TIM9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIM9_HUMAN
• UniProt AC: Q9Y5J7
• Protein Name: Mitochondrial import inner membrane translocase subunit Tim9
• Gene Name: TIMM9
• Organism: Homo sapiens (Human).
• Sequence Length: 89
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side .
• Protein Description: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space..
• Protein Sequence: MAAQIPESDQIKQFKEFLGTYNKLTETCFLDCVKDFTTREVKPEETTCSEHCLQKYLKMTQRISMRFQEYHIQQNEALAAKAGLLGQPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAQIPESD ------CCCCCCCHH	14.20	19413330
15	Succinylation	SDQIKQFKEFLGTYN HHHHHHHHHHHHHHH	45.09	23954790
34	Ubiquitination	TCFLDCVKDFTTREV HHHHHHHCCCCCCCC	54.15	-
46	Phosphorylation	REVKPEETTCSEHCL CCCCCCCCCCCHHHH	31.29	-
55	Acetylation	CSEHCLQKYLKMTQR CCHHHHHHHHHHHHH	39.33	27452117
58	Acetylation	HCLQKYLKMTQRISM HHHHHHHHHHHHHHH	36.49	27452117
70	Phosphorylation	ISMRFQEYHIQQNEA HHHHHHHHHHHHHHH	8.08	27642862
81	Ubiquitination	QNEALAAKAGLLGQP HHHHHHHHHHHCCCC	37.06	21890473
81	Ubiquitination	QNEALAAKAGLLGQP HHHHHHHHHHHCCCC	37.06	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIM9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIM9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIM9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UCRI_HUMAN	UQCRFS1	physical	22939629
COX5A_HUMAN	COX5A	physical	26344197
NUDC_HUMAN	NUDC	physical	26344197
TEBP_HUMAN	PTGES3	physical	26344197
TIM10_HUMAN	TIMM10	physical	26344197
TIM13_HUMAN	TIMM13	physical	26344197
TIM8A_HUMAN	TIMM8A	physical	26344197
TIM8B_HUMAN	TIMM8B	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330