dbPTM

BBX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BBX_HUMAN
UniProt AC	Q8WY36
Protein Name	HMG box transcription factor BBX
Gene Name	BBX
Organism	Homo sapiens (Human).
Sequence Length	941
Subcellular Localization	Nucleus .
Protein Description	Transcription factor that is necessary for cell cycle progression from G1 to S phase..
Protein Sequence	MKGSNRNKDHSAEGEGVGKRPKRKCLQWHPLLAKKLLDFSEEEEEEDEEEDIDKVQLLGADGLEQDVGETEDDESPEQRARRPMNAFLLFCKRHRSLVRQEHPRLDNRGATKILADWWAVLDPKEKQKYTDMAKEYKDAFMKANPGYKWCPTTNKPVKSPTPTVNPRKKLWAFPSDSSRDLPSPKKAKTEEMPQLNFGMADPTQMGGLSMLLLAGEHALGTPEVSSGTCRPDVSESPELRQKSPLFQFAEISSSTSHSDASTKQCQTSALFQFAEISSNTSQLGGAEPVKRCGKSALFQLAEMCLASEGMKMEESKLIKAKESDGGRIKELEKGKEEKEIKMEKTDETRLQKEAEFEKSAKENLRDSKELRNFEALQIDDIMAIKMEDPKEIRKEELEEDHKCSHFPDFSYSASSKIIISDVPSRKDHMCHPHGIMIIEDPAALNKPEKLKKKKKKSKMDRHGNDKSTPKKTCKKRQSSESDIESVIYTIEAVAKGDWGIEKLGDTPRKKVRTSSSGKGSILDAKPPKKKVKSREKKMSKEKSSDTTKESRPPDFISISASKNISGETPEGIKAEPLTPMEDALPPSLSGQAKPEDSDCHRKIETCGSRKSERSCKGALYKTLVSEGMLTSLRANVDRGKRSSGKGNSSDHEGCWNEESWTFSQSGTSGSKKFKKTKPKEDCLLGSAKLDEEFEKKFNSLPQYSPVTFDRKCVPVPRKKKKTGNVSSEPTKTSKGPFQSQKKNLFHKIVSKYKHKKEKPNVPEKGSGDKWSNKQLFLDAIHPTEAIFSEDRNTMEPVHKVKNIPSIFNTPEPTTTQEPLVGSQKRKARKTKITHLVRTADGRVSPAGGTLDDKPKEQLQRSLPKATETDCNDKCSHNTEVGETRSSTPEMPAVSAFFSLAALAEVAAMENVHRGQRSTPLTHDGQPKEMPQAPVLISCADQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	SNRNKDHSAEGEGVG CCCCCCCCCCCCCCC	37.84	20068231
34	Acetylation	QWHPLLAKKLLDFSE HHCHHHHHHHHCCCH	43.88	25953088
40	Phosphorylation	AKKLLDFSEEEEEED HHHHHCCCHHHHCCC	43.71	25159151
70	Phosphorylation	LEQDVGETEDDESPE CCCCCCCCCCCCCHH	38.49	27732954
75	Phosphorylation	GETEDDESPEQRARR CCCCCCCCHHHHHHC	40.51	27732954
96	Phosphorylation	LFCKRHRSLVRQEHP HHHHHHHHHHHCCCC	25.70	-
130	Phosphorylation	PKEKQKYTDMAKEYK HHHHHHHHHHHHHHH	26.74	20860994
137	Sumoylation	TDMAKEYKDAFMKAN HHHHHHHHHHHHHHC	43.61	-
137	Sumoylation	TDMAKEYKDAFMKAN HHHHHHHHHHHHHHC	43.61	-
152	Phosphorylation	PGYKWCPTTNKPVKS CCCCCCCCCCCCCCC	39.60	23927012
153	Phosphorylation	GYKWCPTTNKPVKSP CCCCCCCCCCCCCCC	26.79	23927012
155	Acetylation	KWCPTTNKPVKSPTP CCCCCCCCCCCCCCC	49.44	26051181
159	Phosphorylation	TTNKPVKSPTPTVNP CCCCCCCCCCCCCCC	33.95	29255136
161	Phosphorylation	NKPVKSPTPTVNPRK CCCCCCCCCCCCCCC	38.39	29255136
163	Phosphorylation	PVKSPTPTVNPRKKL CCCCCCCCCCCCCCE	35.08	23927012
169	Sumoylation	PTVNPRKKLWAFPSD CCCCCCCCEECCCCC	51.01	-
169	Sumoylation	PTVNPRKKLWAFPSD CCCCCCCCEECCCCC	51.01	-
169	Ubiquitination	PTVNPRKKLWAFPSD CCCCCCCCEECCCCC	51.01	-
175	Phosphorylation	KKLWAFPSDSSRDLP CCEECCCCCCCCCCC	43.61	25159151
177	Phosphorylation	LWAFPSDSSRDLPSP EECCCCCCCCCCCCC	31.45	25159151
178	Phosphorylation	WAFPSDSSRDLPSPK ECCCCCCCCCCCCCC	34.50	25159151
183	Phosphorylation	DSSRDLPSPKKAKTE CCCCCCCCCCCCCCC	57.56	28355574
189	Phosphorylation	PSPKKAKTEEMPQLN CCCCCCCCCCCCCCC	41.88	26074081
234	Phosphorylation	GTCRPDVSESPELRQ CCCCCCCCCCHHHHH	39.47	26074081
236	Phosphorylation	CRPDVSESPELRQKS CCCCCCCCHHHHHCC	19.03	26074081
243	O-linked_Glycosylation	SPELRQKSPLFQFAE CHHHHHCCCCEEEEE	20.63	30059200
243	Phosphorylation	SPELRQKSPLFQFAE CHHHHHCCCCEEEEE	20.63	25159151
252	O-linked_Glycosylation	LFQFAEISSSTSHSD CEEEEECCCCCCCCC	15.11	30059200
252	Phosphorylation	LFQFAEISSSTSHSD CEEEEECCCCCCCCC	15.11	23927012
253	Phosphorylation	FQFAEISSSTSHSDA EEEEECCCCCCCCCC	43.21	23927012
254	Phosphorylation	QFAEISSSTSHSDAS EEEECCCCCCCCCCC	27.43	23927012
255	Phosphorylation	FAEISSSTSHSDAST EEECCCCCCCCCCCC	32.19	23927012
256	O-linked_Glycosylation	AEISSSTSHSDASTK EECCCCCCCCCCCCC	23.96	30059200
256	Phosphorylation	AEISSSTSHSDASTK EECCCCCCCCCCCCC	23.96	22199227
258	O-linked_Glycosylation	ISSSTSHSDASTKQC CCCCCCCCCCCCCHH	34.34	30059200
258	Phosphorylation	ISSSTSHSDASTKQC CCCCCCCCCCCCCHH	34.34	24117733
261	Phosphorylation	STSHSDASTKQCQTS CCCCCCCCCCHHHHH	40.92	24117733
262	Phosphorylation	TSHSDASTKQCQTSA CCCCCCCCCHHHHHH	27.19	24117733
295	Phosphorylation	PVKRCGKSALFQLAE CCCCCCHHHHHHHHH	18.58	28348404
316	Ubiquitination	GMKMEESKLIKAKES CCCHHHHHCEEEHHH	58.47	-
352	Ubiquitination	TDETRLQKEAEFEKS CHHHHHHHHHHHHHH	64.58	-
361	Sumoylation	AEFEKSAKENLRDSK HHHHHHHHHHHHCCH	54.98	-
361	Sumoylation	AEFEKSAKENLRDSK HHHHHHHHHHHHCCH	54.98	-
367	Phosphorylation	AKENLRDSKELRNFE HHHHHHCCHHHHCCE	22.92	20860994
385	Sumoylation	IDDIMAIKMEDPKEI HHHEEEEECCCHHHH	27.05	-
385	Sumoylation	IDDIMAIKMEDPKEI HHHEEEEECCCHHHH	27.05	28112733
412	Phosphorylation	HFPDFSYSASSKIII CCCCCCCCCCCCEEE	22.07	28555341
420	Phosphorylation	ASSKIIISDVPSRKD CCCCEEEECCCCCCC	23.34	29083192
424	Phosphorylation	IIISDVPSRKDHMCH EEEECCCCCCCCCCC	52.38	29083192
449	Acetylation	AALNKPEKLKKKKKK HHHCCHHHHHHHHHH	74.30	20055403
452	Acetylation	NKPEKLKKKKKKSKM CCHHHHHHHHHHHHC	79.04	20055399
454	Acetylation	PEKLKKKKKKSKMDR HHHHHHHHHHHHCCC	74.45	20055407
467	Phosphorylation	DRHGNDKSTPKKTCK CCCCCCCCCCHHHHC	53.45	30576142
468	Phosphorylation	RHGNDKSTPKKTCKK CCCCCCCCCHHHHCC	44.88	28176443
478	Phosphorylation	KTCKKRQSSESDIES HHHCCCCCCHHHHHH	39.86	30278072
479	Phosphorylation	TCKKRQSSESDIESV HHCCCCCCHHHHHHH	32.55	30278072
481	Phosphorylation	KKRQSSESDIESVIY CCCCCCHHHHHHHHH	45.92	30278072
485	Phosphorylation	SSESDIESVIYTIEA CCHHHHHHHHHHHHH	17.72	30278072
488	Phosphorylation	SDIESVIYTIEAVAK HHHHHHHHHHHHHHC	10.25	23663014
489	Phosphorylation	DIESVIYTIEAVAKG HHHHHHHHHHHHHCC	10.96	23663014
502	Ubiquitination	KGDWGIEKLGDTPRK CCCCCCCCCCCCCCC	56.71	-
506	Phosphorylation	GIEKLGDTPRKKVRT CCCCCCCCCCCEEEC	24.16	27422710
513	Phosphorylation	TPRKKVRTSSSGKGS CCCCEEECCCCCCCC	35.63	23312004
514	Phosphorylation	PRKKVRTSSSGKGSI CCCEEECCCCCCCCC	16.37	21601212
515	Phosphorylation	RKKVRTSSSGKGSIL CCEEECCCCCCCCCC	42.36	29214152
516	Phosphorylation	KKVRTSSSGKGSILD CEEECCCCCCCCCCC	44.27	23532336
520	O-linked_Glycosylation	TSSSGKGSILDAKPP CCCCCCCCCCCCCCC	24.38	30059200
520	Phosphorylation	TSSSGKGSILDAKPP CCCCCCCCCCCCCCC	24.38	21601212
557	Phosphorylation	SRPPDFISISASKNI CCCCCEEEEECCCCC	15.52	28555341
559	Phosphorylation	PPDFISISASKNISG CCCEEEEECCCCCCC	21.50	25159151
565	Phosphorylation	ISASKNISGETPEGI EECCCCCCCCCCCCC	39.71	30266825
568	Phosphorylation	SKNISGETPEGIKAE CCCCCCCCCCCCCCC	30.11	30266825
573	Sumoylation	GETPEGIKAEPLTPM CCCCCCCCCCCCCCH	58.51	28112733
576 (in isoform 3)	Phosphorylation	-	46.52	30206219
578	Phosphorylation	GIKAEPLTPMEDALP CCCCCCCCCHHHCCC	31.16	26657352
587	Phosphorylation	MEDALPPSLSGQAKP HHHCCCCCCCCCCCC	32.97	25002506
589	Phosphorylation	DALPPSLSGQAKPED HCCCCCCCCCCCCCC	32.95	25002506
625	Phosphorylation	ALYKTLVSEGMLTSL HHHHHHHCCCHHHHH	31.39	28555341
630	Phosphorylation	LVSEGMLTSLRANVD HHCCCHHHHHHHHCC	19.47	28555341
631	Phosphorylation	VSEGMLTSLRANVDR HCCCHHHHHHHHCCC	16.34	28555341
648	Phosphorylation	RSSGKGNSSDHEGCW CCCCCCCCCCCCCCC	45.90	23927012
649	Phosphorylation	SSGKGNSSDHEGCWN CCCCCCCCCCCCCCC	47.16	23927012
659	Phosphorylation	EGCWNEESWTFSQSG CCCCCCCCEEEECCC	25.82	28450419
661	Phosphorylation	CWNEESWTFSQSGTS CCCCCCEEEECCCCC	23.76	30108239
663	Phosphorylation	NEESWTFSQSGTSGS CCCCEEEECCCCCCC	18.96	27080861
665	Phosphorylation	ESWTFSQSGTSGSKK CCEEEECCCCCCCCC	42.72	23927012
667	Phosphorylation	WTFSQSGTSGSKKFK EEEECCCCCCCCCCC	34.85	27080861
668	Phosphorylation	TFSQSGTSGSKKFKK EEECCCCCCCCCCCC	44.59	20068231
670	Phosphorylation	SQSGTSGSKKFKKTK ECCCCCCCCCCCCCC	32.23	23927012
676	Phosphorylation	GSKKFKKTKPKEDCL CCCCCCCCCCHHHCC	53.84	-
686	Phosphorylation	KEDCLLGSAKLDEEF HHHCCCCCCCCCHHH	23.38	21815630
696	Sumoylation	LDEEFEKKFNSLPQY CCHHHHHHHHCCCCC	42.45	-
696	Sumoylation	LDEEFEKKFNSLPQY CCHHHHHHHHCCCCC	42.45	28112733
696	Ubiquitination	LDEEFEKKFNSLPQY CCHHHHHHHHCCCCC	42.45	-
699	Phosphorylation	EFEKKFNSLPQYSPV HHHHHHHCCCCCCCC	44.55	23927012
703	Phosphorylation	KFNSLPQYSPVTFDR HHHCCCCCCCCCCCC	17.01	29255136
704	Phosphorylation	FNSLPQYSPVTFDRK HHCCCCCCCCCCCCC	13.98	29255136
707	Phosphorylation	LPQYSPVTFDRKCVP CCCCCCCCCCCCCEE	24.17	29255136
726	Phosphorylation	KKKTGNVSSEPTKTS CCCCCCCCCCCCCCC	32.74	22964224
727	Phosphorylation	KKTGNVSSEPTKTSK CCCCCCCCCCCCCCC	43.22	-
736 (in isoform 2)	Phosphorylation	-	28.04	24719451
750	Phosphorylation	NLFHKIVSKYKHKKE HHHHHHHHHHCCCCC	33.47	26270265
752	Phosphorylation	FHKIVSKYKHKKEKP HHHHHHHHCCCCCCC	15.72	26270265
773	Ubiquitination	SGDKWSNKQLFLDAI CCCCCCCCEEHHHHH	42.75	-
805	Phosphorylation	HKVKNIPSIFNTPEP CHHCCCCCCCCCCCC	35.69	25850435
809	Phosphorylation	NIPSIFNTPEPTTTQ CCCCCCCCCCCCCCC	20.48	25159151
813	Phosphorylation	IFNTPEPTTTQEPLV CCCCCCCCCCCCCCC	40.59	25850435
814	Phosphorylation	FNTPEPTTTQEPLVG CCCCCCCCCCCCCCC	36.88	25850435
815	Phosphorylation	NTPEPTTTQEPLVGS CCCCCCCCCCCCCCC	33.15	25850435
822	Phosphorylation	TQEPLVGSQKRKARK CCCCCCCCHHHHCCC	25.67	25159151
833	Phosphorylation	KARKTKITHLVRTAD HCCCCCCCEEEECCC	15.65	28555341
838	Phosphorylation	KITHLVRTADGRVSP CCCEEEECCCCCCCC	22.94	25159151
844	Phosphorylation	RTADGRVSPAGGTLD ECCCCCCCCCCCCCC	13.99	29255136
849	Phosphorylation	RVSPAGGTLDDKPKE CCCCCCCCCCCCHHH	26.54	20201521
873	Acetylation	TETDCNDKCSHNTEV CCCCCCCCCCCCCCC	24.52	26051181
885	Phosphorylation	TEVGETRSSTPEMPA CCCCCCCCCCCCCHH	46.08	28450419
886	Phosphorylation	EVGETRSSTPEMPAV CCCCCCCCCCCCHHH	44.69	28450419
887	Phosphorylation	VGETRSSTPEMPAVS CCCCCCCCCCCHHHH	25.23	28464451
898	Phosphorylation	PAVSAFFSLAALAEV HHHHHHHHHHHHHHH	15.62	28464451
917	Phosphorylation	NVHRGQRSTPLTHDG CCCCCCCCCCCCCCC	26.87	25159151
918	Phosphorylation	VHRGQRSTPLTHDGQ CCCCCCCCCCCCCCC	25.22	29978859
921	Phosphorylation	GQRSTPLTHDGQPKE CCCCCCCCCCCCCCC	21.08	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BBX_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BBX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BBX_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049
SPAG1_HUMAN	SPAG1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BBX_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-844, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-479; SER-485; THR-809AND SER-822, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-844, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-159 AND THR-161, ANDMASS SPECTROMETRY.	19007248 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-568, AND MASSSPECTROMETRY.	19413330 [Abstract]