dbPTM

MYO1C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MYO1C_HUMAN
UniProt AC	O00159
Protein Name	Unconventional myosin-Ic
Gene Name	MYO1C
Organism	Homo sapiens (Human).
Sequence Length	1063
Subcellular Localization	Isoform 1: Cytoplasm . Nucleus . Colocalizes with RNA polymerase II. Absent from nucleoli and does not colocalize with RNA polymerase I. Translocates to nuclear speckles upon exposure to inhibitors of RNA polymerase II transcription. Isoform 2: Cyto
Protein Description	Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes.; Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation (By similarity)..
Protein Sequence	MALQVELVPTGEIIRVVHPHRPCKLALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDRSELSDKKRPETVATQFKMSLLQLVEILQSKEPAYVRCIKPNDAKQPGRFDEVLIRHQVKYLGLLENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPTWAGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDALEVRRQSLATKIQAAWRGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIRGFVLRHAPRCPENAFFLDHVRTSFLLNLRRQLPQNVLDTSWPTPPPALREASELLRELCIKNMVWKYCRSISPEWKQQLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGTDEISPRVLQALGSEPIQYAVPVVKYDRKGYKPRSRQLLLTPNAVVIVEDAKVKQRIDYANLTGISVSSLSDSLFVLHVQRADNKQKGDVVLQSDHVIETLTKTALSANRVNSININQGSITFAGGPGRDGTIDFTPGSELLITKAKNGHLAVVAPRLNSR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1 (in isoform 2)	Acetylation	-	38.07	22814378
3	Phosphorylation	-----MALQVELVPT -----CCCEEEEEEC	9.98	15302935
3 (in isoform 2)	Phosphorylation	-	9.98	15302935
3 (in isoform 3)	Phosphorylation	-	9.98	26657352
6 (in isoform 3)	Phosphorylation	-	30.96	21815630
10 (in isoform 3)	Phosphorylation	-	39.71	19691289
29	Phosphorylation	PCKLALGSDGVRVTM CCEEEECCCCEEEEH	31.85	28857561
33	Dimethylation	ALGSDGVRVTMESAL EECCCCEEEEHHHCC	24.58	-
33	Methylation	ALGSDGVRVTMESAL EECCCCEEEEHHHCC	24.58	115372683
38	Phosphorylation	GVRVTMESALTARDR CEEEEHHHCCHHHHC	20.11	20068231
41	Phosphorylation	VTMESALTARDRVGV EEHHHCCHHHHCCCC	21.26	20068231
77	Phosphorylation	RFRENLIYTYIGPVL HHHHCCCEEECCCEE	9.17	20068231
78	Phosphorylation	FRENLIYTYIGPVLV HHHCCCEEECCCEEE	11.15	20068231
79	Phosphorylation	RENLIYTYIGPVLVS HHCCCEEECCCEEEE	6.21	20068231
97	Phosphorylation	YRDLQIYSRQHMERY CCCCHHHCHHHHHHH	27.39	24719451
108	Phosphorylation	MERYRGVSFYEVPPH HHHHCCCEECCCCHH	25.57	24719451
111	Ubiquitination	YRGVSFYEVPPHLFA HCCCEECCCCHHHHH	46.68	21963094
116	Ubiquitination	FYEVPPHLFAVADTV ECCCCHHHHHHHHHH	3.48	21963094
122	Ubiquitination	HLFAVADTVYRALRT HHHHHHHHHHHHHHC	15.08	33845483
124	Phosphorylation	FAVADTVYRALRTER HHHHHHHHHHHHCCC	7.71	-
127	Ubiquitination	ADTVYRALRTERRDQ HHHHHHHHHCCCCCC	5.28	21963094
132	Ubiquitination	RALRTERRDQAVMIS HHHHCCCCCCEEEEE	33.87	21963094
139	Phosphorylation	RDQAVMISGESGAGK CCCEEEEECCCCCCH	20.57	26462736
142	Phosphorylation	AVMISGESGAGKTEA EEEEECCCCCCHHHH	37.15	26462736
146	Ubiquitination	SGESGAGKTEATKRL ECCCCCCHHHHHHHH	42.53	21963094
147	Phosphorylation	GESGAGKTEATKRLL CCCCCCHHHHHHHHH	29.90	26462736
150	Phosphorylation	GAGKTEATKRLLQFY CCCHHHHHHHHHHHH	15.51	20068231
151	Ubiquitination	AGKTEATKRLLQFYA CCHHHHHHHHHHHHH	48.36	21963094
153	Ubiquitination	KTEATKRLLQFYAET HHHHHHHHHHHHHHH	4.73	23000965
153 (in isoform 2)	Ubiquitination	-	4.73	21890473
157	Phosphorylation	TKRLLQFYAETCPAP HHHHHHHHHHHCCCC	7.20	28152594
160	Phosphorylation	LLQFYAETCPAPERG HHHHHHHHCCCCCCC	18.67	28152594
161	Glutathionylation	LQFYAETCPAPERGG HHHHHHHCCCCCCCC	1.72	22555962
164	Ubiquitination	YAETCPAPERGGAVR HHHHCCCCCCCCHHH	19.57	33845483
169	Ubiquitination	PAPERGGAVRDRLLQ CCCCCCCHHHHHHHH	8.94	23000965
169 (in isoform 3)	Ubiquitination	-	8.94	21890473
188	Ubiquitination	LEAFGNAKTLRNDNS HHHHCCCCCCCCCCC	52.68	23000965
188 (in isoform 1)	Ubiquitination	-	52.68	21890473
189	Ubiquitination	EAFGNAKTLRNDNSS HHHCCCCCCCCCCCC	28.65	29901268
195	Phosphorylation	KTLRNDNSSRFGKYM CCCCCCCCCCCEEEE	26.25	29514088
196	Phosphorylation	TLRNDNSSRFGKYMD CCCCCCCCCCEEEEE	37.57	29514088
200	Ubiquitination	DNSSRFGKYMDVQFD CCCCCCEEEEEEEEE	34.39	29901268
205	Ubiquitination	FGKYMDVQFDFKGAP CEEEEEEEEEECCCC	28.11	29901268
224	Acetylation	ILSYLLEKSRVVHQN HHHHHHHHHCCCCCC	43.46	26051181
224	Ubiquitination	ILSYLLEKSRVVHQN HHHHHHHHHCCCCCC	43.46	29901268
239	Ubiquitination	HGERNFHIFYQLLEG CCCCEEEEEHHHHCC	2.77	29967540
246	Ubiquitination	IFYQLLEGGEEETLR EEHHHHCCCCHHHHH	49.10	29967540
250	Acetylation	LLEGGEEETLRRLGL HHCCCCHHHHHHHCC	49.17	19608861
255	Ubiquitination	EEETLRRLGLERNPQ CHHHHHHHCCCCCCC	8.10	29967540
262	Ubiquitination	LGLERNPQSYLYLVK HCCCCCCCCEEEEEE	48.54	29967540
263	Phosphorylation	GLERNPQSYLYLVKG CCCCCCCCEEEEEEC	20.54	28152594
264	Phosphorylation	LERNPQSYLYLVKGQ CCCCCCCEEEEEECC	8.30	28152594
266	Acetylation	RNPQSYLYLVKGQCA CCCCCEEEEEECCEE	10.96	19608861
266	Phosphorylation	RNPQSYLYLVKGQCA CCCCCEEEEEECCEE	10.96	28152594
269	Acetylation	QSYLYLVKGQCAKVS CCEEEEEECCEEECC	40.44	26051181
274	Ubiquitination	LVKGQCAKVSSINDK EEECCEEECCCCCCH	50.72	29967540
281	Acetylation	KVSSINDKSDWKVVR ECCCCCCHHCHHHHH	45.91	26051181
281	Malonylation	KVSSINDKSDWKVVR ECCCCCCHHCHHHHH	45.91	26320211
281	Ubiquitination	KVSSINDKSDWKVVR ECCCCCCHHCHHHHH	45.91	29967540
285	Acetylation	INDKSDWKVVRKALT CCCHHCHHHHHHHEE	35.52	19608861
285	Malonylation	INDKSDWKVVRKALT CCCHHCHHHHHHHEE	35.52	26320211
326	Ubiquitination	FAANEESNAQVTTEN EEECCCCCCCCCCHH	37.36	33845483
326 (in isoform 2)	Ubiquitination	-	37.36	21890473
337	Phosphorylation	TTENQLKYLTRLLSV CCHHHHHHHHHHHCC	23.15	27174698
337	Ubiquitination	TTENQLKYLTRLLSV CCHHHHHHHHHHHCC	23.15	33845483
339	Phosphorylation	ENQLKYLTRLLSVEG HHHHHHHHHHHCCCC	19.04	27174698
342	Ubiquitination	LKYLTRLLSVEGSTL HHHHHHHHCCCCCHH	4.93	33845483
342 (in isoform 3)	Ubiquitination	-	4.93	21890473
343	Phosphorylation	KYLTRLLSVEGSTLR HHHHHHHCCCCCHHH	23.78	23403867
347	Phosphorylation	RLLSVEGSTLREALT HHHCCCCCHHHHHHH	15.68	23403867
348	Phosphorylation	LLSVEGSTLREALTH HHCCCCCHHHHHHHC	40.46	23403867
348	Ubiquitination	LLSVEGSTLREALTH HHCCCCCHHHHHHHC	40.46	33845483
359	Ubiquitination	ALTHRKIIAKGEELL HHHCCCHHHCCCHHC	3.48	33845483
361	Ubiquitination	THRKIIAKGEELLSP HCCCHHHCCCHHCCC	57.35	21906983
361 (in isoform 1)	Ubiquitination	-	57.35	21890473
364	Ubiquitination	KIIAKGEELLSPLNL CHHHCCCHHCCCCCH	64.77	33845483
367	Phosphorylation	AKGEELLSPLNLEQA HCCCHHCCCCCHHHH	39.71	-
369	Ubiquitination	GEELLSPLNLEQAAY CCHHCCCCCHHHHHH	11.67	23000965
369 (in isoform 2)	Ubiquitination	-	11.67	21890473
373	Phosphorylation	LSPLNLEQAAYARDA CCCCCHHHHHHHHHH	34.16	17081983
376	Phosphorylation	LNLEQAAYARDALAK CCHHHHHHHHHHHHH	12.75	-
380	Ubiquitination	QAAYARDALAKAVYS HHHHHHHHHHHHHHH	12.13	33845483
383	Methylation	YARDALAKAVYSRTF HHHHHHHHHHHHHHH	38.95	23161681
383	Ubiquitination	YARDALAKAVYSRTF HHHHHHHHHHHHHHH	38.95	33845483
385	Ubiquitination	RDALAKAVYSRTFTW HHHHHHHHHHHHHHH	4.37	23000965
385 (in isoform 3)	Ubiquitination	-	4.37	21890473
396	Acetylation	TFTWLVGKINRSLAS HHHHHHHHHHHHHCC	29.36	26051181
403	Phosphorylation	KINRSLASKDVESPS HHHHHHCCCCCCCCC	34.38	23403867
404	Ubiquitination	INRSLASKDVESPSW HHHHHCCCCCCCCCH	61.25	23000965
404 (in isoform 1)	Ubiquitination	-	61.25	21890473
408	Phosphorylation	LASKDVESPSWRSTT HCCCCCCCCCHHHHH	24.88	22167270
410	Phosphorylation	SKDVESPSWRSTTVL CCCCCCCCHHHHHHH	44.38	30266825
413	Phosphorylation	VESPSWRSTTVLGLL CCCCCHHHHHHHHHH	23.36	18452278
415	Phosphorylation	SPSWRSTTVLGLLDI CCCHHHHHHHHHHHH	18.25	18452278
432	Phosphorylation	FEVFQHNSFEQFCIN CEEECCCCHHHHHHH	28.21	18452278
440	Phosphorylation	FEQFCINYCNEKLQQ HHHHHHHHHHHHHHH	4.09	18452278
451	Ubiquitination	KLQQLFIELTLKSEQ HHHHHHHHHHCCCCH	28.50	33845483
462	Ubiquitination	KSEQEEYEAEGIAWE CCCHHHHHHCCCCCC	43.45	33845483
467	Ubiquitination	EYEAEGIAWEPVQYF HHHHCCCCCCCHHHH	18.55	33845483
473	Phosphorylation	IAWEPVQYFNNKIIC CCCCCHHHHCCEEHH	14.44	-
477	Ubiquitination	PVQYFNNKIICDLVE CHHHHCCEEHHHHHH	34.25	29967540
483	Ubiquitination	NKIICDLVEEKFKGI CEEHHHHHHHHHCCH	5.95	29967540
486	Acetylation	ICDLVEEKFKGIISI HHHHHHHHHCCHHHH	38.58	25825284
486	Malonylation	ICDLVEEKFKGIISI HHHHHHHHHCCHHHH	38.58	26320211
486	Ubiquitination	ICDLVEEKFKGIISI HHHHHHHHHCCHHHH	38.58	33845483
492	Ubiquitination	EKFKGIISILDEECL HHHCCHHHHCCHHHC	18.38	29967540
493	Ubiquitination	KFKGIISILDEECLR HHCCHHHHCCHHHCC	3.86	29967540
499	Ubiquitination	SILDEECLRPGEATD HHCCHHHCCCCCCCC	9.29	29967540
508	Ubiquitination	PGEATDLTFLEKLED CCCCCCCHHHHHHHH	29.05	29967540
512	Ubiquitination	TDLTFLEKLEDTVKH CCCHHHHHHHHHHHH	60.36	29967540
518	Ubiquitination	EKLEDTVKHHPHFLT HHHHHHHHHCCCHHH	37.98	29967540
527	Ubiquitination	HPHFLTHKLADQRTR CCCHHHHHHCCHHHH	39.89	29967540
536	Phosphorylation	ADQRTRKSLGRGEFR CCHHHHHHCCCCCEE	32.53	27422710
536	Ubiquitination	ADQRTRKSLGRGEFR CCHHHHHHCCCCCEE	32.53	29967540
543	Ubiquitination	SLGRGEFRLLHYAGE HCCCCCEEEEEECCE	31.85	21963094
552	Ubiquitination	LHYAGEVTYSVTGFL EEECCEEEEEEEECC	13.04	29967540
554	Ubiquitination	YAGEVTYSVTGFLDK ECCEEEEEEEECCCC	12.11	33845483
559	Ubiquitination	TYSVTGFLDKNNDLL EEEEEECCCCCCCCH	10.96	21963094
560	Ubiquitination	YSVTGFLDKNNDLLF EEEEECCCCCCCCHH	49.75	29967540
571	Acetylation	DLLFRNLKETMCSSK CCHHHHHHHHHHCCC	55.47	26051181
571	Malonylation	DLLFRNLKETMCSSK CCHHHHHHHHHHCCC	55.47	26320211
571	Ubiquitination	DLLFRNLKETMCSSK CCHHHHHHHHHHCCC	55.47	29967540
575	Ubiquitination	RNLKETMCSSKNPIM HHHHHHHHCCCCCHH	5.62	29967540
576	Phosphorylation	NLKETMCSSKNPIMS HHHHHHHCCCCCHHH	33.26	28302921
576	Ubiquitination	NLKETMCSSKNPIMS HHHHHHHCCCCCHHH	33.26	29967540
577	Phosphorylation	LKETMCSSKNPIMSQ HHHHHHCCCCCHHHH	31.37	30631047
578	Ubiquitination	KETMCSSKNPIMSQC HHHHHCCCCCHHHHH	50.91	21963094
583	Phosphorylation	SSKNPIMSQCFDRSE CCCCCHHHHHCCHHH	25.23	28302921
583	Ubiquitination	SSKNPIMSQCFDRSE CCCCCHHHHHCCHHH	25.23	23000965
583 (in isoform 2)	Ubiquitination	-	25.23	-
589	Phosphorylation	MSQCFDRSELSDKKR HHHHCCHHHHCCCCC	44.74	29514088
592	Phosphorylation	CFDRSELSDKKRPET HCCHHHHCCCCCHHH	43.25	23403867
592	Ubiquitination	CFDRSELSDKKRPET HCCHHHHCCCCCHHH	43.25	33845483
594	Ubiquitination	DRSELSDKKRPETVA CHHHHCCCCCHHHHH	47.51	32015554
595	Malonylation	RSELSDKKRPETVAT HHHHCCCCCHHHHHH	77.50	26320211
595	Ubiquitination	RSELSDKKRPETVAT HHHHCCCCCHHHHHH	77.50	29967540
597	Ubiquitination	ELSDKKRPETVATQF HHCCCCCHHHHHHHH	50.95	29967540
599	Phosphorylation	SDKKRPETVATQFKM CCCCCHHHHHHHHHH	20.37	25690035
599	Ubiquitination	SDKKRPETVATQFKM CCCCCHHHHHHHHHH	20.37	23000965
602	Phosphorylation	KRPETVATQFKMSLL CCHHHHHHHHHHHHH	30.15	20071362
603	Ubiquitination	RPETVATQFKMSLLQ CHHHHHHHHHHHHHH	26.65	33845483
607	Phosphorylation	VATQFKMSLLQLVEI HHHHHHHHHHHHHHH	26.90	24719451
608	Ubiquitination	ATQFKMSLLQLVEIL HHHHHHHHHHHHHHH	2.94	33845483
612	Acetylation	KMSLLQLVEILQSKE HHHHHHHHHHHHCCC	2.51	19608861
612	Ubiquitination	KMSLLQLVEILQSKE HHHHHHHHHHHHCCC	2.51	23000965
613	Ubiquitination	MSLLQLVEILQSKEP HHHHHHHHHHHCCCC	46.72	29967540
617	Phosphorylation	QLVEILQSKEPAYVR HHHHHHHCCCCCEEE	35.23	25907765
618	Ubiquitination	LVEILQSKEPAYVRC HHHHHHCCCCCEEEE	55.55	23000965
622	Phosphorylation	LQSKEPAYVRCIKPN HHCCCCCEEEEECCC	10.11	-
627	Ubiquitination	PAYVRCIKPNDAKQP CCEEEEECCCCCCCC	41.20	33845483
628	Acetylation	AYVRCIKPNDAKQPG CEEEEECCCCCCCCC	24.83	19608861
628	Ubiquitination	AYVRCIKPNDAKQPG CEEEEECCCCCCCCC	24.83	23000965
632	Ubiquitination	CIKPNDAKQPGRFDE EECCCCCCCCCCCCH	60.95	29967540
641	Ubiquitination	PGRFDEVLIRHQVKY CCCCCHHHHHHHHHH	2.40	29967540
647	Acetylation	VLIRHQVKYLGLLEN HHHHHHHHHHHHHHH	28.34	19608861
647	Ubiquitination	VLIRHQVKYLGLLEN HHHHHHHHHHHHHHH	28.34	23000965
648	Phosphorylation	LIRHQVKYLGLLENL HHHHHHHHHHHHHHH	13.72	28152594
657	Ubiquitination	GLLENLRVRRAGFAY HHHHHHHHHHCCCCH	5.68	29967540
667	Acetylation	AGFAYRRKYEAFLQR CCCCHHHHHHHHHHH	38.14	27452117
667	Malonylation	AGFAYRRKYEAFLQR CCCCHHHHHHHHHHH	38.14	26320211
669	Acetylation	FAYRRKYEAFLQRYK CCHHHHHHHHHHHHH	35.66	19608861
669	Ubiquitination	FAYRRKYEAFLQRYK CCHHHHHHHHHHHHH	35.66	33845483
676	Acetylation	EAFLQRYKSLCPETW HHHHHHHHHHCCCCC	38.86	26051181
676	Ubiquitination	EAFLQRYKSLCPETW HHHHHHHHHHCCCCC	38.86	29967540
680	Ubiquitination	QRYKSLCPETWPTWA HHHHHHCCCCCCCCC	47.55	33845483
685	Acetylation	LCPETWPTWAGRPQD HCCCCCCCCCCCCCC	21.36	19608861
685	Ubiquitination	LCPETWPTWAGRPQD HCCCCCCCCCCCCCC	21.36	33845483
686	Ubiquitination	CPETWPTWAGRPQDG CCCCCCCCCCCCCCC	7.82	21890473
686 (in isoform 2)	Ubiquitination	-	7.82	21890473
702	Ubiquitination	AVLVRHLGYKPEEYK EEEECCCCCCHHHHC	23.46	21890473
702 (in isoform 3)	Ubiquitination	-	23.46	21890473
704	Acetylation	LVRHLGYKPEEYKMG EECCCCCCHHHHCCC	44.12	19608861
704	Ubiquitination	LVRHLGYKPEEYKMG EECCCCCCHHHHCCC	44.12	33845483
705	Ubiquitination	VRHLGYKPEEYKMGR ECCCCCCHHHHCCCC	31.03	21890473
705 (in isoform 2)	Ubiquitination	-	31.03	21890473
708	Phosphorylation	LGYKPEEYKMGRTKI CCCCHHHHCCCCEEE	12.47	29083192
709	Malonylation	GYKPEEYKMGRTKIF CCCHHHHCCCCEEEE	37.85	26320211
716	Ubiquitination	KMGRTKIFIRFPKTL CCCCEEEEEECCHHH	3.32	32015554
721	Ubiquitination	KIFIRFPKTLFATED EEEEECCHHHEECHH	55.97	23000965
721 (in isoform 1)	Ubiquitination	-	55.97	21890473
721 (in isoform 3)	Ubiquitination	-	55.97	21890473
726	Phosphorylation	FPKTLFATEDALEVR CCHHHEECHHHHHHH	27.36	29514088
736	Phosphorylation	ALEVRRQSLATKIQA HHHHHHHHHHHHHHH	20.40	30266825
739	Phosphorylation	VRRQSLATKIQAAWR HHHHHHHHHHHHHHC	33.69	30242111
740	Ubiquitination	RRQSLATKIQAAWRG HHHHHHHHHHHHHCC	27.49	23000965
740 (in isoform 1)	Ubiquitination	-	27.49	21890473
786	Phosphorylation	KRKWAAQTIRRLIRG HHHHHHHHHHHHHHH	16.24	28857561
802	S-nitrosylation	VLRHAPRCPENAFFL HHHCCCCCCCCCCHH	4.89	22178444
815	Phosphorylation	FLDHVRTSFLLNLRR HHHHHHHHHHHHHHH	11.88	28857561
829	Phosphorylation	RQLPQNVLDTSWPTP HHCCCCCCCCCCCCC	8.57	32645325
833	Ubiquitination	QNVLDTSWPTPPPAL CCCCCCCCCCCCHHH	11.68	23000965
833 (in isoform 2)	Ubiquitination	-	11.68	21890473
839	Ubiquitination	SWPTPPPALREASEL CCCCCCHHHHHHHHH	25.65	23000965
840	Phosphorylation	WPTPPPALREASELL CCCCCHHHHHHHHHH	6.66	32645325
844	Phosphorylation	PPALREASELLRELC CHHHHHHHHHHHHHH	24.83	28857561
844	Ubiquitination	PPALREASELLRELC CHHHHHHHHHHHHHH	24.83	33845483
845	Phosphorylation	PALREASELLRELCI HHHHHHHHHHHHHHH	59.89	32645325
847	Ubiquitination	LREASELLRELCIKN HHHHHHHHHHHHHHH	3.34	33845483
849	Ubiquitination	EASELLRELCIKNMV HHHHHHHHHHHHHHH	48.22	23000965
849 (in isoform 3)	Ubiquitination	-	48.22	21890473
855	Ubiquitination	RELCIKNMVWKYCRS HHHHHHHHHHHHHHH	3.02	23000965
858	Acetylation	CIKNMVWKYCRSISP HHHHHHHHHHHHCCH	24.06	25825284
858	Ubiquitination	CIKNMVWKYCRSISP HHHHHHHHHHHHCCH	24.06	33845483
859	Phosphorylation	IKNMVWKYCRSISPE HHHHHHHHHHHCCHH	4.20	29514088
862	Phosphorylation	MVWKYCRSISPEWKQ HHHHHHHHCCHHHHH	24.69	26657352
863	Ubiquitination	VWKYCRSISPEWKQQ HHHHHHHCCHHHHHH	4.04	33845483
864	Phosphorylation	WKYCRSISPEWKQQL HHHHHHCCHHHHHHH	20.29	30266825
868	Methylation	RSISPEWKQQLQQKA HHCCHHHHHHHHHHH	26.89	44496085
868	Ubiquitination	RSISPEWKQQLQQKA HHCCHHHHHHHHHHH	26.89	23000965
868 (in isoform 1)	Ubiquitination	-	26.89	21890473
874	Ubiquitination	WKQQLQQKAVASEIF HHHHHHHHHHHHHHH	31.69	23000965
882	Ubiquitination	AVASEIFKGKKDNYP HHHHHHHCCCCCCCC	75.40	33845483
888	Phosphorylation	FKGKKDNYPQSVPRL HCCCCCCCCCCCCEE	16.87	28152594
891	Phosphorylation	KKDNYPQSVPRLFIS CCCCCCCCCCEEEEE	29.59	28152594
894	Methylation	NYPQSVPRLFISTRL CCCCCCCEEEEEECC	39.82	115484239
907	Phosphorylation	RLGTDEISPRVLQAL CCCCCCCCHHHHHHH	12.47	28674419
916	Phosphorylation	RVLQALGSEPIQYAV HHHHHHCCCCCEEEE	40.84	27050516
921	Phosphorylation	LGSEPIQYAVPVVKY HCCCCCEEEEEEEEC	15.41	27642862
943	Phosphorylation	RSRQLLLTPNAVVIV CCCEECCCCCEEEEE	17.92	-
970	Ubiquitination	NLTGISVSSLSDSLF CCCCCCHHHHCCEEE	20.83	29967540
986	Ubiquitination	LHVQRADNKQKGDVV EEEEECCCCCCCCEE	47.90	29967540
996	Phosphorylation	KGDVVLQSDHVIETL CCCEEECCHHHHHHH	26.06	30622161
1002	Phosphorylation	QSDHVIETLTKTALS CCHHHHHHHHHHHHH	28.71	30622161
1004	Phosphorylation	DHVIETLTKTALSAN HHHHHHHHHHHHHCC	33.49	30622161
1005	Ubiquitination	HVIETLTKTALSANR HHHHHHHHHHHHCCC	34.61	29967540
1012	Ubiquitination	KTALSANRVNSININ HHHHHCCCCCEEEEC	28.80	29967540
1014	Ubiquitination	ALSANRVNSININQG HHHCCCCCEEEECCC	33.66	29967540
1015	Phosphorylation	LSANRVNSININQGS HHCCCCCEEEECCCC	17.72	28857561
1022	Phosphorylation	SININQGSITFAGGP EEEECCCCEEECCCC	14.53	28857561
1028	Ubiquitination	GSITFAGGPGRDGTI CCEEECCCCCCCCCE	20.33	29967540
1030	Ubiquitination	ITFAGGPGRDGTIDF EEECCCCCCCCCEEC	43.52	29967540
1034	Phosphorylation	GGPGRDGTIDFTPGS CCCCCCCCEECCCCC	22.97	20068231
1038	Phosphorylation	RDGTIDFTPGSELLI CCCCEECCCCCEEEE	24.00	20068231
1041	Phosphorylation	TIDFTPGSELLITKA CEECCCCCEEEEEEC	26.69	20068231
1046	Phosphorylation	PGSELLITKAKNGHL CCCEEEEEECCCCCE	25.56	20068231
1047	Ubiquitination	GSELLITKAKNGHLA CCEEEEEECCCCCEE	50.82	29967540
1049	Ubiquitination	ELLITKAKNGHLAVV EEEEEECCCCCEEEE	66.09	29967540
1062	Phosphorylation	VVAPRLNSR------ EEECCCCCC------	43.91	29514088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MYO1C_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MYO1C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MYO1C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CBL_HUMAN	CBL	physical	9367879
SMCA5_HUMAN	SMARCA5	physical	16514417
SAP18_HUMAN	SAP18	physical	22939629
SEPT7_HUMAN	SEPT7	physical	22939629
RRN3_HUMAN	RRN3	physical	15558034
ACTS_HUMAN	ACTA1	physical	15558034
RPA2_HUMAN	POLR1B	physical	15558034
ACTG_HUMAN	ACTG1	physical	26496610
ACTN4_HUMAN	ACTN4	physical	26496610
ADDA_HUMAN	ADD1	physical	26496610
CAZA2_HUMAN	CAPZA2	physical	26496610
CDN2A_HUMAN	CDKN2A	physical	26496610
ARF_HUMAN	CDKN2A	physical	26496610
COF1_HUMAN	CFL1	physical	26496610
COF2_HUMAN	CFL2	physical	26496610
CRIP2_HUMAN	CRIP2	physical	26496610
DREB_HUMAN	DBN1	physical	26496610
FLII_HUMAN	FLII	physical	26496610
FLNA_HUMAN	FLNA	physical	26496610
T2FA_HUMAN	GTF2F1	physical	26496610
HMGB2_HUMAN	HMGB2	physical	26496610
IMDH1_HUMAN	IMPDH1	physical	26496610
IMDH2_HUMAN	IMPDH2	physical	26496610
ABLM1_HUMAN	ABLIM1	physical	26496610
MYO1B_HUMAN	MYO1B	physical	26496610
MYO5A_HUMAN	MYO5A	physical	26496610
MYPT1_HUMAN	PPP1R12A	physical	26496610
PP1A_HUMAN	PPP1CA	physical	26496610
TWF1_HUMAN	TWF1	physical	26496610
RALA_HUMAN	RALA	physical	26496610
SRSF2_HUMAN	SRSF2	physical	26496610
SIPA1_HUMAN	SIPA1	physical	26496610
SPTN1_HUMAN	SPTAN1	physical	26496610
SPTB2_HUMAN	SPTBN1	physical	26496610
SPTN2_HUMAN	SPTBN2	physical	26496610
SSFA2_HUMAN	SSFA2	physical	26496610
SVIL_HUMAN	SVIL	physical	26496610
ZO1_HUMAN	TJP1	physical	26496610
TMOD1_HUMAN	TMOD1	physical	26496610
UVRAG_HUMAN	UVRAG	physical	26496610
COR2A_HUMAN	CORO2A	physical	26496610
DX39B_HUMAN	DDX39B	physical	26496610
RBM10_HUMAN	RBM10	physical	26496610
SRBS2_HUMAN	SORBS2	physical	26496610
EIF3B_HUMAN	EIF3B	physical	26496610
EIF3I_HUMAN	EIF3I	physical	26496610
RIOK3_HUMAN	RIOK3	physical	26496610
PDLI7_HUMAN	PDLIM7	physical	26496610
ZO2_HUMAN	TJP2	physical	26496610
SAFB2_HUMAN	SAFB2	physical	26496610
RHGBA_HUMAN	ARHGAP11A	physical	26496610
WDR1_HUMAN	WDR1	physical	26496610
MED12_HUMAN	MED12	physical	26496610
MED16_HUMAN	MED16	physical	26496610
ARPC3_HUMAN	ARPC3	physical	26496610
ARC1B_HUMAN	ARPC1B	physical	26496610
FARP1_HUMAN	FARP1	physical	26496610
RBM5_HUMAN	RBM5	physical	26496610
BASP1_HUMAN	BASP1	physical	26496610
TADA3_HUMAN	TADA3	physical	26496610
CHERP_HUMAN	CHERP	physical	26496610
SF3B2_HUMAN	SF3B2	physical	26496610
DEST_HUMAN	DSTN	physical	26496610
TARA_HUMAN	TRIOBP	physical	26496610
TWF2_HUMAN	TWF2	physical	26496610
SYNPO_HUMAN	SYNPO	physical	26496610
SCAF8_HUMAN	SCAF8	physical	26496610
CE162_HUMAN	CEP162	physical	26496610
PALLD_HUMAN	PALLD	physical	26496610
SI1L3_HUMAN	SIPA1L3	physical	26496610
MPRIP_HUMAN	MPRIP	physical	26496610
COBL_HUMAN	COBL	physical	26496610
CSTFT_HUMAN	CSTF2T	physical	26496610
CLAP1_HUMAN	CLASP1	physical	26496610
SR140_HUMAN	U2SURP	physical	26496610
FBX46_HUMAN	FBXO46	physical	26496610
SF3B1_HUMAN	SF3B1	physical	26496610
COR1C_HUMAN	CORO1C	physical	26496610
PKHG3_HUMAN	PLEKHG3	physical	26496610
RAI14_HUMAN	RAI14	physical	26496610
TIM13_HUMAN	TIMM13	physical	26496610
TIM8B_HUMAN	TIMM8B	physical	26496610
AP3M1_HUMAN	AP3M1	physical	26496610
TMOD3_HUMAN	TMOD3	physical	26496610
CAR10_HUMAN	CARD10	physical	26496610
LIMA1_HUMAN	LIMA1	physical	26496610
MED15_HUMAN	MED15	physical	26496610
SSH1_HUMAN	SSH1	physical	26496610
MIC19_HUMAN	CHCHD3	physical	26496610
OXR1_HUMAN	OXR1	physical	26496610
AGGF1_HUMAN	AGGF1	physical	26496610
PNPO_HUMAN	PNPO	physical	26496610
NCBP3_HUMAN	C17orf85	physical	26496610
CCAR1_HUMAN	CCAR1	physical	26496610
UN45A_HUMAN	UNC45A	physical	26496610
PCNP_HUMAN	PCNP	physical	26496610
RHG21_HUMAN	ARHGAP21	physical	26496610
SQOR_HUMAN	SQRDL	physical	26496610
AFAP1_HUMAN	AFAP1	physical	26496610
INF2_HUMAN	INF2	physical	26496610
CS043_HUMAN	C19orf43	physical	26496610
MRM1_HUMAN	MRM1	physical	26496610
BACD3_HUMAN	KCTD10	physical	26496610
NSRP1_HUMAN	NSRP1	physical	26496610
FBX30_HUMAN	FBXO30	physical	26496610
HDGR2_HUMAN	HDGFRP2	physical	26496610
SPF45_HUMAN	RBM17	physical	26496610
DOCK7_HUMAN	DOCK7	physical	26496610
DIXC1_HUMAN	DIXDC1	physical	26496610
PHLB2_HUMAN	PHLDB2	physical	26496610
TIM29_HUMAN	C19orf52	physical	26496610
NEXN_HUMAN	NEXN	physical	26496610
CYTSB_HUMAN	SPECC1	physical	26496610
LARP4_HUMAN	LARP4	physical	26496610
BAP18_HUMAN	C17orf49	physical	26496610
MISP_HUMAN	MISP	physical	26496610
RM55_HUMAN	MRPL55	physical	26496610
JMY_HUMAN	JMY	physical	26496610
CC127_HUMAN	CCDC127	physical	26496610
RBM33_HUMAN	RBM33	physical	26496610
TPRN_HUMAN	TPRN	physical	26496610
BAZ1B_HUMAN	BAZ1B	physical	23555303
SMCA5_HUMAN	SMARCA5	physical	23555303
KAT2B_HUMAN	KAT2B	physical	23555303

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MYO1C_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-285; LYS-647 AND LYS-704,AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38, AND MASSSPECTROMETRY.	15302935 [Abstract]