dbPTM

CORO7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CORO7_HUMAN
UniProt AC	P57737
Protein Name	Coronin-7
Gene Name	CORO7
Organism	Homo sapiens (Human).
Sequence Length	925
Subcellular Localization	Golgi apparatus membrane. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle. Cytoplasm, cytosol. Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments.
Protein Description	F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology..
Protein Sequence	MNRFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAFNSDRPGVLGIVPLQGQGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREVKLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQPALSPVTQCVLESVLRGAALVPRQALAVMSCEVLRVLQLSDTAIVPIGYHVPRKAVEFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSLNPACRPHPSFTSCLVPPAEPLPDTAQPAVMETPVGDADASEGFSSPPSSLTSPSTPSSLGPSLSSTSGIGTSPSLRSLQSLLGPSSKFRHAQGTVLHRDSHITNLKGLNLTTPGESDGFCANKLRVAVPLLSSGGQVAVLELRKPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSERQLLLYEAEALAGGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFLECNSFTSPDPHKGLVLLPKTECDVREVELMRCLRLRQSSLEPVAFRLPRVRKEFFQDDVFPDTAVIWEPVLSAEAWLQGANGQPWLLSLQPPDMSPVSQAPREAPARRAPSSAQYLEEKSDQQKKEELLNAMVAKLGNREDPLPQDSFEGVDEDEWD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	ARPPRRESWISDIRA CCCCCCHHHHHHHHC	28.09	23401153
21 (in isoform 3)	Phosphorylation	-	28.09	24719451
24	Phosphorylation	PRRESWISDIRAGTA CCCHHHHHHHHCCCC	22.26	23403867
24 (in isoform 3)	Phosphorylation	-	22.26	27251275
40	Phosphorylation	SCRNHIKSSCSLIAF HHHHHHHHCCEEEEE	35.65	24247654
41	Phosphorylation	CRNHIKSSCSLIAFN HHHHHHHCCEEEEEC	11.61	27251275
43	Phosphorylation	NHIKSSCSLIAFNSD HHHHHCCEEEEECCC	25.43	28857561
43 (in isoform 3)	Phosphorylation	-	25.43	27251275
67	Ubiquitination	LQGQGEDKRRVAHLG CCCCCCCCCCEEECC	37.49	29967540
103	Ubiquitination	GSADRTVKLWRLPGP CCCCCEEEEEECCCC	41.54	22817900
105	Ubiquitination	ADRTVKLWRLPGPGQ CCCEEEEEECCCCCC	8.27	22817900
139	Ubiquitination	LQFHPTSDGILVSAA EEECCCCCCEEEECC	51.10	29967540
157	Ubiquitination	VKVWDAAKQQPLTEL EEEHHHHHCCCHHHH	51.71	29967540
170	Ubiquitination	ELAAHGDLVQSAVWS HHHHCCCHHHHHHHC	4.46	22817900
172	Ubiquitination	AAHGDLVQSAVWSRD HHCCCHHHHHHHCCC	32.73	22817900
188	Ubiquitination	ALVGTACKDKQLRIF CEEEEEECCCCEEEE	66.55	21906983
190	Ubiquitination	VGTACKDKQLRIFDP EEEEECCCCEEEECC	36.41	22817900
241	Ubiquitination	QMREREVKLWDTRFF HHHHHHHHHHHHHHH	38.82	-
242	Phosphorylation	MREREVKLWDTRFFS HHHHHHHHHHHHHHH	6.38	32142685
252	Ubiquitination	TRFFSSALASLTLDT HHHHHHHHHHCHHCC	3.43	30230243
263	Ubiquitination	TLDTSLGCLVPLLDP HHCCCCCCEEEEECC	4.14	29967540
288	Phosphorylation	GERQLYCYEVVPQQP CCEEEEEEEECCCCC	9.75	22817900
288	Ubiquitination	GERQLYCYEVVPQQP CCEEEEEEEECCCCC	9.75	30230243
297	Ubiquitination	VVPQQPALSPVTQCV ECCCCCCCCHHHHHH	8.28	29967540
330	Ubiquitination	MSCEVLRVLQLSDTA HHHHHHHHCCCCCCE	3.32	29967540
348	Ubiquitination	IGYHVPRKAVEFHED CCEECCHHHHHHCHH	51.19	29967540
364	Ubiquitination	FPDTAGCVPATDPHS CCCCCCCEECCCCCC	3.37	29967540
376	Ubiquitination	PHSWWAGDNQQVQKV CCCCCCCCCCCEEEE	41.85	30230243
377	Phosphorylation	HSWWAGDNQQVQKVS CCCCCCCCCCEEEEE	33.01	32142685
382	Ubiquitination	GDNQQVQKVSLNPAC CCCCCEEEEECCCCC	34.63	29967540
387	Acetylation	VQKVSLNPACRPHPS EEEEECCCCCCCCCC	37.72	19608861
387	Ubiquitination	VQKVSLNPACRPHPS EEEEECCCCCCCCCC	37.72	23000965
387 (in isoform 2)	Ubiquitination	-	37.72	21890473
406	Ubiquitination	LVPPAEPLPDTAQPA CCCCCCCCCCCCCCE	4.51	22817900
423	Ubiquitination	ETPVGDADASEGFSS ECCCCCCCCCCCCCC	56.20	22817900
444	Phosphorylation	SPSTPSSLGPSLSST CCCCCHHCCCCCCCC	15.97	32142685
454	Acetylation	SLSSTSGIGTSPSLR CCCCCCCCCCCHHHH	5.65	19608861
454	Ubiquitination	SLSSTSGIGTSPSLR CCCCCCCCCCCHHHH	5.65	23000965
460	Ubiquitination	GIGTSPSLRSLQSLL CCCCCHHHHHHHHHH	4.97	30230243
462	Phosphorylation	GTSPSLRSLQSLLGP CCCHHHHHHHHHHCC	35.73	30576142
462 (in isoform 3)	Phosphorylation	-	35.73	24719451
465	Phosphorylation	PSLRSLQSLLGPSSK HHHHHHHHHHCCCHH	30.75	23401153
465 (in isoform 3)	Phosphorylation	-	30.75	24719451
470	Phosphorylation	LQSLLGPSSKFRHAQ HHHHHCCCHHHHCCC	44.34	28857561
470 (in isoform 3)	Phosphorylation	-	44.34	27251275
471	Phosphorylation	QSLLGPSSKFRHAQG HHHHCCCHHHHCCCC	38.66	28857561
472	Ubiquitination	SLLGPSSKFRHAQGT HHHCCCHHHHCCCCC	51.24	21890473
472	Acetylation	SLLGPSSKFRHAQGT HHHCCCHHHHCCCCC	51.24	19608861
472	Ubiquitination	SLLGPSSKFRHAQGT HHHCCCHHHHCCCCC	51.24	23000965
472 (in isoform 1)	Ubiquitination	-	51.24	21890473
473	Ubiquitination	LLGPSSKFRHAQGTV HHCCCHHHHCCCCCE	8.16	22817900
479	Phosphorylation	KFRHAQGTVLHRDSH HHHCCCCCEECCCCC	14.07	28857561
485	Phosphorylation	GTVLHRDSHITNLKG CCEECCCCCCCCCCC	19.42	28857561
490	Ubiquitination	RDSHITNLKGLNLTT CCCCCCCCCCCCCCC	3.31	22817900
491	Ubiquitination	DSHITNLKGLNLTTP CCCCCCCCCCCCCCC	64.52	21906983
508	Ubiquitination	SDGFCANKLRVAVPL CCCCCCCCEEEEEEE	21.10	21906983
511	Ubiquitination	FCANKLRVAVPLLSS CCCCCEEEEEEEECC	10.24	22817900
517	Phosphorylation	RVAVPLLSSGGQVAV EEEEEEECCCCEEEE	34.32	28348404
517 (in isoform 3)	Phosphorylation	-	34.32	27251275
518	Phosphorylation	VAVPLLSSGGQVAVL EEEEEECCCCEEEEE	47.08	20068231
529	Ubiquitination	VAVLELRKPGRLPDT EEEEEECCCCCCCCC	65.53	-
572	Ubiquitination	EDARIRLWRVPAEGL CCCEEEEEECCCCCH	6.86	29967540
578	Ubiquitination	LWRVPAEGLEEVLTT EEECCCCCHHHHHCC	40.26	22817900
584	Phosphorylation	EGLEEVLTTPETVLT CCHHHHHCCCCEEEC	45.54	23312004
584 (in isoform 3)	Phosphorylation	-	45.54	27251275
585	Phosphorylation	GLEEVLTTPETVLTG CHHHHHCCCCEEECC	18.24	30377224
587	Phosphorylation	EEVLTTPETVLTGHT HHHHCCCCEEECCCC	49.83	32142685
588	Phosphorylation	EVLTTPETVLTGHTE HHHCCCCEEECCCCH	23.24	23312004
595	Ubiquitination	TVLTGHTEKICSLRF EEECCCCHHEEECCC	34.45	22817900
596	Ubiquitination	VLTGHTEKICSLRFH EECCCCHHEEECCCC	50.60	21906983
612	Phosphorylation	LAANVLASSSYDLTV HHHHHHHCCCCEEEE	18.69	27251275
612 (in isoform 3)	Phosphorylation	-	18.69	27251275
613	Phosphorylation	AANVLASSSYDLTVR HHHHHHCCCCEEEEE	27.58	24247654
615	Phosphorylation	NVLASSSYDLTVRIW HHHHCCCCEEEEEEE	19.54	-
632	Ubiquitination	QAGADRLKLQGHQDQ CCCCCEEEECCCHHH	39.39	-
639	Ubiquitination	KLQGHQDQIFSLAWS EECCCHHHEEEEEEC	31.86	29967540
657	Ubiquitination	QQLATVCKDGRVRVY CCEEEEECCCCEEEE	59.90	29967540
662	Ubiquitination	VCKDGRVRVYRPRSG EECCCCEEEECCCCC	20.56	22817900
667	Ubiquitination	RVRVYRPRSGPEPLQ CEEEECCCCCCCCCC	45.29	32015554
668	Phosphorylation	VRVYRPRSGPEPLQE EEEECCCCCCCCCCC	62.47	30108239
680	Ubiquitination	LQEGPGPKGGRGARI CCCCCCCCCCCCCEE	78.78	21906983
702	Ubiquitination	CLLVSGFDSQSERQL EEEEECCCCHHHHHH	49.66	29967540
722	Phosphorylation	EALAGGPLAVLGLDV HHHHCCCEEEECEEE	6.10	32142685
758	Phosphorylation	GDTRVFLYELLPESP CCCEEEEEECCCCCC	7.96	22817900
764	Phosphorylation	LYELLPESPFFLECN EEECCCCCCCEEECC	25.68	-
769	Ubiquitination	PESPFFLECNSFTSP CCCCCEEECCCCCCC	26.88	29967540
772	Phosphorylation	PFFLECNSFTSPDPH CCEEECCCCCCCCCC	41.37	25627689
774	Phosphorylation	FLECNSFTSPDPHKG EEECCCCCCCCCCCC	38.89	25627689
775	Phosphorylation	LECNSFTSPDPHKGL EECCCCCCCCCCCCE	25.87	25627689
780	Ubiquitination	FTSPDPHKGLVLLPK CCCCCCCCCEEEEEC	60.37	-
787	Ubiquitination	KGLVLLPKTECDVRE CCEEEEECCCCCHHH	57.85	29967540
789	Phosphorylation	LVLLPKTECDVREVE EEEEECCCCCHHHHH	34.54	32142685
802	Ubiquitination	VELMRCLRLRQSSLE HHHHHHHHHHHHCCC	31.30	32015554
806	Phosphorylation	RCLRLRQSSLEPVAF HHHHHHHHCCCCCHH	30.38	23403867
806 (in isoform 3)	Phosphorylation	-	30.38	24719451
807	Phosphorylation	CLRLRQSSLEPVAFR HHHHHHHCCCCCHHC	28.54	23403867
808	Ubiquitination	LRLRQSSLEPVAFRL HHHHHHCCCCCHHCC	11.90	29967540
818	Ubiquitination	VAFRLPRVRKEFFQD CHHCCHHHHHHHHCC	10.94	21890473
818 (in isoform 2)	Ubiquitination	-	10.94	21890473
869	Ubiquitination	MSPVSQAPREAPARR CCCCCCCCCCCCCCC	27.32	32015554
875	Ubiquitination	APREAPARRAPSSAQ CCCCCCCCCCCCHHH	33.95	29967540
879	Phosphorylation	APARRAPSSAQYLEE CCCCCCCCHHHHHHH	37.00	25159151
879 (in isoform 3)	Phosphorylation	-	37.00	24719451
880	Phosphorylation	PARRAPSSAQYLEEK CCCCCCCHHHHHHHH	20.52	21815630
883	Phosphorylation	RAPSSAQYLEEKSDQ CCCCHHHHHHHHCHH	18.79	30108239
883 (in isoform 3)	Phosphorylation	-	18.79	27642862
885	Ubiquitination	PSSAQYLEEKSDQQK CCHHHHHHHHCHHHH	59.45	21890473
887	Ubiquitination	SAQYLEEKSDQQKKE HHHHHHHHCHHHHHH	50.38	32015554
892	Ubiquitination	EEKSDQQKKEELLNA HHHCHHHHHHHHHHH	57.42	-
893	Ubiquitination	EKSDQQKKEELLNAM HHCHHHHHHHHHHHH	52.67	29967540
900	Sulfoxidation	KEELLNAMVAKLGNR HHHHHHHHHHHHCCC	2.68	21406390
903	Ubiquitination	LLNAMVAKLGNREDP HHHHHHHHHCCCCCC	45.58	21890473
903	Ubiquitination	LLNAMVAKLGNREDP HHHHHHHHHCCCCCC	45.58	22817900
903 (in isoform 1)	Ubiquitination	-	45.58	21890473
915	Phosphorylation	EDPLPQDSFEGVDED CCCCCCCCCCCCCCC	21.68	25159151
927 (in isoform 3)	Phosphorylation	-		-
989 (in isoform 3)	Phosphorylation	-		27251275
992 (in isoform 3)	Phosphorylation	-		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
288	Y	Phosphorylation	Kinase	SRC	P12931	PSP
758	Y	Phosphorylation	Kinase	SRC	P12931	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	KLHL20	Q9Y2M5	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CORO7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CORO7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TOB1_HUMAN	TOB1	physical	21130766
DAG1_HUMAN	DAG1	physical	22939629
ACTB_HUMAN	ACTB	physical	24768539
EPS15_HUMAN	EPS15	physical	24768539
JUN_HUMAN	JUN	physical	24768539
AP1G1_HUMAN	AP1G1	physical	16905771

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CORO7_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-472, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-915, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21 AND SER-915, AND MASSSPECTROMETRY.	18669648 [Abstract]