FBX46_HUMAN - dbPTM
FBX46_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FBX46_HUMAN
UniProt AC Q6PJ61
Protein Name F-box only protein 46
Gene Name FBXO46
Organism Homo sapiens (Human).
Sequence Length 603
Subcellular Localization
Protein Description Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex..
Protein Sequence MDRGSLLPFQLWCPRPFGTYSQNQPRPPSAALKPSACPEPGGGAEPDHGPAHSENTPPALATEVPASQPAPLLSAAAAGDEGRVLLDTWYVIKPGNTKEKVAFFVAHQCGGGSRASSMKVKGHWGSDSSKAKRRRRCLDPTKAPPDPGGREGPPAAEEGPASAGEDVDLLSVAEMVALVEQRAALALQSYPRPTTPAPVVFVSAEQGGPAKGVGSERRSGGGDCSRVAEAVAHFEAQRDSPPTKGLRKEERPGPGPGEVRIAFRISNGREPRAPDSGLPSGGGGRPGCAYPGSPGPGARAKDKITCDLYQLISPSRDALPSNVEFLLARADEASEGDSPAPARPEDTPPAPPPPPARDCGASGFHVDVVVTGVVDECIFFGKDGTKNVKEETVCLTVSPEEPPPPGQLFFLQNRGPDGPPEPPPADSPATAPGPDDAEGTADTSLCRLYRHVSHDFLEIRFKIQRLLEPRQYMLLLPEHVLVKIFSFLPTRALAALKCTCHHFKGIIEAFGVRATDSRWSRDPLYRDDPCKQCRKRYEKGDVSLCRWHPKPYHHDLPYGRSYWMCCRRADRETPGCRLGLHDNNWVLPCNGPGGGRAGREEGR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
21PhosphorylationPRPFGTYSQNQPRPP
CCCCCCCCCCCCCCC		23.61-
67PhosphorylationLATEVPASQPAPLLS
CCCCCCCCCCHHHHH		30.54-
113PhosphorylationAHQCGGGSRASSMKV
EECCCCCCCCCCCEE		28.1330108239
116PhosphorylationCGGGSRASSMKVKGH
CCCCCCCCCCEECCC		29.8326074081
117PhosphorylationGGGSRASSMKVKGHW
CCCCCCCCCEECCCC		22.9526074081
121UbiquitinationRASSMKVKGHWGSDS
CCCCCEECCCCCCCC		39.2729967540
126PhosphorylationKVKGHWGSDSSKAKR
EECCCCCCCCHHHHH		29.1828674419
128PhosphorylationKGHWGSDSSKAKRRR
CCCCCCCCHHHHHHH		35.1228348404
129PhosphorylationGHWGSDSSKAKRRRR
CCCCCCCHHHHHHHH		41.4429396449
162PhosphorylationAAEEGPASAGEDVDL
CHHHCCCCCCCCCHH		39.6828348404
171PhosphorylationGEDVDLLSVAEMVAL
CCCCHHHCHHHHHHH		26.9528348404
189PhosphorylationRAALALQSYPRPTTP
HHHHHHHCCCCCCCC		37.6428450419
190PhosphorylationAALALQSYPRPTTPA
HHHHHHCCCCCCCCC		7.1228450419
194PhosphorylationLQSYPRPTTPAPVVF
HHCCCCCCCCCCEEE		46.8428450419
195PhosphorylationQSYPRPTTPAPVVFV
HCCCCCCCCCCEEEE		21.8228450419
203PhosphorylationPAPVVFVSAEQGGPA
CCCEEEEECCCCCCC		18.0227251275
215PhosphorylationGPAKGVGSERRSGGG
CCCCCCCCCCCCCCC		26.0628102081
219PhosphorylationGVGSERRSGGGDCSR
CCCCCCCCCCCCHHH		48.2728102081
225PhosphorylationRSGGGDCSRVAEAVA
CCCCCCHHHHHHHHH		34.2317081983
240PhosphorylationHFEAQRDSPPTKGLR
HHHHHCCCCCCCCCC		34.6630266825
243PhosphorylationAQRDSPPTKGLRKEE
HHCCCCCCCCCCCCC		40.9230266825
266PhosphorylationVRIAFRISNGREPRA
EEEEEEECCCCCCCC		29.0424719451
276PhosphorylationREPRAPDSGLPSGGG
CCCCCCCCCCCCCCC		40.9624732914
280PhosphorylationAPDSGLPSGGGGRPG
CCCCCCCCCCCCCCC		55.9324732914
290PhosphorylationGGRPGCAYPGSPGPG
CCCCCCCCCCCCCCC		16.5321712546
293PhosphorylationPGCAYPGSPGPGARA
CCCCCCCCCCCCCCC		23.3725159151
309PhosphorylationDKITCDLYQLISPSR
CCEEEEHHHHHCCCC		6.5021945579
313PhosphorylationCDLYQLISPSRDALP
EEHHHHHCCCCCCCC		25.9721945579
315PhosphorylationLYQLISPSRDALPSN
HHHHHCCCCCCCCCC		35.6821945579
334PhosphorylationLARADEASEGDSPAP
HHCCHHHCCCCCCCC		39.8124732914
338PhosphorylationDEASEGDSPAPARPE
HHHCCCCCCCCCCCC		33.5426055452
347PhosphorylationAPARPEDTPPAPPPP
CCCCCCCCCCCCCCC		29.5223401153
396PhosphorylationKEETVCLTVSPEEPP
CEEEEEEEECCCCCC		17.5127251275
398PhosphorylationETVCLTVSPEEPPPP
EEEEEEECCCCCCCC		22.7427251275
427PhosphorylationPEPPPADSPATAPGP
CCCCCCCCCCCCCCC		20.6728985074
453PhosphorylationCRLYRHVSHDFLEIR
HHHHHHCCCCHHHHH		15.9430108239
472PhosphorylationRLLEPRQYMLLLPEH
HHHCHHHHHHHCCHH		7.3322210691
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FBX46_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FBX46_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FBX46_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SKP1_HUMANSKP1physical
19159283
TCPA_HUMANTCP1physical
23658844
M2OM_HUMANSLC25A11physical
23658844
SKP1_HUMANSKP1physical
23658844
DHX9_HUMANDHX9physical
23658844
RUVB1_HUMANRUVBL1physical
23658844
DDX5_HUMANDDX5physical
23658844
HNRPR_HUMANHNRNPRphysical
23658844
MCM4_HUMANMCM4physical
23658844
CUL1_HUMANCUL1physical
23319600
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FBX46_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338 AND THR-347, ANDMASS SPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338 AND THR-347, ANDMASS SPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225, AND MASSSPECTROMETRY.

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