dbPTM

TOB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TOB1_HUMAN
UniProt AC	P50616
Protein Name	Protein Tob1
Gene Name	TOB1
Organism	Homo sapiens (Human).
Sequence Length	345
Subcellular Localization	Cytoplasm. Nucleus. Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic..
Protein Description	Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. [PubMed: 8632892]
Protein Sequence	MQLEIQVALNFIISYLYNKLPRRRVNIFGEELERLLKKKYEGHWYPEKPYKGSGFRCIHIGEKVDPVIEQASKESGLDIDDVRGNLPQDLSVWIDPFEVSYQIGEKGPVKVLYVDDNNENGCELDKEIKNSFNPEAQVFMPISDPASSVSSSPSPPFGHSAAVSPTFMPRSTQPLTFTTATFAATKFGSTKMKNSGRSNKVARTSPINLGLNVNDLLKQKAISSSMHSLYGLGLGSQQQPQQQQQPAQPPPPPPPPQQQQQQKTSALSPNAKEFIFPNMQGQGSSTNGMFPGDSPLNLSPLQYSNAFDVFAAYGGLNEKSFVDGLNFSLNNMQYSNQQFQPVMAN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	VALNFIISYLYNKLP HHHHHHHHHHHHHCC	12.31	24043423
15	Phosphorylation	ALNFIISYLYNKLPR HHHHHHHHHHHHCCC	11.64	24043423
17	Phosphorylation	NFIISYLYNKLPRRR HHHHHHHHHHCCCHH	11.30	24043423
40	Phosphorylation	ERLLKKKYEGHWYPE HHHHHHHHCCCCCCC	35.70	20090780
66	Phosphorylation	HIGEKVDPVIEQASK ECCCCCCHHHHHHHH	31.79	32142685
73	Ubiquitination	PVIEQASKESGLDID HHHHHHHHHHCCCHH	59.94	29967540
110	Ubiquitination	IGEKGPVKVLYVDDN CCCCCCEEEEEECCC	29.65	29967540
126	Ubiquitination	ENGCELDKEIKNSFN CCCCCCCHHHHHCCC	74.16	29967540
143	Phosphorylation	AQVFMPISDPASSVS CEEEEECCCCCHHCC	31.50	28348404
147	Phosphorylation	MPISDPASSVSSSPS EECCCCCHHCCCCCC	36.34	25841592
148	Phosphorylation	PISDPASSVSSSPSP ECCCCCHHCCCCCCC	28.29	25841592
150	Phosphorylation	SDPASSVSSSPSPPF CCCCHHCCCCCCCCC	27.35	25841592
151	Phosphorylation	DPASSVSSSPSPPFG CCCHHCCCCCCCCCC	44.08	25841592
152	Phosphorylation	PASSVSSSPSPPFGH CCHHCCCCCCCCCCC	23.14	20068231
154	Phosphorylation	SSVSSSPSPPFGHSA HHCCCCCCCCCCCCC	47.34	20068231
160	Phosphorylation	PSPPFGHSAAVSPTF CCCCCCCCCCCCCCC	20.50	22210691
164	Phosphorylation	FGHSAAVSPTFMPRS CCCCCCCCCCCCCCC	17.31	20068231
166	Phosphorylation	HSAAVSPTFMPRSTQ CCCCCCCCCCCCCCC	25.67	25841592
172	Phosphorylation	PTFMPRSTQPLTFTT CCCCCCCCCCCEEEE	35.17	-
190	Phosphorylation	AATKFGSTKMKNSGR EHHHHCCCCCCCCCC	35.22	29759185
204	Phosphorylation	RSNKVARTSPINLGL CCCCCCCCCCCCCCC	29.17	30278072
205	Phosphorylation	SNKVARTSPINLGLN CCCCCCCCCCCCCCC	20.45	25159151
268	Phosphorylation	QQKTSALSPNAKEFI HHHHCCCCCCHHHHC	18.80	25849741
320	Phosphorylation	YGGLNEKSFVDGLNF CCCCCHHHHHCCCCE	25.07	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
152	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
152	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
152	S	Phosphorylation	Kinase	MAPK9	P45984	GPS
154	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
154	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
154	S	Phosphorylation	Kinase	MAPK9	P45984	GPS
164	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
164	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
164	S	Phosphorylation	Kinase	MAPK9	P45984	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	SKP2	Q13309	PMID:16951159

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TOB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TOB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PABP1_HUMAN	PABPC1	physical	18056425
CNOT7_HUMAN	CNOT7	physical	18056425
SCMH1_HUMAN	SCMH1	physical	16169070
SETB1_HUMAN	SETDB1	physical	16169070
SMAD4_HUMAN	SMAD4	physical	11163184
SMAD5_HUMAN	SMAD5	physical	11163184
SMAD1_HUMAN	SMAD1	physical	11163184
SMAD9_HUMAN	SMAD9	physical	11163184
CNOT7_HUMAN	CNOT7	physical	10602502
MK01_HUMAN	MAPK1	physical	12151396
MK09_HUMAN	MAPK9	physical	12151396
KS6A1_HUMAN	RPS6KA1	physical	11260258
SKP2_HUMAN	SKP2	physical	16951159
CTNB1_HUMAN	CTNNB1	physical	16890162
SMAD3_HUMAN	SMAD3	physical	16890162
PABP1_HUMAN	PABPC1	physical	17785442
CAF1A_HUMAN	CHAF1A	physical	17785442
PAN2_HUMAN	PAN2	physical	17785442
CDC7_HUMAN	CDC7	physical	23066029
A4_HUMAN	APP	physical	21832049
CORO7_HUMAN	CORO7	physical	21130766
CNOT6_HUMAN	CNOT6	physical	28514442
CNO6L_HUMAN	CNOT6L	physical	28514442
CNOT2_HUMAN	CNOT2	physical	28514442
TB182_HUMAN	TNKS1BP1	physical	28514442
CNOT3_HUMAN	CNOT3	physical	28514442
CNOT9_HUMAN	RQCD1	physical	28514442
CNO11_HUMAN	CNOT11	physical	28514442
CNOT8_HUMAN	CNOT8	physical	28514442
CNOT1_HUMAN	CNOT1	physical	28514442
CNO10_HUMAN	CNOT10	physical	28514442
RAVR1_HUMAN	RAVER1	physical	28514442
FHL2_HUMAN	FHL2	physical	28514442
RN219_HUMAN	RNF219	physical	28514442
ATE1_HUMAN	ATE1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TOB1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-204, AND MASSSPECTROMETRY.	19690332 [Abstract]