CNO11_HUMAN - dbPTM
CNO11_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CNO11_HUMAN
UniProt AC Q9UKZ1
Protein Name CCR4-NOT transcription complex subunit 11
Gene Name CNOT11
Organism Homo sapiens (Human).
Sequence Length 510
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function..
Protein Sequence MPGGGASAASGRLLTAAEQRGSREAAGSASRSGFGGSGGGRGGASGPGSGSGGPGGPAGRMSLTPKELSSLLSIISEEAGGGSTFEGLSTAFHHYFSKADHFRLGSVLVMLLQQPDLLPSAAQRLTALYLLWEMYRTEPLAANPFAASFAHLLNPAPPARGGQEPDRPPLSGFLPPITPPEKFFLSQLMLAPPRELFKKTPRQIALMDVGNMGQSVDISGLQLALAERQSELPTQSKASFPSILSDPDPDSSNSGFDSSVASQITEALVSGPKPPIESHFRPEFIRPPPPLHICEDELAWLNPTEPDHAIQWDKSMCVKNSTGVEIKRIMAKAFKSPLSSPQQTQLLGELEKDPKLVYHIGLTPAKLPDLVENNPLVAIEMLLKLMQSSQITEYFSVLVNMDMSLHSMEVVNRLTTAVDLPPEFIHLYISNCISTCEQIKDKYMQNRLVRLVCVFLQSLIRNKIINVQDLFIEVQAFCIEFSRIREAAGLFRLLKTLDTGETPSETKMSK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MPGGGASAASGRLL
-CCCCCCCHHHHHHH		21130716
10PhosphorylationGGGASAASGRLLTAA
CCCCCHHHHHHHHHH		21130716
28PhosphorylationGSREAAGSASRSGFG
CCHHHCCCCCCCCCC		28555341
30PhosphorylationREAAGSASRSGFGGS
HHHCCCCCCCCCCCC		26546556
41MethylationFGGSGGGRGGASGPG
CCCCCCCCCCCCCCC		24129315
49PhosphorylationGGASGPGSGSGGPGG
CCCCCCCCCCCCCCC		23532336
51PhosphorylationASGPGSGSGGPGGPA
CCCCCCCCCCCCCCC		23532336
60MethylationGPGGPAGRMSLTPKE
CCCCCCCCCCCCHHH		-
64PhosphorylationPAGRMSLTPKELSSL
CCCCCCCCHHHHHHH		23532336
106PhosphorylationADHFRLGSVLVMLLQ
CCCHHHHHHHHHHHH		-
129PhosphorylationAQRLTALYLLWEMYR
HHHHHHHHHHHHHHC		-
171PhosphorylationEPDRPPLSGFLPPIT
CCCCCCCCCCCCCCC		-
186PhosphorylationPPEKFFLSQLMLAPP
CCHHHHHHHHHCCCH		-
319UbiquitinationWDKSMCVKNSTGVEI
CCHHHHCCCCCCHHH		32015554
327UbiquitinationNSTGVEIKRIMAKAF
CCCCHHHHHHHHHHH		21906983
327AcetylationNSTGVEIKRIMAKAF
CCCCHHHHHHHHHHH		25953088
332UbiquitinationEIKRIMAKAFKSPLS
HHHHHHHHHHCCCCC		22817900
335UbiquitinationRIMAKAFKSPLSSPQ
HHHHHHHCCCCCCHH		21906983
336PhosphorylationIMAKAFKSPLSSPQQ
HHHHHHCCCCCCHHH		25159151
339PhosphorylationKAFKSPLSSPQQTQL
HHHCCCCCCHHHHHH		25159151
340PhosphorylationAFKSPLSSPQQTQLL
HHCCCCCCHHHHHHH		21815630
344PhosphorylationPLSSPQQTQLLGELE
CCCCHHHHHHHHHHH		29514088
352UbiquitinationQLLGELEKDPKLVYH
HHHHHHHCCCCEEEE		21906983
355UbiquitinationGELEKDPKLVYHIGL
HHHHCCCCEEEEECC		22817900
358PhosphorylationEKDPKLVYHIGLTPA
HCCCCEEEEECCCHH		27642862
388PhosphorylationMLLKLMQSSQITEYF
HHHHHHHCCCCHHHH		24043423
389PhosphorylationLLKLMQSSQITEYFS
HHHHHHCCCCHHHHH		24043423
392O-linked_GlycosylationLMQSSQITEYFSVLV
HHHCCCCHHHHHHHH		29351928
392PhosphorylationLMQSSQITEYFSVLV
HHHCCCCHHHHHHHH		24043423
394PhosphorylationQSSQITEYFSVLVNM
HCCCCHHHHHHHHCC		24043423
396O-linked_GlycosylationSQITEYFSVLVNMDM
CCCHHHHHHHHCCCC		29351928
396PhosphorylationSQITEYFSVLVNMDM
CCCHHHHHHHHCCCC		24043423
404PhosphorylationVLVNMDMSLHSMEVV
HHHCCCCCHHHHHHH		24043423
407PhosphorylationNMDMSLHSMEVVNRL
CCCCCHHHHHHHHHH		24043423
458PhosphorylationLVCVFLQSLIRNKII
HHHHHHHHHHHCCCC		24719451
495UbiquitinationAGLFRLLKTLDTGET
HHHHHHHHHCCCCCC		27667366
495AcetylationAGLFRLLKTLDTGET
HHHHHHHHHCCCCCC		26051181
496PhosphorylationGLFRLLKTLDTGETP
HHHHHHHHCCCCCCC		29507054
499PhosphorylationRLLKTLDTGETPSET
HHHHHCCCCCCCCHH		23403867
502PhosphorylationKTLDTGETPSETKMS
HHCCCCCCCCHHCCC		23403867
504PhosphorylationLDTGETPSETKMSK-
CCCCCCCCHHCCCC-		29507054
506PhosphorylationTGETPSETKMSK---
CCCCCCHHCCCC---		23403867
507UbiquitinationGETPSETKMSK----
CCCCCHHCCCC----		21906983
510UbiquitinationPSETKMSK-------
CCHHCCCC-------		24816145
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CNO11_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CNO11_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CNO11_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CNOT6_HUMANCNOT6physical
28514442
CNO6L_HUMANCNOT6Lphysical
28514442
CNO10_HUMANCNOT10physical
28514442
CNOT2_HUMANCNOT2physical
28514442
TB182_HUMANTNKS1BP1physical
28514442
CNOT3_HUMANCNOT3physical
28514442
CNOT8_HUMANCNOT8physical
28514442
CNOT1_HUMANCNOT1physical
28514442
RAVR1_HUMANRAVER1physical
28514442
BTG3_HUMANBTG3physical
28514442
CNOT9_HUMANRQCD1physical
28514442
GGNB2_HUMANGGNBP2physical
28514442
FHL2_HUMANFHL2physical
28514442
TB10A_HUMANTBC1D10Aphysical
28514442
EDRF1_HUMANEDRF1physical
28514442
M4K4_HUMANMAP4K4physical
28514442
CNOT9_HUMANRQCD1physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CNO11_HUMAN

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Related Literatures of Post-Translational Modification

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