CNOT4_HUMAN - dbPTM
CNOT4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CNOT4_HUMAN
UniProt AC O95628
Protein Name CCR4-NOT transcription complex subunit 4
Gene Name CNOT4
Organism Homo sapiens (Human).
Sequence Length 575
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. [PubMed: 11823428]
Protein Sequence MSRSPDAKEDPVECPLCMEPLEIDDINFFPCTCGYQICRFCWHRIRTDENGLCPACRKPYPEDPAVYKPLSQEELQRIKNEKKQKQNERKQKISENRKHLASVRVVQKNLVFVVGLSQRLADPEVLKRPEYFGKFGKIHKVVINNSTSYAGSQGPSASAYVTYIRSEDALRAIQCVNNVVVDGRTLKASLGTTKYCSYFLKNMQCPKPDCMYLHELGDEAASFTKEEMQAGKHQEYEQKLLQELYKLNPNFLQLSTGSVDKNKNKVTPLQRYDTPIDKPSDSLSIGNGDNSQQISNSDTPSPPPGLSKSNPVIPISSSNHSARSPFEGAVTESQSLFSDNFRHPNPIPSGLPPFPSSPQTSSDWPTAPEPQSLFTSETIPVSSSTDWQAAFGFGSSKQPEDDLGFDPFDVTRKALADLIEKELSVQDQPSLSPTSLQNSSSHTTTAKGPGSGFLHPAAATNANSLNSTFSVLPQRFPQFQQHRAVYNSFSFPGQAARYPWMAFPRNSIMHLNHTANPTSNSNFLDLNLPPQHNTGLGGIPVAGEEEVKVSTMPLSTSSHSLQQGQQPTSLHTTVA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSRSPDAKE
------CCCCCCCCC		41.2728464451
2 (in isoform 2)Phosphorylation-41.2721406692
4Phosphorylation----MSRSPDAKEDP
----CCCCCCCCCCC		21.5926657352
4 (in isoform 10)Phosphorylation-21.5927251275
67PhosphorylationYPEDPAVYKPLSQEE
CCCCCCCCCCCCHHH		14.7029214152
67 (in isoform 10)Phosphorylation-14.7027642862
71PhosphorylationPAVYKPLSQEELQRI
CCCCCCCCHHHHHHH		44.0317525332
71 (in isoform 10)Phosphorylation-44.0324719451
71 (in isoform 2)Phosphorylation-44.03-
71 (in isoform 8)Phosphorylation-44.03-
131PhosphorylationEVLKRPEYFGKFGKI
HHHCCHHHHCCCCCE		21.95-
185PhosphorylationNVVVDGRTLKASLGT
CEEECCCEEEEECCC		37.8328270605
189PhosphorylationDGRTLKASLGTTKYC
CCCEEEEECCCHHHH		26.2428270605
192PhosphorylationTLKASLGTTKYCSYF
EEEEECCCHHHHHHH		25.9628270605
193PhosphorylationLKASLGTTKYCSYFL
EEEECCCHHHHHHHH		20.4428270605
195PhosphorylationASLGTTKYCSYFLKN
EECCCHHHHHHHHHH		5.6428270605
197PhosphorylationLGTTKYCSYFLKNMQ
CCCHHHHHHHHHHCC		18.8128270605
198PhosphorylationGTTKYCSYFLKNMQC
CCHHHHHHHHHHCCC		14.9028270605
222PhosphorylationELGDEAASFTKEEMQ
ECCHHHHHCCHHHHH		40.2624719451
239UbiquitinationKHQEYEQKLLQELYK
CCHHHHHHHHHHHHH		38.94-
255PhosphorylationNPNFLQLSTGSVDKN
CCCCEECCCCCCCCC		20.1229507054
255 (in isoform 10)Phosphorylation-20.1227251275
256PhosphorylationPNFLQLSTGSVDKNK
CCCEECCCCCCCCCC		41.9130576142
256 (in isoform 2)Phosphorylation-41.9129507054
256 (in isoform 8)Phosphorylation-41.9129507054
256 (in isoform 9)Phosphorylation-41.9129507054
258PhosphorylationFLQLSTGSVDKNKNK
CEECCCCCCCCCCCC		27.5130576142
258 (in isoform 2)Phosphorylation-27.5121406692
258 (in isoform 8)Phosphorylation-27.5125159151
258 (in isoform 9)Phosphorylation-27.5125159151
267 (in isoform 2)Phosphorylation-21.6425849741
267 (in isoform 8)Phosphorylation-21.6425849741
267 (in isoform 9)Phosphorylation-21.6425849741
271 (in isoform 2)Phosphorylation-38.6925849741
271 (in isoform 8)Phosphorylation-38.6925849741
271 (in isoform 9)Phosphorylation-38.6925849741
277 (in isoform 2)Phosphorylation-59.0021406692
277 (in isoform 8)Phosphorylation-59.0021406692
277 (in isoform 9)Phosphorylation-59.0021406692
279 (in isoform 2)Phosphorylation-39.3521406692
279 (in isoform 8)Phosphorylation-39.3521406692
279 (in isoform 9)Phosphorylation-39.3521406692
281 (in isoform 2)Phosphorylation-63.2221406692
281 (in isoform 8)Phosphorylation-63.2221406692
281 (in isoform 9)Phosphorylation-63.2221406692
288 (in isoform 2)Phosphorylation-30.2023663014
288 (in isoform 8)Phosphorylation-30.2023663014
288 (in isoform 9)Phosphorylation-30.2023663014
291PhosphorylationSIGNGDNSQQISNSD
CCCCCCCCCCCCCCC		28.3527080861
292 (in isoform 2)Phosphorylation-51.3723663014
292 (in isoform 8)Phosphorylation-51.3723663014
292 (in isoform 9)Phosphorylation-51.3723663014
294 (in isoform 2)Phosphorylation-3.0623663014
294 (in isoform 8)Phosphorylation-3.0623663014
294 (in isoform 9)Phosphorylation-3.0623663014
295PhosphorylationGDNSQQISNSDTPSP
CCCCCCCCCCCCCCC		26.4125159151
296 (in isoform 2)Phosphorylation-45.6023663014
296 (in isoform 8)Phosphorylation-45.6023663014
296 (in isoform 9)Phosphorylation-45.6023663014
297PhosphorylationNSQQISNSDTPSPPP
CCCCCCCCCCCCCCC		35.7525159151
298 (in isoform 2)Phosphorylation-67.8723663014
298 (in isoform 8)Phosphorylation-67.8723663014
298 (in isoform 9)Phosphorylation-67.8723663014
299PhosphorylationQQISNSDTPSPPPGL
CCCCCCCCCCCCCCC		26.0325159151
301PhosphorylationISNSDTPSPPPGLSK
CCCCCCCCCCCCCCC		52.7325159151
301 (in isoform 10)Phosphorylation-52.7327251275
304 (in isoform 2)Phosphorylation-60.7923663014
304 (in isoform 8)Phosphorylation-60.7923663014
304 (in isoform 9)Phosphorylation-60.7923663014
306 (in isoform 2)Phosphorylation-7.80-
306 (in isoform 8)Phosphorylation-7.80-
307PhosphorylationPSPPPGLSKSNPVIP
CCCCCCCCCCCCEEE		39.7023663014
309O-linked_GlycosylationPPPGLSKSNPVIPIS
CCCCCCCCCCEEECC		42.8830059200
309PhosphorylationPPPGLSKSNPVIPIS
CCCCCCCCCCEEECC		42.8820068231
316O-linked_GlycosylationSNPVIPISSSNHSAR
CCCEEECCCCCCCCC		23.5130059200
316PhosphorylationSNPVIPISSSNHSAR
CCCEEECCCCCCCCC		23.5128464451
317O-linked_GlycosylationNPVIPISSSNHSARS
CCEEECCCCCCCCCC		35.5630059200
317PhosphorylationNPVIPISSSNHSARS
CCEEECCCCCCCCCC		35.5630576142
318O-linked_GlycosylationPVIPISSSNHSARSP
CEEECCCCCCCCCCC		31.6030059200
318PhosphorylationPVIPISSSNHSARSP
CEEECCCCCCCCCCC		31.6029507054
318 (in isoform 2)Phosphorylation-31.60-
318 (in isoform 8)Phosphorylation-31.60-
321O-linked_GlycosylationPISSSNHSARSPFEG
ECCCCCCCCCCCCCC		29.6330059200
321PhosphorylationPISSSNHSARSPFEG
ECCCCCCCCCCCCCC		29.6328464451
321 (in isoform 2)Phosphorylation-29.63-
321 (in isoform 8)Phosphorylation-29.63-
324O-linked_GlycosylationSSNHSARSPFEGAVT
CCCCCCCCCCCCCCC		33.3930059200
324PhosphorylationSSNHSARSPFEGAVT
CCCCCCCCCCCCCCC		33.3922167270
324 (in isoform 10)Phosphorylation-33.3924719451
328 (in isoform 2)Phosphorylation-26.23-
328 (in isoform 8)Phosphorylation-26.23-
331O-linked_GlycosylationSPFEGAVTESQSLFS
CCCCCCCCCCHHHCC		29.4130059200
331PhosphorylationSPFEGAVTESQSLFS
CCCCCCCCCCHHHCC		29.4128464451
333PhosphorylationFEGAVTESQSLFSDN
CCCCCCCCHHHCCCC		18.7228450419
335PhosphorylationGAVTESQSLFSDNFR
CCCCCCHHHCCCCCC		40.4328450419
338PhosphorylationTESQSLFSDNFRHPN
CCCHHHCCCCCCCCC		36.6228122231
349PhosphorylationRHPNPIPSGLPPFPS
CCCCCCCCCCCCCCC		54.4026074081
356PhosphorylationSGLPPFPSSPQTSSD
CCCCCCCCCCCCCCC		55.8426074081
357PhosphorylationGLPPFPSSPQTSSDW
CCCCCCCCCCCCCCC		22.6726074081
360PhosphorylationPFPSSPQTSSDWPTA
CCCCCCCCCCCCCCC		33.3226074081
361PhosphorylationFPSSPQTSSDWPTAP
CCCCCCCCCCCCCCC		22.5126074081
362PhosphorylationPSSPQTSSDWPTAPE
CCCCCCCCCCCCCCC		47.2726074081
375O-linked_GlycosylationPEPQSLFTSETIPVS
CCCCCCCCCCCCCCC		30.8330059200
396O-linked_GlycosylationAAFGFGSSKQPEDDL
HHHCCCCCCCCCCCC		35.3730059200
413UbiquitinationDPFDVTRKALADLIE
CHHHHHHHHHHHHHH		38.08-
424PhosphorylationDLIEKELSVQDQPSL
HHHHHHCCCCCCCCC		20.8729255136
429 (in isoform 2)Phosphorylation-45.5921406692
429 (in isoform 8)Phosphorylation-45.59-
430PhosphorylationLSVQDQPSLSPTSLQ
CCCCCCCCCCCCCCC		35.5323401153
432PhosphorylationVQDQPSLSPTSLQNS
CCCCCCCCCCCCCCC		30.3929255136
432 (in isoform 10)Phosphorylation-30.3924719451
434PhosphorylationDQPSLSPTSLQNSSS
CCCCCCCCCCCCCCC		38.4029255136
435O-linked_GlycosylationQPSLSPTSLQNSSSH
CCCCCCCCCCCCCCC		31.2030059200
435PhosphorylationQPSLSPTSLQNSSSH
CCCCCCCCCCCCCCC		31.2029255136
439PhosphorylationSPTSLQNSSSHTTTA
CCCCCCCCCCCCCCC		21.9123401153
440PhosphorylationPTSLQNSSSHTTTAK
CCCCCCCCCCCCCCC		33.4223927012
441PhosphorylationTSLQNSSSHTTTAKG
CCCCCCCCCCCCCCC		25.3623927012
443PhosphorylationLQNSSSHTTTAKGPG
CCCCCCCCCCCCCCC		27.9923927012
444PhosphorylationQNSSSHTTTAKGPGS
CCCCCCCCCCCCCCC		21.2323927012
445PhosphorylationNSSSHTTTAKGPGSG
CCCCCCCCCCCCCCC		27.7723927012
475Asymmetric dimethylarginineTFSVLPQRFPQFQQH
HHCCCCCCCHHHHHH		43.18-
475MethylationTFSVLPQRFPQFQQH
HHCCCCCCCHHHHHH		43.1824129315
483Asymmetric dimethylarginineFPQFQQHRAVYNSFS
CHHHHHHHHHHCCCC		22.78-
483MethylationFPQFQQHRAVYNSFS
CHHHHHHHHHHCCCC		22.7824129315
486PhosphorylationFQQHRAVYNSFSFPG
HHHHHHHHCCCCCCC		12.24-
488PhosphorylationQHRAVYNSFSFPGQA
HHHHHHCCCCCCCCH		12.4626852163
490PhosphorylationRAVYNSFSFPGQAAR
HHHHCCCCCCCCHHC		30.2824260401
490 (in isoform 10)Phosphorylation-30.2827251275
497Asymmetric dimethylarginineSFPGQAARYPWMAFP
CCCCCHHCCCCEECC		40.85-
497MethylationSFPGQAARYPWMAFP
CCCCCHHCCCCEECC		40.8524129315
505MethylationYPWMAFPRNSIMHLN
CCCEECCCCCCEECC		42.97-
556PhosphorylationVSTMPLSTSSHSLQQ
EEECCCCCCCCCCCC		41.7623186163
557PhosphorylationSTMPLSTSSHSLQQG
EECCCCCCCCCCCCC		23.7623186163
558PhosphorylationTMPLSTSSHSLQQGQ
ECCCCCCCCCCCCCC		19.7223186163
560PhosphorylationPLSTSSHSLQQGQQP
CCCCCCCCCCCCCCC		29.8023186163
597 (in isoform 4)Methylation--
604 (in isoform 8)Phosphorylation-28152594
607 (in isoform 4)Phosphorylation-28152594
607 (in isoform 8)Phosphorylation-28152594
608 (in isoform 8)Phosphorylation-28152594
610 (in isoform 4)Phosphorylation-28152594
611 (in isoform 4)Phosphorylation-28152594
611 (in isoform 8)Phosphorylation-28152594
614 (in isoform 4)Phosphorylation-28152594
618 (in isoform 8)Phosphorylation-28152594
621 (in isoform 4)Phosphorylation-28152594
624 (in isoform 8)Phosphorylation-28111955
626 (in isoform 8)Phosphorylation-21815630
627 (in isoform 4)Phosphorylation-28111955
628 (in isoform 8)Phosphorylation-21815630
629 (in isoform 4)Phosphorylation-21815630
631 (in isoform 4)Phosphorylation-21815630
641 (in isoform 4)Methylation--
675 (in isoform 9)Phosphorylation-28152594
678 (in isoform 10)Phosphorylation-28152594
678 (in isoform 9)Phosphorylation-28152594
679 (in isoform 9)Phosphorylation-28152594
681 (in isoform 10)Phosphorylation-28152594
682 (in isoform 10)Phosphorylation-28152594
682 (in isoform 9)Phosphorylation-28152594
685 (in isoform 10)Phosphorylation-28152594
689 (in isoform 9)Phosphorylation-28152594
692 (in isoform 10)Phosphorylation-28152594
695 (in isoform 9)Phosphorylation-28111955
697 (in isoform 9)Phosphorylation-21815630
698 (in isoform 10)Phosphorylation-28111955
699 (in isoform 9)Phosphorylation-21815630
700 (in isoform 10)Phosphorylation-21815630
702 (in isoform 10)Phosphorylation-21815630
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseCNOT4O95628
PMID:11823428
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CNOT4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CNOT4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KDM5C_HUMANKDM5Cphysical
19346402
UB2D2_HUMANUBE2D2physical
15001359
UB2E1_HUMANUBE2E1physical
15001359
UB2E3_HUMANUBE2E3physical
15001359
CNOT4_HUMANCNOT4physical
15001359
UB2D2_HUMANUBE2D2physical
11823428
UB2E1_HUMANUBE2E1physical
11823428
UB2E3_HUMANUBE2E3physical
11823428
UBC5_YEASTUBC5physical
11823428
CNOT4_HUMANCNOT4physical
11823428
UB2D1_HUMANUBE2D1physical
19346402
EP300_HUMANEP300physical
21988832
RBM15_HUMANRBM15physical
26575292
UB2D2_HUMANUBE2D2physical
26575292
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CNOT4_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-324; SER-432 ANDSER-490, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-324, AND MASSSPECTROMETRY.
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71, AND MASSSPECTROMETRY.

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