TIM29_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIM29_HUMAN
• UniProt AC: Q9BSF4
• Protein Name: Mitochondrial import inner membrane translocase subunit Tim29 {ECO:0000303|PubMed:27554484}
• Gene Name: TIMM29 {ECO:0000312|HGNC:HGNC:25152}
• Organism: Homo sapiens (Human).
• Sequence Length: 260
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein ; Intermembrane side .
• Protein Description: Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. Required for the stability of the TIM22 complex and functions in the assembly of the TIMM22 protein into the TIM22 complex. May facilitate cooperation between TIM22 and TOM complexes by interacting with TOMM40..
• Protein Sequence: MAAAALRRFWSRRRAEAGDAVVAKPGVWARLGSWARALLRDYAEACRDASAEARARPGRAAVYVGLLGGAAACFTLAPSEGAFEEALLEASGTLLLLAPATRNRESEAFVQRLLWLRGRGRLRYVNLGLCSLVYEAPFDAQASLYQARCRYLQPRWTDFPGRVLDVGFVGRWWVLGAWMRDCDINDDEFLHLPAHLRVVGPQQLHSETNERLFDEKYKPVVLTDDQVDQALWEEQVLQKEKKDRLALSQAHSLVQAEAPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Ubiquitination	AGDAVVAKPGVWARL CCCCEEECCCHHHHH		21906983
50	Phosphorylation	AEACRDASAEARARP HHHHHHHCHHHHCCC		28102081
216	Ubiquitination	NERLFDEKYKPVVLT CHHHCCCCCCCEEEC		22817900
218	Ubiquitination	RLFDEKYKPVVLTDD HHCCCCCCCEEECHH		21906983
239	Ubiquitination	WEEQVLQKEKKDRLA HHHHHHHHHHHHHHH		29967540
241	Ubiquitination	EQVLQKEKKDRLALS HHHHHHHHHHHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIM29_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIM29_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIM29_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TIM10_HUMAN	TIMM10	physical	27173435
TIM9_HUMAN	TIMM9	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.