MRM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MRM1_HUMAN
• UniProt AC: Q6IN84
• Protein Name: rRNA methyltransferase 1, mitochondrial {ECO:0000303|PubMed:24036117}
• Gene Name: MRM1 {ECO:0000303|PubMed:24036117}
• Organism: Homo sapiens (Human).
• Sequence Length: 353
• Subcellular Localization: Mitochondrion .
• Protein Description: S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA..
• Protein Sequence: MALLSTVRGATWGRLVTRHFSHAARHGERPGGEELSRLLLDDLVPTSRLELLFGMTPCLLALQAARRSVARLLLQAGKAGLQGKRAELLRMAEARDIPVLRPRRQKLDTMCRYQVHQGVCMEVSPLRPRPWREAGEASPGDDPQQLWLVLDGIQDPRNFGAVLRSAHFLGVDKVITSRRNSCPLTPVVSKSSAGAMEVMDVFSTDDLTGFLQTKAQQGWLVAGTVGCPSTEDPQSSEIPIMSCLEFLWERPTLLVLGNEGSGLSQEVQASCQLLLTILPRRQLPPGLESLNVSVAAGILLHSICSQRKGFPTEGERRQLLQDPQEPSARSEGLSMAQHPGLSSGPEKERQNEG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
84	Acetylation	GKAGLQGKRAELLRM HHHCCCCHHHHHHHH	35.16	7338907
124	Phosphorylation	QGVCMEVSPLRPRPW CCCCEEECCCCCCCC	12.62	24719451
289	Phosphorylation	QLPPGLESLNVSVAA CCCCCHHHCCHHHHH	30.22	-
293	Phosphorylation	GLESLNVSVAAGILL CHHHCCHHHHHHHHH	12.64	-
316	Methylation	GFPTEGERRQLLQDP CCCCHHHHHHHHCCC	42.37	54557421
330	Phosphorylation	PQEPSARSEGLSMAQ CCCCCHHHCCCHHHC	35.41	24114839
334	Phosphorylation	SARSEGLSMAQHPGL CHHHCCCHHHCCCCC	23.95	24114839
343	Phosphorylation	AQHPGLSSGPEKERQ HCCCCCCCCHHHHHC	64.51	24114839

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MRM1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MRM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MRM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EF1A1_HUMAN	EEF1A1	physical	21900206
CGBP1_HUMAN	CGGBP1	physical	26186194
VPS35_HUMAN	VPS35	physical	26186194
MRRP3_HUMAN	KIAA0391	physical	26186194
UBR1_HUMAN	UBR1	physical	26186194
TOP3A_HUMAN	TOP3A	physical	26186194
ZZEF1_HUMAN	ZZEF1	physical	26186194
CUL2_HUMAN	CUL2	physical	26186194
ZY11B_HUMAN	ZYG11B	physical	26186194
ODB2_HUMAN	DBT	physical	26186194
HECD3_HUMAN	HECTD3	physical	26186194
ZER1_HUMAN	ZER1	physical	26186194
GLSK_HUMAN	GLS	physical	26186194
GRPE2_HUMAN	GRPEL2	physical	26186194
ATE1_HUMAN	ATE1	physical	26186194
GCSP_HUMAN	GLDC	physical	26186194
UBR2_HUMAN	UBR2	physical	26186194
IF1AX_HUMAN	EIF1AX	physical	26186194
ACADV_HUMAN	ACADVL	physical	26186194
MIPEP_HUMAN	MIPEP	physical	26186194
LYRM7_HUMAN	LYRM7	physical	26186194
IF2M_HUMAN	MTIF2	physical	26186194
VP26B_HUMAN	VPS26B	physical	26186194
WDR20_HUMAN	WDR20	physical	26186194
UQCC1_HUMAN	UQCC1	physical	26186194
ATPF2_HUMAN	ATPAF2	physical	26186194
MRM3_HUMAN	RNMTL1	physical	26186194
SELO_HUMAN	SELO	physical	26186194
CGBP1_HUMAN	CGGBP1	physical	28514442
UBR1_HUMAN	UBR1	physical	28514442
GRPE2_HUMAN	GRPEL2	physical	28514442
SELO_HUMAN	SELO	physical	28514442
ATE1_HUMAN	ATE1	physical	28514442
ZZEF1_HUMAN	ZZEF1	physical	28514442
ZY11B_HUMAN	ZYG11B	physical	28514442
ATPF2_HUMAN	ATPAF2	physical	28514442
ODB2_HUMAN	DBT	physical	28514442
HECD3_HUMAN	HECTD3	physical	28514442
VP26B_HUMAN	VPS26B	physical	28514442
ZER1_HUMAN	ZER1	physical	28514442
UBR2_HUMAN	UBR2	physical	28514442
WDR20_HUMAN	WDR20	physical	28514442
MRRP3_HUMAN	KIAA0391	physical	28514442
VPS35_HUMAN	VPS35	physical	28514442
CUL2_HUMAN	CUL2	physical	28514442
MIPEP_HUMAN	MIPEP	physical	28514442
SYYM_HUMAN	YARS2	physical	28514442
GLSK_HUMAN	GLS	physical	28514442
IF2M_HUMAN	MTIF2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.