CNOT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNOT1_HUMAN
• UniProt AC: A5YKK6
• Protein Name: CCR4-NOT transcription complex subunit 1
• Gene Name: CNOT1
• Organism: Homo sapiens (Human).
• Sequence Length: 2376
• Subcellular Localization: Cytoplasm, P-body . Nucleus . NANOS2 promotes its localization to P-body..
• Protein Description: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity..
• Protein Sequence: MNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECALLITKPNFISTLSYAIDNPLHYQKSLKPAPHLFAQLSKVLKLSKVQEVIFGLALLNSSSSDLRGFAAQFIKQKLPDLLRSYIDADVSGNQEGGFQDIAIEVLHLLLSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQERCPVVLAPLLYPEKRDILMDRILPDSGGVAKTMMESSLADFMQEVGYGFCASIEECRNIIVQFGVREVTAAQVARVLGMMARTHSGLTDGIPLQSISAPGSGIWSDGKDKSDGAQAHTWNVEVLIDVLKELNPSLNFKEVTYELDHPGFQIRDSKGLHNVVYGIQRGLGMEVFPVDLIYRPWKHAEGQLSFIQHSLINPEIFCFADYPCHTVATDILKAPPEDDNREIATWKSLDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPSIRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQDLKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRRCPSILGGLAPEKDQPKSAQLPPETLATMLACLQACAGSVSQELSETILTMVANCSNVMNKARQPPPGVMPKGRPPSASSLDAISPVQIDPLAGMTSLSIGGSAAPHTQSMQGFPPNLGSAFSTPQSPAKAFPPLSTPNQTTAFSGIGGLSSQLPVGGLGTGSLTGIGTGALGLPAVNNDPFVQRKLGTSGLNQPTFQQSKMKPSDLSQVWPEANQHFSKEIDDEANSYFQRIYNHPPHPTMSVDEVLEMLQRFKDSTIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGGIIEKGLVTYMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASISHFMQFPHHLQEYIEYGQQSRDPPVKMQGSITTPGSIALAQAQAQAQVPAKAPLAGQVSTMVTTSTTTTVAKTVTVTRPTGVSFKKDVPPSINTTNIDTLLVATDQTERIVEPPENIQEKIAFIFNNLSQSNMTQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNPEFNKMVLNETYRNIKVLLTSDKAAANFSDRSLLKNLGHWLGMITLAKNKPILHTDLDVKSLLLEAYVKGQQELLYVVPFVAKVLESSIRSVVFRPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLCKNLALDINELKPGNLLKDKDRLKNLDEQLSAPKKDVKQPEELPPITTTTTSTTPATNTTCTATVPPQPQYSYHDINVYSLAGLAPHITLNPTIPLFQAHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRIAAHHMMRNLTAGMAMITCREPLLMSISTNLKNSFASALRTASPQQREMMDQAAAQLAQDNCELACCFIQKTAVEKAGPEMDKRLATEFELRKHARQEGRRYCDPVVLTYQAERMPEQIRLKVGGVDPKQLAVYEEFARNVPGFLPTNDLSQPTGFLAQPMKQAWATDDVAQIYDKCITELEQHLHAIPPTLAMNPQAQALRSLLEVVVLSRNSRDAIAALGLLQKAVEGLLDATSGADADLLLRYRECHLLVLKALQDGRAYGSPWCNKQITRCLIECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNYMAVAFAMQLVKILLVDERSVAHVTEADLFHTIETLMRINAHSRGNAPEGLPQLMEVVRSNYEAMIDRAHGGPNFMMHSGISQASEYDDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQMHQQGILKTDDLITRFFRLCTEMCVEISYRAQAEQQHNPAANPTMIRAKCYHNLDAFVRLIALLVKHSGEATNTVTKINLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFIMLLLELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAHTPQQKGWPMYAQLLIDLFKYLAPFLRNVELTKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKVDMLSEINIAPRILTNFTGVMPPQFKKDLDSYLKTRSPVTFLSDLRSNLQVSNEPGNRYNLQLINALVLYVGTQAIAHIHNKGSTPSMSTITHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANTEAIQEQITRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEKLFQSVAQCCMGQKQAQQVMEGTGAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MNLDSLSLALSQ ---CCHHHHHHHHHH	24.03	23401153
7	Phosphorylation	-MNLDSLSLALSQIS -CCHHHHHHHHHHHH	18.62	23401153
11	Phosphorylation	DSLSLALSQISYLVD HHHHHHHHHHHHHHH	21.62	27762562
14	Phosphorylation	SLALSQISYLVDNLT HHHHHHHHHHHHHHC	12.55	23401153
21	Phosphorylation	SYLVDNLTKKNYRAS HHHHHHHCHHCHHHH	46.34	27762562
45	Methylation	RHGPEADRHLLRCLF HHCHHHHHHHHHHHH	29.42	115485447
231	Ubiquitination	APLLYPEKRDILMDR CCCCCHHHHCHHHHH	51.36	29967540
238	Methylation	KRDILMDRILPDSGG HHCHHHHHCCCCCCC	20.55	115485453
243	Phosphorylation	MDRILPDSGGVAKTM HHHCCCCCCCHHHHH	35.19	25599653
253	Phosphorylation	VAKTMMESSLADFMQ HHHHHHHHHHHHHHH	16.86	25332170
286	Phosphorylation	QFGVREVTAAQVARV HHCCCHHHHHHHHHH	16.12	23403867
318	Phosphorylation	QSISAPGSGIWSDGK CCCCCCCCCCCCCCC	26.50	30576142
322	Phosphorylation	APGSGIWSDGKDKSD CCCCCCCCCCCCCCC	34.27	22067460
355	Ubiquitination	LNPSLNFKEVTYELD HCCCCCCEEEEEECC	50.64	32015554
358	Phosphorylation	SLNFKEVTYELDHPG CCCCEEEEEECCCCC	16.63	28152594
359	Phosphorylation	LNFKEVTYELDHPGF CCCEEEEEECCCCCE	21.48	28152594
372	Ubiquitination	GFQIRDSKGLHNVVY CEEEECCCCHHHHHH	70.54	29967540
379	Phosphorylation	KGLHNVVYGIQRGLG CCHHHHHHHHHCCCC	12.29	29496907
435	Ubiquitination	TVATDILKAPPEDDN CHHHHHHCCCCCCCC	60.21	29967540
449	Ubiquitination	NREIATWKSLDLIES CCHHCHHHHHHHHHH	36.46	29967540
466	Phosphorylation	RLAEVGQYEQVKQLF HHHHHCCHHHHHHHH	11.47	28152594
556	2-Hydroxyisobutyrylation	GEQYDQAKLSRILDV CHHHCHHHHHHHHHH	41.17	-
556	Ubiquitination	GEQYDQAKLSRILDV CHHHCHHHHHHHHHH	41.17	24816145
556 (in isoform 2)	Ubiquitination	-	41.17	-
599	Ubiquitination	REYLKLDKWLTDKIR HHHHHHHHHHHHHHH	55.31	29967540
626	Phosphorylation	FLKRRCPSILGGLAP HHHHHCHHHHCCCCC	33.79	24719451
635	Acetylation	LGGLAPEKDQPKSAQ HCCCCCCCCCCCCCC	61.68	26051181
635	Ubiquitination	LGGLAPEKDQPKSAQ HCCCCCCCCCCCCCC	61.68	29967540
640	Phosphorylation	PEKDQPKSAQLPPET CCCCCCCCCCCCHHH	28.12	24043423
647	Phosphorylation	SAQLPPETLATMLAC CCCCCHHHHHHHHHH	27.71	24043423
650	Phosphorylation	LPPETLATMLACLQA CCHHHHHHHHHHHHH	18.81	24043423
661	Phosphorylation	CLQACAGSVSQELSE HHHHHCCCCCHHHHH	10.48	24043423
663	Phosphorylation	QACAGSVSQELSETI HHHCCCCCHHHHHHH	21.45	24043423
667	Phosphorylation	GSVSQELSETILTMV CCCCHHHHHHHHHHH	31.76	24043423
669	Phosphorylation	VSQELSETILTMVAN CCHHHHHHHHHHHHH	20.22	24043423
672	Phosphorylation	ELSETILTMVANCSN HHHHHHHHHHHHHHH	13.02	24043423
678	Phosphorylation	LTMVANCSNVMNKAR HHHHHHHHHHHHHHC	32.06	24043423
699	Phosphorylation	MPKGRPPSASSLDAI CCCCCCCCCHHCCCC	43.39	26074081
701	Phosphorylation	KGRPPSASSLDAISP CCCCCCCHHCCCCCC	35.45	26074081
702	Phosphorylation	GRPPSASSLDAISPV CCCCCCHHCCCCCCC	29.95	26074081
707	Phosphorylation	ASSLDAISPVQIDPL CHHCCCCCCCCCCCC	22.27	26074081
725	Phosphorylation	TSLSIGGSAAPHTQS CEEEECCCCCCCCCC	18.95	-
730	Phosphorylation	GGSAAPHTQSMQGFP CCCCCCCCCCCCCCC	22.68	-
745	Phosphorylation	PNLGSAFSTPQSPAK CCCCCCCCCCCCCCC	38.60	26074081
746	Phosphorylation	NLGSAFSTPQSPAKA CCCCCCCCCCCCCCC	20.92	26074081
749	Phosphorylation	SAFSTPQSPAKAFPP CCCCCCCCCCCCCCC	28.20	26074081
808	Ubiquitination	NDPFVQRKLGTSGLN CCHHHHHHHCCCCCC	33.89	21906983
808 (in isoform 1)	Ubiquitination	-	33.89	21890473
808 (in isoform 4)	Ubiquitination	-	33.89	21890473
811	Phosphorylation	FVQRKLGTSGLNQPT HHHHHHCCCCCCCCC	30.02	28555341
812	Phosphorylation	VQRKLGTSGLNQPTF HHHHHCCCCCCCCCC	39.21	28555341
822	Phosphorylation	NQPTFQQSKMKPSDL CCCCCCCCCCCHHHH	24.76	28857561
823	Ubiquitination	QPTFQQSKMKPSDLS CCCCCCCCCCHHHHH	46.75	29967540
851	Phosphorylation	IDDEANSYFQRIYNH CCHHHHHHHHHHHCC	11.98	-
872	Ubiquitination	SVDEVLEMLQRFKDS CHHHHHHHHHHHHHH	3.19	24816145
877	Acetylation	LEMLQRFKDSTIKRE HHHHHHHHHHHHHHH	53.62	19818057
877	Ubiquitination	LEMLQRFKDSTIKRE HHHHHHHHHHHHHHH	53.62	24816145
879	Phosphorylation	MLQRFKDSTIKRERE HHHHHHHHHHHHHHH	32.40	20068231
882	Acetylation	RFKDSTIKREREVFN HHHHHHHHHHHHHHH	48.58	25953088
927	Phosphorylation	IIEKGLVTYMALGLA HHHHHHHHHHHHHHH	16.78	20068231
928	Phosphorylation	IEKGLVTYMALGLAL HHHHHHHHHHHHHHH	3.49	20068231
937	Phosphorylation	ALGLALRYVLEALRK HHHHHHHHHHHHHHC	15.38	-
948	Phosphorylation	ALRKPFGSKMYYFGI HHHCCCCCCCHHHHH	18.03	20068231
951	Phosphorylation	KPFGSKMYYFGIAAL CCCCCCCHHHHHHHH	10.20	20068231
952	Phosphorylation	PFGSKMYYFGIAALD CCCCCCHHHHHHHHH	7.57	20068231
1008	Phosphorylation	PPVKMQGSITTPGSI CCCCCCCCCCCCHHH	10.40	25159151
1010	Phosphorylation	VKMQGSITTPGSIAL CCCCCCCCCCHHHHH	28.74	25159151
1011	Phosphorylation	KMQGSITTPGSIALA CCCCCCCCCHHHHHH	24.79	25159151
1038	Phosphorylation	PLAGQVSTMVTTSTT CCCCCEEEEEEECCC	19.46	30576142
1043	Phosphorylation	VSTMVTTSTTTTVAK EEEEEEECCCCEEEE	17.87	30576142
1045	Phosphorylation	TMVTTSTTTTVAKTV EEEEECCCCEEEEEE	21.90	30576142
1051	Phosphorylation	TTTTVAKTVTVTRPT CCCEEEEEEEEECCC	16.21	23403867
1053	Phosphorylation	TTVAKTVTVTRPTGV CEEEEEEEEECCCCC	22.76	23403867
1055	Phosphorylation	VAKTVTVTRPTGVSF EEEEEEEECCCCCCC	22.89	23403867
1058	Phosphorylation	TVTVTRPTGVSFKKD EEEEECCCCCCCCCC	47.10	23401153
1058	Ubiquitination	TVTVTRPTGVSFKKD EEEEECCCCCCCCCC	47.10	27667366
1059	Ubiquitination	VTVTRPTGVSFKKDV EEEECCCCCCCCCCC	18.76	29967540
1061	Phosphorylation	VTRPTGVSFKKDVPP EECCCCCCCCCCCCC	32.47	25159151
1063	Acetylation	RPTGVSFKKDVPPSI CCCCCCCCCCCCCCC	40.32	25953088
1063	Ubiquitination	RPTGVSFKKDVPPSI CCCCCCCCCCCCCCC	40.32	27667366
1064	Ubiquitination	PTGVSFKKDVPPSIN CCCCCCCCCCCCCCC	63.05	29967540
1073	Phosphorylation	VPPSINTTNIDTLLV CCCCCCCCCCCEEEE	26.20	-
1109	Ubiquitination	IFNNLSQSNMTQKVE HHHCCCCCCCHHHHH	25.78	29967540
1114	Ubiquitination	SQSNMTQKVEELKET CCCCCHHHHHHHHHH	42.31	29967540
1158	Ubiquitination	NFLDTLKNPEFNKMV HHHHHHCCHHHHHHH	44.43	21890473
1158 (in isoform 2)	Ubiquitination	-	44.43	21890473
1158 (in isoform 3)	Ubiquitination	-	44.43	21890473
1163	Ubiquitination	LKNPEFNKMVLNETY HCCHHHHHHHHCHHH	35.39	22817900
1163 (in isoform 1)	Ubiquitination	-	35.39	21890473
1163 (in isoform 4)	Ubiquitination	-	35.39	21890473
1181	2-Hydroxyisobutyrylation	KVLLTSDKAAANFSD EEEECCCHHHCCCCC	39.43	-
1189	Methylation	AAANFSDRSLLKNLG HHCCCCCHHHHHHHH	28.18	115485441
1190	Phosphorylation	AANFSDRSLLKNLGH HCCCCCHHHHHHHHH	42.94	24719451
1203	Ubiquitination	GHWLGMITLAKNKPI HHHHHHHHHHCCCCC	16.27	29967540
1208	Ubiquitination	MITLAKNKPILHTDL HHHHHCCCCCCCCCC	32.50	29967540
1234	Phosphorylation	KGQQELLYVVPFVAK HCCCHHHHHHHHHHH	16.42	-
1305	Ubiquitination	KPGNLLKDKDRLKNL CCCCCCCCHHHHCCH	59.04	29967540
1310	Ubiquitination	LKDKDRLKNLDEQLS CCCHHHHCCHHHHHC	57.25	29967540
1315	Ubiquitination	RLKNLDEQLSAPKKD HHCCHHHHHCCCCCC	40.14	29967540
1320	Ubiquitination	DEQLSAPKKDVKQPE HHHHCCCCCCCCCCH	62.41	29967540
1321	Ubiquitination	EQLSAPKKDVKQPEE HHHCCCCCCCCCCHH	67.69	-
1418	Phosphorylation	RSIKIAMTTCEQIVR CHHHHHHHCHHHHHH	21.19	-
1419	Phosphorylation	SIKIAMTTCEQIVRK HHHHHHHCHHHHHHH	10.85	-
1421	Ubiquitination	KIAMTTCEQIVRKDF HHHHHCHHHHHHHCC	41.05	22817900
1421 (in isoform 2)	Ubiquitination	-	41.05	21890473
1421 (in isoform 3)	Ubiquitination	-	41.05	21890473
1426	Ubiquitination	TCEQIVRKDFALDSE CHHHHHHHCCCCCCH	46.43	21906983
1426 (in isoform 1)	Ubiquitination	-	46.43	21890473
1426 (in isoform 4)	Ubiquitination	-	46.43	21890473
1432	Phosphorylation	RKDFALDSEESRMRI HHCCCCCCHHHHHHH	44.08	-
1479	Phosphorylation	SFASALRTASPQQRE HHHHHHHCCCHHHHH	32.13	29052541
1481	Phosphorylation	ASALRTASPQQREMM HHHHHCCCHHHHHHH	23.72	29052541
1491 (in isoform 4)	Phosphorylation	-	10.66	-
1503 (in isoform 4)	Phosphorylation	-	2.58	-
1514	Acetylation	IQKTAVEKAGPEMDK HHHHHHHHHCHHHHH	52.63	23749302
1514	Ubiquitination	IQKTAVEKAGPEMDK HHHHHHHHHCHHHHH	52.63	-
1525	Phosphorylation	EMDKRLATEFELRKH HHHHHHHHHHHHHHH	45.88	-
1541	Glutathionylation	RQEGRRYCDPVVLTY HHHCHHCCCCEEEEE	4.52	22555962
1547	Phosphorylation	YCDPVVLTYQAERMP CCCCEEEEEEHHCCC	11.28	20068231
1548	Phosphorylation	CDPVVLTYQAERMPE CCCEEEEEEHHCCCC	11.10	20068231
1555	Ubiquitination	YQAERMPEQIRLKVG EEHHCCCCCEEEEEC	49.66	29967540
1560	Ubiquitination	MPEQIRLKVGGVDPK CCCCEEEEECCCCHH	29.05	29967540
1562	Ubiquitination	EQIRLKVGGVDPKQL CCEEEEECCCCHHHH	28.90	22817900
1562 (in isoform 2)	Ubiquitination	-	28.90	21890473
1562 (in isoform 3)	Ubiquitination	-	28.90	21890473
1567	Ubiquitination	KVGGVDPKQLAVYEE EECCCCHHHHHHHHH	54.18	21906983
1567 (in isoform 1)	Ubiquitination	-	54.18	21890473
1572	Phosphorylation	DPKQLAVYEEFARNV CHHHHHHHHHHHHHC	12.25	27642862
1595	Ubiquitination	LSQPTGFLAQPMKQA CCCCCCCCCCCHHHH	4.59	22817900
1595 (in isoform 2)	Ubiquitination	-	4.59	21890473
1595 (in isoform 3)	Ubiquitination	-	4.59	21890473
1600	Ubiquitination	GFLAQPMKQAWATDD CCCCCCHHHHHCCHH	43.47	22817900
1600 (in isoform 1)	Ubiquitination	-	43.47	21890473
1612	Phosphorylation	TDDVAQIYDKCITEL CHHHHHHHHHHHHHH	9.40	27642862
1649	Phosphorylation	LLEVVVLSRNSRDAI HHHHHHHCCCCHHHH	20.15	20860994
1703	Phosphorylation	QDGRAYGSPWCNKQI HCCCCCCCHHHCHHH	11.53	20873877
1703	Ubiquitination	QDGRAYGSPWCNKQI HCCCCCCCHHHCHHH	11.53	23000965
1708	Acetylation	YGSPWCNKQITRCLI CCCHHHCHHHHHHHH	39.68	26051181
1708	Malonylation	YGSPWCNKQITRCLI CCCHHHCHHHHHHHH	39.68	26320211
1708	Ubiquitination	YGSPWCNKQITRCLI CCCHHHCHHHHHHHH	39.68	23000965
1775	Phosphorylation	ILLVDERSVAHVTEA HHCCCCCHHCCCCHH	22.93	20860994
1780	Phosphorylation	ERSVAHVTEADLFHT CCHHCCCCHHHHHHH	18.65	20860994
1787	Phosphorylation	TEADLFHTIETLMRI CHHHHHHHHHHHHHH	17.11	20860994
1790	Phosphorylation	DLFHTIETLMRINAH HHHHHHHHHHHHCCC	23.23	20860994
1817	Phosphorylation	MEVVRSNYEAMIDRA HHHHHHCHHHHHHHH	13.30	28796482
1834	Phosphorylation	GPNFMMHSGISQASE CCCCCCCCCCCCCCC	21.67	28555341
1837	Phosphorylation	FMMHSGISQASEYDD CCCCCCCCCCCCCCC	24.18	28555341
1842	Phosphorylation	GISQASEYDDPPGLR CCCCCCCCCCCCCHH	24.13	27642862
1846	Ubiquitination	ASEYDDPPGLREKAE CCCCCCCCCHHHHHH	62.54	27667366
1851	Ubiquitination	DPPGLREKAEYLLRE CCCCHHHHHHHHHHH	39.83	27667366
1863	Phosphorylation	LREWVNLYHSAAAGR HHHHHHHHHHHHCCC	6.63	21406692
1865	Phosphorylation	EWVNLYHSAAAGRDS HHHHHHHHHHCCCCC	13.17	21406692
1927	Sulfoxidation	NPAANPTMIRAKCYH CCCCCCHHHHHHHHC	1.74	21406390
1933	Phosphorylation	TMIRAKCYHNLDAFV HHHHHHHHCCHHHHH	7.95	19060867
1959	Ubiquitination	EATNTVTKINLLNKV CCCCHHHHHHHHHHH	25.84	-
2074	Phosphorylation	LLIDLFKYLAPFLRN HHHHHHHHHHHHHHC	10.76	20068231
2081	Ubiquitination	YLAPFLRNVELTKPM HHHHHHHCCCCCCCC	33.49	21890473
2081 (in isoform 2)	Ubiquitination	-	33.49	21890473
2081 (in isoform 3)	Ubiquitination	-	33.49	21890473
2086	Ubiquitination	LRNVELTKPMQILYK HHCCCCCCCCHHHHH	51.63	27667366
2086 (in isoform 1)	Ubiquitination	-	51.63	21890473
2146	Ubiquitination	NMRLPDPFTPNLKVD CCCCCCCCCCCCCCC	26.75	21963094
2146 (in isoform 2)	Ubiquitination	-	26.75	21890473
2151	Ubiquitination	DPFTPNLKVDMLSEI CCCCCCCCCCHHHHC	42.71	21906983
2151 (in isoform 1)	Ubiquitination	-	42.71	21890473
2154	Sulfoxidation	TPNLKVDMLSEINIA CCCCCCCHHHHCCCC	5.06	21406390
2172	Ubiquitination	LTNFTGVMPPQFKKD HHCCCCCCCCHHHHH	4.19	29967540
2173	Ubiquitination	TNFTGVMPPQFKKDL HCCCCCCCCHHHHHH	19.68	29967540
2177	Ubiquitination	GVMPPQFKKDLDSYL CCCCCHHHHHHHHHH	39.88	29967540
2178	Ubiquitination	VMPPQFKKDLDSYLK CCCCHHHHHHHHHHH	65.89	29967540
2180	Ubiquitination	PPQFKKDLDSYLKTR CCHHHHHHHHHHHCC	6.91	33845483
2180 (in isoform 2)	Ubiquitination	-	6.91	21890473
2185	Acetylation	KDLDSYLKTRSPVTF HHHHHHHHCCCCCCH	33.39	25953088
2185	Ubiquitination	KDLDSYLKTRSPVTF HHHHHHHHCCCCCCH	33.39	27667366
2185 (in isoform 1)	Ubiquitination	-	33.39	21890473
2186	Phosphorylation	DLDSYLKTRSPVTFL HHHHHHHCCCCCCHH	33.51	28450419
2188	Phosphorylation	DSYLKTRSPVTFLSD HHHHHCCCCCCHHHH	29.02	28450419
2191	Phosphorylation	LKTRSPVTFLSDLRS HHCCCCCCHHHHHHH	23.42	28450419
2194	Phosphorylation	RSPVTFLSDLRSNLQ CCCCCHHHHHHHCCC	30.33	26091039
2264	Phosphorylation	DLDTEGRYLFLNAIA CCCCCCCHHHHHHHH	16.80	-
2359	Ubiquitination	LFQSVAQCCMGQKQA HHHHHHHHHCCHHHH	0.93	29967540
2361	Sulfoxidation	QSVAQCCMGQKQAQQ HHHHHHHCCHHHHHH	9.30	21406390
2364	Ubiquitination	AQCCMGQKQAQQVME HHHHCCHHHHHHHHH	41.70	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CNOT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNOT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNOT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CNOT2_HUMAN	CNOT2	physical	10637334
CNOT4_HUMAN	CNOT4	physical	10637334
CNOT8_HUMAN	CNOT8	physical	10637334
CNOT4_HUMAN	CNOT4	physical	11823428
NOT4_YEAST	MOT2	physical	11823428
CNOT3_HUMAN	CNOT3	physical	22939629
CNOT9_HUMAN	RQCD1	physical	22939629
RPAC1_HUMAN	POLR1C	physical	22863883
CNOT2_HUMAN	CNOT2	physical	16778766
CNOT3_HUMAN	CNOT3	physical	16778766
CNOT8_HUMAN	CNOT8	physical	16778766
RXRA_HUMAN	RXRA	physical	16778766
ESR1_MOUSE	Esr1	physical	16778766
TNR6C_HUMAN	TNRC6C	physical	21981923
TNR6A_HUMAN	TNRC6A	physical	23172285
CNOT7_HUMAN	CNOT7	physical	26344197
ABCF1_HUMAN	ABCF1	physical	26496610
ATRX_HUMAN	ATRX	physical	26496610
CAZA1_HUMAN	CAPZA1	physical	26496610
CAZA2_HUMAN	CAPZA2	physical	26496610
CAPZB_HUMAN	CAPZB	physical	26496610
FHL2_HUMAN	FHL2	physical	26496610
CNOT2_HUMAN	CNOT2	physical	26496610
CNOT3_HUMAN	CNOT3	physical	26496610
RS27_HUMAN	RPS27	physical	26496610
SDCB1_HUMAN	SDCBP	physical	26496610
UBF1_HUMAN	UBTF	physical	26496610
CNOT9_HUMAN	RQCD1	physical	26496610
CNOT8_HUMAN	CNOT8	physical	26496610
TOB1_HUMAN	TOB1	physical	26496610
TOB2_HUMAN	TOB2	physical	26496610
BTG3_HUMAN	BTG3	physical	26496610
NUPL2_HUMAN	NUPL2	physical	26496610
CNO10_HUMAN	CNOT10	physical	26496610
IBTK_HUMAN	IBTK	physical	26496610
SND1_HUMAN	SND1	physical	26496610
AFF4_HUMAN	AFF4	physical	26496610
CNOT7_HUMAN	CNOT7	physical	26496610
AKIP_HUMAN	AURKAIP1	physical	26496610
P4K2A_HUMAN	PI4K2A	physical	26496610
CNO11_HUMAN	CNOT11	physical	26496610
CNOT6_HUMAN	CNOT6	physical	26496610
GPBL1_HUMAN	GPBP1L1	physical	26496610
RN219_HUMAN	RNF219	physical	26496610
INT5_HUMAN	INTS5	physical	26496610
TB182_HUMAN	TNKS1BP1	physical	26496610
RAVR1_HUMAN	RAVER1	physical	26496610
CNO6L_HUMAN	CNOT6L	physical	26496610
CNOT9_HUMAN	RQCD1	physical	24768540
DDX6_HUMAN	DDX6	physical	24768540
TNR6A_HUMAN	TNRC6A	physical	24768540
CNOT6_HUMAN	CNOT6	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteome profiling of Wnt3a-mediated signalingnetwork: indicating the involvement of ribonucleoside-diphosphatereductase M2 subunit phosphorylation at residue serine 20 in canonicalWnt signal transduction.";
Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S.,Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.;
Mol. Cell. Proteomics 6:1952-1967(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1933, AND MASSSPECTROMETRY.
PubMed: 17693683