| UniProt ID | CNOT9_HUMAN | |
|---|---|---|
| UniProt AC | Q92600 | |
| Protein Name | CCR4-NOT transcription complex subunit 9 {ECO:0000312|HGNC:HGNC:10445} | |
| Gene Name | CNOT9 {ECO:0000312|HGNC:HGNC:10445} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 299 | |
| Subcellular Localization | Nucleus . Cytoplasm, P-body . NANOS2 promotes its localization to P-body. | |
| Protein Description | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.. | |
| Protein Sequence | MHSLATAAPVPTTLAQVDREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGTIAALLQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTFAQVLKDDTTTKRWLAQLVKNLQEGQVTDPRGIPLPPQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MHSLATAA -------CCCCCCCC | 19413330 | ||
| 3 | Phosphorylation | -----MHSLATAAPV -----CCCCCCCCCC | 21406692 | ||
| 6 | Phosphorylation | --MHSLATAAPVPTT --CCCCCCCCCCCCC | 21406692 | ||
| 12 | Phosphorylation | ATAAPVPTTLAQVDR CCCCCCCCCHHHCCH | 21406692 | ||
| 13 | Phosphorylation | TAAPVPTTLAQVDRE CCCCCCCCHHHCCHH | 21406692 | ||
| 21 | Ubiquitination | LAQVDREKIYQWINE HHHCCHHHHHHHHHH | - | ||
| 23 | Phosphorylation | QVDREKIYQWINELS HCCHHHHHHHHHHCC | 28152594 | ||
| 30 | Phosphorylation | YQWINELSSPETREN HHHHHHCCCHHHHHH | - | ||
| 44 | Ubiquitination | NALLELSKKRESVPD HHHHHHHHHHCCCCC | - | ||
| 44 | Acetylation | NALLELSKKRESVPD HHHHHHHHHHCCCCC | 25953088 | ||
| 44 | Ubiquitination | NALLELSKKRESVPD HHHHHHHHHHCCCCC | - | ||
| 45 | Ubiquitination | ALLELSKKRESVPDL HHHHHHHHHCCCCCH | - | ||
| 45 | Ubiquitination | ALLELSKKRESVPDL HHHHHHHHHCCCCCH | - | ||
| 91 | S-nitrosocysteine | AHQSNRVCNALALLQ HHHHHHHHHHHHHHH | - | ||
| 99 | S-nitrosocysteine | NALALLQCVASHPET HHHHHHHHHHCCHHH | - | ||
| 139 | Phosphorylation | FEYLRLTSLGVIGAL CHHHHHHHHHHHHEE | 22210691 | ||
| 149 | Phosphorylation | VIGALVKTDEQEVIN HHHEEECCCHHHHHH | 22210691 | ||
| 207 | Phosphorylation | CQTYERFSHVAMILG HHHHHHHHHHHHHHH | 20068231 | ||
| 221 | Phosphorylation | GKMVLQLSKEPSARL HHHHHHHCCCHHHHH | - | ||
| 222 | Ubiquitination | KMVLQLSKEPSARLL HHHHHHCCCHHHHHH | 21890473 | ||
| 222 | Ubiquitination | KMVLQLSKEPSARLL HHHHHHCCCHHHHHH | 21890473 | ||
| 225 | Phosphorylation | LQLSKEPSARLLKHV HHHCCCHHHHHHHHH | 29970186 | ||
| 230 | Acetylation | EPSARLLKHVVRCYL CHHHHHHHHHHHHHH | 25953088 | ||
| 267 | Ubiquitination | TTFAQVLKDDTTTKR CCHHHHCCCCHHHHH | - | ||
| 281 | Ubiquitination | RWLAQLVKNLQEGQV HHHHHHHHHHHCCCC | - | ||
| 313 | Ubiquitination | --------------------- --------------------- | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CNOT9_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CNOT9_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CNOT9_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| AKT1_HUMAN | AKT1 | physical | 20878056 | |
| GRB10_HUMAN | GRB10 | physical | 20878056 | |
| EGFR_HUMAN | EGFR | physical | 20878056 | |
| GGYF1_HUMAN | GIGYF1 | physical | 20878056 | |
| GGYF2_HUMAN | GIGYF2 | physical | 20878056 | |
| CNOT1_HUMAN | CNOT1 | physical | 26344197 | |
| CNOT7_HUMAN | CNOT7 | physical | 26344197 | |
| 2A5G_HUMAN | PPP2R5C | physical | 26344197 | |
| CNOT9_HUMAN | RQCD1 | physical | 24768540 | |
| CNOT1_HUMAN | CNOT1 | physical | 24768540 | |
| TNR6A_HUMAN | TNRC6A | physical | 24768540 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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