCCCCHHHH	30.74	27732954
16	Phosphorylation	RFRNDSVTSVDDLLH CCCCCCCCCHHHHHH	27.30	27732954
17	Phosphorylation	FRNDSVTSVDDLLHS CCCCCCCCHHHHHHH	22.76	24719451
22 (in isoform 2)	Phosphorylation	-	3.12	-
26	Phosphorylation	DDLLHSLSVSGGGGK HHHHHHCCCCCCCCC	19.77	27732954
46	Phosphorylation	ATPAAAPYLVSGEAL CCCCCCCEEECHHHH	18.27	-
77	Phosphorylation	KVSHLKLSSSGLRGL HHHCCCCCHHHHCCH	22.37	24719451
78	Phosphorylation	VSHLKLSSSGLRGLS HHCCCCCHHHHCCHH	38.57	27251275
79	Phosphorylation	SHLKLSSSGLRGLSS HCCCCCHHHHCCHHH	38.17	23927012
97	Phosphorylation	ERAGARLSGSCSAPS HHHCCCCCCCCCCCC	24.09	27732954
99	Phosphorylation	AGARLSGSCSAPSLA HCCCCCCCCCCCCCC	11.09	27732954
101	Phosphorylation	ARLSGSCSAPSLAAP CCCCCCCCCCCCCCC	44.93	27732954
104	Phosphorylation	SGSCSAPSLAAPDGS CCCCCCCCCCCCCCC	30.29	27732954
171	Phosphorylation	EVLRSMRSLDFSTRT HHHHHHHCCCCCCCH	24.53	24719451
196	Ubiquitination	CEAVPGAKGAFKKRK HHHCCCCCCHHHCCC	57.60	30230243
210	Phosphorylation	KPPSKMLSSILGKSN CCCHHHHHHHHCCCC	16.31	-
224	Phosphorylation	NLQFAGMSISLTIST CCEECCEEEEEEEEE	14.22	-
272	Ubiquitination	DYVAYVAKDPVNRRA CCHHHCCCCCCCCHH	53.15	30230243
308	Phosphorylation	FELRFKQYLQCPTKI HHHHHHHHHCCCCCC	10.18	25884760
324	Phosphorylation	ALHDRMQSLDEPWTE HHHHHHHHCCCCCCC	28.57	26356563
330	Phosphorylation	QSLDEPWTEEEGDGS HHCCCCCCCCCCCCC	44.21	26356563
337	Phosphorylation	TEEEGDGSDHPYYNS CCCCCCCCCCCCCCC	37.17	26356563
341	Phosphorylation	GDGSDHPYYNSIPSK CCCCCCCCCCCCCCC	16.32	25884760
342	Phosphorylation	DGSDHPYYNSIPSKM CCCCCCCCCCCCCCC	13.59	25884760
344	Phosphorylation	SDHPYYNSIPSKMPP CCCCCCCCCCCCCCC	21.54	25884760
347	Phosphorylation	PYYNSIPSKMPPPGG CCCCCCCCCCCCCCC	39.66	24719451
358	Phosphorylation	PPGGFLDTRLKPRPH CCCCCCCCCCCCCCC	39.80	28634120
378	Phosphorylation	QFAGKEQTYYQGRHL HHCCCCCCEECCCCC	25.86	28152594
379	Phosphorylation	FAGKEQTYYQGRHLG HCCCCCCEECCCCCC	8.09	28152594
380	Phosphorylation	AGKEQTYYQGRHLGD CCCCCCEECCCCCCC	14.10	25884760
402	Phosphorylation	QTPLRQGSSDIYSTP HCCCCCCCCCCEECC	19.25	-
406	Phosphorylation	RQGSSDIYSTPEGKL CCCCCCCEECCCCCE	16.10	25884760
407	Phosphorylation	QGSSDIYSTPEGKLH CCCCCCEECCCCCEE	37.51	-
424	Phosphorylation	PTGEAPTYVNTQQIP CCCCCCCEECCCCCC	7.22	12242309
440	Phosphorylation	QAWPAAVSSAESSPR CCCCCCHHCCCCCCC	21.07	27732954
441	Phosphorylation	AWPAAVSSAESSPRK CCCCCHHCCCCCCCH	29.47	27732954
444	Phosphorylation	AAVSSAESSPRKDLF CCHHCCCCCCCHHCC	45.41	27732954
445	Phosphorylation	AVSSAESSPRKDLFD CHHCCCCCCCHHCCC	21.89	27732954
474	Phosphorylation	PVLSKAASVECISPV HHHHHCCEEEEECCC	24.25	29255136
479	Phosphorylation	AASVECISPVSPRAP CCEEEEECCCCCCCC	30.79	25850435
482	Phosphorylation	VECISPVSPRAPDAK EEEECCCCCCCCCHH	16.44	25850435

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
218	Y	Phosphorylation	Kinase	EGFR	P00533	PSP
218	Y	Phosphorylation	Kinase	SRC	P12931	PSP
218	Y	Phosphorylation	Kinase	NTRK2	Q16620	GPS
218	Y	Phosphorylation	Kinase	NTRK1	P04629	GPS
219	Y	Phosphorylation	Kinase	SRC	P12931	PSP
219	Y	Phosphorylation	Kinase	EGFR	P00533	PSP
219	Y	Phosphorylation	Kinase	NTRK1	P04629	GPS
219	Y	Phosphorylation	Kinase	NTRK2	Q16620	GPS
256	Y	Phosphorylation	Kinase	EGFR	P00533	PSP
256	Y	Phosphorylation	Kinase	SRC	P12931	PSP
256	Y	Phosphorylation	Kinase	NTRK2	Q16620	GPS
256	Y	Phosphorylation	Kinase	NTRK1	P04629	GPS
257	Y	Phosphorylation	Kinase	NTRK2	Q16620	GPS
257	Y	Phosphorylation	Kinase	NTRK1	P04629	GPS
257	Y	Phosphorylation	Kinase	EGFR	P00533	PSP
257	Y	Phosphorylation	Kinase	SRC	P12931	PSP
283	Y	Phosphorylation	Kinase	NTRK1	P04629	GPS
283	Y	Phosphorylation	Kinase	NTRK2	Q16620	GPS
283	Y	Phosphorylation	Kinase	EGFR	P00533	PSP
283	Y	Phosphorylation	Kinase	SRC	P12931	PSP
301	Y	Phosphorylation	Kinase	NTRK2	Q16620	GPS
301	Y	Phosphorylation	Kinase	NTRK1	P04629	GPS
301	Y	Phosphorylation	Kinase	SRC	P12931	PSP
301	Y	Phosphorylation	Kinase	EGFR	P00533	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SHC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SHC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHG32_HUMAN	ARHGAP32	physical	12446789
EGFR_HUMAN	EGFR	physical	9507002
NTRK1_HUMAN	NTRK1	physical	9507002
NTRK2_HUMAN	NTRK2	physical	9507002
SH3G3_HUMAN	SH3GL3	physical	21900206
K1C40_HUMAN	KRT40	physical	25416956
EGFR_HUMAN	EGFR	physical	8662772

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SHC3_HUMAN

Related Literatures of Post-Translational Modification