| UniProt ID | SQOR_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y6N5 | |
| Protein Name | Sulfide:quinone oxidoreductase, mitochondrial {ECO:0000305} | |
| Gene Name | SQOR {ECO:0000312|HGNC:HGNC:20390} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 450 | |
| Subcellular Localization | Mitochondrion . | |
| Protein Description | Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro).. | |
| Protein Sequence | MVPLVAVVSGPRAQLFACLLRLGTQQVGPLQLHTGASHAARNHYEVLVLGGGSGGITMAARMKRKVGAENVAIVEPSERHFYQPIWTLVGAGAKQLSSSGRPTASVIPSGVEWIKARVTELNPDKNCIHTDDDEKISYRYLIIALGIQLDYEKIKGLPEGFAHPKIGSNYSVKTVEKTWKALQDFKEGNAIFTFPNTPVKCAGAPQKIMYLSEAYFRKTGKRSKANIIFNTSLGAIFGVKKYADALQEIIQERNLTVNYKKNLIEVRADKQEAVFENLDKPGETQVISYEMLHVTPPMSPPDVLKTSPVADAAGWVDVDKETLQHRRYPNVFGIGDCTNLPTSKTAAAVAAQSGILDRTISVIMKNQTPTKKYDGYTSCPLVTGYNRVILAEFDYKAEPLETFPFDQSKERLSMYLMKADLMPFLYWNMMLRGYWGGPAFLRKLFHLGMS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | VPLVAVVSGPRAQLF CCEEEEECCHHHHHH | 22210691 | ||
| 97 | Phosphorylation | GAGAKQLSSSGRPTA HHCHHHCCCCCCCCC | 27080861 | ||
| 98 | Phosphorylation | AGAKQLSSSGRPTAS HCHHHCCCCCCCCCE | 27080861 | ||
| 99 | Phosphorylation | GAKQLSSSGRPTASV CHHHCCCCCCCCCEE | 27080861 | ||
| 103 | Phosphorylation | LSSSGRPTASVIPSG CCCCCCCCCEECCCC | 27080861 | ||
| 105 | Phosphorylation | SSGRPTASVIPSGVE CCCCCCCEECCCCCH | 27080861 | ||
| 115 | Acetylation | PSGVEWIKARVTELN CCCCHHHHHHHCCCC | 7706167 | ||
| 115 | 2-Hydroxyisobutyrylation | PSGVEWIKARVTELN CCCCHHHHHHHCCCC | - | ||
| 115 | Ubiquitination | PSGVEWIKARVTELN CCCCHHHHHHHCCCC | - | ||
| 125 | Ubiquitination | VTELNPDKNCIHTDD HCCCCCCCCCCCCCC | - | ||
| 125 | Succinylation | VTELNPDKNCIHTDD HCCCCCCCCCCCCCC | 27452117 | ||
| 125 | Acetylation | VTELNPDKNCIHTDD HCCCCCCCCCCCCCC | 25953088 | ||
| 125 | 2-Hydroxyisobutyrylation | VTELNPDKNCIHTDD HCCCCCCCCCCCCCC | - | ||
| 125 | Malonylation | VTELNPDKNCIHTDD HCCCCCCCCCCCCCC | 26320211 | ||
| 135 | 2-Hydroxyisobutyrylation | IHTDDDEKISYRYLI CCCCCCCHHHHHHHH | - | ||
| 135 | Malonylation | IHTDDDEKISYRYLI CCCCCCCHHHHHHHH | 26320211 | ||
| 135 | Acetylation | IHTDDDEKISYRYLI CCCCCCCHHHHHHHH | 23954790 | ||
| 135 | Succinylation | IHTDDDEKISYRYLI CCCCCCCHHHHHHHH | 27452117 | ||
| 137 | Phosphorylation | TDDDEKISYRYLIIA CCCCCHHHHHHHHHH | 21712546 | ||
| 151 | Phosphorylation | ALGIQLDYEKIKGLP HHCCCCCHHHHCCCC | 21712546 | ||
| 155 | Malonylation | QLDYEKIKGLPEGFA CCCHHHHCCCCCCCC | 26320211 | ||
| 155 | Ubiquitination | QLDYEKIKGLPEGFA CCCHHHHCCCCCCCC | - | ||
| 165 | Ubiquitination | PEGFAHPKIGSNYSV CCCCCCCCCCCCCEE | - | ||
| 168 | Phosphorylation | FAHPKIGSNYSVKTV CCCCCCCCCCEEEHH | 29759185 | ||
| 170 | Phosphorylation | HPKIGSNYSVKTVEK CCCCCCCCEEEHHHH | 29759185 | ||
| 171 | Phosphorylation | PKIGSNYSVKTVEKT CCCCCCCEEEHHHHH | 29759185 | ||
| 173 | Malonylation | IGSNYSVKTVEKTWK CCCCCEEEHHHHHHH | 26320211 | ||
| 173 | Ubiquitination | IGSNYSVKTVEKTWK CCCCCEEEHHHHHHH | 19608861 | ||
| 173 | Acetylation | IGSNYSVKTVEKTWK CCCCCEEEHHHHHHH | 19608861 | ||
| 173 | Succinylation | IGSNYSVKTVEKTWK CCCCCEEEHHHHHHH | 27452117 | ||
| 174 | Phosphorylation | GSNYSVKTVEKTWKA CCCCEEEHHHHHHHH | 29759185 | ||
| 177 | Ubiquitination | YSVKTVEKTWKALQD CEEEHHHHHHHHHHH | - | ||
| 177 | Malonylation | YSVKTVEKTWKALQD CEEEHHHHHHHHHHH | 26320211 | ||
| 177 | 2-Hydroxyisobutyrylation | YSVKTVEKTWKALQD CEEEHHHHHHHHHHH | - | ||
| 180 | Succinylation | KTVEKTWKALQDFKE EHHHHHHHHHHHHHC | 23954790 | ||
| 180 | Malonylation | KTVEKTWKALQDFKE EHHHHHHHHHHHHHC | 26320211 | ||
| 180 | Acetylation | KTVEKTWKALQDFKE EHHHHHHHHHHHHHC | 19608861 | ||
| 186 | Ubiquitination | WKALQDFKEGNAIFT HHHHHHHHCCCEEEE | - | ||
| 186 | Acetylation | WKALQDFKEGNAIFT HHHHHHHHCCCEEEE | 25953088 | ||
| 186 | Succinylation | WKALQDFKEGNAIFT HHHHHHHHCCCEEEE | 23954790 | ||
| 193 | Phosphorylation | KEGNAIFTFPNTPVK HCCCEEEECCCCCCC | 27050516 | ||
| 197 | Phosphorylation | AIFTFPNTPVKCAGA EEEECCCCCCCCCCC | 28450419 | ||
| 241 | 2-Hydroxyisobutyrylation | GAIFGVKKYADALQE HHHHCHHHHHHHHHH | - | ||
| 259 | Phosphorylation | ERNLTVNYKKNLIEV HCCCCCCCCCCEEEE | - | ||
| 260 | Succinylation | RNLTVNYKKNLIEVR CCCCCCCCCCEEEEE | 23954790 | ||
| 260 | Acetylation | RNLTVNYKKNLIEVR CCCCCCCCCCEEEEE | 25953088 | ||
| 260 | 2-Hydroxyisobutyrylation | RNLTVNYKKNLIEVR CCCCCCCCCCEEEEE | - | ||
| 261 | Malonylation | NLTVNYKKNLIEVRA CCCCCCCCCEEEEEC | 26320211 | ||
| 261 | Ubiquitination | NLTVNYKKNLIEVRA CCCCCCCCCEEEEEC | - | ||
| 320 | Acetylation | AGWVDVDKETLQHRR CCCEECCHHHHHCCC | 23954790 | ||
| 322 | Phosphorylation | WVDVDKETLQHRRYP CEECCHHHHHCCCCC | 27080861 | ||
| 328 | Phosphorylation | ETLQHRRYPNVFGIG HHHHCCCCCCCCCCC | 28152594 | ||
| 338 | Phosphorylation | VFGIGDCTNLPTSKT CCCCCCCCCCCCHHH | 23403867 | ||
| 342 | Phosphorylation | GDCTNLPTSKTAAAV CCCCCCCCHHHHHHH | 29691806 | ||
| 343 | Phosphorylation | DCTNLPTSKTAAAVA CCCCCCCHHHHHHHH | 23401153 | ||
| 345 | Phosphorylation | TNLPTSKTAAAVAAQ CCCCCHHHHHHHHHH | 28857561 | ||
| 359 | Phosphorylation | QSGILDRTISVIMKN HCCCHHHHHHHHCCC | 27080861 | ||
| 361 | Phosphorylation | GILDRTISVIMKNQT CCHHHHHHHHCCCCC | 23312004 | ||
| 365 | Malonylation | RTISVIMKNQTPTKK HHHHHHCCCCCCCCC | 26320211 | ||
| 365 | Succinylation | RTISVIMKNQTPTKK HHHHHHCCCCCCCCC | 27452117 | ||
| 371 | 2-Hydroxyisobutyrylation | MKNQTPTKKYDGYTS CCCCCCCCCCCCCCC | - | ||
| 372 | Acetylation | KNQTPTKKYDGYTSC CCCCCCCCCCCCCCC | 27452117 | ||
| 372 | 2-Hydroxyisobutyrylation | KNQTPTKKYDGYTSC CCCCCCCCCCCCCCC | - | ||
| 373 | Phosphorylation | NQTPTKKYDGYTSCP CCCCCCCCCCCCCCC | 26552605 | ||
| 376 | Phosphorylation | PTKKYDGYTSCPLVT CCCCCCCCCCCCCCC | 26552605 | ||
| 377 | Phosphorylation | TKKYDGYTSCPLVTG CCCCCCCCCCCCCCC | 26552605 | ||
| 378 | Phosphorylation | KKYDGYTSCPLVTGY CCCCCCCCCCCCCCC | 26552605 | ||
| 383 | Phosphorylation | YTSCPLVTGYNRVIL CCCCCCCCCCCEEEE | 26552605 | ||
| 385 | Phosphorylation | SCPLVTGYNRVILAE CCCCCCCCCEEEEEE | 26552605 | ||
| 395 | Phosphorylation | VILAEFDYKAEPLET EEEEECCCCCCCCCC | - | ||
| 408 | Phosphorylation | ETFPFDQSKERLSMY CCCCCCCCHHHHHHH | 24719451 | ||
| 409 | Ubiquitination | TFPFDQSKERLSMYL CCCCCCCHHHHHHHH | - | ||
| 409 | 2-Hydroxyisobutyrylation | TFPFDQSKERLSMYL CCCCCCCHHHHHHHH | - | ||
| 413 | Phosphorylation | DQSKERLSMYLMKAD CCCHHHHHHHHHHHC | 20068231 | ||
| 415 | Phosphorylation | SKERLSMYLMKADLM CHHHHHHHHHHHCHH | 20068231 | ||
| 426 | Phosphorylation | ADLMPFLYWNMMLRG HCHHHHHHHHHHHCC | 20068231 | ||
| 443 | Malonylation | GGPAFLRKLFHLGMS CHHHHHHHHHHCCCC | 26320211 | ||
| 443 | 2-Hydroxyisobutyrylation | GGPAFLRKLFHLGMS CHHHHHHHHHHCCCC | - | ||
| 443 | Acetylation | GGPAFLRKLFHLGMS CHHHHHHHHHHCCCC | 25825284 | ||
| 450 | Phosphorylation | KLFHLGMS------- HHHHCCCC------- | 23312004 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SQOR_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SQOR_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SQOR_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SQOR_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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