POTEI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: POTEI_HUMAN
• UniProt AC: P0CG38
• Protein Name: POTE ankyrin domain family member I
• Gene Name: POTEI
• Organism: Homo sapiens (Human).
• Sequence Length: 1075
• Protein Sequence: MVAEVDSMPAASSVKKPFVLRSKMGKWCRHCFPCCRGSGKSNVGTSGDQDDSTMKTLRSKMGKWCCHCFPCCRGSGKSNVGTSGDHDDSAMKTLRSKMGKWCCHCFPCCRGSGKSNVGAWGDYDDSAFVEPRYHVRREDLDKLHRAAWWGKVARKDLIVMLRDTDVNKQDKQKRTALHLASANGNSGVVKLLLDRRCQLNVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLSDYKEKQMLKISSENSNPEQDLKLTSEEESQRFKGSENSQPEKMSQEPEINKDGDREVEEEMKKHESNNVGLLENLSNGVTAGNGDDGLIPQRKSRTPENQQFPDNESEEYHRICELVSDYKEKQMPKYSSENSNPEQDLKLTSEEESQRLKGSENGQPEKRSQEPEINKDGDRELENFMAIEEMKKHGSTHVGFPENLTNGATAGNGDDGLIPPRKSRTPESQQFPDTENEEYHSDEQNDTQKQFCEEQNTGILHDEILIHEEKQIEVVEKMNSELSLSCKKEKDFLHENSTLREEIAMLRLELDTMKHQSQLRKKKYLEDIESVKKKNDNLLKALQLNELTMDDDTAVLVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRQQGMMGGMHQKESYVGKEAQSKRGILTLKYPMEHGIITNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAMLSLYTSGRTTGIVMDSGDGVTHTVPIYDGNALPHATLRLDLAGRELTDYLMKILTERGYRFTTMAEREIVRDIKEKLCYVALDFEQEMAMAASSSSLEKSYELPDGQVITIGNEWFRCPEALFQPCFLGMESCGIHETTFNSIMKSDVDIRKDLYTNTVLSGGTTMYPGMAHRMQKEIAALAPSMLKIRIIAPPKRKYSVWVGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MVAEVDSMPAASSV -CCCCCCCCCCCCCC	31.66	23663014
12	Phosphorylation	VDSMPAASSVKKPFV CCCCCCCCCCCCCEE	37.46	23663014
13	Phosphorylation	DSMPAASSVKKPFVL CCCCCCCCCCCCEEH	32.98	23663014
14	Ubiquitination	SMPAASSVKKPFVLR CCCCCCCCCCCEEHH	9.53	22817900
22	Phosphorylation	KKPFVLRSKMGKWCR CCCEEHHCCCCCCHH	23.88	21406692
38	Phosphorylation	CFPCCRGSGKSNVGT HCCCCCCCCCCCCCC	24.56	22210691
43	Ubiquitination	RGSGKSNVGTSGDQD CCCCCCCCCCCCCCC	13.12	22817900
46	Phosphorylation	GKSNVGTSGDQDDST CCCCCCCCCCCCHHH	34.15	-
48	Ubiquitination	SNVGTSGDQDDSTMK CCCCCCCCCCHHHHH	48.80	22817900
53	Phosphorylation	SGDQDDSTMKTLRSK CCCCCHHHHHHHHHH	29.67	22210691
56	Phosphorylation	QDDSTMKTLRSKMGK CCHHHHHHHHHHCCC	19.31	-
78	Phosphorylation	CCRGSGKSNVGTSGD CCCCCCCCCCCCCCC	40.03	30576142
89	Phosphorylation	TSGDHDDSAMKTLRS CCCCCCHHHHHHHHH	36.00	30576142
92	Ubiquitination	DHDDSAMKTLRSKMG CCCHHHHHHHHHHHC	44.09	23000965
93	Phosphorylation	HDDSAMKTLRSKMGK CCHHHHHHHHHHHCC	17.83	7657233
97	Ubiquitination	AMKTLRSKMGKWCCH HHHHHHHHHCCCHHH	45.28	23000965
114	Ubiquitination	PCCRGSGKSNVGAWG CCCCCCCCCCCCCCC	40.32	32142685
121	Ubiquitination	KSNVGAWGDYDDSAF CCCCCCCCCCCCCCC	24.06	22817900
143	Ubiquitination	RREDLDKLHRAAWWG CHHHHHHHHHHHHHH	3.10	22817900
145	Ubiquitination	EDLDKLHRAAWWGKV HHHHHHHHHHHHHHH	36.12	22817900
168	Ubiquitination	LRDTDVNKQDKQKRT EECCCCCHHHHHHHH	60.77	22817900
175	Phosphorylation	KQDKQKRTALHLASA HHHHHHHHHHHHHHC	40.38	-
208	Phosphorylation	VLDNKKRTALTKAVQ ECCCHHHHHHHHHHH	34.59	-
266	Ubiquitination	LLYGADIESKNKHGL HHHCCCHHHCCCCCC	57.09	22817900
267	Phosphorylation	LYGADIESKNKHGLT HHCCCHHHCCCCCCC	41.69	26074081
267	Ubiquitination	LYGADIESKNKHGLT HHCCCHHHCCCCCCC	41.69	22817900
268	Ubiquitination	YGADIESKNKHGLTP HCCCHHHCCCCCCCC	58.17	23000965
270	Ubiquitination	ADIESKNKHGLTPLL CCHHHCCCCCCCCCE	42.67	23000965
274	Phosphorylation	SKNKHGLTPLLLGVH HCCCCCCCCCEEEHH	19.24	-
278	Ubiquitination	HGLTPLLLGVHEQKQ CCCCCCEEEHHHHHH	9.92	23000965
280	Ubiquitination	LTPLLLGVHEQKQQV CCCCEEEHHHHHHHH	4.53	23000965
284	Ubiquitination	LLGVHEQKQQVVKFL EEEHHHHHHHHHHHH	39.45	22817900
285	Ubiquitination	LGVHEQKQQVVKFLI EEHHHHHHHHHHHHH	40.78	22817900
286	Ubiquitination	GVHEQKQQVVKFLIK EHHHHHHHHHHHHHH	49.35	22817900
295	Ubiquitination	VKFLIKKKANLNALD HHHHHHHCCCCCHHH	37.19	-
300	Ubiquitination	KKKANLNALDRYGRT HHCCCCCHHHHHCCH	17.63	22817900
318	Ubiquitination	LAVCCGSASIVSLLL HHHHCCCHHHHHHHH	6.64	22817900
366	Ubiquitination	DYKEKQMLKISSENS CHHHHHCCCCCCCCC	4.06	22817900
370	Phosphorylation	KQMLKISSENSNPEQ HHCCCCCCCCCCHHH	44.25	-
383	Phosphorylation	EQDLKLTSEEESQRF HHHCCCCCHHHHHHH	54.14	-
384	Ubiquitination	QDLKLTSEEESQRFK HHCCCCCHHHHHHHC	61.62	22817900
395	Ubiquitination	QRFKGSENSQPEKMS HHHCCCCCCCCCHHC	47.87	22817900
400	Ubiquitination	SENSQPEKMSQEPEI CCCCCCCHHCCCCCC	51.00	22817900
413	Ubiquitination	EINKDGDREVEEEMK CCCCCCCHHHHHHHH	56.22	22817900
418	Ubiquitination	GDREVEEEMKKHESN CCHHHHHHHHHHHCC	42.68	22817900
468	Phosphorylation	PDNESEEYHRICELV CCCCCHHHHHHHHHH	7.73	-
473	Ubiquitination	EEYHRICELVSDYKE HHHHHHHHHHHHHHH	50.24	22817900
476	Phosphorylation	HRICELVSDYKEKQM HHHHHHHHHHHHHHC	48.09	-
478	Phosphorylation	ICELVSDYKEKQMPK HHHHHHHHHHHHCCC	17.34	-
488	Phosphorylation	KQMPKYSSENSNPEQ HHCCCCCCCCCCHHH	37.39	-
491	Ubiquitination	PKYSSENSNPEQDLK CCCCCCCCCHHHHHC	50.11	22817900
495	Ubiquitination	SENSNPEQDLKLTSE CCCCCHHHHHCCCCH	63.69	22817900
497	Ubiquitination	NSNPEQDLKLTSEEE CCCHHHHHCCCCHHH	4.97	22817900
501	Phosphorylation	EQDLKLTSEEESQRL HHHHCCCCHHHHHHH	54.14	-
513	Ubiquitination	QRLKGSENGQPEKRS HHHCCCCCCCCCCCC	56.98	22817900
515	Ubiquitination	LKGSENGQPEKRSQE HCCCCCCCCCCCCCC	55.34	22817900
520	Ubiquitination	NGQPEKRSQEPEINK CCCCCCCCCCCCCCC	50.38	22817900
538	Ubiquitination	RELENFMAIEEMKKH HHHHHHHHHHHHHHH	11.25	22817900
547	Phosphorylation	EEMKKHGSTHVGFPE HHHHHHCCCCCCCCC	18.30	20860994
548	Phosphorylation	EMKKHGSTHVGFPEN HHHHHCCCCCCCCCC	25.77	20860994
561	Phosphorylation	ENLTNGATAGNGDDG CCCCCCCCCCCCCCC	36.17	20860994
676	Phosphorylation	SQLRKKKYLEDIESV HHHHHHHHHHHHHHH	24.97	28258704
682	Phosphorylation	KYLEDIESVKKKNDN HHHHHHHHHHHHCCH	39.30	20068231
684	Ubiquitination	LEDIESVKKKNDNLL HHHHHHHHHHCCHHH	68.27	22817900
685	Ubiquitination	EDIESVKKKNDNLLK HHHHHHHHHCCHHHH	55.44	22817900
686	Ubiquitination	DIESVKKKNDNLLKA HHHHHHHHCCHHHHH	64.91	22817900
694	Ubiquitination	NDNLLKALQLNELTM CCHHHHHHHCCCCCC	5.94	22817900
695	Ubiquitination	DNLLKALQLNELTMD CHHHHHHHCCCCCCC	47.29	22817900
696	Ubiquitination	NLLKALQLNELTMDD HHHHHHHCCCCCCCC	5.82	22817900
705	Phosphorylation	ELTMDDDTAVLVIDN CCCCCCCCEEEEEEC	26.17	24850871
714	Phosphorylation	VLVIDNGSGMCKAGF EEEEECCCCCCCCCC	29.61	-
718	Ubiquitination	DNGSGMCKAGFAGDD ECCCCCCCCCCCCCC	42.52	22817900
728	Ubiquitination	FAGDDAPRAVFPSIV CCCCCCCHHHCHHHC	45.14	22817900
733	Phosphorylation	APRAVFPSIVGRPRQ CCHHHCHHHCCCCCC	20.59	30266825
752	Phosphorylation	GGMHQKESYVGKEAQ CCCCCCCCCCCHHHH	31.96	29978859
753	Phosphorylation	GMHQKESYVGKEAQS CCCCCCCCCCHHHHC	17.82	29978859
755	Phosphorylation	HQKESYVGKEAQSKR CCCCCCCCHHHHCCC	17.53	32142685
760	Phosphorylation	YVGKEAQSKRGILTL CCCHHHHCCCCEEEE	31.22	29978859
766	Phosphorylation	QSKRGILTLKYPMEH HCCCCEEEEECCCHH	21.20	23403867
768	Methylation	KRGILTLKYPMEHGI CCCEEEEECCCHHCC	41.91	-
769	Phosphorylation	RGILTLKYPMEHGII CCEEEEECCCHHCCC	15.78	-
777	Phosphorylation	PMEHGIITNWDDMEK CCHHCCCCCHHHHHH	28.47	22817900
784	Acetylation	TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH	44.45	23236377
784	Methylation	TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH	44.45	23748837
784	Sumoylation	TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH	44.45	-
784	Ubiquitination	TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH	44.45	22817900
789	Phosphorylation	MEKIWHHTFYNELRV HHHHHHHHHHCCCCC	18.22	27273156
791	Phosphorylation	KIWHHTFYNELRVAP HHHHHHHHCCCCCCC	14.64	27273156
794	Ubiquitination	HHTFYNELRVAPEEH HHHHHCCCCCCCCCC	4.80	22817900
806	Phosphorylation	EEHPILLTEAPLNPK CCCCEEEEECCCCCC	27.01	-
813	Acetylation	TEAPLNPKANREKMT EECCCCCCCCHHHHH	58.16	21466224
813	Ubiquitination	TEAPLNPKANREKMT EECCCCCCCCHHHHH	58.16	27667366
818	Ubiquitination	NPKANREKMTQIMFE CCCCCHHHHHHHHHH	43.97	22817900
820	Phosphorylation	KANREKMTQIMFETF CCCHHHHHHHHHHHC	26.47	-
823	Ubiquitination	REKMTQIMFETFNTP HHHHHHHHHHHCCCH	1.46	22817900
826	Phosphorylation	MTQIMFETFNTPAMY HHHHHHHHCCCHHHH	15.77	28188228
828	Ubiquitination	QIMFETFNTPAMYVA HHHHHHCCCHHHHHH	53.20	22817900
833	Phosphorylation	TFNTPAMYVAIQAML HCCCHHHHHHHHHHH	6.71	28188228
835	Ubiquitination	NTPAMYVAIQAMLSL CCHHHHHHHHHHHHH	3.18	32142685
841	Phosphorylation	VAIQAMLSLYTSGRT HHHHHHHHHHHCCCC	13.27	24719451
847	Methylation	LSLYTSGRTTGIVMD HHHHHCCCCEEEEEE	28.96	-
855	Phosphorylation	TTGIVMDSGDGVTHT CEEEEEECCCCCEEE	22.23	30140170
875	Phosphorylation	GNALPHATLRLDLAG CCCCCCEEEEEECCC	14.91	-
886	Phosphorylation	DLAGRELTDYLMKIL ECCCHHHHHHHHHHH	20.18	25072903
888	Phosphorylation	AGRELTDYLMKILTE CCHHHHHHHHHHHHH	11.94	25072903
891	Acetylation	ELTDYLMKILTERGY HHHHHHHHHHHHCCC	31.78	26051181
891	Ubiquitination	ELTDYLMKILTERGY HHHHHHHHHHHHCCC	31.78	22817900
901	Phosphorylation	TERGYRFTTMAEREI HHCCCCCCCHHHHHH	13.48	23403867
901	Ubiquitination	TERGYRFTTMAEREI HHCCCCCCCHHHHHH	13.48	22817900
902	Phosphorylation	ERGYRFTTMAEREIV HCCCCCCCHHHHHHH	16.21	23403867
913	Acetylation	REIVRDIKEKLCYVA HHHHHHHHHHHHEEE	53.75	26051181
913	Ubiquitination	REIVRDIKEKLCYVA HHHHHHHHHHHHEEE	53.75	21906983
915	Acetylation	IVRDIKEKLCYVALD HHHHHHHHHHEEECC	38.56	26051181
915	Ubiquitination	IVRDIKEKLCYVALD HHHHHHHHHHEEECC	38.56	22817900
918	Phosphorylation	DIKEKLCYVALDFEQ HHHHHHHEEECCHHH	10.13	17360941
923	Ubiquitination	LCYVALDFEQEMAMA HHEEECCHHHHHHHH	12.42	22817900
925	Ubiquitination	YVALDFEQEMAMAAS EEECCHHHHHHHHHC	45.84	22817900
927	Sulfoxidation	ALDFEQEMAMAASSS ECCHHHHHHHHHCCC	2.86	28183972
929	Sulfoxidation	DFEQEMAMAASSSSL CHHHHHHHHHCCCCC	2.86	28183972
932	Phosphorylation	QEMAMAASSSSLEKS HHHHHHHCCCCCCHH	22.63	27251275
933	Phosphorylation	EMAMAASSSSLEKSY HHHHHHCCCCCCHHE	21.15	27461979
934	Phosphorylation	MAMAASSSSLEKSYE HHHHHCCCCCCHHEE	36.13	27251275
935	Phosphorylation	AMAASSSSLEKSYEL HHHHCCCCCCHHEEC	42.36	27251275
935	Ubiquitination	AMAASSSSLEKSYEL HHHHCCCCCCHHEEC	42.36	32142685
938	Ubiquitination	ASSSSLEKSYELPDG HCCCCCCHHEECCCC	64.73	22817900
939	Phosphorylation	SSSSLEKSYELPDGQ CCCCCCHHEECCCCC	17.92	20068231
940	Phosphorylation	SSSLEKSYELPDGQV CCCCCHHEECCCCCE	32.33	54897
948	Ubiquitination	ELPDGQVITIGNEWF ECCCCCEEEECCCEE	1.46	22817900
949	Phosphorylation	LPDGQVITIGNEWFR CCCCCEEEECCCEEC	24.79	-
961	Phosphorylation	WFRCPEALFQPCFLG EECCCHHHCCCCCCC	3.80	32142685
971	Phosphorylation	PCFLGMESCGIHETT CCCCCHHHCCCCHHH	14.57	27251275
977	Phosphorylation	ESCGIHETTFNSIMK HHCCCCHHHHHHHHH	23.64	30140170
978	Phosphorylation	SCGIHETTFNSIMKS HCCCCHHHHHHHHHC	20.17	30140170
985	Phosphorylation	TFNSIMKSDVDIRKD HHHHHHHCCCCCCHH	26.03	-
991	Sumoylation	KSDVDIRKDLYTNTV HCCCCCCHHHCCCCE	53.04	-
994	Phosphorylation	VDIRKDLYTNTVLSG CCCCHHHCCCCEECC	14.21	21955146
995	Phosphorylation	DIRKDLYTNTVLSGG CCCHHHCCCCEECCC	31.54	21955146
997	Phosphorylation	RKDLYTNTVLSGGTT CHHHCCCCEECCCCC	18.28	21955146
1000	Phosphorylation	LYTNTVLSGGTTMYP HCCCCEECCCCCCCC	30.73	21955146
1003	Phosphorylation	NTVLSGGTTMYPGMA CCEECCCCCCCCCHH	16.35	21955146
1004	Phosphorylation	TVLSGGTTMYPGMAH CEECCCCCCCCCHHH	20.27	21955146
1006	Phosphorylation	LSGGTTMYPGMAHRM ECCCCCCCCCHHHHH	8.44	19534553
1023	Phosphorylation	EIAALAPSMLKIRII HHHHHCHHHEEEEEE	31.01	21955146
1059	Ubiquitination	FQQMWISKQEYDESG HHHHHHHCCCCCCCC	37.71	-
1062	Phosphorylation	MWISKQEYDESGPSI HHHHCCCCCCCCCCC	23.63	23401153
1065	Phosphorylation	SKQEYDESGPSIVHR HCCCCCCCCCCCCCC	53.78	23401153
1068	Phosphorylation	EYDESGPSIVHRKCF CCCCCCCCCCCCCCC	40.54	30266825
1073	Neddylation	GPSIVHRKCF----- CCCCCCCCCC-----	25.72	32015554
1073	Ubiquitination	GPSIVHRKCF----- CCCCCCCCCC-----	25.72	29967540
1095	Neddylation	--------------------------- ---------------------------		32015554

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of POTEI_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of POTEI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of POTEI_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of POTEI_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.