LRP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRP2_HUMAN
• UniProt AC: P98164
• Protein Name: Low-density lipoprotein receptor-related protein 2
• Gene Name: LRP2 {ECO:0000312|HGNC:HGNC:6694}
• Organism: Homo sapiens (Human).
• Sequence Length: 4655
• Subcellular Localization: Apical cell membrane ; Single-pass type I membrane protein . Endosome lumen . Membrane, coated pit . Cell projection, dendrite . Cell projection, axon . Localizes to brush border membranes in the kidney. In the endolymphatic sac of the inner ear, loc
• Protein Description: Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (By similarity). Mediates renal uptake of metallothionein-bound heavy metals. [PubMed: 15126248 Together with CUBN, mediates renal reabsorption of myoglobin (By similarity Mediates renal uptake and subsequent lysosomal degradation of APOM (By similarity Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (By similarity Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney]
• Protein Sequence: MDRGPAAVACTLLLALVACLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGYILERGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSRCSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSDGKNCAISTENFLIFALSNSLRSLHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIARVPKPRAIVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQLRYNKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPPCRCMHGGNCYFDETDLPKCKCPSGYTGKYCEMAFSKGISPGTTAVAVLLTILLIVVIGALAIAGFFHYRRTGSLLPALPKLPSLSSLVKPSENGNGVTFRSGADLNMDIGVSGFGPETAIDRSMAMSEDFVMEMGKQPIIFENPMYSARDSAVKVVQPIQVTVSENVDNKNYGSPINPSEIVPETNPTSPAADGTQVTKWNLFKRKSKQTTNFENPIYAQMENEQKESVAATPPPSPSLPAKPKPPSRRDPTPTYSATEDTFKDTANLVKEDSEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	O-linked_Glycosylation	EIGCAVVTCQQGYFK HHCEEEEEECCCEEE	9.67	OGP
107	O-linked_Glycosylation	RQDCSQSTCSSHQIT CCCCCCCCCCCCEEE	14.58	OGP
109	O-linked_Glycosylation	DCSQSTCSSHQITCS CCCCCCCCCCEEEEC	30.83	OGP
110	O-linked_Glycosylation	CSQSTCSSHQITCSN CCCCCCCCCEEEECC	22.89	OGP
146	O-linked_Glycosylation	ENDCQYPTCEQLTCD CCCCCCCCCCEEEEC	24.60	OGP
159	N-linked_Glycosylation	CDNGACYNTSQKCDW ECCCCCCCCCCCCCE	32.89	UniProtKB CARBOHYD
178	N-linked_Glycosylation	RDSSDEINCTEICLH CCCCCCCCCEEEEEC	25.30	UniProtKB CARBOHYD
212	O-linked_Glycosylation	DNDCQDGSDEHACNY CCCCCCCCCCCCCCC	48.38	OGP
221	O-linked_Glycosylation	EHACNYPTCGGYQFT CCCCCCCCCCCEEEE	17.27	OGP
299	N-linked_Glycosylation	CPGREDENNTSTGKY CCCCCCCCCCCCCCC	70.20	UniProtKB CARBOHYD
300	N-linked_Glycosylation	PGREDENNTSTGKYC CCCCCCCCCCCCCCC	33.10	UniProtKB CARBOHYD
341	N-linked_Glycosylation	PGYIINHNDSRTCVE CCEEEECCCCCEEEE	44.45	UniProtKB CARBOHYD
388	N-linked_Glycosylation	RGQYCKANDSFGEAS CCCEEECCCCCCCEE	30.84	UniProtKB CARBOHYD
463	N-linked_Glycosylation	LNIQEVLNVSVETPE CCHHEEEEEECCCCC	29.24	UniProtKB CARBOHYD
563	Phosphorylation	LGWPAGVTLDMISKR CCCCCCCCHHHHHCE	19.00	-
572	Phosphorylation	DMISKRVYWVDSRFD HHHHCEEEEECCCCC	12.07	-
580	Phosphorylation	WVDSRFDYIETVTYD EECCCCCEEEEEEEC	9.65	-
586	Phosphorylation	DYIETVTYDGIQRKT CEEEEEEECCCCCCE	14.08	-
767	Ubiquitination	MSKHMIFKQKIDGTG CCCCEEEEEECCCCC	39.49	-
805	Phosphorylation	LYWTDSHYKSISVMR CCCCCCCCCCEEHHH	15.47	-
866	N-linked_Glycosylation	SHLLPVINTTLGWPN CCEECEEECCCCCCC	27.52	UniProtKB CARBOHYD
897	Phosphorylation	YFDKIEHSTFDGLDR HHHHHCCCCCCCCCH	20.27	-
898	Phosphorylation	FDKIEHSTFDGLDRR HHHHCCCCCCCCCHH	27.87	-
1018	O-linked_Glycosylation	LTCEGDPTNEPPTEQ EEECCCCCCCCCCCC	57.88	OGP
1023	O-linked_Glycosylation	DPTNEPPTEQCGLFS CCCCCCCCCCCCCEE	49.78	OGP
1030	Phosphorylation	TEQCGLFSFPCKNGR CCCCCCEEEECCCCE	33.06	-
1064	N-linked_Glycosylation	EQLCGTLNNTCSSSA HHCHHHHCCCCCCCC	41.42	UniProtKB CARBOHYD
1066	O-linked_Glycosylation	LCGTLNNTCSSSAFT CHHHHCCCCCCCCEE	16.82	OGP
1103	O-linked_Glycosylation	SDEHNCPTHAPASCL CCCCCCCCCCCHHHC	32.63	OGP
1108	O-linked_Glycosylation	CPTHAPASCLDTQYT CCCCCCHHHCCCEEE	17.72	OGP
1138	Phosphorylation	DNDCGDGSDEKNCNS CCCCCCCCCCCCCCC	47.54	29759185
1144	N-linked_Glycosylation	GSDEKNCNSTETCQP CCCCCCCCCCCCCCH	62.45	UniProtKB CARBOHYD
1148	O-linked_Glycosylation	KNCNSTETCQPSQFN CCCCCCCCCCHHHCC	19.27	OGP
1186	N-linked_Glycosylation	DEVGCVLNCTASQFK CCCCEEEEECHHHEE	10.74	UniProtKB CARBOHYD
1270	O-linked_Glycosylation	HNACVPKTCPSSYFH CCCCCCCCCCCCEEE	24.47	55828189
1273	O-linked_Glycosylation	CVPKTCPSSYFHCDN CCCCCCCCCEEECCC	39.56	55828195
1327	N-linked_Glycosylation	LGHNICVNLSVVCDG CCCCEEEEEEEEECC	23.37	UniProtKB CARBOHYD
1340	N-linked_Glycosylation	DGIFDCPNGTDESPL CCCCCCCCCCCCCCC	72.78	UniProtKB CARBOHYD
1383	N-linked_Glycosylation	PLGFLLANDSKTCED CHHHHCCCCCCCCCC	54.80	UniProtKB CARBOHYD
1414	Phosphorylation	MRGSFRCSCDTGYML CCCCEEEECCCCEEE	15.69	24043423
1417	Phosphorylation	SFRCSCDTGYMLESD CEEEECCCCEEEEEC	34.24	24043423
1419	Phosphorylation	RCSCDTGYMLESDGR EEECCCCEEEEECCC	10.71	24043423
1423	Phosphorylation	DTGYMLESDGRTCKV CCCEEEEECCCEEEE	41.21	24043423
1464	N-linked_Glycosylation	NIYSLVENGSYIVAV HHHHHHHCCCEEEEE	36.91	UniProtKB CARBOHYD
1496	N-linked_Glycosylation	KTWSAFQNGTDRRVV CCEEECCCCCCCEEE	49.21	UniProtKB CARBOHYD
1550	N-linked_Glycosylation	RTVLISKNLTNPRGL CEEEEECCCCCCCCC	45.36	UniProtKB CARBOHYD
1638	Phosphorylation	HRRQVIASDLIIRHP CCCEEHHHHHHCCCC	23.09	-
1675	N-linked_Glycosylation	ANKWHGGNQSVVMYN HCCCCCCCCEEEEEE	35.23	UniProtKB CARBOHYD
1677	Phosphorylation	KWHGGNQSVVMYNIQ CCCCCCCEEEEEEEE	22.22	29083192
1681	Phosphorylation	GNQSVVMYNIQWPLG CCCEEEEEEEECCCE	9.48	29083192
1695	Phosphorylation	GIVAVHPSKQPNSVN EEEEECCCCCCCCCC	29.10	29083192
1810	N-linked_Glycosylation	RVKTDGTNRTVFASI EEECCCCCCEEEEEE	43.06	UniProtKB CARBOHYD
1884	Ubiquitination	TVDPARGKLYWSDQG EEECCCCCEEECCCC	32.61	-
1902	Phosphorylation	GVPAKIASANMDGTS CCCCEEEEECCCCCC	24.53	-
1912	Phosphorylation	MDGTSVKTLFTGNLE CCCCCEEEEECCCCC	25.58	-
2010	Phosphorylation	NLRGLQVYHRRNAAE CCCCCHHEECCCHHH	4.07	25278378
2055	N-linked_Glycosylation	GFKLNPDNRSCSPYN CCCCCCCCCCCCCCC	38.74	UniProtKB CARBOHYD
2057	Phosphorylation	KLNPDNRSCSPYNSF CCCCCCCCCCCCCCH	25.79	30631047
2059	Phosphorylation	NPDNRSCSPYNSFIV CCCCCCCCCCCCHHH	31.50	24719451
2061	Phosphorylation	DNRSCSPYNSFIVVS CCCCCCCCCCHHHHH	13.72	29759185
2071	Phosphorylation	FIVVSMLSAIRGFSL HHHHHHHHHHCCCEE	17.01	24719451
2177	N-linked_Glycosylation	LIEVLRINTTYRRVL HHHHHCCCCCCCEEE	21.67	UniProtKB CARBOHYD
2224	N-linked_Glycosylation	RSFLDCTNRTVLVSE CHHCCCCCCEEEEEC	43.91	UniProtKB CARBOHYD
2249	Phosphorylation	DRSDGYVYWVDDSLD ECCCCEEEEECCCCC	7.39	22210691
2254	Phosphorylation	YVYWVDDSLDIIARI EEEEECCCCCEEEEE	24.39	22210691
2268	Phosphorylation	IRINGENSEVIRYGS EEECCCCCCEEECCC	29.01	22210691
2273	Phosphorylation	ENSEVIRYGSRYPTP CCCCEEECCCCCCCC	14.34	22210691
2289	Phosphorylation	GITVFENSIIWVDRN CEEEECCCEEEEECC	14.30	22210691
2305	Ubiquitination	KKIFQASKEPENTEP HHHHHCCCCCCCCCC	79.07	-
2485	Phosphorylation	RRIYYSDYLNQMINS CHHHHHHHHHHHHHH	11.12	30576142
2492	Phosphorylation	YLNQMINSMAEDGSN HHHHHHHHHCCCCCC	14.40	30576142
2498	Phosphorylation	NSMAEDGSNRTVIAR HHHCCCCCCCEEEEE	35.15	30576142
2499	N-linked_Glycosylation	SMAEDGSNRTVIARV HHCCCCCCCEEEEEC	49.53	UniProtKB CARBOHYD
2547	N-linked_Glycosylation	NFRVPIVNSSLVMPS CCEEEECCCCEECCC	26.97	UniProtKB CARBOHYD
2578	Phosphorylation	SLQRIERSTLTGVDR HHHHHHHHCCCCCCH	18.25	29449344
2579	Phosphorylation	LQRIERSTLTGVDRE HHHHHHHCCCCCCHH	34.26	29449344
2581	Phosphorylation	RIERSTLTGVDREVI HHHHHCCCCCCHHHH	34.94	29449344
2635	Phosphorylation	AMTTNLLSQPRGINT EEEECHHCCCCCCCH	41.11	24719451
2704	Phosphorylation	GERCGASSFTCSNGR CCCCCCCCEEECCCE	24.84	-
2740	O-linked_Glycosylation	ESVCALHTCSPTAFT HHHEEEEECCCCEEE	18.61	OGP
2757	Phosphorylation	NGRCVQYSYRCDYYN CCEEEEEEEECCCCC	6.76	24719451
2781	N-linked_Glycosylation	GCLFRDCNATTEFMC CEEEECCCCCCCEEC	44.61	UniProtKB CARBOHYD
2809	N-linked_Glycosylation	GVDNCHDNNTSDEKN CCCCCCCCCCCCCCC	29.98	UniProtKB CARBOHYD
2810	N-linked_Glycosylation	VDNCHDNNTSDEKNC CCCCCCCCCCCCCCC	47.20	UniProtKB CARBOHYD
2821	O-linked_Glycosylation	EKNCPDRTCQSGYTK CCCCCCCCCCCCCCC	23.44	OGP
2863	O-linked_Glycosylation	PTYCTTHTCSSSEFQ CCEEECCCCCCCCEE	16.40	OGP
2905	O-linked_Glycosylation	SCGHSERTCLADEFK CCCCCCCEEECCEEE	14.07	OGP
2947	N-linked_Glycosylation	RHQCQNQNCSDSEFL HHHHHCCCCCCCCEE	34.51	UniProtKB CARBOHYD
2987	N-linked_Glycosylation	DGYDENQNCTRRTCS CCCCCCCCCCCCCCC	40.48	UniProtKB CARBOHYD
2992	O-linked_Glycosylation	NQNCTRRTCSENEFT CCCCCCCCCCCCCCC	19.66	OGP
3021	Phosphorylation	RHNDCGDYSDERGCL CCCCCCCCCCCCCCC	11.87	-
3022	Phosphorylation	HNDCGDYSDERGCLY CCCCCCCCCCCCCCH	37.42	-
3029	Phosphorylation	SDERGCLYQTCQQNQ CCCCCCCHHHHHCCC	13.07	-
3031	O-linked_Glycosylation	ERGCLYQTCQQNQFT CCCCCHHHHHCCCCE	9.95	OGP
3031	Phosphorylation	ERGCLYQTCQQNQFT CCCCCHHHHHCCCCE	9.95	-
3070	O-linked_Glycosylation	ELMHLCHTPEPTCPP HHHHHCCCCCCCCCC	28.49	55831989
3074	O-linked_Glycosylation	LCHTPEPTCPPHEFK HCCCCCCCCCCHHCC	35.66	55831995
3125	N-linked_Glycosylation	SISGCDHNCTDTLTS CCCCCCCCCCHHCHH	19.68	UniProtKB CARBOHYD
3190	Phosphorylation	LREPDGKTCRQNSNI CCCCCCCCCCCCCCC	20.60	29759185
3195	Phosphorylation	GKTCRQNSNIEPYLI CCCCCCCCCCCCEEE	30.74	29083192
3200	Phosphorylation	QNSNIEPYLIFSNRY CCCCCCCEEEECCCE	10.31	29759185
3207	Phosphorylation	YLIFSNRYYLRNLTI EEEECCCEEEEECEE	15.88	29759185
3208	Phosphorylation	LIFSNRYYLRNLTID EEECCCEEEEECEEC	8.92	29759185
3211	N-linked_Glycosylation	SNRYYLRNLTIDGYF CCCEEEEECEECHHH	38.65	UniProtKB CARBOHYD
3242	Phosphorylation	DRVEKRLYWIDTQRQ HHHHHEEEHHHHHHH	12.35	22817900
3257	N-linked_Glycosylation	VIERMFLNKTNKETI HHHHHHCCCCCCHHH	37.53	UniProtKB CARBOHYD
3315	N-linked_Glycosylation	AQHCVDANNTFCFDN HHHHCCCCCCEECCC	43.54	UniProtKB CARBOHYD
3355	N-linked_Glycosylation	RVGMDGTNKSVIIST EEECCCCCCEEEEEE	39.88	UniProtKB CARBOHYD
3436	Phosphorylation	TVEKGNKYDGSNRQT EEECCCCCCCCCCCE	29.54	24719451
3446	N-linked_Glycosylation	SNRQTLVNTTHRPFD CCCCEEEECCCCCEE	42.23	UniProtKB CARBOHYD
3448	Phosphorylation	RQTLVNTTHRPFDIH CCEEEECCCCCEEEE	15.64	24719451
3564	N-linked_Glycosylation	QFQCSDGNCTSPQTL CEECCCCCCCCHHHH	30.77	UniProtKB CARBOHYD
3680	N-linked_Glycosylation	SSAHLCDNFTEFSCK HHHHHCCCCCCCCCC	44.75	UniProtKB CARBOHYD
3718	O-linked_Glycosylation	EQGCEERTCHPVGDF CCCCCCCCCEECCCE	20.60	OGP
3797	O-linked_Glycosylation	ERDCEMRTCHPEYFQ HHCCCCCCCCHHHEE	17.54	55825413
3834	O-linked_Glycosylation	SDEADCPTRFPDGAY CCCCCCCCCCCCCCC	51.80	OGP
3924	O-linked_Glycosylation	EEHCRKPTPKPCTEY HHHCCCCCCCCCCCC	47.16	OGP
3978	N-linked_Glycosylation	AENICEQNCTQLNEG HHHHHHCCCCEECCC	14.44	UniProtKB CARBOHYD
4028	Phosphorylation	CRNTKGSYECVCADG HCCCCCCEEEEECCC	23.24	-
4045	Acetylation	SMSDRPGKRCAAEGS CCCCCCCCCCCCCCC	47.16	20167786
4068	N-linked_Glycosylation	NVRIRKYNLSSERFS CEEEEECCCCCHHHH	36.16	UniProtKB CARBOHYD
4104	Phosphorylation	GLSVVYYTVRGEGSR CEEEEEEEECCCCCC	6.00	-
4181	Phosphorylation	RYRKWLISTDLDQPA HHHEEEEECCCCCCC	17.44	-
4308	Phosphorylation	GQGKKEKTLVVNPWL CCCCCCCEEEECCHH	26.35	-
4327	N-linked_Glycosylation	IFHQLRYNKSVPNLC HHHHHHCCCCHHHHH	24.56	UniProtKB CARBOHYD
4451	Phosphorylation	GFFHYRRTGSLLPAL HHHHHHCCCCCCCCC	23.32	30576142
4463	Phosphorylation	PALPKLPSLSSLVKP CCCCCCCCHHHCCCC	51.85	28857561
4465	Phosphorylation	LPKLPSLSSLVKPSE CCCCCCHHHCCCCCC	26.43	28857561
4466	Phosphorylation	PKLPSLSSLVKPSEN CCCCCHHHCCCCCCC	42.34	28857561
4478	Phosphorylation	SENGNGVTFRSGADL CCCCCCCEECCCCCC	18.09	22817900
4481	Phosphorylation	GNGVTFRSGADLNMD CCCCEECCCCCCCCE	33.86	27251275
4507	Phosphorylation	IDRSMAMSEDFVMEM HHHHHHCCHHHHHHC	25.19	28857561
4526	Phosphorylation	IIFENPMYSARDSAV EEEECCCCCCCHHCE	10.63	24173317
4527	Phosphorylation	IFENPMYSARDSAVK EEECCCCCCCHHCEE	15.58	22817900
4531	Phosphorylation	PMYSARDSAVKVVQP CCCCCCHHCEEEECC	29.43	28348404
4552	Phosphorylation	ENVDNKNYGSPINPS CCCCCCCCCCCCCHH	22.16	24173317
4554	Phosphorylation	VDNKNYGSPINPSEI CCCCCCCCCCCHHHC	16.55	28348404
4565	Phosphorylation	PSEIVPETNPTSPAA HHHCCCCCCCCCCCC	40.19	28857561
4568	Phosphorylation	IVPETNPTSPAADGT CCCCCCCCCCCCCCC	49.79	24173317
4569	Phosphorylation	VPETNPTSPAADGTQ CCCCCCCCCCCCCCE	17.50	28450419
4575	Phosphorylation	TSPAADGTQVTKWNL CCCCCCCCEEEEEEC	22.03	28450419
4578	Phosphorylation	AADGTQVTKWNLFKR CCCCCEEEEEECCCC	22.11	28857561
4587	Phosphorylation	WNLFKRKSKQTTNFE EECCCCCCCCCCCCC	33.75	28857561
4590	Phosphorylation	FKRKSKQTTNFENPI CCCCCCCCCCCCCCH	27.69	28857561
4591	Phosphorylation	KRKSKQTTNFENPIY CCCCCCCCCCCCCHH	35.10	28857561
4598	Phosphorylation	TNFENPIYAQMENEQ CCCCCCHHHHCCHHC	7.64	24173317
4608	Phosphorylation	MENEQKESVAATPPP CCHHCCCCCCCCCCC	24.88	28450419
4612	Phosphorylation	QKESVAATPPPSPSL CCCCCCCCCCCCCCC	26.96	28450419
4616	Phosphorylation	VAATPPPSPSLPAKP CCCCCCCCCCCCCCC	32.66	28450419
4618	Phosphorylation	ATPPPSPSLPAKPKP CCCCCCCCCCCCCCC	51.85	28450419
4627	Phosphorylation	PAKPKPPSRRDPTPT CCCCCCCCCCCCCCC	48.77	29978859
4632	Phosphorylation	PPSRRDPTPTYSATE CCCCCCCCCCCCCCC	32.33	28857561
4634	Phosphorylation	SRRDPTPTYSATEDT CCCCCCCCCCCCCCH	32.36	28857561
4635	Phosphorylation	RRDPTPTYSATEDTF CCCCCCCCCCCCCHH	9.49	22817900
4636	Phosphorylation	RDPTPTYSATEDTFK CCCCCCCCCCCCHHH	31.06	28857561
4638	Phosphorylation	PTPTYSATEDTFKDT CCCCCCCCCCHHHHH	28.58	28857561
4641	Phosphorylation	TYSATEDTFKDTANL CCCCCCCHHHHHHHH	26.76	22817900
4645	Phosphorylation	TEDTFKDTANLVKED CCCHHHHHHHHHHCC	20.31	-
4653	Phosphorylation	ANLVKEDSEV----- HHHHHCCCCC-----	41.15	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DLG3_HUMAN	DLG3	physical	12713445
MAGI1_HUMAN	MAGI1	physical	11274227
LR2BP_HUMAN	LRP2BP	physical	12508107
DAB2_HUMAN	DAB2	physical	10769163
DLG2_HUMAN	DLG2	physical	12713445
ARH_HUMAN	LDLRAP1	physical	14528014
DLG4_HUMAN	DLG4	physical	12713445
JIP1_HUMAN	MAPK8IP1	physical	10827173
SYJ2B_HUMAN	SYNJ2BP	physical	10827173
CAPON_HUMAN	NOS1AP	physical	10827173
SCN3A_HUMAN	SCN3A	physical	10827173
APBA2_HUMAN	APBA2	physical	10827173
APC10_HUMAN	ANAPC10	physical	10827173
DAB1_HUMAN	DAB1	physical	10827173
DLG4_HUMAN	DLG4	physical	10827173
JIP2_HUMAN	MAPK8IP2	physical	10827173
ITBP1_HUMAN	ITGB1BP1	physical	10827173
GIPC1_HUMAN	GIPC1	physical	10827173
GIPC1_HUMAN	GIPC1	physical	12508107
JIP1_HUMAN	MAPK8IP1	physical	12508107
JIP2_HUMAN	MAPK8IP2	physical	12508107
ANS1B_HUMAN	ANKS1B	physical	12508107
GIPC1_HUMAN	GIPC1	physical	11912251
AMRP_HUMAN	LRPAP1	physical	11912251
ALBU_BOVIN	ALB	physical	8898021
LIPL_HUMAN	LPL	physical	7686151
UROK_HUMAN	PLAU	physical	8344937
SNX17_HUMAN	SNX17	physical	12169628
TSP1_HUMAN	THBS1	physical	7775583
CLUS_HUMAN	CLU	physical	17260971

Drug and Disease Associations

• Kegg Disease
• H00886: Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome
• OMIM Disease
• 222448: Donnai-Barrow syndrome (DBS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4569, AND MASSSPECTROMETRY.
PubMed: 19413330