HECD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HECD3_HUMAN
• UniProt AC: Q5T447
• Protein Name: E3 ubiquitin-protein ligase HECTD3
• Gene Name: HECTD3
• Organism: Homo sapiens (Human).
• Sequence Length: 861
• Subcellular Localization: Cytoplasm, perinuclear region.
• Protein Description: E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity)..
• Protein Sequence: MAGPGPGAVLESPRQLLGRVRFLAEAARSLRAGRPLPAALAFVPREVLYKLYKDPAGPSRVLLPVWEAEGLGLRVGAAGPAPGTGSGPLRAARDSIELRRGACVRTTGEELCNGHGLWVKLTKEQLAEHLGDCGLQEGWLLVCRPAEGGARLVPIDTPNHLQRQQQLFGVDYRPVLRWEQVVDLTYSHRLGSRPQPAEAYAEAVQRLLYVPPTWTYECDEDLIHFLYDHLGKEDENLGSVKQYVESIDVSSYTEEFNVSCLTDSNADTYWESDGSQCQHWVRLTMKKGTIVKKLLLTVDTTDDNFMPKRVVVYGGEGDNLKKLSDVSIDETLIGDVCVLEDMTVHLPIIEIRIVECRDDGIDVRLRGVKIKSSRQRELGLNADLFQPTSLVRYPRLEGTDPEVLYRRAVLLQRFIKILDSVLHHLVPAWDHTLGTFSEIKQVKQFLLLSRQRPGLVAQCLRDSESSKPSFMPRLYINRRLAMEHRACPSRDPACKNAVFTQVYEGLKPSDKYEKPLDYRWPMRYDQWWECKFIAEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQGNGTGEARDMYVPNPSCRDFAKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVKLLEVMEGMDKETFEFKFGKELTFTTVLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQKARLEESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFEPSDSRVQYFWEALNNFTNEDRSRFLRFVTGRSRLPARIYIYPDKLGYETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAIDTDMSPWEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGPGPGAV ------CCCCCCCCC	32.65	22223895
12	Phosphorylation	GPGAVLESPRQLLGR CCCCCCCCHHHHHHH	22.63	21815630
49	Phosphorylation	FVPREVLYKLYKDPA CCCHHHHHHHHCCCC	12.24	29496907
50	Acetylation	VPREVLYKLYKDPAG CCHHHHHHHHCCCCC	40.97	25953088
50	Ubiquitination	VPREVLYKLYKDPAG CCHHHHHHHHCCCCC	40.97	-
52	Phosphorylation	REVLYKLYKDPAGPS HHHHHHHHCCCCCCC	14.81	29496907
53	Ubiquitination	EVLYKLYKDPAGPSR HHHHHHHCCCCCCCC	68.61	-
59	Phosphorylation	YKDPAGPSRVLLPVW HCCCCCCCCEEEEEE	33.82	-
84	Phosphorylation	AAGPAPGTGSGPLRA ECCCCCCCCCCCCHH	27.41	28555341
86	Phosphorylation	GPAPGTGSGPLRAAR CCCCCCCCCCCHHHH	36.76	27251275
95	Phosphorylation	PLRAARDSIELRRGA CCHHHHHHHHHCCCC	16.65	-
157	Phosphorylation	ARLVPIDTPNHLQRQ CCEEECCCCCHHHHH	27.06	28555341
192	Phosphorylation	TYSHRLGSRPQPAEA HHHCCCCCCCCCHHH	45.43	-
289	Phosphorylation	RLTMKKGTIVKKLLL HHEECCCCEEEEEEE	31.32	25690035
308	Ubiquitination	TDDNFMPKRVVVYGG CCCCCCCCEEEEECC	46.14	-
321	Ubiquitination	GGEGDNLKKLSDVSI CCCCCCCHHHCCCCC	58.90	-
322	Ubiquitination	GEGDNLKKLSDVSID CCCCCCHHHCCCCCC	57.29	-
327	Phosphorylation	LKKLSDVSIDETLIG CHHHCCCCCCCCCCC	29.34	26074081
331	Phosphorylation	SDVSIDETLIGDVCV CCCCCCCCCCCCEEE	21.67	26074081
343	Phosphorylation	VCVLEDMTVHLPIIE EEEECCCEEEECEEE	19.66	26074081
372	Phosphorylation	LRGVKIKSSRQRELG EECEEECCHHHHHCC	33.94	27174698
373	Phosphorylation	RGVKIKSSRQRELGL ECEEECCHHHHHCCC	27.68	27174698
388	Phosphorylation	NADLFQPTSLVRYPR CCCCCCCCCCCCCCC	24.74	27174698
389	Phosphorylation	ADLFQPTSLVRYPRL CCCCCCCCCCCCCCC	31.39	27174698
393	Phosphorylation	QPTSLVRYPRLEGTD CCCCCCCCCCCCCCC	5.80	27174698
467	Ubiquitination	LRDSESSKPSFMPRL HCCCCCCCCCCCCHH	54.69	-
507	Ubiquitination	TQVYEGLKPSDKYEK HHHHCCCCCCCCCCC	54.02	-
511	Ubiquitination	EGLKPSDKYEKPLDY CCCCCCCCCCCCCCC	60.70	-
512	Phosphorylation	GLKPSDKYEKPLDYR CCCCCCCCCCCCCCC	33.89	28634298
518	Phosphorylation	KYEKPLDYRWPMRYD CCCCCCCCCCCCCCC	23.43	28634298
586	Phosphorylation	TGEARDMYVPNPSCR CCCCCEEECCCCCHH	19.62	-
636	Ubiquitination	GEEVSWSKDFPAVDS CCCCCCCCCCHHHHH	58.07	-
643	Phosphorylation	KDFPAVDSVLVKLLE CCCHHHHHHHHHHHH	15.68	21406692
663	Ubiquitination	DKETFEFKFGKELTF CCCEEEEECCCEEEE	46.11	-
705	Ubiquitination	RFIQLVQKARLEESK HHHHHHHHHCHHHHH	28.17	-
712	Ubiquitination	KARLEESKEQVAAMQ HHCHHHHHHHHHHHH	56.28	-
742	Ubiquitination	TWQELEKKVCGDPEV CHHHHHHHHCCCCCC	33.12	-
793	Phosphorylation	SRFLRFVTGRSRLPA HHHHHHHHCCCCCCE	24.94	24719451
808	Ubiquitination	RIYIYPDKLGYETTD EEEECCCCCCCCCCC	39.03	-
841	Ubiquitination	SAKVCEEKLRYAAYN CHHHHHHHHHHHHHC	18.90	-
854	Phosphorylation	YNCVAIDTDMSPWEE HCCEEEECCCCCCCC	27.73	27251275
857	Phosphorylation	VAIDTDMSPWEE--- EEEECCCCCCCC---	29.66	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
157	T	Phosphorylation	Kinase	MAPK1	P28482	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HECD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HECD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STX8_HUMAN	STX8	physical	18821010
P53_HUMAN	TP53	physical	23358872
MALT1_HUMAN	MALT1	physical	23358872
CASP8_HUMAN	CASP8	physical	24287696
RS4X_HUMAN	RPS4X	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.