ATG2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATG2B_HUMAN
• UniProt AC: Q96BY7
• Protein Name: Autophagy-related protein 2 homolog B
• Gene Name: ATG2B
• Organism: Homo sapiens (Human).
• Sequence Length: 2078
• Subcellular Localization: Preautophagosomal structure membrane ; Peripheral membrane protein . Lipid droplet .
• Protein Description: Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion..
• Protein Sequence: MPWPFSESIKKRACRYLLQRYLGHFLQEKLSLEQLSLDLYQGTGSLAQVPLDKWCLNEILESADAPLEVTEGFIQSISLSVPWGSLLQDNCALEVRGLEMVFRPRPRPATGSEPMYWSSFMTSSMQLAKECLSQKLTDEQGEGSQPFEGLEKFAETIETVLRRVKVTFIDTVLRIEHVPENSKTGTALEIRIERTVYCDETADESSGINVHQPTAFAHKLLQLSGVSLFWDEFSASAKSSPVCSTAPVETEPKLSPSWNPKIIYEPHPQLTRNLPEIAPSDPVQIGRLIGRLELSLTLKQNEVLPGAKLDVDGQIDSIHLLLSPRQVHLLLDMLAAIAGPENSSKIGLANKDRKNRPMQQEDEYRIQMELNRYYLRKDSLSVGVSSEQSFYETETARTPSSREEEVFFSMADMDMSHSLSSLPPLGDPPNMDLELSLTSTYTNTPAGSPLSATVLQPTWGEFLDHHKEQPVRGSTFPSNLVHPTPLQKTSLPSRSVSVDESRPELIFRLAVGTFSISVLHIDPLSPPETSQNLNPLTPMAVAFFTCIEKIDPARFSTEDFKSFRAVFAEACSHDHLRFIGTGIKVSYEQRQRSASRYFSTDMSIGQMEFLECLFPTDFHSVPPHYTELLTFHSKEETGSHSPVCLQLHYKHSENRGPQGNQARLSSVPHKAELQIKLNPVCCELDISIVDRLNSLLQPQKLATVEMMASHMYTSYNKHISLHKAFTEVFLDDSHSPANCRISVQVATPALNLSVRFPIPDLRSDQERGPWFKKSLQKEILYLAFTDLEFKTEFIGGSTPEQIKLELTFRELIGSFQEEKGDPSIKFFHVSSGVDGDTTSSDDFDWPRIVLKINPPAMHSILERIAAEEEEENDGHYQEEEEGGAHSLKDVCDLRRPAPSPFSSRRVMFENEQMVMPGDPVEMTEFQDKAISNSHYVLELTLPNIYVTLPNKSFYEKLYNRIFNDLLLWEPTAPSPVETFENISYGIGLSVASQLINTFNKDSFSAFKSAVHYDEESGSEEETLQYFSTVDPNYRSRRKKKLDSQNKNSQSFLSVLLNINHGLIAVFTDVKQDNGDLLENKHGEFWLEFNSGSLFCVTKYEGFDDKHYICLHSSSFSLYHKGIVNGVILPTETRLPSSTRPHWLEPTIYSSEEDGLSKTSSDGVGGDSLNMLSVAVKILSDKSESNTKEFLIAVGLKGATLQHRMLPSGLSWHEQILYFLNIADEPVLGYNPPTSFTTFHVHLWSCALDYRPLYLPIRSLLTVETFSVSSSVALDKSSSTLRIILDEAALHLSDKCNTVTINLSRDYVRVMDMGLLELTITAVKSDSDGEQTEPRFELHCSSDVVHIRTCSDSCAALMNLIQYIASYGDLQTPNKADMKPGAFQRRSKVDSSGRSSSRGPVLPEADQQMLRDLMSDAMEEIDMQQGTSSVKPQANGVLDEKSQIQEPCCSDLFLFPDESGNVSQESGPTYASFSHHFISDAMTGVPTENDDFCILFAPKAAMQEKEEEPVIKIMVDDAIVIRDNYFSLPVNKTDTSKAPLHFPIPVIRYVVKEVSLVWHLYGGKDFGIVPPTSPAKSYISPHSSPSHTPTRHGRNTVCGGKGRNHDFLMEIQLSKVKFQHEVYPPCKPDCDSSLSEHPVSRQVFIVQDLEIRDRLATSQMNKFLYLYCSKEMPRKAHSNMLTVKALHVCPESGRSPQECCLRVSLMPLRLNIDQDALFFLKDFFTSLSAEVELQMTPDPEVKKSPGADVTCSLPRHLSTSKEPNLVISFSGPKQPSQNDSANSVEVVNGMEEKNFSAEEASFRDQPVFFREFRFTSEVPIRLDYHGKHVSMDQGTLAGILIGLAQLNCSELKLKRLSYRHGLLGVDKLFSYAITEWLNDIKKNQLPGILGGVGPMHSLVQLVQGLKDLVWLPIEQYRKDGRIVRGFQRGAASFGTSTAMAALELTNRMVQTIQAAAETAYDMVSPGTLSIEPKKTKRFPHHRLAHQPVDLREGVAKAYSVVKEGITDTAQTIYETAAREHESRGVTGAVGEVLRQIPPAVVKPLIVATEATSNVLGGMRNQIRPDVRQDESQKWRHGDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MPWPFSESIKKRA --CCCCCCHHHHHHH	26.76	22617229
8	Phosphorylation	MPWPFSESIKKRACR CCCCCCHHHHHHHHH	38.21	28450419
10	Ubiquitination	WPFSESIKKRACRYL CCCCHHHHHHHHHHH	45.55	32142685
118	Phosphorylation	GSEPMYWSSFMTSSM CCCCCHHHHHHHHHH	9.01	22210691
182	Phosphorylation	IEHVPENSKTGTALE EEECCCCCCCCCEEE	29.90	20068231
224	Phosphorylation	AHKLLQLSGVSLFWD HHHHHHHHCCCEEHH	24.96	28060719
227	Phosphorylation	LLQLSGVSLFWDEFS HHHHHCCCEEHHHHC	22.75	28060719
234	Phosphorylation	SLFWDEFSASAKSSP CEEHHHHCCCCCCCC	21.19	28060719
236	Phosphorylation	FWDEFSASAKSSPVC EHHHHCCCCCCCCCC	34.72	28060719
239	Phosphorylation	EFSASAKSSPVCSTA HHCCCCCCCCCCCCC	39.32	23401153
240	Phosphorylation	FSASAKSSPVCSTAP HCCCCCCCCCCCCCC	22.20	30278072
244	Phosphorylation	AKSSPVCSTAPVETE CCCCCCCCCCCCCCC	28.04	23927012
245	Phosphorylation	KSSPVCSTAPVETEP CCCCCCCCCCCCCCC	29.83	23927012
250	Phosphorylation	CSTAPVETEPKLSPS CCCCCCCCCCCCCCC	58.80	23927012
255	Phosphorylation	VETEPKLSPSWNPKI CCCCCCCCCCCCCCC	24.02	23401153
257	Phosphorylation	TEPKLSPSWNPKIIY CCCCCCCCCCCCCCC	35.79	30266825
264	Phosphorylation	SWNPKIIYEPHPQLT CCCCCCCCCCCHHHC	27.21	25394399
271	Phosphorylation	YEPHPQLTRNLPEIA CCCCHHHCCCCCCCC	16.56	28555341
295	Phosphorylation	LIGRLELSLTLKQNE HHHEEEEEEEEECCC	15.21	24719451
323	Phosphorylation	DSIHLLLSPRQVHLL CEEEEECCHHHHHHH	20.29	24719451
343	Phosphorylation	AIAGPENSSKIGLAN HHHCCCCCCCCCCCC	31.20	28787133
364	Phosphorylation	PMQQEDEYRIQMELN CCCHHHHHHHHHHHH	25.90	-
379	Phosphorylation	RYYLRKDSLSVGVSS HHEECCCCEEECCCC	26.11	24719451
381	Phosphorylation	YLRKDSLSVGVSSEQ EECCCCEEECCCCCC	22.30	28348404
395	Phosphorylation	QSFYETETARTPSSR CCEEEECCCCCCCCC	28.94	28985074
474	Phosphorylation	KEQPVRGSTFPSNLV CCCCCCCCCCCCCCC	19.13	24719451
475	Phosphorylation	EQPVRGSTFPSNLVH CCCCCCCCCCCCCCC	42.25	24719451
484	Phosphorylation	PSNLVHPTPLQKTSL CCCCCCCCCCCCCCC	23.04	28555341
489	Phosphorylation	HPTPLQKTSLPSRSV CCCCCCCCCCCCCCC	23.64	23090842
490	Phosphorylation	PTPLQKTSLPSRSVS CCCCCCCCCCCCCCC	45.37	23090842
493	Phosphorylation	LQKTSLPSRSVSVDE CCCCCCCCCCCCCCC	42.34	23090842
495	Phosphorylation	KTSLPSRSVSVDESR CCCCCCCCCCCCCCC	24.07	30266825
497	Phosphorylation	SLPSRSVSVDESRPE CCCCCCCCCCCCCHH	25.71	29255136
501	Phosphorylation	RSVSVDESRPELIFR CCCCCCCCCHHHHHH	48.98	23927012
616	Phosphorylation	FLECLFPTDFHSVPP HHHHHCCCCCCCCCC	43.92	22210691
630	Phosphorylation	PHYTELLTFHSKEET CCCEEEEEEECCCCC	31.74	22210691
633	Phosphorylation	TELLTFHSKEETGSH EEEEEEECCCCCCCC	37.26	22210691
665	Phosphorylation	QGNQARLSSVPHKAE CCCCHHHCCCCCCEE	24.60	23312004
666	Phosphorylation	GNQARLSSVPHKAEL CCCHHHCCCCCCEEE	44.23	23312004
694	Phosphorylation	SIVDRLNSLLQPQKL HHHHHHHHHCCHHHH	34.74	26074081
703	Phosphorylation	LQPQKLATVEMMASH CCHHHHHHHHHHHHH	27.69	26074081
709	Phosphorylation	ATVEMMASHMYTSYN HHHHHHHHHHHHHHH	7.29	26074081
712	Phosphorylation	EMMASHMYTSYNKHI HHHHHHHHHHHHHHC	6.26	26074081
713	Phosphorylation	MMASHMYTSYNKHIS HHHHHHHHHHHHHCC	19.70	26074081
714	Phosphorylation	MASHMYTSYNKHISL HHHHHHHHHHHHCCH	14.82	26074081
715	Phosphorylation	ASHMYTSYNKHISLH HHHHHHHHHHHCCHH	22.04	26074081
720	Phosphorylation	TSYNKHISLHKAFTE HHHHHHCCHHHHHEE	24.92	24719451
726	Phosphorylation	ISLHKAFTEVFLDDS CCHHHHHEEEECCCC	35.78	23312004
733	Phosphorylation	TEVFLDDSHSPANCR EEEECCCCCCCCCCE	26.07	28348404
735	Phosphorylation	VFLDDSHSPANCRIS EECCCCCCCCCCEEE	29.65	23312004
753	Phosphorylation	ATPALNLSVRFPIPD ECCCCEEEEEECCCC	15.35	23403867
798	Phosphorylation	TEFIGGSTPEQIKLE EEECCCCCHHHHEEE	33.83	25307156
819	Ubiquitination	IGSFQEEKGDPSIKF HHHHHHHCCCCCCEE	68.79	29967540
830	Phosphorylation	SIKFFHVSSGVDGDT CCEEEEEECCCCCCC	16.89	27251275
831	Phosphorylation	IKFFHVSSGVDGDTT CEEEEEECCCCCCCC	41.57	27251275
837	Phosphorylation	SSGVDGDTTSSDDFD ECCCCCCCCCCCCCC	33.82	29978859
838	Phosphorylation	SGVDGDTTSSDDFDW CCCCCCCCCCCCCCC	30.85	30576142
839	Phosphorylation	GVDGDTTSSDDFDWP CCCCCCCCCCCCCCC	33.58	30576142
840	Phosphorylation	VDGDTTSSDDFDWPR CCCCCCCCCCCCCCE	38.82	25849741
876	Phosphorylation	EEENDGHYQEEEEGG HHHCCCCCCHHHCCC	24.13	28796482
886	Phosphorylation	EEEGGAHSLKDVCDL HHCCCCCCHHHHHCC	36.26	25159151
899	Phosphorylation	DLRRPAPSPFSSRRV CCCCCCCCCCCCCEE	40.46	28985074
902	Phosphorylation	RPAPSPFSSRRVMFE CCCCCCCCCCEEEEE	26.73	23186163
903	Phosphorylation	PAPSPFSSRRVMFEN CCCCCCCCCEEEEEC	25.20	23186163
1002	Phosphorylation	INTFNKDSFSAFKSA HHHCCHHHCHHHHHH	23.78	21815630
1008	Phosphorylation	DSFSAFKSAVHYDEE HHCHHHHHHCCCCCC	29.12	28450419
1012	Phosphorylation	AFKSAVHYDEESGSE HHHHHCCCCCCCCCH	20.60	28450419
1016	Phosphorylation	AVHYDEESGSEEETL HCCCCCCCCCHHHHH	45.64	22115753
1018	Phosphorylation	HYDEESGSEEETLQY CCCCCCCCHHHHHHH	51.63	22115753
1022	Phosphorylation	ESGSEEETLQYFSTV CCCCHHHHHHHHHCC	23.57	28450419
1025	Phosphorylation	SEEETLQYFSTVDPN CHHHHHHHHHCCCCC	11.56	28450419
1027	Phosphorylation	EETLQYFSTVDPNYR HHHHHHHHCCCCCHH	23.69	28450419
1028	Phosphorylation	ETLQYFSTVDPNYRS HHHHHHHCCCCCHHH	21.01	28450419
1033	Phosphorylation	FSTVDPNYRSRRKKK HHCCCCCHHHHHHHH	18.49	27080861
1159	Phosphorylation	EDGLSKTSSDGVGGD CCCCCCCCCCCCCHH	30.12	28674419
1179	Phosphorylation	SVAVKILSDKSESNT HHHHHHHCCCCCCCC	46.60	-
1394	Phosphorylation	KVDSSGRSSSRGPVL CCCCCCCCCCCCCCC	35.87	23312004
1395	Phosphorylation	VDSSGRSSSRGPVLP CCCCCCCCCCCCCCC	23.77	23312004
1396	Phosphorylation	DSSGRSSSRGPVLPE CCCCCCCCCCCCCCH	42.37	23312004
1524	Phosphorylation	AIVIRDNYFSLPVNK EEEEECCEEECCCCC	9.99	29978859
1526	Phosphorylation	VIRDNYFSLPVNKTD EEECCEEECCCCCCC	22.77	25850435
1531	Ubiquitination	YFSLPVNKTDTSKAP EEECCCCCCCCCCCC	48.27	29967540
1572	Phosphorylation	FGIVPPTSPAKSYIS CEECCCCCCCCCCCC	28.74	22985185
1576	Phosphorylation	PPTSPAKSYISPHSS CCCCCCCCCCCCCCC	29.79	23927012
1577	Phosphorylation	PTSPAKSYISPHSSP CCCCCCCCCCCCCCC	12.52	23927012
1579	Phosphorylation	SPAKSYISPHSSPSH CCCCCCCCCCCCCCC	14.34	22167270
1582	Phosphorylation	KSYISPHSSPSHTPT CCCCCCCCCCCCCCC	47.53	23401153
1583	Phosphorylation	SYISPHSSPSHTPTR CCCCCCCCCCCCCCC	27.64	23401153
1585	Phosphorylation	ISPHSSPSHTPTRHG CCCCCCCCCCCCCCC	41.77	22167270
1587	Phosphorylation	PHSSPSHTPTRHGRN CCCCCCCCCCCCCCC	30.60	25159151
1589	Phosphorylation	SSPSHTPTRHGRNTV CCCCCCCCCCCCCCC	36.13	25159151
1631	Phosphorylation	PCKPDCDSSLSEHPV CCCCCCCCCCCCCCC	39.24	24275569
1632	Phosphorylation	CKPDCDSSLSEHPVS CCCCCCCCCCCCCCC	23.74	24275569
1656	Phosphorylation	EIRDRLATSQMNKFL HHHHHHHHHHHHHHH	24.88	26552605
1657	Phosphorylation	IRDRLATSQMNKFLY HHHHHHHHHHHHHHH	23.09	26552605
1664	Phosphorylation	SQMNKFLYLYCSKEM HHHHHHHHHHHCCCC	9.96	26552605
1666	Phosphorylation	MNKFLYLYCSKEMPR HHHHHHHHHCCCCCC	4.90	26552605
1668	Phosphorylation	KFLYLYCSKEMPRKA HHHHHHHCCCCCCCC	20.35	26552605
1674	Ubiquitination	CSKEMPRKAHSNMLT HCCCCCCCCCCCCEE	44.58	29967540
1677	Phosphorylation	EMPRKAHSNMLTVKA CCCCCCCCCCEEEEE	28.88	27794612
1681	Phosphorylation	KAHSNMLTVKALHVC CCCCCCEEEEEEEEC	14.80	28674151
1743	Phosphorylation	PDPEVKKSPGADVTC CCCCCCCCCCCCCEE	23.89	30266825
1749	Phosphorylation	KSPGADVTCSLPRHL CCCCCCCEEECCCCC	9.27	23927012
1751	Phosphorylation	PGADVTCSLPRHLST CCCCCEEECCCCCCC	31.85	23927012
1757	Phosphorylation	CSLPRHLSTSKEPNL EECCCCCCCCCCCCE	25.22	28450419
1758	Phosphorylation	SLPRHLSTSKEPNLV ECCCCCCCCCCCCEE	50.61	28450419
1759	Phosphorylation	LPRHLSTSKEPNLVI CCCCCCCCCCCCEEE	31.48	28450419
1767	Phosphorylation	KEPNLVISFSGPKQP CCCCEEEEECCCCCC	13.09	23312004
1769	Phosphorylation	PNLVISFSGPKQPSQ CCEEEEECCCCCCCC	47.60	23312004
1934	Phosphorylation	RGAASFGTSTAMAAL CCCHHCCHHHHHHHH	22.39	24850871
2005	Phosphorylation	SVVKEGITDTAQTIY HHHHHCCCCHHHHHH	37.85	21945579
2007	Phosphorylation	VKEGITDTAQTIYET HHHCCCCHHHHHHHH	16.41	21945579
2010	Phosphorylation	GITDTAQTIYETAAR CCCCHHHHHHHHHHH	24.06	21945579
2012	Phosphorylation	TDTAQTIYETAAREH CCHHHHHHHHHHHHH	15.60	21945579
2014	Phosphorylation	TAQTIYETAAREHES HHHHHHHHHHHHHHH	14.51	21945579
2025	O-linked_Glycosylation	EHESRGVTGAVGEVL HHHHCCCCHHHHHHH	23.42	30379171
2070	Phosphorylation	PDVRQDESQKWRHGD CCCCCCHHHCCCCCC	45.40	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATG2B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATG2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATG2B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WIPI4_HUMAN	WDR45	physical	28514442
TKT_HUMAN	TKT	physical	28514442
UBP15_HUMAN	USP15	physical	27173435
MCM2_HUMAN	MCM2	physical	27173435
MCM4_HUMAN	MCM4	physical	27173435
MCM6_HUMAN	MCM6	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240, AND MASSSPECTROMETRY.
PubMed: 19413330

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-497, AND MASSSPECTROMETRY.
PubMed: 18691976