SCN3A_HUMAN - dbPTM
SCN3A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SCN3A_HUMAN
UniProt AC Q9NY46
Protein Name Sodium channel protein type 3 subunit alpha
Gene Name SCN3A
Organism Homo sapiens (Human).
Sequence Length 2000
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient..
Protein Sequence MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGPSALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDKEKFEKDKPEKESKGKEVRENQK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
33AcetylationEKRAAEEKAKKPKKE
HHHHHHHHHHCCCCC		57.947706135
169PhosphorylationTGIYTFESLIKILAR
EEEEEHHHHHHHHHH		31.0724719451
184PhosphorylationGFCLEDFTFLRDPWN
CCCCCCCCCCCCCCC		33.8022210691
204PhosphorylationVIVMAYVTEFVSLGN
HHHHHHHHHHHHCCC		15.8422210691
208PhosphorylationAYVTEFVSLGNVSAL
HHHHHHHHCCCHHHH		35.5622210691
211N-linked_GlycosylationTEFVSLGNVSALRTF
HHHHHCCCHHHHHHH		29.84UniProtKB CARBOHYD
213PhosphorylationFVSLGNVSALRTFRV
HHHCCCHHHHHHHHH		26.1122210691
290N-linked_GlycosylationSDSAFETNTTSYFNG
CCCCCCCCCCCCCCC		33.87UniProtKB CARBOHYD
296N-linked_GlycosylationTNTTSYFNGTMDSNG
CCCCCCCCCEECCCC		36.47UniProtKB CARBOHYD
302N-linked_GlycosylationFNGTMDSNGTFVNVT
CCCEECCCCCEEEEE		49.62UniProtKB CARBOHYD
307N-linked_GlycosylationDSNGTFVNVTMSTFN
CCCCCEEEEEEEEEC		21.25UniProtKB CARBOHYD
339N-linked_GlycosylationKDPLLCGNGSDAGQC
CCCEECCCCCCCCCC		45.88UniProtKB CARBOHYD
375PhosphorylationTFSWAFLSLFRLMTQ
HHHHHHHHHHHHHCH		21.0024719451
466PhosphorylationAQAVAAASAASRDFS
HHHHHHHHHHCCCCC		21.46-
473PhosphorylationSAASRDFSGIGGLGE
HHHCCCCCCCCHHHH		33.52-
484PhosphorylationGLGELLESSSEASKL
HHHHHHHCCHHHHHH		38.8528122231
485PhosphorylationLGELLESSSEASKLS
HHHHHHCCHHHHHHC		23.8728122231
486PhosphorylationGELLESSSEASKLSS
HHHHHCCHHHHHHCH		46.6028122231
489PhosphorylationLESSSEASKLSSKSA
HHCCHHHHHHCHHHH		30.0328122231
493PhosphorylationSEASKLSSKSAKEWR
HHHHHHCHHHHHHHH		40.8623403867
495PhosphorylationASKLSSKSAKEWRNR
HHHHCHHHHHHHHHH		46.6623403867
535PhosphorylationSEDSVKRSSFLFSMD
CCCCCCHHHEEEEEC		21.5228122231
536PhosphorylationEDSVKRSSFLFSMDG
CCCCCHHHEEEEECC		29.9628122231
554PhosphorylationTSDKKFCSPHQSLLS
CCCCCCCCHHHHHHH		28.6627732954
558PhosphorylationKFCSPHQSLLSIRGS
CCCCHHHHHHHHCCC		28.3927732954
561PhosphorylationSPHQSLLSIRGSLFS
CHHHHHHHHCCCCCC		18.6127732954
568PhosphorylationSIRGSLFSPRRNSKT
HHCCCCCCCCCCCCC		23.8425332170
573PhosphorylationLFSPRRNSKTSIFSF
CCCCCCCCCCCEEEE		35.18-
576PhosphorylationPRRNSKTSIFSFRGR
CCCCCCCCEEEECCC		25.93-
579PhosphorylationNSKTSIFSFRGRAKD
CCCCCEEEECCCCCC		16.6224719451
589PhosphorylationGRAKDVGSENDFADD
CCCCCCCCCCCCCCC		32.83-
610PhosphorylationDSESRRDSLFVPHRH
CCCHHHHCCCCCCCC		23.1528348404
623PhosphorylationRHGERRNSNVSQASM
CCCCCCCCCCCHHHH		36.4823532336
630 (in isoform 2)Phosphorylation-4.77-
630 (in isoform 4)Phosphorylation-4.77-
646PhosphorylationPANGKMHSTVDCNGV
CCCCCEECEEECCCE		26.99-
647PhosphorylationANGKMHSTVDCNGVV
CCCCEECEEECCCEE		12.99-
687PhosphorylationEVRKRRLSSYQISME
HHHHHHHHHCCCCHH		25.7828122231
688PhosphorylationVRKRRLSSYQISMEM
HHHHHHHHCCCCHHH		26.1628122231
707PhosphorylationSGRQRAVSIASILTN
CCHHHHHHHHHHHHH		16.0827732954
710PhosphorylationQRAVSIASILTNTME
HHHHHHHHHHHHHHH		19.2327732954
713PhosphorylationVSIASILTNTMEELE
HHHHHHHHHHHHHHH		27.2927732954
715PhosphorylationIASILTNTMEELEES
HHHHHHHHHHHHHHH		22.2628270605
722PhosphorylationTMEELEESRQKCPPC
HHHHHHHHHHHCCCH		30.5428270605
842PhosphorylationSLMELGLSNVEGLSV
HHHHHCCCCCCCHHH		36.71-
848PhosphorylationLSNVEGLSVLRSFRL
CCCCCCHHHHHHHHH		29.9324719451
852PhosphorylationEGLSVLRSFRLLRVF
CCHHHHHHHHHHHHH		15.57-
1019UbiquitinationQKGIDYVKNKMRECF
HHHHHHHHHHHHHHH		44.62-
1021UbiquitinationGIDYVKNKMRECFQK
HHHHHHHHHHHHHHH		33.35-
1028UbiquitinationKMRECFQKAFFRKPK
HHHHHHHHHHHCCCC		27.23-
1053PhosphorylationDSCMSNNTGIEISKE
CCCCCCCCCCEEHHH		43.7326270265
1058PhosphorylationNNTGIEISKELNYLR
CCCCCEEHHHHCCCC		13.7926270265
1063PhosphorylationEISKELNYLRDGNGT
EEHHHHCCCCCCCCC		18.7526270265
1139PhosphorylationKLNATSSSEGSTVDV
HHCCCCCCCCCEEEE		45.8230631047
1142PhosphorylationATSSSEGSTVDVVLP
CCCCCCCCEEEEEEC		22.6230631047
1157PhosphorylationREGEQAETEPEEDLK
CCCCCCCCCCHHHCC		60.9130576142
1170PhosphorylationLKPEACFTEGCIKKF
CCCCHHCCCCHHHCC		31.2127542207
1175UbiquitinationCFTEGCIKKFPFCQV
HCCCCHHHCCCCEEE		53.06-
1176UbiquitinationFTEGCIKKFPFCQVS
CCCCHHHCCCCEEEE		38.06-
1366N-linked_GlycosylationGKFYHCVNMTTGNMF
CCHHHEEECCCCCCC		27.72UniProtKB CARBOHYD
1380N-linked_GlycosylationFDISDVNNLSDCQAL
CCHHHCCCHHHHHHH		40.55UniProtKB CARBOHYD
1491AcetylationFMTEEQKKYYNAMKK
CCCHHHHHHHHHHHH		53.3030592213
1492PhosphorylationMTEEQKKYYNAMKKL
CCHHHHHHHHHHHHH		14.6922817900
1493PhosphorylationTEEQKKYYNAMKKLG
CHHHHHHHHHHHHHC		12.8122817900
1501PhosphorylationNAMKKLGSKKPQKPI
HHHHHHCCCCCCCCC		48.2010532948
1531PhosphorylationTRQVFDISIMILICL
HHHHHHHHHHHHHHH		14.1428122231
1542PhosphorylationLICLNMVTMMVETDD
HHHHHHHHHCEECCC		6.7028122231
1559PhosphorylationKYMTLVLSRINLVFI
CCHHHHHHHCCEEEE		24.5124719451
1570PhosphorylationLVFIVLFTGEFVLKL
EEEEECCCCCHHHHH		31.47-
1579PhosphorylationEFVLKLVSLRHYYFT
CHHHHHHHHHHHHHC		30.0724719451
1613PhosphorylationLAEMIEKYFVSPTLF
HHHHHHHHCCCHHHH		9.0919664994
1616PhosphorylationMIEKYFVSPTLFRVI
HHHHHCCCHHHHHHH		11.4119664994
1618PhosphorylationEKYFVSPTLFRVIRL
HHHCCCHHHHHHHHH		30.9028348404
1669PhosphorylationLFLVMFIYAIFGMSN
HHHHHHHHHHHCCCC		5.16-
1679PhosphorylationFGMSNFAYVKKEAGI
HCCCCCHHHHHHHCC		14.52-
1884PhosphorylationRFMASNPSKVSYEPI
HHHCCCCCCCCCCCC		50.36-
1888PhosphorylationSNPSKVSYEPITTTL
CCCCCCCCCCCCHHH		28.8125884760
1892PhosphorylationKVSYEPITTTLKRKQ
CCCCCCCCHHHHHCH		25.17-
1893PhosphorylationVSYEPITTTLKRKQE
CCCCCCCHHHHHCHH		30.74-
1894PhosphorylationSYEPITTTLKRKQEE
CCCCCCHHHHHCHHH		22.95-
1927PhosphorylationLKNISSNYNKEAIKG
HHHCCCCCCHHHHCC		29.56-
1953PhosphorylationIDKLNGNSTPEKTDG
EECCCCCCCCCCCCC		46.8929978859
1954PhosphorylationDKLNGNSTPEKTDGS
ECCCCCCCCCCCCCC		39.1929978859
1958PhosphorylationGNSTPEKTDGSSSTT
CCCCCCCCCCCCCCC		43.8825002506
1961PhosphorylationTPEKTDGSSSTTSPP
CCCCCCCCCCCCCCC		24.7525002506
1962PhosphorylationPEKTDGSSSTTSPPS
CCCCCCCCCCCCCCC		36.9125002506
1963PhosphorylationEKTDGSSSTTSPPSY
CCCCCCCCCCCCCCC		37.0825002506
1964PhosphorylationKTDGSSSTTSPPSYD
CCCCCCCCCCCCCCC		32.9925002506
1965PhosphorylationTDGSSSTTSPPSYDS
CCCCCCCCCCCCCCC		40.9825002506
1966PhosphorylationDGSSSTTSPPSYDSV
CCCCCCCCCCCCCCC		34.6025002506
1969PhosphorylationSSTTSPPSYDSVTKP
CCCCCCCCCCCCCCC		44.9825002506
1970PhosphorylationSTTSPPSYDSVTKPD
CCCCCCCCCCCCCCC		20.2925884760
1972PhosphorylationTSPPSYDSVTKPDKE
CCCCCCCCCCCCCHH		24.3725002506
1974PhosphorylationPPSYDSVTKPDKEKF
CCCCCCCCCCCHHHH		40.5925002506
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
1501SPhosphorylationKinasePKC-Uniprot
-KUbiquitinationE3 ubiquitin ligaseNEDD4LQ96PU5
PMID:15548568
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
1501SPhosphorylation

-
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SCN3A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NEDD4_MOUSENedd4physical
15548568
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00110 Cocaine (USP); Cocaine (TN)
D00199 Ajmaline (JP16); Ajimalin (TN)
D00252 Carbamazepine (JP16/USP/INN); Equetro (TN); Tegretol (TN)
D00303 Disopyramide (JP16/USAN/INN); Rythmodan P (TN)
D00354 Lamotrigine (JAN/USAN/INN); Lamictal (TN)
D00358 Lidocaine (JP16/USP/INN); Dentipatch (TN); Xylocaine (TN)
D00375 Mephenytoin (USP/INN); Mesantoin (TN)
D00477 Procainamide hydrochloride (JP16/USP); Procan SR (TN); Procanbid (TN); Pronestyl (TN)
D00512 Phenytoin (JP16/USP/INN); Dilantin (TN)
D00533 Oxcarbazepine (USAN/INN); Oxtellar (TN); Trileptal (TN)
D00537 Topiramate (JAN/USAN/INN); Topamax (TN); Trokendi xr (TN)
D00538 Zonisamide (JAN/USAN/INN); Excegran (TN)
D00551 Tetracaine (USP/INN); Amethocaine; Amethocaine (TN)
D00552 Ethyl aminobenzoate (JP16); Benzocaine (USP/INN); Parathesin (TN)
D00553 Propitocaine (JAN); Prilocaine (USP/INN)
D00637 Disopyramide phosphate (JAN/USP); Norpace (TN)
D00638 Flecainide acetate (JP16/USP); Tambocor (TN)
D00639 Mexiletine hydrochloride (JP16/USP); Mexitil (TN)
D00640 Propafenone hydrochloride (JP16/USP); Rythmol (TN)
D00642 Quinidine gluconate (USP); Quinaglute (TN)
D00643 Quinidine polygalacturonate; Cardioquin (TN)
D00732 Chloroprocaine hydrochloride (USP); Nesacaine (TN)
D00733 Dibucaine (USP); Cinchocaine (INN); Nupercaine (TN)
D00735 Dyclonine hydrochloride (USP); Dyclone (TN)
D00738 Mepivacaine hydrochloride (JP16/USP); Carbocaine (TN); Polocaine (TN); Scandonest plain (TN)
D00740 Procaine hydrochloride (JP16/USP); Novocain (TN)
D00741 Tetracaine hydrochloride (JP16/USP); Protocaine hydrochloride (TN)
D01287 Levobupivacaine hydrochloride (JAN/USAN); Chirocaine (TN)
D01326 Aprindine hydrochloride (JP16/USAN); Aspenon (TN)
D01450 Bupivacaine hydrochloride hydrate (JP16); Bupivacaine hydrochloride (USP); Marcaine (TN)
D01455 Cibenzoline succinate (JP16); Cifenline succinate (USAN); Cibenol (TN); Cipralan (TN)
D01479 Ambroxol hydrochloride (JAN); Hustless (TN)
D01554 Pilsicainide hydrochloride hydrate (JAN); Pilsicainide hydrochloride; SUN 1165 (TN); Sunrythm (TN)
D01785 Pirmenol hydrochloride hydrate (JAN); Pimenol (TN)
D02086 Lidocaine injection (JP16); Lidocaine hydrochloride (JAN/USP); Dalcaine (TN); Xylocaine (TN)
D02087 Moricizine hydrochloride (USP); Ethmozine (TN)
D02088 Tocainide hydrochloride (USP); Tonocard (TN)
D02096 Fosphenytoin sodium (USP); Cerebyx (TN)
D02098 Proparacaine hydrochloride (USP); Alcaine (TN); Ophthetic (TN)
D02103 Phenytoin sodium for injection (JP16); Phenytoin sodium (USP); Aleviatin (TN); Dilantin (TN)
D02182 Cocaine hydrochloride (JP16/USP); Cocaine hydrochloride (TN)
D02272 Quinidine sulfate hydrate (JP16); Quinidine sulfate (USP); Quinidex (TN)
D02969 Aprindine (USAN/INN)
D03492 Cifenline (USAN); Cibenzoline (INN)
D03991 Encainide hydrochloride (USAN)
D04048 Ropivacaine hydrochloride hydrate (JAN); Ropivacaine hydrochloride (USP); Anapeine (TN)
D05077 Moricizine (USAN); Moracizine (INN)
D06172 Tocainide (USAN/INN)
D06517 Pirmenol hydrochloride (USAN); Pirmavar (TN)
D07428 Bunaftine (INN)
D07442 Ambroxol (INN); Tabcin (TN)
D07595 Fosphenytoin sodium hydrate (JAN); Fostoin (TN)
D07894 Encainide (INN)
D07962 Flecainide (INN)
D07993 Fosphenytoin (INN)
D08048 Hydroquinidine (DCF); Dihydroquinidine
D08127 Lidocaine hydrochloride monohydrate; Lidocaine (TN)
D08215 Mexiletine (INN)
D08377 Pilsicainide (INN)
D08394 Pirmenol (INN)
D08421 Procainamide (INN)
D08422 Procaine (INN); Solution of novocain (TN)
D08435 Propafenone (INN); Propafenon hexal (TN)
D08458 Quinidine (BAN); Kinidin (TN)
D08459 Quinidine phenylethylbarbiturate; Quinidine 5-ethyl 5-phenyl barbiturate; Natisedine (TN)
D08490 Ropivacaine (INN); Naropin (TN)
D09215 Eslicarbazepine (USAN/INN)
D09612 Eslicarbazepine acetate (USAN)
DrugBank
DB06218Lacosamide
DB00313Valproic Acid
DB00909Zonisamide
Regulatory Network of SCN3A_HUMAN

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