RHGBA_HUMAN - dbPTM
RHGBA_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RHGBA_HUMAN
UniProt AC Q6P4F7
Protein Name Rho GTPase-activating protein 11A
Gene Name ARHGAP11A
Organism Homo sapiens (Human).
Sequence Length 1023
Subcellular Localization
Protein Description
Protein Sequence MWDQRLVRLALLQHLRAFYGIKVKGVRGQCDRRRHETAATEIGGKIFGVPFNALPHSAVPEYGHIPSFLVDACTSLEDHIHTEGLFRKSGSVIRLKALKNKVDHGEGCLSSAPPCDIAGLLKQFFRELPEPILPADLHEALLKAQQLGTEEKNKATLLLSCLLADHTVHVLRYFFNFLRNVSLRSSENKMDSSNLAVIFAPNLLQTSEGHEKMSSNTEKKLRLQAAVVQTLIDYASDIGRVPDFILEKIPAMLGIDGLCATPSLEGFEEGEYETPGEYKRKRRQSVGDFVSGALNKFKPNRTPSITPQEERIAQLSESPVILTPNAKRTLPVDSSHGFSSKKRKSIKHNFNFELLPSNLFNSSSTPVSVHIDTSSEGSSQSSLSPVLIGGNHLITAGVPRRSKRIAGKKVCRVESGKAGCFSPKISHKEKVRRSLRLKFNLGKNGREVNGCSGVNRYESVGWRLANQQSLKNRIESVKTGLLFSPDVDEKLPKKGSEKISKSEETLLTPERLVGTNYRMSWTGPNNSSFQEVDANEASSMVENLEVENSLEPDIMVEKSPATSCELTPSNLNNKHNSNITSSPLSGDENNMTKETLVKVQKAFSESGSNLHALMNQRQSSVTNVGKVKLTEPSYLEDSPEENLFETNDLTIVESKEKYEHHTGKGEKCFSERDFSPLQTQTFNRETTIKCYSTQMKMEHEKDIHSNMPKDYLSKQEFSSDEEIKKQQSPKDKLNNKLKENENMMEGNLPKCAAHSKDEARSSFSQQSTCVVTNLSKPRPMRIAKQQSLETCEKTVSESSQMTEHRKVSDHIQWFNKLSLNEPNRIKVKSPLKFQRTPVRQSVRRINSLLEYSRQPTGHKLASLGDTASPLVKSVSCDGALSSCIESASKDSSVSCIKSGPKEQKSMSCEESNIGAISKSSMELPSKSFLKMRKHPDSVNASLRSTTVYKQKILSDGQVKVPLDDLTNHDIVKPVVNNNMGISSGINNRVLRRPSERGRAWYKGSPKHPIGKTQLLPTSKPVDL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24UbiquitinationAFYGIKVKGVRGQCD
HHHCCCCEECCCCCC		46.84-
37PhosphorylationCDRRRHETAATEIGG
CCCCCCHHCHHEECC		18.5728555341
91PhosphorylationGLFRKSGSVIRLKAL
CHHHCCCCEEEEEEH		22.8227067055
138UbiquitinationPILPADLHEALLKAQ
CCCCHHHHHHHHHHH		20.8729967540
143UbiquitinationDLHEALLKAQQLGTE
HHHHHHHHHHHHCCH		45.0329967540
152UbiquitinationQQLGTEEKNKATLLL
HHHCCHHHHHHHHHH		58.4729967540
154UbiquitinationLGTEEKNKATLLLSC
HCCHHHHHHHHHHHH		54.5433845483
228UbiquitinationLRLQAAVVQTLIDYA
HHHHHHHHHHHHHHH		2.8529967540
249UbiquitinationPDFILEKIPAMLGID
CHHHHHHHHHHHCCC		1.60-
249UbiquitinationPDFILEKIPAMLGID
CHHHHHHHHHHHCCC		1.6027667366
261PhosphorylationGIDGLCATPSLEGFE
CCCCEECCCCCCCCC		16.6521712546
263PhosphorylationDGLCATPSLEGFEEG
CCEECCCCCCCCCCC		34.40-
274PhosphorylationFEEGEYETPGEYKRK
CCCCCCCCCCHHHCH		35.3721712546
282UbiquitinationPGEYKRKRRQSVGDF
CCHHHCHHHHCHHHH		46.00-
282UbiquitinationPGEYKRKRRQSVGDF
CCHHHCHHHHCHHHH		46.0029967540
285PhosphorylationYKRKRRQSVGDFVSG
HHCHHHHCHHHHHHH		26.6822167270
289UbiquitinationRRQSVGDFVSGALNK
HHHCHHHHHHHHHHH		3.7629967540
291PhosphorylationQSVGDFVSGALNKFK
HCHHHHHHHHHHHCC		20.5230266825
301UbiquitinationLNKFKPNRTPSITPQ
HHHCCCCCCCCCCCH		57.4529967540
302PhosphorylationNKFKPNRTPSITPQE
HHCCCCCCCCCCCHH		28.2029255136
304PhosphorylationFKPNRTPSITPQEER
CCCCCCCCCCCHHHH		38.1819691289
306PhosphorylationPNRTPSITPQEERIA
CCCCCCCCCHHHHHH		24.2125159151
312UbiquitinationITPQEERIAQLSESP
CCCHHHHHHHHHCCC		3.0329967540
316PhosphorylationEERIAQLSESPVILT
HHHHHHHHCCCEEEC		24.7730266825
318PhosphorylationRIAQLSESPVILTPN
HHHHHHCCCEEECCC		22.5325159151
323PhosphorylationSESPVILTPNAKRTL
HCCCEEECCCCCCCC		11.9029255136
327UbiquitinationVILTPNAKRTLPVDS
EEECCCCCCCCCCCC		53.1829967540
329PhosphorylationLTPNAKRTLPVDSSH
ECCCCCCCCCCCCCC		34.4122199227
334PhosphorylationKRTLPVDSSHGFSSK
CCCCCCCCCCCCCCC		25.1924732914
335PhosphorylationRTLPVDSSHGFSSKK
CCCCCCCCCCCCCCC		24.1424732914
339PhosphorylationVDSSHGFSSKKRKSI
CCCCCCCCCCCCCCC		45.9325159151
340PhosphorylationDSSHGFSSKKRKSIK
CCCCCCCCCCCCCCC		39.6825159151
341UbiquitinationSSHGFSSKKRKSIKH
CCCCCCCCCCCCCCC		56.2329967540
412UbiquitinationIAGKKVCRVESGKAG
CCCCEEEEECCCCCC		37.9229967540
415PhosphorylationKKVCRVESGKAGCFS
CEEEEECCCCCCCCC		42.6129496963
417UbiquitinationVCRVESGKAGCFSPK
EEEECCCCCCCCCCC		51.3829967540
422PhosphorylationSGKAGCFSPKISHKE
CCCCCCCCCCCCCHH		29.3830266825
426PhosphorylationGCFSPKISHKEKVRR
CCCCCCCCCHHHHHH		34.33-
434PhosphorylationHKEKVRRSLRLKFNL
CHHHHHHHHHHHEEC		13.79-
437UbiquitinationKVRRSLRLKFNLGKN
HHHHHHHHHEECCCC		10.0929967540
438UbiquitinationVRRSLRLKFNLGKNG
HHHHHHHHEECCCCC		26.2727667366
452PhosphorylationGREVNGCSGVNRYES
CCEECCCCCCCCHHH		47.3725159151
457PhosphorylationGCSGVNRYESVGWRL
CCCCCCCHHHHHHHH		13.8327642862
469PhosphorylationWRLANQQSLKNRIES
HHHHCCHHHHHHHHH		31.3923401153
471UbiquitinationLANQQSLKNRIESVK
HHCCHHHHHHHHHHH		49.8029967540
475UbiquitinationQSLKNRIESVKTGLL
HHHHHHHHHHHHCCC		46.3629967540
478UbiquitinationKNRIESVKTGLLFSP
HHHHHHHHHCCCCCC		46.2729967540
479PhosphorylationNRIESVKTGLLFSPD
HHHHHHHHCCCCCCC		30.7924732914
484PhosphorylationVKTGLLFSPDVDEKL
HHHCCCCCCCCCCCC		21.8425159151
484 (in isoform 2)Phosphorylation-21.8425159151
490UbiquitinationFSPDVDEKLPKKGSE
CCCCCCCCCCCCCCC		66.6729967540
501UbiquitinationKGSEKISKSEETLLT
CCCCCCCCCCCCCCC		66.4229967540
502PhosphorylationGSEKISKSEETLLTP
CCCCCCCCCCCCCCH		33.6029396449
505PhosphorylationKISKSEETLLTPERL
CCCCCCCCCCCHHHH		24.0229255136
508PhosphorylationKSEETLLTPERLVGT
CCCCCCCCHHHHCCC		26.6423401153
515PhosphorylationTPERLVGTNYRMSWT
CHHHHCCCCCCCCCC		22.9222199227
517PhosphorylationERLVGTNYRMSWTGP
HHHCCCCCCCCCCCC		13.9222199227
525UbiquitinationRMSWTGPNNSSFQEV
CCCCCCCCCCCCEEE		63.4629967540
541AcetylationANEASSMVENLEVEN
HHHHHHHHHCCEECC		4.82-
559PhosphorylationPDIMVEKSPATSCEL
CCEEEECCCCCCCCC		13.2725850435
562PhosphorylationMVEKSPATSCELTPS
EEECCCCCCCCCCHH		36.9822199227
563PhosphorylationVEKSPATSCELTPSN
EECCCCCCCCCCHHH		14.0125159151
567PhosphorylationPATSCELTPSNLNNK
CCCCCCCCHHHCCCC		11.4625850435
569PhosphorylationTSCELTPSNLNNKHN
CCCCCCHHHCCCCCC		49.0325850435
577PhosphorylationNLNNKHNSNITSSPL
HCCCCCCCCCCCCCC		29.3622167270
580PhosphorylationNKHNSNITSSPLSGD
CCCCCCCCCCCCCCC		27.6622167270
581PhosphorylationKHNSNITSSPLSGDE
CCCCCCCCCCCCCCC		26.6022167270
582PhosphorylationHNSNITSSPLSGDEN
CCCCCCCCCCCCCCC		22.6223401153
585PhosphorylationNITSSPLSGDENNMT
CCCCCCCCCCCCCCC		47.8122167270
592PhosphorylationSGDENNMTKETLVKV
CCCCCCCCHHHHHHH		28.0522167270
601UbiquitinationETLVKVQKAFSESGS
HHHHHHHHHHHCCCC		55.1529967540
604PhosphorylationVKVQKAFSESGSNLH
HHHHHHHHCCCCHHH		35.3928450419
606PhosphorylationVQKAFSESGSNLHAL
HHHHHHCCCCHHHHH		46.4528450419
608PhosphorylationKAFSESGSNLHALMN
HHHHCCCCHHHHHHH		45.5628450419
619PhosphorylationALMNQRQSSVTNVGK
HHHHHCCCCCCCCCE		29.0329396449
620PhosphorylationLMNQRQSSVTNVGKV
HHHHCCCCCCCCCEE		25.3126657352
622PhosphorylationNQRQSSVTNVGKVKL
HHCCCCCCCCCEEEC		26.5729396449
626UbiquitinationSSVTNVGKVKLTEPS
CCCCCCCEEECCCCH		31.7329967540
627UbiquitinationSVTNVGKVKLTEPSY
CCCCCCEEECCCCHH		5.1629967540
630PhosphorylationNVGKVKLTEPSYLED
CCCEEECCCCHHCCC		39.8827732954
633PhosphorylationKVKLTEPSYLEDSPE
EEECCCCHHCCCCCC		35.8027732954
634PhosphorylationVKLTEPSYLEDSPEE
EECCCCHHCCCCCCC		25.4827732954
638PhosphorylationEPSYLEDSPEENLFE
CCHHCCCCCCCCCCC		25.4918669648
664UbiquitinationKYEHHTGKGEKCFSE
HHCCCCCCCCCCCCC		66.1229967540
670PhosphorylationGKGEKCFSERDFSPL
CCCCCCCCCCCCCCC		40.9924732914
675PhosphorylationCFSERDFSPLQTQTF
CCCCCCCCCCCCEEC		29.0530266825
679PhosphorylationRDFSPLQTQTFNRET
CCCCCCCCEECCCCC		36.9430266825
681PhosphorylationFSPLQTQTFNRETTI
CCCCCCEECCCCCEE		26.6824732914
714UbiquitinationMPKDYLSKQEFSSDE
CCHHHHCCCCCCCHH		51.7829967540
718PhosphorylationYLSKQEFSSDEEIKK
HHCCCCCCCHHHHHH		35.8128985074
719PhosphorylationLSKQEFSSDEEIKKQ
HCCCCCCCHHHHHHH		55.1321815630
728PhosphorylationEEIKKQQSPKDKLNN
HHHHHHCCHHHHHHH		31.2724719451
730AcetylationIKKQQSPKDKLNNKL
HHHHCCHHHHHHHHH		73.1421466224
732AcetylationKQQSPKDKLNNKLKE
HHCCHHHHHHHHHHH		60.2820167786
737UbiquitinationKDKLNNKLKENENMM
HHHHHHHHHHCHHHH		10.2629967540
760UbiquitinationAHSKDEARSSFSQQS
HCCHHHHHHHHHCCC		30.6823000965
761PhosphorylationHSKDEARSSFSQQST
CCHHHHHHHHHCCCE		42.6625627689
762PhosphorylationSKDEARSSFSQQSTC
CHHHHHHHHHCCCEE		24.3025627689
762UbiquitinationSKDEARSSFSQQSTC
CHHHHHHHHHCCCEE		24.3023000965
764PhosphorylationDEARSSFSQQSTCVV
HHHHHHHHCCCEEEE		29.2928348404
787PhosphorylationMRIAKQQSLETCEKT
CCCHHHHCHHHHHHH		26.1925159151
790PhosphorylationAKQQSLETCEKTVSE
HHHHCHHHHHHHHCH		31.1224732914
794PhosphorylationSLETCEKTVSESSQM
CHHHHHHHHCHHHHH		13.6320860994
796PhosphorylationETCEKTVSESSQMTE
HHHHHHHCHHHHHHC		36.6720860994
808PhosphorylationMTEHRKVSDHIQWFN
HHCCCHHHHHHHHHH		26.8928555341
816UbiquitinationDHIQWFNKLSLNEPN
HHHHHHHHCCCCCCC		29.9429967540
829PhosphorylationPNRIKVKSPLKFQRT
CCCCCCCCCCCCCCC		38.1523927012
830AcetylationNRIKVKSPLKFQRTP
CCCCCCCCCCCCCCC		33.58-
836PhosphorylationSPLKFQRTPVRQSVR
CCCCCCCCCHHHHHH		18.4920860994
841PhosphorylationQRTPVRQSVRRINSL
CCCCHHHHHHHHHHH		13.6628555341
847PhosphorylationQSVRRINSLLEYSRQ
HHHHHHHHHHHHHCC		31.7723401153
851PhosphorylationRINSLLEYSRQPTGH
HHHHHHHHHCCCCCC		14.7728555341
852PhosphorylationINSLLEYSRQPTGHK
HHHHHHHHCCCCCCC		18.3123312004
862PhosphorylationPTGHKLASLGDTASP
CCCCCCCCCCCCCCC		43.2324732914
866PhosphorylationKLASLGDTASPLVKS
CCCCCCCCCCCCHHE		27.5130266825
868PhosphorylationASLGDTASPLVKSVS
CCCCCCCCCCHHEEC		22.3630266825
873PhosphorylationTASPLVKSVSCDGAL
CCCCCHHEECCCCHH		16.2828387310
875PhosphorylationSPLVKSVSCDGALSS
CCCHHEECCCCHHHH		17.3725159151
881PhosphorylationVSCDGALSSCIESAS
ECCCCHHHHHHHHCC		23.7224732914
882PhosphorylationSCDGALSSCIESASK
CCCCHHHHHHHHCCC		21.6924732914
886PhosphorylationALSSCIESASKDSSV
HHHHHHHHCCCCCCC		20.2421815630
888PhosphorylationSSCIESASKDSSVSC
HHHHHHCCCCCCCCH		46.4021815630
891PhosphorylationIESASKDSSVSCIKS
HHHCCCCCCCCHHHC		36.0524732914
892PhosphorylationESASKDSSVSCIKSG
HHCCCCCCCCHHHCC		28.3424732914
894PhosphorylationASKDSSVSCIKSGPK
CCCCCCCCHHHCCCC		16.4524732914
907PhosphorylationPKEQKSMSCEESNIG
CCHHHCCCCCCCCCC		26.0127134283
917PhosphorylationESNIGAISKSSMELP
CCCCCCCCHHHCCCC		26.42-
925PhosphorylationKSSMELPSKSFLKMR
HHHCCCCCHHHHHHH		54.2624719451
926UbiquitinationSSMELPSKSFLKMRK
HHCCCCCHHHHHHHC		43.2029967540
927PhosphorylationSMELPSKSFLKMRKH
HCCCCCHHHHHHHCC		39.9024719451
930MethylationLPSKSFLKMRKHPDS
CCCHHHHHHHCCCCC		34.35-
937PhosphorylationKMRKHPDSVNASLRS
HHHCCCCCCCHHHCC		23.0125159151
941PhosphorylationHPDSVNASLRSTTVY
CCCCCCHHHCCCCEE		21.0725159151
949UbiquitinationLRSTTVYKQKILSDG
HCCCCEEEEEECCCC		40.5623000965
951UbiquitinationSTTVYKQKILSDGQV
CCCEEEEEECCCCCE		41.2723000965
1001PhosphorylationSERGRAWYKGSPKHP
HHHCCCCCCCCCCCC		12.4121712546
1004PhosphorylationGRAWYKGSPKHPIGK
CCCCCCCCCCCCCCC		26.9920068231
1011AcetylationSPKHPIGKTQLLPTS
CCCCCCCCCCCCCCC		33.5425953088
1012PhosphorylationPKHPIGKTQLLPTSK
CCCCCCCCCCCCCCC		21.1625690035
1017PhosphorylationGKTQLLPTSKPVDL-
CCCCCCCCCCCCCC-		49.7225690035
1018PhosphorylationKTQLLPTSKPVDL--
CCCCCCCCCCCCC--		32.7828555341
1019AcetylationTQLLPTSKPVDL---
CCCCCCCCCCCC---		52.0922424773
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RHGBA_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RHGBA_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RHGBA_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of RHGBA_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RHGBA_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-285; SER-318; THR-323;SER-675 AND SER-847, AND MASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-318; THR-323; SER-559AND SER-569, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-285; SER-316; SER-318;THR-323; SER-339; SER-340; SER-415; SER-422; SER-484; THR-508;SER-582; SER-585 AND SER-675, AND MASS SPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-285 AND SER-675, ANDMASS SPECTROMETRY.
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-306; SER-484; THR-508;SER-675 AND SER-868, AND MASS SPECTROMETRY.
"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-675, AND MASSSPECTROMETRY.

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