S10A4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S10A4_HUMAN
• UniProt AC: P26447
• Protein Name: Protein S100-A4
• Gene Name: S100A4
• Organism: Homo sapiens (Human).
• Sequence Length: 101
• Protein Sequence: MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMSNLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MACPLEKAL ------CCCCHHHHH	12.02	-
7	Acetylation	-MACPLEKALDVMVS -CCCCHHHHHHHHHH	63.03	19608861
7	Ubiquitination	-MACPLEKALDVMVS -CCCCHHHHHHHHHH	63.03	33845483
7	2-Hydroxyisobutyrylation	-MACPLEKALDVMVS -CCCCHHHHHHHHHH	63.03	-
12	Sulfoxidation	LEKALDVMVSTFHKY HHHHHHHHHHHHHHH	1.65	30846556
14	Phosphorylation	KALDVMVSTFHKYSG HHHHHHHHHHHHHCC	13.78	28348404
15	Phosphorylation	ALDVMVSTFHKYSGK HHHHHHHHHHHHCCC	20.53	28348404
18	Ubiquitination	VMVSTFHKYSGKEGD HHHHHHHHHCCCCCC	36.60	33845483
18	2-Hydroxyisobutyrylation	VMVSTFHKYSGKEGD HHHHHHHHHCCCCCC	36.60	-
18	Acetylation	VMVSTFHKYSGKEGD HHHHHHHHHCCCCCC	36.60	23954790
22	Acetylation	TFHKYSGKEGDKFKL HHHHHCCCCCCCCCC	53.21	26051181
22	2-Hydroxyisobutyrylation	TFHKYSGKEGDKFKL HHHHHCCCCCCCCCC	53.21	-
22	Ubiquitination	TFHKYSGKEGDKFKL HHHHHCCCCCCCCCC	53.21	33845483
22	Sumoylation	TFHKYSGKEGDKFKL HHHHHCCCCCCCCCC	53.21	-
22	Sumoylation	TFHKYSGKEGDKFKL HHHHHCCCCCCCCCC	53.21	-
26	Acetylation	YSGKEGDKFKLNKSE HCCCCCCCCCCCHHH	56.08	26051181
28	Sumoylation	GKEGDKFKLNKSELK CCCCCCCCCCHHHHH	57.82	-
31	Succinylation	GDKFKLNKSELKELL CCCCCCCHHHHHHHH	56.60	23954790
31	Sumoylation	GDKFKLNKSELKELL CCCCCCCHHHHHHHH	56.60	-
31	Acetylation	GDKFKLNKSELKELL CCCCCCCHHHHHHHH	56.60	25825284
31	Sumoylation	GDKFKLNKSELKELL CCCCCCCHHHHHHHH	56.60	-
31	Ubiquitination	GDKFKLNKSELKELL CCCCCCCHHHHHHHH	56.60	22817900
32	Phosphorylation	DKFKLNKSELKELLT CCCCCCHHHHHHHHH	47.27	20068231
35	Acetylation	KLNKSELKELLTREL CCCHHHHHHHHHHHC	42.11	19608861
35	Ubiquitination	KLNKSELKELLTREL CCCHHHHHHHHHHHC	42.11	21906983
44	Phosphorylation	LLTRELPSFLGKRTD HHHHHCHHHHCCCCC	45.81	21712546
48	Acetylation	ELPSFLGKRTDEAAF HCHHHHCCCCCHHHH	55.03	26051181
48	Succinylation	ELPSFLGKRTDEAAF HCHHHHCCCCCHHHH	55.03	23954790
48	2-Hydroxyisobutyrylation	ELPSFLGKRTDEAAF HCHHHHCCCCCHHHH	55.03	-
48	Ubiquitination	ELPSFLGKRTDEAAF HCHHHHCCCCCHHHH	55.03	21963094
57	Acetylation	TDEAAFQKLMSNLDS CCHHHHHHHHHCCCC	39.44	26051181
57	Ubiquitination	TDEAAFQKLMSNLDS CCHHHHHHHHHCCCC	39.44	21906983
59	Sulfoxidation	EAAFQKLMSNLDSNR HHHHHHHHHCCCCCC	3.00	30846556
60	Phosphorylation	AAFQKLMSNLDSNRD HHHHHHHHCCCCCCC	44.68	24850871
64	Phosphorylation	KLMSNLDSNRDNEVD HHHHCCCCCCCCCCC	36.61	21815630
84	Sulfoxidation	VFLSCIAMMCNEFFE HHHHHHHHHHHHHHC	1.27	30846556
85	Sulfoxidation	FLSCIAMMCNEFFEG HHHHHHHHHHHHHCC	1.32	30846556
96	Ubiquitination	FFEGFPDKQPRKK-- HHCCCCCCCCCCC--	63.54	-
96	Sumoylation	FFEGFPDKQPRKK-- HHCCCCCCCCCCC--	63.54	-
96	Sumoylation	FFEGFPDKQPRKK-- HHCCCCCCCCCCC--	63.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S10A4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S10A4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S10A4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAG6_HUMAN	BAG6	physical	16169070
U119A_HUMAN	UNC119	physical	16169070
P53_HUMAN	TP53	physical	11527429
LIPB1_HUMAN	PPFIBP1	physical	11836260
S10A1_HUMAN	S100A1	physical	10753920
SMAD3_HUMAN	SMAD3	physical	20070253
SMAD2_HUMAN	SMAD2	physical	20070253
P53_HUMAN	TP53	physical	20070253
TM1L2_HUMAN	TOM1L2	physical	22939629
UNK_HUMAN	UNK	physical	22939629
SGT1_HUMAN	SUGT1	physical	22939629
SBP1_HUMAN	SELENBP1	physical	22939629
S100B_HUMAN	S100B	physical	25416956
S100B_HUMAN	S100B	physical	21516116
XIAP_HUMAN	XIAP	physical	26496610
NPAT_HUMAN	NPAT	physical	26496610
S10A6_HUMAN	S100A6	physical	26496610
SUV91_HUMAN	SUV39H1	physical	26496610
DYL1_HUMAN	DYNLL1	physical	26496610
DNJA3_HUMAN	DNAJA3	physical	26496610
DNJB6_HUMAN	DNAJB6	physical	26496610
RPP29_HUMAN	POP4	physical	26496610
CNTRL_HUMAN	CNTRL	physical	26496610
KAT7_HUMAN	KAT7	physical	26496610
WDFY3_HUMAN	WDFY3	physical	26496610
SYNE2_HUMAN	SYNE2	physical	26496610
BRD1_HUMAN	BRD1	physical	26496610
QCR9_HUMAN	UQCR10	physical	26496610
BBX_HUMAN	BBX	physical	26496610
CORO7_HUMAN	CORO7	physical	26496610
PTGR2_HUMAN	PTGR2	physical	26496610
ESCO2_HUMAN	ESCO2	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00831: Trifluoperazine

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-7 AND LYS-35, AND MASSSPECTROMETRY.
PubMed: 19608861