dbPTM

RPGF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RPGF1_HUMAN
UniProt AC	Q13905
Protein Name	Rap guanine nucleotide exchange factor 1
Gene Name	RAPGEF1
Organism	Homo sapiens (Human).
Sequence Length	1077
Subcellular Localization	Early endosome .
Protein Description	Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth..
Protein Sequence	MDTDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVKIPEKPVNKEATDRFLPEGYPLPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGPAELPLTDREVEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYGGESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQTAWNLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRRSAASQTADGSGCRVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPVEFVGDFTAPESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQKNKLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQLEPPAGKDGHPRDPSAVSGVPGKDSRDGSERAPKSPDALESAQSEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MDTDSQRSHLSSFTM CCCHHHHHHHHHHHH	22.57	22210691
10 (in isoform 4)	Phosphorylation	-	4.90	25627689
11	Phosphorylation	DSQRSHLSSFTMKLM HHHHHHHHHHHHHHH	20.27	22210691
12	Phosphorylation	SQRSHLSSFTMKLMD HHHHHHHHHHHHHHH	30.97	23401153
14	Phosphorylation	RSHLSSFTMKLMDKF HHHHHHHHHHHHHHH	18.49	27251275
23	Phosphorylation	KLMDKFHSPKIKRTP HHHHHHCCCCCCCCC	30.90	29214152
29 (in isoform 4)	Phosphorylation	-	27.23	25627689
30 (in isoform 3)	Phosphorylation	-	48.46	24719451
41 (in isoform 3)	Phosphorylation	-	8.66	24719451
57 (in isoform 2)	Sumoylation	-	3.83	-
61	Phosphorylation	DRFLPEGYPLPLDLE HCCCCCCCCCCCCHH	10.43	20736484
76	Phosphorylation	QQAVEFMSTSAVASR HHHHHHHCHHHHHCH	25.24	-
109	Phosphorylation	SALRYFKTIVDKMAI HHHHHHHHHHHHHCC	19.14	19664994
109 (in isoform 2)	Phosphorylation	-	19.14	21406692
110 (in isoform 2)	Phosphorylation	-	3.78	21406692
122 (in isoform 2)	Phosphorylation	-	41.48	21406692
127 (in isoform 3)	Phosphorylation	-	27.68	-
148	Phosphorylation	NDPRIQHSSALSSCY CCCCCCCHHHHHHHH	10.84	21406692
149	Phosphorylation	DPRIQHSSALSSCYS CCCCCCHHHHHHHHH	30.98	21406692
152	Phosphorylation	IQHSSALSSCYSRVY CCCHHHHHHHHHHHH	20.34	21406692
153	Phosphorylation	QHSSALSSCYSRVYQ CCHHHHHHHHHHHHH	20.23	21406692
155	Phosphorylation	SSALSSCYSRVYQSL HHHHHHHHHHHHHHH	11.06	21406692
156	Phosphorylation	SALSSCYSRVYQSLA HHHHHHHHHHHHHHH	21.43	21406692
159	Phosphorylation	SSCYSRVYQSLANLI HHHHHHHHHHHHHHH	7.41	21406692
161	Phosphorylation	CYSRVYQSLANLIRW HHHHHHHHHHHHHHH	16.26	21406692
200	Ubiquitination	KAVLDGVKELVRLTI HHHHHHHHHHHHHHH	51.35	29967540
214	Phosphorylation	IEKQGRPSPTSPVKP HHCCCCCCCCCCCCC	39.18	25159151
216	Phosphorylation	KQGRPSPTSPVKPSS CCCCCCCCCCCCCCC	50.42	26657352
217	Phosphorylation	QGRPSPTSPVKPSSP CCCCCCCCCCCCCCC	30.95	25159151
217	Ubiquitination	QGRPSPTSPVKPSSP CCCCCCCCCCCCCCC	30.95	29967540
218	Ubiquitination	GRPSPTSPVKPSSPA CCCCCCCCCCCCCCC	40.40	29967540
218 (in isoform 3)	Ubiquitination	-	40.40	-
222	Phosphorylation	PTSPVKPSSPASKPD CCCCCCCCCCCCCCC	43.14	25159151
223	Phosphorylation	TSPVKPSSPASKPDG CCCCCCCCCCCCCCC	32.77	26657352
226	Phosphorylation	VKPSSPASKPDGPAE CCCCCCCCCCCCCCC	48.37	30108239
232 (in isoform 3)	Phosphorylation	-	36.17	24719451
233	Phosphorylation	SKPDGPAELPLTDRE CCCCCCCCCCCCHHH	54.79	32142685
234 (in isoform 3)	Phosphorylation	-	4.59	27251275
235 (in isoform 3)	Phosphorylation	-	25.39	24719451
237	Phosphorylation	GPAELPLTDREVEIL CCCCCCCCHHHHHHH	30.94	26074081
240 (in isoform 3)	Phosphorylation	-	47.51	27251275
247	Phosphorylation	EVEILNKTTGMSQST HHHHHHHCCCCCCCC	27.75	23403867
248	Phosphorylation	VEILNKTTGMSQSTE HHHHHHCCCCCCCCC	32.28	28450419
249	Phosphorylation	EILNKTTGMSQSTEL HHHHHCCCCCCCCCC	20.98	32142685
251	Phosphorylation	LNKTTGMSQSTELLP HHHCCCCCCCCCCCC	23.48	28450419
253	Phosphorylation	KTTGMSQSTELLPDA HCCCCCCCCCCCCCC	19.28	28102081
254	Phosphorylation	TTGMSQSTELLPDAT CCCCCCCCCCCCCCC	24.02	28464451
254 (in isoform 2)	Phosphorylation	-	24.02	21406692
257 (in isoform 2)	Phosphorylation	-	2.69	21406692
259 (in isoform 2)	Phosphorylation	-	63.17	21406692
260	Phosphorylation	STELLPDATDEEVAP CCCCCCCCCCCCCCC	18.27	32142685
261	Phosphorylation	TELLPDATDEEVAPP CCCCCCCCCCCCCCC	51.85	26074081
264	Phosphorylation	LPDATDEEVAPPKPP CCCCCCCCCCCCCCC	46.95	32645325
271	Phosphorylation	EVAPPKPPLPGIRVV CCCCCCCCCCCEEEE	58.26	32142685
272	Phosphorylation	VAPPKPPLPGIRVVD CCCCCCCCCCEEEEC	9.11	32142685
272 (in isoform 3)	Phosphorylation	-	9.11	27251275
275	Phosphorylation	PKPPLPGIRVVDNSP CCCCCCCEEEECCCC	2.59	32645325
281	Phosphorylation	GIRVVDNSPPPALPP CEEEECCCCCCCCCC	34.03	29255136
292	Phosphorylation	ALPPKKRQSAPSPTR CCCCCCCCCCCCCCE	53.47	32142685
293	Phosphorylation	LPPKKRQSAPSPTRV CCCCCCCCCCCCCEE	46.29	27794612
296	Phosphorylation	KKRQSAPSPTRVAVV CCCCCCCCCCEEEEE	38.32	22617229
296 (in isoform 2)	Phosphorylation	-	38.32	21406692
298	Phosphorylation	RQSAPSPTRVAVVAP CCCCCCCCEEEEEEE	41.96	27794612
299	Phosphorylation	QSAPSPTRVAVVAPM CCCCCCCEEEEEEEC	20.13	32142685
299 (in isoform 3)	Phosphorylation	-	20.13	24719451
301 (in isoform 2)	Phosphorylation	-	6.18	21406692
303	Phosphorylation	SPTRVAVVAPMSRAT CCCEEEEEEECCCCC	3.40	33259812
306 (in isoform 2)	Phosphorylation	-	2.82	21406692
307	Phosphorylation	VAVVAPMSRATSGSS EEEEEECCCCCCCCC	20.08	29978859
310	Phosphorylation	VAPMSRATSGSSLPV EEECCCCCCCCCCCC	32.29	30266825
311	Phosphorylation	APMSRATSGSSLPVG EECCCCCCCCCCCCC	35.38	23401153
311 (in isoform 3)	Phosphorylation	-	35.38	24719451
313	Phosphorylation	MSRATSGSSLPVGIN CCCCCCCCCCCCCCC	28.59	30266825
314	Phosphorylation	SRATSGSSLPVGINR CCCCCCCCCCCCCCC	39.97	23401153
314 (in isoform 3)	Phosphorylation	-	39.97	24719451
316 (in isoform 3)	Phosphorylation	-	25.00	-
317	Phosphorylation	TSGSSLPVGINRQDF CCCCCCCCCCCCCCC	17.02	32142685
328	Phosphorylation	RQDFDVDCYAQRRLS CCCCCCEEEEECCCC	2.81	32142685
328 (in isoform 3)	Phosphorylation	-	2.81	24719451
329	Phosphorylation	QDFDVDCYAQRRLSG CCCCCEEEEECCCCC	10.99	25884760
329 (in isoform 3)	Phosphorylation	-	10.99	-
330	Phosphorylation	DFDVDCYAQRRLSGG CCCCEEEEECCCCCC	11.61	32142685
331	Phosphorylation	FDVDCYAQRRLSGGS CCCEEEEECCCCCCC	12.45	32142685
332 (in isoform 3)	Phosphorylation	-	33.08	24719451
335	Phosphorylation	CYAQRRLSGGSHSYG EEEECCCCCCCCCCC	39.02	21955146
338	Phosphorylation	QRRLSGGSHSYGGES ECCCCCCCCCCCCCC	16.88	21955146
339	Phosphorylation	RRLSGGSHSYGGESP CCCCCCCCCCCCCCC	28.45	32142685
340	Phosphorylation	RLSGGSHSYGGESPR CCCCCCCCCCCCCCC	27.46	21955146
341	Phosphorylation	LSGGSHSYGGESPRL CCCCCCCCCCCCCCC	24.59	21955146
345	Phosphorylation	SHSYGGESPRLSPCS CCCCCCCCCCCCCCC	20.70	23401153
347 (in isoform 3)	Phosphorylation	-	58.01	27642862
349	Phosphorylation	GGESPRLSPCSSIGK CCCCCCCCCCCCCCC	25.74	21955146
352	Phosphorylation	SPRLSPCSSIGKLSK CCCCCCCCCCCCCCC	28.51	30108239
353	Phosphorylation	PRLSPCSSIGKLSKS CCCCCCCCCCCCCCC	41.92	30108239
353 (in isoform 3)	Phosphorylation	-	41.92	24719451
356	Acetylation	SPCSSIGKLSKSDEQ CCCCCCCCCCCCHHH	48.17	25953088
356 (in isoform 3)	Phosphorylation	-	48.17	24719451
358	Phosphorylation	CSSIGKLSKSDEQLS CCCCCCCCCCHHHHH	33.33	23401153
360	Phosphorylation	SIGKLSKSDEQLSSL CCCCCCCCHHHHHCC	42.90	29255136
363 (in isoform 3)	Phosphorylation	-	52.19	24719451
365	Phosphorylation	SKSDEQLSSLDRDSG CCCHHHHHCCCCCCC	28.66	23927012
366	Phosphorylation	KSDEQLSSLDRDSGQ CCHHHHHCCCCCCCC	42.77	23927012
367	Phosphorylation	SDEQLSSLDRDSGQC CHHHHHCCCCCCCCC	5.86	32142685
367 (in isoform 3)	Phosphorylation	-	5.86	27251275
371	Phosphorylation	LSSLDRDSGQCSRNT HHCCCCCCCCCCCCC	31.49	27794612
375	Phosphorylation	DRDSGQCSRNTSCET CCCCCCCCCCCCCCC	22.22	23403867
376 (in isoform 3)	Phosphorylation	-	59.06	27251275
377	Phosphorylation	DSGQCSRNTSCETLD CCCCCCCCCCCCCCC	21.76	32142685
378	Phosphorylation	SGQCSRNTSCETLDH CCCCCCCCCCCCCCC	33.37	32142685
378 (in isoform 3)	Phosphorylation	-	33.37	24719451
383 (in isoform 3)	Phosphorylation	-	1.46	27251275
389 (in isoform 3)	Phosphorylation	-	53.33	24719451
390	Phosphorylation	LDHYDPDYEFLQQDL CCCCCCCHHHHHHHH	17.61	20736484
412	Phosphorylation	QQTAWNLSPLPESLG HHHCCCCCCCCHHHC	22.60	26074081
423	Phosphorylation	ESLGESGSPFLGPPF HHHCCCCCCCCCCCC	23.04	-
463	Phosphorylation	LPEKKRRSAASQTAD CCHHHHHCCCCCCCC	32.02	25849741
466	Phosphorylation	KKRRSAASQTADGSG HHHHCCCCCCCCCCC	27.99	26552605
468	Phosphorylation	RRSAASQTADGSGCR HHCCCCCCCCCCCCE	24.99	23312004
472	Phosphorylation	ASQTADGSGCRVSYE CCCCCCCCCCEEEEE	34.95	27794612
477	Phosphorylation	DGSGCRVSYERHPSQ CCCCCEEEEECCHHH	11.26	28857561
478	Phosphorylation	GSGCRVSYERHPSQY CCCCEEEEECCHHHC	17.71	27794612
504	Phosphorylation	APIPSVPYAPFAAIL CCCCCCCCCCEEEEE	25.42	17974005
522 (in isoform 3)	Phosphorylation	-	9.98	-
561	Phosphorylation	YMQLLEDYSEPQPSM HHHHHHHCCCCCCCC	12.93	27259358
562	Phosphorylation	MQLLEDYSEPQPSMF HHHHHHCCCCCCCCC	55.94	27259358
570	Phosphorylation	EPQPSMFYQTPQNEH CCCCCCCCCCCCCHH	11.66	30576142
572	Phosphorylation	QPSMFYQTPQNEHIY CCCCCCCCCCCHHHH	18.57	30576142
579	Phosphorylation	TPQNEHIYQQKNKLL CCCCHHHHHHHHHHH	13.54	-
590	Phosphorylation	NKLLMEVYGFSDSFS HHHHHHHHCCCCCCC	10.11	28985074
595	Phosphorylation	EVYGFSDSFSGVDSV HHHCCCCCCCCCCCH	21.80	28985074
631	Phosphorylation	KDGHPRDPSAVSGVP CCCCCCCHHHCCCCC	26.01	32142685
651	Phosphorylation	DGSERAPKSPDALES CCCCCCCCCHHHHHH	73.89	32142685
652	Phosphorylation	GSERAPKSPDALESA CCCCCCCCHHHHHHC	27.27	26055452
658	Phosphorylation	KSPDALESAQSEEEV CCHHHHHHCCCHHHH	32.24	28450419
669	Phosphorylation	EEEVDELSLIDHNEI HHHHCHHHHCCHHHH	22.64	32142685
670	Phosphorylation	EEVDELSLIDHNEIM HHHCHHHHCCHHHHH	9.25	32142685
670 (in isoform 3)	Phosphorylation	-	9.25	24719451
683	Ubiquitination	IMSRLTLKQEGDDGP HHHHHCCEECCCCCC	40.86	24816145
700	Ubiquitination	RGGSGDILLVHATET CCCCCCEEEEEEECC	4.93	24816145
701	Ubiquitination	GGSGDILLVHATETD CCCCCEEEEEEECCC	2.44	24816145
701 (in isoform 3)	Ubiquitination	-	2.44	-
706	Ubiquitination	ILLVHATETDRKDLV EEEEEEECCCHHHHH	49.87	24816145
714	Ubiquitination	TDRKDLVLYCEAFLT CCHHHHHHHHHHHHH	5.42	24816145
715	Phosphorylation	DRKDLVLYCEAFLTT CHHHHHHHHHHHHHH	4.83	-
723	Phosphorylation	CEAFLTTYRTFISPE HHHHHHHHHHCCCHH	11.47	-
745	Ubiquitination	YRYEKFSPFADTFKK HHHHHHCCCHHHHHH	31.42	24816145
753 (in isoform 3)	Ubiquitination	-	38.23	-
766	Ubiquitination	FFVLVRVVDELCLVE EEEEEECCHHHHHHH	3.11	24816145
767	Ubiquitination	FVLVRVVDELCLVEL EEEEECCHHHHHHHH	40.05	24816145
798	Ubiquitination	CNGELSLARVLRKNI HCCCCHHHHHHHHHC	9.00	24816145
800	Ubiquitination	GELSLARVLRKNILD CCCHHHHHHHHHCCH	5.15	24816145
801	Phosphorylation	ELSLARVLRKNILDK CCHHHHHHHHHCCHH	5.56	32142685
808	Ubiquitination	LRKNILDKVDQKKLL HHHHCCHHCCHHHHH	44.24	29967540
819	Phosphorylation	KKLLRCATSSQPLAA HHHHHHHHCCCCCHH	32.32	28857561
820	Phosphorylation	KLLRCATSSQPLAAR HHHHHHHCCCCCHHH	14.40	-
825	Ubiquitination	ATSSQPLAARGVAAR HHCCCCCHHHCCCCC	11.20	29967540
826	Ubiquitination	TSSQPLAARGVAARP HCCCCCHHHCCCCCC	19.22	29967540
831	Ubiquitination	LAARGVAARPGTLHD CHHHCCCCCCCCCCC	18.78	24816145
831 (in isoform 3)	Ubiquitination	-	18.78	-
832	Ubiquitination	AARGVAARPGTLHDF HHHCCCCCCCCCCCC	22.05	24816145
838	Phosphorylation	ARPGTLHDFHSHEIA CCCCCCCCCCHHHHH	46.17	32142685
838	Ubiquitination	ARPGTLHDFHSHEIA CCCCCCCCCCHHHHH	46.17	24816145
839	Ubiquitination	RPGTLHDFHSHEIAE CCCCCCCCCHHHHHH	4.42	24816145
847	Ubiquitination	HSHEIAEQLTLLDAE CHHHHHHHHHHHCHH	30.63	24816145
852	Ubiquitination	AEQLTLLDAELFYKI HHHHHHHCHHHHHHC	40.90	24816145
853	Ubiquitination	EQLTLLDAELFYKIE HHHHHHCHHHHHHCC	18.50	24816145
861	Ubiquitination	ELFYKIEIPEVLLWA HHHHHCCCCHHHHHH	3.92	24816145
869	Ubiquitination	PEVLLWAKEQNEEKS CHHHHHHHHCCCCCC	48.53	29967540
870	Ubiquitination	EVLLWAKEQNEEKSP HHHHHHHHCCCCCCC	51.39	24816145
876	Phosphorylation	KEQNEEKSPNLTQFT HHCCCCCCCCHHHHH	23.46	25693802
876	Ubiquitination	KEQNEEKSPNLTQFT HHCCCCCCCCHHHHH	23.46	24816145
878	Ubiquitination	QNEEKSPNLTQFTEH CCCCCCCCHHHHHHH	63.91	24816145
879	Ubiquitination	NEEKSPNLTQFTEHF CCCCCCCHHHHHHHH	4.52	24816145
880	Phosphorylation	EEKSPNLTQFTEHFN CCCCCCHHHHHHHHH	28.42	25693802
883	Phosphorylation	SPNLTQFTEHFNNMS CCCHHHHHHHHHHHH	20.80	25693802
883	Ubiquitination	SPNLTQFTEHFNNMS CCCHHHHHHHHHHHH	20.80	24816145
884	Ubiquitination	PNLTQFTEHFNNMSY CCHHHHHHHHHHHHH	48.01	24816145
886	Ubiquitination	LTQFTEHFNNMSYWV HHHHHHHHHHHHHHH	6.02	29967540
887	Ubiquitination	TQFTEHFNNMSYWVR HHHHHHHHHHHHHHH	45.24	29967540
890	Phosphorylation	TEHFNNMSYWVRSII HHHHHHHHHHHHHHH	20.26	25693802
891	Phosphorylation	EHFNNMSYWVRSIIM HHHHHHHHHHHHHHH	9.35	25693802
950	Phosphorylation	RLEWQKQTSEGLAEY HHHHHHHCCCHHHHH	35.46	24850871
951	Phosphorylation	LEWQKQTSEGLAEYC HHHHHHCCCHHHHHH	27.46	-
965	Phosphorylation	CTLIDSSSSFRAYRA HHHHCCCHHHHHHHH	37.13	-
966	Phosphorylation	TLIDSSSSFRAYRAA HHHCCCHHHHHHHHH	22.24	-
1021	Phosphorylation	QQFNILDSMRCFQQA HHHCHHHHHHHHHHH	12.51	24719451
1067	Phosphorylation	KIKPRNITRRKTDRE CCCCCCCCCCCCCCC	28.15	-
1071	Phosphorylation	RNITRRKTDREEKT- CCCCCCCCCCCCCC-	38.18	27273156

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
504	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
504	Y	Phosphorylation	Kinase	HCK	P08631	Uniprot
504	Y	Phosphorylation	Kinase	SRC	P12931	PSP
504	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RPGF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RPGF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HCK_HUMAN	HCK	physical	14551197
CRKL_HUMAN	CRKL	physical	8621483
GRB2_HUMAN	GRB2	physical	8621483
CRK_HUMAN	CRK	physical	7512734
GRB2_HUMAN	GRB2	physical	7512734
CRKL_HUMAN	CRKL	physical	11466412
CRK_HUMAN	CRK	physical	18835194
CRKL_HUMAN	CRKL	physical	18835194
RS15_HUMAN	RPS15	physical	21988832
S20A1_HUMAN	SLC20A1	physical	21988832
RAP1A_HUMAN	RAP1A	physical	9266971
RAP2B_HUMAN	RAP2B	physical	9266971
RSR1_YEAST	RSR1	physical	9266971

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RPGF1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314; SER-360 ANDSER-652, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Physical and functional interaction between Hck tyrosine kinase andguanine nucleotide exchange factor C3G results in apoptosis, which isindependent of C3G catalytic domain."; Shivakrupa R., Radha V., Sudhakar C., Swarup G.; J. Biol. Chem. 278:52188-52194(2003). Cited for: INTERACTION WITH HCK, MUTAGENESIS OF TYR-504, AND PHOSPHORYLATION ATTYR-504.	14551197 [Abstract]