VTDB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VTDB_HUMAN
• UniProt AC: P02774
• Protein Name: Vitamin D-binding protein
• Gene Name: GC
• Organism: Homo sapiens (Human).
• Sequence Length: 474
• Subcellular Localization: Secreted .
• Protein Description: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation..
• Protein Sequence: MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVFLSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKKKLAERLKAKLPDATPKELAKLVNKRSDFASNCCSINSPPLYCDSEIDAELKNIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	LGKEDFTSLSLVLYS CCCCCCCHHHEEEEC	18.89	-
49	Phosphorylation	SLSLVLYSRKFPSGT HHHEEEECCCCCCCH	25.49	24719451
51	Glycation	SLVLYSRKFPSGTFE HEEEECCCCCCCHHH	56.54	-
54	Phosphorylation	LYSRKFPSGTFEQVS EECCCCCCCHHHHHH	54.31	24043423
56	Phosphorylation	SRKFPSGTFEQVSQL CCCCCCCHHHHHHHH	28.47	24043423
61	Phosphorylation	SGTFEQVSQLVKEVV CCHHHHHHHHHHHHH	19.93	24043423
69	Phosphorylation	QLVKEVVSLTEACCA HHHHHHHHHHHHHHH	34.45	24505115
88	Phosphorylation	PDCYDTRTSALSAKS CCHHCCCCHHHCCCC	22.05	29396449
89	Phosphorylation	DCYDTRTSALSAKSC CHHCCCCHHHCCCCC	24.75	24260401
92	Phosphorylation	DTRTSALSAKSCESN CCCCHHHCCCCCCCC	33.11	24260401
95	Phosphorylation	TSALSAKSCESNSPF CHHHCCCCCCCCCCC	23.88	27130503
98	Phosphorylation	LSAKSCESNSPFPVH HCCCCCCCCCCCCCC	47.11	24505115
100	Phosphorylation	AKSCESNSPFPVHPG CCCCCCCCCCCCCCC	36.88	27130503
108	Phosphorylation	PFPVHPGTAECCTKE CCCCCCCCHHHCCHH	24.59	24505115
114	Phosphorylation	GTAECCTKEGLERKL CCHHHCCHHHHHHHH	35.55	27251275
155	Phosphorylation	FRKDPKEYANQFMWE HHHCHHHHHHHHHHH	19.58	-
184	Phosphorylation	SYTKSYLSMVGSCCT HCHHHHHHHHHHHHC	11.82	24505115
188	Phosphorylation	SYLSMVGSCCTSASP HHHHHHHHHHCCCCH	8.46	24505115
210	Phosphorylation	RLQLKHLSLLTTLSN HHHHHHHHHHHHHHH	22.50	23911959
213	Phosphorylation	LKHLSLLTTLSNRVC HHHHHHHHHHHHHHH	30.86	-
214	Phosphorylation	KHLSLLTTLSNRVCS HHHHHHHHHHHHHHH	28.32	-
288	N-linked_Glycosylation	HTVKLCDNLSTKNSK HHHHHCCCCCCCCCC	34.59	17623646
288	N-linked_Glycosylation	HTVKLCDNLSTKNSK HHHHHCCCCCCCCCC	34.59	-
345	Acetylation	GNTKVMDKYTFELSR CCCEEECHHHHHHCC	28.26	27178108
346	Phosphorylation	NTKVMDKYTFELSRR CCEEECHHHHHHCCC	16.64	27251275
347	Phosphorylation	TKVMDKYTFELSRRT CEEECHHHHHHCCCC	19.17	27251275
351	Phosphorylation	DKYTFELSRRTHLPE CHHHHHHCCCCCCCH	16.72	27251275
366	Phosphorylation	VFLSKVLEPTLKSLG HHHHHHHHHHHHHHH	38.95	27251275
370	Phosphorylation	KVLEPTLKSLGECCD HHHHHHHHHHHCCCC	46.22	27251275
419	Acetylation	ENTFTEYKKKLAERL CCCHHHHHHHHHHHH	36.88	155667
434	O-linked_Glycosylation	KAKLPDATPKELAKL HHHCCCCCHHHHHHH	42.12	OGP
436	O-linked_Glycosylation	KLPDATPKELAKLVN HCCCCCHHHHHHHHH	62.09	OGP
457	Phosphorylation	SNCCSINSPPLYCDS HHCCCCCCCCCCCCH	26.65	19690332
461	Phosphorylation	SINSPPLYCDSEIDA CCCCCCCCCCHHHHH	10.45	19690332

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VTDB_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
288	N	Glycosylation	The potential N-glycosylation site predicted at Asn-288 is thought to be nonglycosylated.	16302727
436	T	Glycosylation	Allele GC*1S is O-glycosylated at Thr-436.	20079467

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
457	Phosphorylation	451;455 (6;2)	D;T ⇒ E;K;M	rs7041;rs4588	Serum vitamin D-binding protein levels Vitamin D levels	24740207 28757204
461	Phosphorylation	451;455 (10;6)	D;T ⇒ E;K;M	rs7041;rs4588	Serum vitamin D-binding protein levels Vitamin D levels	24740207 28757204

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SERF2_HUMAN	SERF2	physical	16169070
CDC73_HUMAN	CDC73	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
CUBN_HUMAN	CUBN	physical	11717447
LRP2_HUMAN	LRP2	physical	11717447
VTDB_HUMAN	GC	physical	12048248
POTEF_HUMAN	POTEF	physical	28514442
POTEI_HUMAN	POTEI	physical	28514442
ACTB_HUMAN	ACTB	physical	28514442
ACTA_HUMAN	ACTA2	physical	28514442
ACTBL_HUMAN	ACTBL2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.