dbPTM

M2OM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	M2OM_HUMAN
UniProt AC	Q02978
Protein Name	Mitochondrial 2-oxoglutarate/malate carrier protein
Gene Name	SLC25A11
Organism	Homo sapiens (Human).
Sequence Length	314
Subcellular Localization	Mitochondrion inner membrane Multi-pass membrane protein .
Protein Description	Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. [PubMed: 21448454 Involved in the regulation of apoptosis (By similarity]
Protein Sequence	MAATASAGAGGIDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKAYKRLFLSG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAATASAGA ------CCCCCCCCC	17.33	19413330
4	Phosphorylation	----MAATASAGAGG ----CCCCCCCCCCC	16.17	25850435
6	Phosphorylation	--MAATASAGAGGID --CCCCCCCCCCCCC	23.92	29255136
15	Ubiquitination	GAGGIDGKPRTSPKS CCCCCCCCCCCCHHH	27.81	-
15	Acetylation	GAGGIDGKPRTSPKS CCCCCCCCCCCCHHH	27.81	21339330
18 (in isoform 2)	Phosphorylation	-	58.89	25056879
18	Phosphorylation	GIDGKPRTSPKSVKF CCCCCCCCCHHHHHH	58.89	22199227
19 (in isoform 2)	Phosphorylation	-	31.45	25056879
19	Phosphorylation	IDGKPRTSPKSVKFL CCCCCCCCHHHHHHH	31.45	22199227
22	Phosphorylation	KPRTSPKSVKFLFGG CCCCCHHHHHHHHCC	33.64	-
33	Sulfoxidation	LFGGLAGMGATVFVQ HHCCCCCCCCEEEEE	2.48	28183972
34 (in isoform 2)	Phosphorylation	-	19.71	-
34	Phosphorylation	FGGLAGMGATVFVQP HCCCCCCCCEEEEEE	19.71	-
52	Phosphorylation	VKNRMQLSGEGAKTR HHHHHHHCCCCCCCH	20.22	21406692
57	2-Hydroxyisobutyrylation	QLSGEGAKTREYKTS HHCCCCCCCHHHHHH	60.00	-
57	Ubiquitination	QLSGEGAKTREYKTS HHCCCCCCCHHHHHH	60.00	21890473
57	Succinylation	QLSGEGAKTREYKTS HHCCCCCCCHHHHHH	60.00	21890473
57	Succinylation	QLSGEGAKTREYKTS HHCCCCCCCHHHHHH	60.00	-
62	Ubiquitination	GAKTREYKTSFHALT CCCCHHHHHHHHHHH	32.70	21890473
63	Phosphorylation	AKTREYKTSFHALTS CCCHHHHHHHHHHHH	35.41	27050516
64	Phosphorylation	KTREYKTSFHALTSI CCHHHHHHHHHHHHH	15.75	27050516
69	Phosphorylation	KTSFHALTSILKAEG HHHHHHHHHHHHHCC	17.95	27050516
70	Phosphorylation	TSFHALTSILKAEGL HHHHHHHHHHHHCCC	27.12	27050516
73	Ubiquitination	HALTSILKAEGLRGI HHHHHHHHHCCCCHH	42.60	73
73	Acetylation	HALTSILKAEGLRGI HHHHHHHHHCCCCHH	42.60	19608861
78	Methylation	ILKAEGLRGIYTGLS HHHHCCCCHHHHHHC	40.08	115917065
95	Phosphorylation	LLRQATYTTTRLGIY HHHHCCCCCHHHCHH	19.82	26437602
102	Phosphorylation	TTTRLGIYTVLFERL CCHHHCHHHHHHHHH	6.76	25147952
103	Phosphorylation	TTRLGIYTVLFERLT CHHHCHHHHHHHHHH	14.60	22673903
115	Phosphorylation	RLTGADGTPPGFLLK HHHCCCCCCCCHHHH	27.19	24641631
127	Sulfoxidation	LLKAVIGMTAGATGA HHHHHHCCCCCCCCC	1.27	28183972
161	Phosphorylation	PADQRRGYKNVFNAL CHHHHHCHHHHHHHH	9.51	-
162	Ubiquitination	ADQRRGYKNVFNALI HHHHHCHHHHHHHHH	49.84	21890473
201	Phosphorylation	VNAAQLASYSQSKQF HCHHHHHHHHCCCCH	33.63	28152594
202	Phosphorylation	NAAQLASYSQSKQFL CHHHHHHHHCCCCHH	12.72	28152594
203	Phosphorylation	AAQLASYSQSKQFLL HHHHHHHHCCCCHHH	26.03	28152594
205	Phosphorylation	QLASYSQSKQFLLDS HHHHHHCCCCHHHHC	23.60	28152594
256	Succinylation	NMRMIDGKPEYKNGL HCEEECCCCCCCCCH	30.81	23954790
256	Acetylation	NMRMIDGKPEYKNGL HCEEECCCCCCCCCH	30.81	-
256	Ubiquitination	NMRMIDGKPEYKNGL HCEEECCCCCCCCCH	30.81	-
303	Sulfoxidation	TFIFLEQMNKAYKRL HHHHHHHHHHHHHHH	3.97	28183972

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of M2OM_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of M2OM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of M2OM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COPA_HUMAN	COPA	physical	16169070
M2OM_HUMAN	SLC25A11	physical	8597574
POTEI_HUMAN	POTEI	physical	26186194
ACTBL_HUMAN	ACTBL2	physical	26186194
YTHD1_HUMAN	YTHDF1	physical	26186194
FYN_HUMAN	FYN	physical	26186194
YES_HUMAN	YES1	physical	26186194
PPR1A_HUMAN	PPP1R1A	physical	26186194
REN3B_HUMAN	UPF3B	physical	26186194
SMAP2_HUMAN	SMAP2	physical	26186194
KPCA_HUMAN	PRKCA	physical	26186194
ZN703_HUMAN	ZNF703	physical	26186194
WIPI4_HUMAN	WDR45	physical	26186194
PRG2_HUMAN	PRG2	physical	26186194
VDAC1_HUMAN	VDAC1	physical	26344197
VDAC2_HUMAN	VDAC2	physical	26344197
VDAC3_HUMAN	VDAC3	physical	26344197
POTEI_HUMAN	POTEI	physical	28514442
PPR1A_HUMAN	PPP1R1A	physical	28514442
SMAP2_HUMAN	SMAP2	physical	28514442
ACTBL_HUMAN	ACTBL2	physical	28514442
YTHD1_HUMAN	YTHDF1	physical	28514442
PRG2_HUMAN	PRG2	physical	28514442
WIPI4_HUMAN	WDR45	physical	28514442
ACTB_HUMAN	ACTB	physical	28514442
YES_HUMAN	YES1	physical	28514442
ZN703_HUMAN	ZNF703	physical	28514442

Drug and Disease Associations

Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of M2OM_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-73, AND MASS SPECTROMETRY.	19608861 [Abstract]