GIPC1_HUMAN - dbPTM
GIPC1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GIPC1_HUMAN
UniProt AC O14908
Protein Name PDZ domain-containing protein GIPC1
Gene Name GIPC1
Organism Homo sapiens (Human).
Sequence Length 333
Subcellular Localization Cytoplasm. Membrane
Peripheral membrane protein.
Protein Description May be involved in G protein-linked signaling..
Protein Sequence MPLGLGRRKKAPPLVENEEAEPGRGGLGVGEPGPLGGGGSGGPQMGLPPPPPALRPRLVFHTQLAHGSPTGRIEGFTNVKELYGKIAEAFRLPTAEVMFCTLNTHKVDMDKLLGGQIGLEDFIFAHVKGQRKEVEVFKSEDALGLTITDNGAGYAFIKRIKEGSVIDHIHLISVGDMIEAINGQSLLGCRHYEVARLLKELPRGRTFTLKLTEPRKAFDMISQRSAGGRPGSGPQLGTGRGTLRLRSRGPATVEDLPSAFEEKAIEKVDDLLESYMGIRDTELAATMVELGKDKRNPDELAEALDERLGDFAFPDEFVFDVWGAIGDAKVGRY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10UbiquitinationLGLGRRKKAPPLVEN
CCCCCCCCCCCCCCC		65.4021906983
10MethylationLGLGRRKKAPPLVEN
CCCCCCCCCCCCCCC		65.40-
24MethylationNEEAEPGRGGLGVGE
CCCCCCCCCCCCCCC		46.88-
62PhosphorylationRPRLVFHTQLAHGSP
CCEEEEEEECCCCCC		17.5128857561
68PhosphorylationHTQLAHGSPTGRIEG
EEECCCCCCCCCEEC		14.9320873877
70PhosphorylationQLAHGSPTGRIEGFT
ECCCCCCCCCEECCC		40.5723186163
80UbiquitinationIEGFTNVKELYGKIA
EECCCCHHHHHHHHH		44.0321906983
80UbiquitinationIEGFTNVKELYGKIA
EECCCCHHHHHHHHH		44.0321890473
83PhosphorylationFTNVKELYGKIAEAF
CCCHHHHHHHHHHHH		19.9129496907
85UbiquitinationNVKELYGKIAEAFRL
CHHHHHHHHHHHHCC		25.78-
128UbiquitinationDFIFAHVKGQRKEVE
HEEEEHCCCCCEEEE		39.1921906983
132UbiquitinationAHVKGQRKEVEVFKS
EHCCCCCEEEEEEEC		59.22-
132AcetylationAHVKGQRKEVEVFKS
EHCCCCCEEEEEEEC		59.2219807305
138AcetylationRKEVEVFKSEDALGL
CEEEEEEECCCCCCC		59.1019807313
154PhosphorylationITDNGAGYAFIKRIK
EECCCCCEEEEECCC		9.6021406692
173PhosphorylationIDHIHLISVGDMIEA
CEEEEEEEHHHHHHH		26.80-
185PhosphorylationIEAINGQSLLGCRHY
HHHHCCCCCCCCCHH		27.28-
196MethylationCRHYEVARLLKELPR
CCHHHHHHHHHHCCC		45.81-
199UbiquitinationYEVARLLKELPRGRT
HHHHHHHHHCCCCCE		62.89-
203MethylationRLLKELPRGRTFTLK
HHHHHCCCCCEEEEE		60.91-
206PhosphorylationKELPRGRTFTLKLTE
HHCCCCCEEEEEECC		24.6427251275
208PhosphorylationLPRGRTFTLKLTEPR
CCCCCEEEEEECCCH		23.5228857561
210SumoylationRGRTFTLKLTEPRKA
CCCEEEEEECCCHHH		50.75-
210SumoylationRGRTFTLKLTEPRKA
CCCEEEEEECCCHHH		50.75-
210UbiquitinationRGRTFTLKLTEPRKA
CCCEEEEEECCCHHH		50.7521906983
216UbiquitinationLKLTEPRKAFDMISQ
EEECCCHHHHHHHHH		65.21-
222PhosphorylationRKAFDMISQRSAGGR
HHHHHHHHHCCCCCC		16.9521815630
225PhosphorylationFDMISQRSAGGRPGS
HHHHHHCCCCCCCCC		24.5130266825
232PhosphorylationSAGGRPGSGPQLGTG
CCCCCCCCCCCCCCC		50.4030266825
238PhosphorylationGSGPQLGTGRGTLRL
CCCCCCCCCCCEEEE		32.0929255136
240MethylationGPQLGTGRGTLRLRS
CCCCCCCCCEEEEEC		34.46-
240DimethylationGPQLGTGRGTLRLRS
CCCCCCCCCEEEEEC		34.46-
242PhosphorylationQLGTGRGTLRLRSRG
CCCCCCCEEEEECCC		13.8221712546
247PhosphorylationRGTLRLRSRGPATVE
CCEEEEECCCCCCHH		46.2925159151
248MethylationGTLRLRSRGPATVED
CEEEEECCCCCCHHH		48.99-
252PhosphorylationLRSRGPATVEDLPSA
EECCCCCCHHHCCHH		27.8026657352
258PhosphorylationATVEDLPSAFEEKAI
CCHHHCCHHHHHHHH		53.5428555341
263UbiquitinationLPSAFEEKAIEKVDD
CCHHHHHHHHHHHHH		47.6821906983
267UbiquitinationFEEKAIEKVDDLLES
HHHHHHHHHHHHHHH		44.87-
274PhosphorylationKVDDLLESYMGIRDT
HHHHHHHHHHCCCHH		22.0127642862
275PhosphorylationVDDLLESYMGIRDTE
HHHHHHHHHCCCHHH		7.0322817900
292UbiquitinationATMVELGKDKRNPDE
HHHHHHCCCCCCHHH		73.10-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GIPC1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GIPC1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GIPC1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MYO6_HUMANMYO6physical
17353931
SH3B4_HUMANSH3BP4physical
17353931
GEMI4_HUMANGEMIN4physical
17353931
NUP93_HUMANNUP93physical
17353931
MCM7_HUMANMCM7physical
17353931
SYMC_HUMANMARSphysical
17353931
MMS19_HUMANMMS19physical
17353931
TAGL_HUMANTAGLNphysical
17353931
PDXD1_HUMANPDXDC1physical
17353931
MYO1C_HUMANMYO1Cphysical
17353931
LSHR_HUMANLHCGRphysical
14507927
LRP2_HUMANLRP2physical
10827173
LRP1_HUMANLRP1physical
10827173
TPBG_HUMANTPBGphysical
11798178
ITA6_HUMANITGA6physical
11479315
ITA5_HUMANITGA5physical
11479315
KIF1B_HUMANKIF1Bphysical
10198040
GTR1_HUMANSLC2A1physical
10198040
ACTN1_HUMANACTN1physical
10198040
RGS19_HUMANRGS19physical
11251075
MYO6_HUMANMYO6physical
16908842
OGT1_HUMANOGTphysical
26344197
FCL_HUMANTSTA3physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GIPC1_HUMAN

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Related Literatures of Post-Translational Modification

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