TIM8B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIM8B_HUMAN
• UniProt AC: Q9Y5J9
• Protein Name: Mitochondrial import inner membrane translocase subunit Tim8 B
• Gene Name: TIMM8B
• Organism: Homo sapiens (Human).
• Sequence Length: 83
• Subcellular Localization: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
• Protein Description: Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity)..
• Protein Sequence: MAELGEADEAELQRLVAAEQQKAQFTAQVHHFMELCWDKCVEKPGNRLDSRTENCLSSCVDRFIDTTLAITSRFAQIVQKGGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAELGEADE ------CCCCCCCCH	22.26	22223895
43	Ubiquitination	CWDKCVEKPGNRLDS HHHHHHCCCCCCCCH	37.52	21906983
50	Phosphorylation	KPGNRLDSRTENCLS CCCCCCCHHHHHHHH	45.77	28348404
52	Phosphorylation	GNRLDSRTENCLSSC CCCCCHHHHHHHHHH	35.19	28348404
58	Ubiquitination	RTENCLSSCVDRFID HHHHHHHHHHHHHHH	12.76	-
65	Phosphorylation	SCVDRFIDTTLAITS HHHHHHHHHHHHHHH	30.81	27251275
80	Ubiquitination	RFAQIVQKGGQ---- HHHHHHHCCCC----	54.86	21906983
80	Acetylation	RFAQIVQKGGQ---- HHHHHHHCCCC----	54.86	25953088
95	Ubiquitination	------------------- -------------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIM8B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIM8B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIM8B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TIM8B_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330