WIPI4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WIPI4_HUMAN
• UniProt AC: Q9Y484
• Protein Name: WD repeat domain phosphoinositide-interacting protein 4
• Gene Name: WDR45
• Organism: Homo sapiens (Human).
• Sequence Length: 360
• Protein Description: Plays an important role in the autophagy pathway, which is the major intracellular degradation system by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation..
• Protein Sequence: MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
134	Ubiquitination	SFPDNPRKLFEFDTR ECCCCHHEEEEECCC	59.80	-
145	Ubiquitination	FDTRDNPKGLCDLCP ECCCCCCCCHHHCCH	71.43	-
146 (in isoform 3)	Ubiquitination	-	32.56	-
156	Ubiquitination	DLCPSLEKQLLVFPG HCCHHHCEEEEEECC	52.09	-
157 (in isoform 3)	Ubiquitination	-	30.56	-
225	Ubiquitination	RLFDTQSKEKLVELR EEEECCCHHHHHHHH	49.39	2190698
225 (in isoform 1)	Ubiquitination	-	49.39	21906983
226 (in isoform 3)	Ubiquitination	-	57.79	21906983
227	Ubiquitination	FDTQSKEKLVELRRG EECCCHHHHHHHHCC	62.66	-
236 (in isoform 2)	Ubiquitination	-	33.39	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WIPI4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WIPI4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WIPI4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATG2B_HUMAN	ATG2B	physical	20562859
ATG2A_HUMAN	ATG2A	physical	20562859
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 300894: Neurodegeneration with brain iron accumulation 5 (NBIA5)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.