ZZEF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZZEF1_HUMAN
• UniProt AC: O43149
• Protein Name: Zinc finger ZZ-type and EF-hand domain-containing protein 1
• Gene Name: ZZEF1
• Organism: Homo sapiens (Human).
• Sequence Length: 2961
• Protein Sequence: MGNAPSHSSEDEAAAAGGEGWGPHQDWAAVSGTTPGPGVAAPALPPAAALLEPARLREAAAALLPTPPCESLVSRHRGALFRWLEERLGRGEESVTLEQFRELLEARGAGCSSEQFEEAFAQFDAEGDGTVDAENMLEALKNSSGANLQGELSHIIRQLQACSLVPGFTDIFSESKEGLDIHSSMILRFLHRNRLSSAVMPYPMLEHCNNMCTMRSSVLKESLDQLVQKEKESPGDLTRSPEMDKLKSVAKCYAYIETSSNSADIDKMTNGETSSYWQSDGSACSHWIRLKMKPDVVLRHLSIAVAATDQSYMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDTRIHGLRAVGFQRVKKSGVSVSDASAIWYWSLLTSLVTASMETNPAFVQTVLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAFALARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKYGKPLQLTLQACDVKGKEDKSGPENLLVEPWTRDGFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIGAQCGLVFAYNSSSDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGWFELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLTISGYLRPARAEAEQSVTCAHCRKDTEESVCGATLLLRTLQFIQQLAHDLVQQKESGLKYKSFLDFAGLDLQIFWNFYSKLKQNPREECVSAQTLLLQLLQSCFSVLQGDVLAASEEEKAPIQSPKGVEAAKELYTHLCDVVDKVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFTMMNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLVSVAARECELLMLSGAPGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVGQFLASMRAILESLFSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCTLDIPHCVLLREFSVLTELLKKLCSGPEGGLRKLDVETWQQEQPVVLHTWTKESAHNYENNCHEVSVFVSPGATYFEVEFDDRCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHSDSSHNEWGYKFTVTACGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVRQLGSNMVVPQAKMALVLSSPLWKPVFRHQVCPELELEASWPTHPHRNSKEVKNIPDDPCRHFLLDFAQSEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQKYVNSGGKIALSEEFAQVYSLADGIRIWMLEMKQKSLMSLGNEAEEKHSSEATEVNPESLAKECIEKSLLLLKFLPTGISSKESCEKLETADETSHLQPLNKRQRTSSVVEEHFQASVSPTEAAPPATGDQSPGLGTQPKLPSSSGLPAADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSMEEARLVPTVKEKYPVLKDVMDFIKDQSLSHRSVVKVLSLRKAQAQSILEVLKITQHCAESLGQPHCFHPPFILFLLELLTCQKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLNDRSLLPALSCVQTALLHLLDMGWEPNDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSEWMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVDISCDGCDEIAPWHRYRCLQCSDMDLCKTCFLGGVKPEGHGDDHEMVNMEFTCDHCQGLIIGRRMNCNVCDDFDLCYGCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASAEDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGKGLKALALLGVLPDGDSSLEDQALPVTVPTGASEEQLEKKAVQGAELSEAGNGKRAVHEEIRPVDFKQRNKADKGVSLSKDPSCQTQISDSPADASPPTGLPDAEDSEVSSQKPIEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGPTVPLIDLEHVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDSSIVPDGWKTTHLLFSLGAVCLDSRVGLDWACSMAEILRSLNSAPLWRDVIATFTDHCIKQLPFQLKHTNIFTLLVLVGFPQVLCVGTRCVYMDNANEPHNVIILKHFTEKNRAVIVDVKTRKRKTVKDYQLVQKGGGQECGDSRAQLSQYSQHFAFIASHLLQSSMDSHCPEAVEATWVLSLALKGLYKTLKAHGFEEIRATFLQTDLLKLLVKKCSKGTGFSKTWLLRDLEILSIMLYSSKKEINALAEHGDLELDERGDREEEVERPVSSPGDPEQKKLDPLEGLDEPTRICFLMAHDALNAPLHILRAIYELQMKKTDYFFLEVQKRFDGDELTTDERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISSTESELQQSYAKQRRSKSAALLHKELNCKSKRAVRDYLFRVNEATAVLYARHVLASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLGTMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDELAMSSSSDFQQDRHSFSGSQQKWKDFELPGDTLYYRFTSDMSNTEWGYRFTVTAGHLGRFQTGFEILKQMLSEERVVPHLPLAKIWEWLVGVACRQTGHQRLKAIHLLLRIVRCCGHSDLCDLALLKPLWQLFTHMEYGLFEDVTQPGILLPLHRALTELFFVTENRAQELGVLQDYLLALTTDDHLLRCAAQALQNIAAISLAINYPNKATRLWNVEC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGNAPSHSS ------CCCCCCCCC	50.76	-
2	Myristoylation	------MGNAPSHSS ------CCCCCCCCC	50.76	24223779
66	Phosphorylation	AAAALLPTPPCESLV HHHHHCCCCCHHHHH	39.57	28060719
71	Phosphorylation	LPTPPCESLVSRHRG CCCCCHHHHHHHHHH	40.56	28060719
74	Phosphorylation	PPCESLVSRHRGALF CCHHHHHHHHHHHHH	27.88	28060719
94	Phosphorylation	RLGRGEESVTLEQFR HHCCCCCCCCHHHHH	18.99	21815630
220	Ubiquitination	TMRSSVLKESLDQLV HHCHHHHHHHHHHHH	43.00	33845483
229	Ubiquitination	SLDQLVQKEKESPGD HHHHHHHHHHCCCCC	64.37	29967540
233	Phosphorylation	LVQKEKESPGDLTRS HHHHHHCCCCCCCCC	45.29	23403867
238	Phosphorylation	KESPGDLTRSPEMDK HCCCCCCCCCHHHHH	33.56	25159151
240	Phosphorylation	SPGDLTRSPEMDKLK CCCCCCCCHHHHHHH	21.70	23401153
245	Ubiquitination	TRSPEMDKLKSVAKC CCCHHHHHHHHHHHH	57.41	29967540
251	Ubiquitination	DKLKSVAKCYAYIET HHHHHHHHHHHHHHC	26.14	29967540
291	Ubiquitination	CSHWIRLKMKPDVVL CCHHHHCCCCCCHHH	34.72	-
293	Ubiquitination	HWIRLKMKPDVVLRH HHHHCCCCCCHHHHH	36.16	-
338	Phosphorylation	VRDVHIPSNVTGYVT HHHCCCCCCCCEEEE	43.24	23403867
341	Phosphorylation	VHIPSNVTGYVTLLE CCCCCCCCEEEEEEC	27.35	23403867
345	Phosphorylation	SNVTGYVTLLENANV CCCCEEEEEECCCCC	19.69	23403867
371	Phosphorylation	CLSDGCDTRIHGLRA HHCCCCCCEEECHHH	35.28	23403867
515	Phosphorylation	SLILSMASVRQNLLL HHHHHHHHHHHHHHH	14.80	24719451
523	Acetylation	VRQNLLLKYGKPLQL HHHHHHHHHCCCEEE	52.50	7683213
526	Acetylation	NLLLKYGKPLQLTLQ HHHHHHCCCEEEEEE	39.19	7683223
526	Ubiquitination	NLLLKYGKPLQLTLQ HHHHHHCCCEEEEEE	39.19	29967540
540	Ubiquitination	QACDVKGKEDKSGPE EECCCCCCCCCCCCC	57.95	29967540
543	Acetylation	DVKGKEDKSGPENLL CCCCCCCCCCCCCEE	59.40	7683233
543	Ubiquitination	DVKGKEDKSGPENLL CCCCCCCCCCCCCEE	59.40	29967540
565	Ubiquitination	GFLTETGKTRASTIF CCCCCCCCCCEEEEE	42.11	24816145
566	Phosphorylation	FLTETGKTRASTIFS CCCCCCCCCEEEEEC	32.58	27174698
569	Phosphorylation	ETGKTRASTIFSTGT CCCCCCEEEEECCCC	20.81	27174698
570	Phosphorylation	TGKTRASTIFSTGTE CCCCCEEEEECCCCC	25.67	27174698
573	Phosphorylation	TRASTIFSTGTESAF CCEEEEECCCCCCCE	23.29	27174698
574	Phosphorylation	RASTIFSTGTESAFQ CEEEEECCCCCCCEE	37.06	27174698
576	Phosphorylation	STIFSTGTESAFQVT EEEECCCCCCCEEEE	27.19	27174698
578	Phosphorylation	IFSTGTESAFQVTQI EECCCCCCCEEEEEE	33.93	27174698
583	Phosphorylation	TESAFQVTQIRIMVR CCCCEEEEEEEEEEE	13.90	27174698
606	Phosphorylation	GLVFAYNSSSDKFCA EEEEEECCCCCCCCH	20.67	23403867
607	Phosphorylation	LVFAYNSSSDKFCAE EEEEECCCCCCCCHH	38.63	23403867
608	Phosphorylation	VFAYNSSSDKFCAEE EEEECCCCCCCCHHH	44.64	23403867
676	Phosphorylation	QQCRVAKYLMVKFLC HHHHHHHHHHHHHHH	7.12	28331001
702	Phosphorylation	QGLTISGYLRPARAE CCEEEEEEECCCHHH	7.86	-
723	Phosphorylation	CAHCRKDTEESVCGA ECCCCCCCCCCHHHH	44.69	-
821	Phosphorylation	EEKAPIQSPKGVEAA HHCCCCCCCCHHHHH	29.33	26852163
823	Ubiquitination	KAPIQSPKGVEAAKE CCCCCCCCHHHHHHH	79.44	29967540
829	Ubiquitination	PKGVEAAKELYTHLC CCHHHHHHHHHHHHH	56.13	29967540
846	Phosphorylation	VDKVDGDSVPMEILK HHHCCCCCCCHHHHH	33.38	-
859	Phosphorylation	LKQEVRNTLLNGAAI HHHHHHHHHHCCCEE	23.27	26270265
915	Ubiquitination	DPGGLLLLPEKNDLA CCCCEEEECCCCCHH	5.34	24816145
927	Phosphorylation	DLAKMNISEVLAVMD CHHCCCHHHHHHHHH	19.35	29978859
935	Phosphorylation	EVLAVMDTLVSVAAR HHHHHHHHHHHHHHH	15.80	29978859
938	Phosphorylation	AVMDTLVSVAARECE HHHHHHHHHHHHHCC	14.78	29978859
976	Phosphorylation	GSLLSWCYLQLKSTD HHHHHHHHHHCCCCC	7.39	17053785
1014	Phosphorylation	AILESLFSQYSGKTI HHHHHHHHHCCCHHH	33.24	24719451
1016	Phosphorylation	LESLFSQYSGKTIVE HHHHHHHCCCHHHHH	20.42	24719451
1017	Phosphorylation	ESLFSQYSGKTIVER HHHHHHCCCHHHHHH	26.61	24719451
1059	Phosphorylation	CVLLREFSVLTELLK HHHHHHHHHHHHHHH	16.09	23532336
1062	Phosphorylation	LREFSVLTELLKKLC HHHHHHHHHHHHHHC	23.56	23532336
1078	Ubiquitination	GPEGGLRKLDVETWQ CCCCCCCCCCCCHHC	54.82	-
1117	Ubiquitination	VSVFVSPGATYFEVE EEEEECCCCEEEEEE	24.04	23000965
1135	Phosphorylation	RCETEKRYDYLEFTD CCCCCCCCCEEEEEC	21.73	27642862
1158	Ubiquitination	DTKVGTDKWPKKVTF CCCCCCCCCCCEEEE	66.29	29967540
1211	Phosphorylation	LDLQLLVSRLMGRLA CCHHHHHHHHHHHHH	21.48	24719451
1251	Ubiquitination	VLSSPLWKPVFRHQV HHCCCCCCHHCCCCC	38.70	-
1267	Phosphorylation	PELELEASWPTHPHR CCCEEHHCCCCCCCC	24.98	30108239
1270	Phosphorylation	ELEASWPTHPHRNSK EEHHCCCCCCCCCCH	41.61	30108239
1276	Phosphorylation	PTHPHRNSKEVKNIP CCCCCCCCHHHCCCC	30.10	30576142
1297	Phosphorylation	FLLDFAQSEPAQNFC HHHHHHCCCHHHCCC	41.96	30576142
1308	Phosphorylation	QNFCGPYSELFKGFI HCCCCCHHHHHHHHH	30.84	30576142
1357	Ubiquitination	DLYEKLQKYVNSGGK HHHHHHHHHHHCCCC	62.70	29967540
1368	Phosphorylation	SGGKIALSEEFAQVY CCCCEEECHHHHHHH	26.51	-
1391	Ubiquitination	WMLEMKQKSLMSLGN EEHHHHHHHHHHCCH	39.79	29967540
1392	Phosphorylation	MLEMKQKSLMSLGNE EHHHHHHHHHHCCHH	27.15	28674419
1394	Sulfoxidation	EMKQKSLMSLGNEAE HHHHHHHHHCCHHHH	3.92	21406390
1395	Phosphorylation	MKQKSLMSLGNEAEE HHHHHHHHCCHHHHH	38.12	28674419
1405	Phosphorylation	NEAEEKHSSEATEVN HHHHHHHCCCCCCCC	40.73	21955146
1406	Phosphorylation	EAEEKHSSEATEVNP HHHHHHCCCCCCCCH	30.85	21955146
1409	Phosphorylation	EKHSSEATEVNPESL HHHCCCCCCCCHHHH	36.09	21955146
1415	Phosphorylation	ATEVNPESLAKECIE CCCCCHHHHHHHHHH	34.58	21955146
1458	Ubiquitination	SHLQPLNKRQRTSSV CCCCCCCHHHCCHHH	58.55	33845483
1462	Phosphorylation	PLNKRQRTSSVVEEH CCCHHHCCHHHHHHH	19.60	30278072
1463	Phosphorylation	LNKRQRTSSVVEEHF CCHHHCCHHHHHHHH	24.27	30278072
1464	Phosphorylation	NKRQRTSSVVEEHFQ CHHHCCHHHHHHHHH	29.57	30278072
1473	Phosphorylation	VEEHFQASVSPTEAA HHHHHHHCCCCCCCC	16.61	25159151
1475	Phosphorylation	EHFQASVSPTEAAPP HHHHHCCCCCCCCCC	24.49	21712546
1477	Phosphorylation	FQASVSPTEAAPPAT HHHCCCCCCCCCCCC	30.65	28348404
1484	Phosphorylation	TEAAPPATGDQSPGL CCCCCCCCCCCCCCC	47.25	26657352
1488	Phosphorylation	PPATGDQSPGLGTQP CCCCCCCCCCCCCCC	26.19	26657352
1493	Phosphorylation	DQSPGLGTQPKLPSS CCCCCCCCCCCCCCC	46.90	23403867
1499	Phosphorylation	GTQPKLPSSSGLPAA CCCCCCCCCCCCCCC	47.80	29255136
1500	Phosphorylation	TQPKLPSSSGLPAAD CCCCCCCCCCCCCCC	26.87	29255136
1501	Phosphorylation	QPKLPSSSGLPAADV CCCCCCCCCCCCCCC	49.00	29255136
1509	O-linked_Glycosylation	GLPAADVSPATAEEP CCCCCCCCCCCCCCC	14.90	30379171
1509	Phosphorylation	GLPAADVSPATAEEP CCCCCCCCCCCCCCC	14.90	29255136
1512	O-linked_Glycosylation	AADVSPATAEEPLSP CCCCCCCCCCCCCCC	37.68	30379171
1512	Phosphorylation	AADVSPATAEEPLSP CCCCCCCCCCCCCCC	37.68	29255136
1518	Phosphorylation	ATAEEPLSPSTPTRR CCCCCCCCCCCCCCC	27.76	29255136
1520	Phosphorylation	AEEPLSPSTPTRRPP CCCCCCCCCCCCCCC	43.58	29255136
1521	Phosphorylation	EEPLSPSTPTRRPPF CCCCCCCCCCCCCCC	31.87	29255136
1523	Phosphorylation	PLSPSTPTRRPPFTR CCCCCCCCCCCCCCH	39.12	29255136
1529	Phosphorylation	PTRRPPFTRGRLRLL CCCCCCCCHHHEEEE	37.68	23898821
1537	Phosphorylation	RGRLRLLSFRSMEEA HHHEEEEEECCHHHH	24.17	23927012
1540	Phosphorylation	LRLLSFRSMEEARLV EEEEEECCHHHHHCC	28.65	23401153
1549	Phosphorylation	EEARLVPTVKEKYPV HHHHCCCCHHHHCHH	36.41	22210691
1565	Ubiquitination	KDVMDFIKDQSLSHR HHHHHHHHCCCCCCH	50.11	32015554
1568	Phosphorylation	MDFIKDQSLSHRSVV HHHHHCCCCCCHHHH	41.81	-
1737	Phosphorylation	LADAKQNSEWMDECQ HHHHHHCCHHHHHHH	30.09	24043423
1752	Phosphorylation	DGMFEAWYEKIAQED HCHHHHHHHHHHHHC	17.88	24043423
1765	Ubiquitination	EDPEKQRKMHMFIAR HCHHHHHHHHHHHHH	30.57	-
1801	Phosphorylation	RYRCLQCSDMDLCKT HEECCCCCCHHHCHH	24.02	24719451
1862	Ubiquitination	CYGCYAAKKYSYGHL CHHHHHCHHCCCCCC	44.03	32015554
1863	Ubiquitination	YGCYAAKKYSYGHLP HHHHHCHHCCCCCCC	34.40	-
1864	Phosphorylation	GCYAAKKYSYGHLPT HHHHCHHCCCCCCCC	13.35	23401153
1866	Phosphorylation	YAAKKYSYGHLPTHS HHCHHCCCCCCCCCC	12.89	23401153
1875	Phosphorylation	HLPTHSITAHPMVTI CCCCCCEECCCEEEE	23.17	23401153
1971	Phosphorylation	VLPDGDSSLEDQALP CCCCCCCCHHHCCCC	40.28	26657352
2007	Ubiquitination	LSEAGNGKRAVHEEI HHHCCCCCCCCCCCC	40.98	33845483
2027	Ubiquitination	KQRNKADKGVSLSKD HHCCCCCCCCCCCCC	67.10	33845483
2036	Phosphorylation	VSLSKDPSCQTQISD CCCCCCCCCCCCCCC	29.05	27251275
2042	Phosphorylation	PSCQTQISDSPADAS CCCCCCCCCCCCCCC	23.40	27251275
2044	Phosphorylation	CQTQISDSPADASPP CCCCCCCCCCCCCCC	18.39	26657352
2049	Phosphorylation	SDSPADASPPTGLPD CCCCCCCCCCCCCCC	31.77	26657352
2052	Phosphorylation	PADASPPTGLPDAED CCCCCCCCCCCCCCC	55.52	27251275
2074	Phosphorylation	PIEEKAVTPSPEQVF CCCCCCCCCCHHHHH	23.94	25850435
2076	Phosphorylation	EEKAVTPSPEQVFAE CCCCCCCCHHHHHHH	31.53	26657352
2087	Ubiquitination	VFAECSQKRILGLLA HHHHHHHHHHHHHHH	25.72	33845483
2291	Ubiquitination	RAVIVDVKTRKRKTV CEEEEECCCCCCCCC	37.84	33845483
2299	Ubiquitination	TRKRKTVKDYQLVQK CCCCCCCCCHHHHCC	56.82	24816145
2300	Ubiquitination	RKRKTVKDYQLVQKG CCCCCCCCHHHHCCC	31.88	24816145
2306	Acetylation	KDYQLVQKGGGQECG CCHHHHCCCCCCCCC	52.63	25953088
2306	Ubiquitination	KDYQLVQKGGGQECG CCHHHHCCCCCCCCC	52.63	33845483
2374	Phosphorylation	GFEEIRATFLQTDLL CHHHHHHHHHHHHHH	18.28	20071362
2407	Phosphorylation	LRDLEILSIMLYSSK HHHHHHHHHHHHCCH	16.18	20068231
2411	Phosphorylation	EILSIMLYSSKKEIN HHHHHHHHCCHHHHH	8.10	20068231
2412	Phosphorylation	ILSIMLYSSKKEINA HHHHHHHCCHHHHHH	31.55	20068231
2413	Phosphorylation	LSIMLYSSKKEINAL HHHHHHCCHHHHHHH	33.90	20068231
2443	Phosphorylation	EEVERPVSSPGDPEQ HHCCCCCCCCCCHHH	33.23	23401153
2444	Phosphorylation	EVERPVSSPGDPEQK HCCCCCCCCCCHHHH	32.89	29255136
2490	Ubiquitination	AIYELQMKKTDYFFL HHHHHHCCCCCEEEE	39.29	32015554
2491	Ubiquitination	IYELQMKKTDYFFLE HHHHHCCCCCEEEEE	41.09	33845483
2494	Phosphorylation	LQMKKTDYFFLEVQK HHCCCCCEEEEEEHH	11.06	27642862
2501	Ubiquitination	YFFLEVQKRFDGDEL EEEEEEHHHCCCCCC	61.27	23000965
2501 (in isoform 1)	Ubiquitination	-	61.27	21890473
2502	Ubiquitination	FFLEVQKRFDGDELT EEEEEHHHCCCCCCC	20.14	23000965
2525	Ubiquitination	AQRWQPSKSLRLEEQ HHHHCCCCCCCHHHH	61.26	29967540
2526	Phosphorylation	QRWQPSKSLRLEEQS HHHCCCCCCCHHHHH	24.06	25159151
2560	Phosphorylation	CDQATAESNPVTQKL CCHHHHHCCHHHHHH	43.92	22210691
2566	Ubiquitination	ESNPVTQKLISSTES HCCHHHHHHHHCCHH	38.12	29967540
2581	Ubiquitination	ELQQSYAKQRRSKSA HHHHHHHHHHHHHHH	35.78	29967540
2586	Ubiquitination	YAKQRRSKSAALLHK HHHHHHHHHHHHHHH	42.15	29967540
2593	Ubiquitination	KSAALLHKELNCKSK HHHHHHHHHHCCCCH	64.96	29967540
2667	Acetylation	EEKHEWEKILQKVLQ HHHHHHHHHHHHHHH	50.19	19608861
2667	Ubiquitination	EEKHEWEKILQKVLQ HHHHHHHHHHHHHHH	50.19	19608861
2671	Ubiquitination	EWEKILQKVLQGCRE HHHHHHHHHHHHHCH	41.28	29967540
2759	Phosphorylation	QQDRHSFSGSQQKWK HHCCCCCCCCHHHEE	40.32	-
2761	Phosphorylation	DRHSFSGSQQKWKDF CCCCCCCCHHHEECC	28.39	-
2764	Ubiquitination	SFSGSQQKWKDFELP CCCCCHHHEECCCCC	48.88	29967540
2776	Phosphorylation	ELPGDTLYYRFTSDM CCCCCEEEEEEECCC	8.49	25147952

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZZEF1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZZEF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZZEF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HECD3_HUMAN	HECTD3	physical	22863883
MYCBP_HUMAN	MYCBP	physical	22863883
S10A4_HUMAN	S100A4	physical	22863883

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-2667, AND MASS SPECTROMETRY.
PubMed: 19608861

Myristoylation

"Strategy for comprehensive identification of human N-myristoylatedproteins using an insect cell-free protein synthesis system.";
Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E.,Tsunasawa S., Utsumi T.;
Proteomics 10:1780-1793(2010).
Cited for: MYRISTOYLATION AT GLY-2.
PubMed: 20213681

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1475, AND MASSSPECTROMETRY.
PubMed: 19690332

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1518 AND SER-1520, ANDMASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1509; SER-1518 ANDTHR-1521, AND MASS SPECTROMETRY.
PubMed: 18669648

"Tyrosine phosphorylated Par3 regulates epithelial tight junctionassembly promoted by EGFR signaling.";
Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,Lottspeich F., Chen Z.;
EMBO J. 25:5058-5070(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-976, AND MASSSPECTROMETRY.
PubMed: 17053785