dbPTM

TB182_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TB182_HUMAN
UniProt AC	Q9C0C2
Protein Name	182 kDa tankyrase-1-binding protein
Gene Name	TNKS1BP1
Organism	Homo sapiens (Human).
Sequence Length	1729
Subcellular Localization	Nucleus. Cytoplasm, cytoskeleton. Chromosome. Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin.
Protein Description
Protein Sequence	MKVSTLRESSAMASPLPREMEEELVPTGSEPGDTRAKPPVKPKPRALPAKPALPAKPSLLVPVGPRPPRGPLAELPSARKMNMLAGPQPYGGSKRPLPFAPRPAVEASTGGEATQETGKEEAGKEEPPPLTPPARCAAPGGVRKAPAPFRPASERFAATTVEEILAKMEQPRKEVLASPDRLWGSRLTFNHDGSSRYGPRTYGTTTAPRDEDGSTLFRGWSQEGPVKSPAECREEHSKTPEERSLPSDLAFNGDLAKAASSELPADISKPWIPSSPAPSSENGGPASPGLPAEASGSGPGSPHLHPPDKSSPCHSQLLEAQTPEASQASPCPAVTPSAPSAALPDEGSRHTPSPGLPAEGAPEAPRPSSPPPEVLEPHSLDQPPATSPRPLIEVGELLDLTRTFPSGGEEEAKGDAHLRPTSLVQRRFSEGVLQSPSQDQEKLGGSLAALPQGQGSQLALDRPFGAESNWSLSQSFEWTFPTRPSGLGVWRLDSPPPSPITEASEAAEAAEAGNLAVSSREEGVSQQGQGAGSAPSGSGSSWVQGDDPSMSLTQKGDGESQPQFPAVPLEPLPTTEGTPGLPLQQAEERYESQEPLAGQESPLPLATREAALPILEPVLGQEQPAAPDQPCVLFADAPEPGQALPVEEEAVTLARAETTQARTEAQDLCRASPEPPGPESSSRWLDDLLASPPPSGGGARRGAGAELKDTQSPSTCSEGLLGWSQKDLQSEFGITGDPQPSSFSPSSWCQGASQDYGLGGASPRGDPGLGERDWTSKYGQGAGEGSTREWASRCGIGQEEMEASSSQDQSKVSAPGVLTAQDRVVGKPAQLGTQRSQEADVQDWEFRKRDSQGTYSSRDAELQDQEFGKRDSLGTYSSRDVSLGDWEFGKRDSLGAYASQDANEQGQDLGKRDHHGRYSSQDADEQDWEFQKRDVSLGTYGSRAAEPQEQEFGKSAWIRDYSSGGSSRTLDAQDRSFGTRPLSSGFSPEEAQQQDEEFEKKIPSVEDSLGEGSRDAGRPGERGSGGLFSPSTAHVPDGALGQRDQSSWQNSDASQEVGGHQERQQAGAQGPGSADLEDGEMGKRGWVGEFSLSVGPQREAAFSPGQQDWSRDFCIEASERSYQFGIIGNDRVSGAGFSPSSKMEGGHFVPPGKTTAGSVDWTDQLGLRNLEVSSCVGSGGSSEARESAVGQMGWSGGLSLRDMNLTGCLESGGSEEPGGIGVGEKDWTSDVNVKSKDLAEVGEGGGHSQARESGVGQTDWSGVEAGEFLKSRERGVGQADWTPDLGLRNMAPGAVCSPGESKELGVGQMDWGNNLGLRDLEVTCDPDSGGSQGLRGCGVGQMDWTQDLAPQNVELFGAPSEAREHGVGGVSQCPEPGLRHNGSLSPGLEARDPLEARELGVGETSGPETQGEDYSSSSLEPHPADPGMETGEALSFGASPGRCPARPPPSGSQGLLEEMLAASSSKAVARRESAASGLGGLLEEEGAGAGAAQEEVLEPGRDSPPSWRPQPDGEASQTEDVDGTWGSSAARWSDQGPAQTSRRPSQGPPARSPSQDFSFIEDTEILDSAMYRSRANLGRKRGHRAPVIRPGGTLGLSEAADSDAHLFQDSTEPRASRVPSSDEEVVEEPQSRRTRMSLGTKGLKVNLFPGLSPSALKAKLRPRNRSAEEGELAESKSSQKESAVQRSKSCKVPGLGKPLTLPPKPEKSSGSEGSSPNWLQALKLKKKKV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Methylation	------MKVSTLRES ------CCCCCCHHH	57.08	72610147
4	Phosphorylation	----MKVSTLRESSA ----CCCCCCHHHCC	32.57	30631047
5	Phosphorylation	---MKVSTLRESSAM ---CCCCCCHHHCCC	32.59	20044836
9	Phosphorylation	KVSTLRESSAMASPL CCCCCHHHCCCCCCC	19.57	25850435
10	Phosphorylation	VSTLRESSAMASPLP CCCCHHHCCCCCCCC	19.81	25850435
14	Phosphorylation	RESSAMASPLPREME HHHCCCCCCCCHHHH	17.55	20044836
27	Phosphorylation	MEEELVPTGSEPGDT HHHHHCCCCCCCCCC	45.95	28348404
29	Phosphorylation	EELVPTGSEPGDTRA HHHCCCCCCCCCCCC	43.00	24719451
50	Acetylation	KPRALPAKPALPAKP CCCCCCCCCCCCCCC	28.96	23954790
77	Phosphorylation	GPLAELPSARKMNML CCHHHCCCCCCCCCC	54.02	28674419
80	Ubiquitination	AELPSARKMNMLAGP HHCCCCCCCCCCCCC	34.05	-
90	Phosphorylation	MLAGPQPYGGSKRPL CCCCCCCCCCCCCCC	28.95	21406692
93	Phosphorylation	GPQPYGGSKRPLPFA CCCCCCCCCCCCCCC	22.56	21406692
108	Phosphorylation	PRPAVEASTGGEATQ CCCCEECCCCCCCCH	17.68	21406692
109	Phosphorylation	RPAVEASTGGEATQE CCCEECCCCCCCCHH	57.14	29978859
114	Phosphorylation	ASTGGEATQETGKEE CCCCCCCCHHCCCCC	23.72	29978859
117	Phosphorylation	GGEATQETGKEEAGK CCCCCHHCCCCCCCC	43.68	26657352
131	Phosphorylation	KEEPPPLTPPARCAA CCCCCCCCCCHHCCC	32.76	30266825
153	Phosphorylation	PAPFRPASERFAATT CCCCCCHHHHHCCCC	31.80	23312004
159	Phosphorylation	ASERFAATTVEEILA HHHHHCCCCHHHHHH	28.13	20068231
160	Phosphorylation	SERFAATTVEEILAK HHHHCCCCHHHHHHH	22.61	20068231
173	Methylation	AKMEQPRKEVLASPD HHCCCCHHHHCCCCC	59.88	116253719
178	Phosphorylation	PRKEVLASPDRLWGS CHHHHCCCCCCCCCC	24.15	29255136
185	Phosphorylation	SPDRLWGSRLTFNHD CCCCCCCCCEEECCC	16.72	23927012
188	Phosphorylation	RLWGSRLTFNHDGSS CCCCCCEEECCCCCC	22.68	24719451
194	Phosphorylation	LTFNHDGSSRYGPRT EEECCCCCCCCCCCC	20.07	24961811
195	Phosphorylation	TFNHDGSSRYGPRTY EECCCCCCCCCCCCC	34.74	28348404
201	Phosphorylation	SSRYGPRTYGTTTAP CCCCCCCCCCCCCCC	29.45	22115753
202	Phosphorylation	SRYGPRTYGTTTAPR CCCCCCCCCCCCCCC	17.47	22115753
204	Phosphorylation	YGPRTYGTTTAPRDE CCCCCCCCCCCCCCC	15.57	22115753
205	Phosphorylation	GPRTYGTTTAPRDED CCCCCCCCCCCCCCC	19.32	22115753
206	Phosphorylation	PRTYGTTTAPRDEDG CCCCCCCCCCCCCCC	34.21	22115753
214	Phosphorylation	APRDEDGSTLFRGWS CCCCCCCCEECCCCC	33.97	23403867
215	Phosphorylation	PRDEDGSTLFRGWSQ CCCCCCCEECCCCCC	35.13	23403867
221	Phosphorylation	STLFRGWSQEGPVKS CEECCCCCCCCCCCC	22.60	25159151
228	Phosphorylation	SQEGPVKSPAECREE CCCCCCCCHHHHHHH	29.58	30266825
237	Phosphorylation	AECREEHSKTPEERS HHHHHHHCCCHHHHC	41.31	23403867
239	Phosphorylation	CREEHSKTPEERSLP HHHHHCCCHHHHCCC	38.66	25159151
244	Phosphorylation	SKTPEERSLPSDLAF CCCHHHHCCCCHHHC	48.16	25159151
247	Phosphorylation	PEERSLPSDLAFNGD HHHHCCCCHHHCCCH	51.02	25072903
260	Phosphorylation	GDLAKAASSELPADI CHHHHHHHCCCCCCC	29.25	25849741
261	Phosphorylation	DLAKAASSELPADIS HHHHHHHCCCCCCCC	38.12	20068231
268	Phosphorylation	SELPADISKPWIPSS CCCCCCCCCCCCCCC	32.96	20873877
274	Phosphorylation	ISKPWIPSSPAPSSE CCCCCCCCCCCCCCC	39.56	20068231
275	Phosphorylation	SKPWIPSSPAPSSEN CCCCCCCCCCCCCCC	21.52	22199227
279	Phosphorylation	IPSSPAPSSENGGPA CCCCCCCCCCCCCCC	53.01	22199227
280	Phosphorylation	PSSPAPSSENGGPAS CCCCCCCCCCCCCCC	33.74	22199227
287	Phosphorylation	SENGGPASPGLPAEA CCCCCCCCCCCCCCC	23.72	28355574
295	Phosphorylation	PGLPAEASGSGPGSP CCCCCCCCCCCCCCC	25.62	25159151
297	Phosphorylation	LPAEASGSGPGSPHL CCCCCCCCCCCCCCC	39.04	25159151
301	Phosphorylation	ASGSGPGSPHLHPPD CCCCCCCCCCCCCCC	16.57	28355574
310	Phosphorylation	HLHPPDKSSPCHSQL CCCCCCCCCHHHHHH	47.06	23663014
311	Phosphorylation	LHPPDKSSPCHSQLL CCCCCCCCHHHHHHH	36.97	23663014
315	Phosphorylation	DKSSPCHSQLLEAQT CCCCHHHHHHHHCCC	29.28	23663014
322	Phosphorylation	SQLLEAQTPEASQAS HHHHHCCCCCHHHCC	30.09	23663014
326	Phosphorylation	EAQTPEASQASPCPA HCCCCCHHHCCCCCC	25.31	23663014
329	Phosphorylation	TPEASQASPCPAVTP CCCHHHCCCCCCCCC	21.28	23663014
335	Phosphorylation	ASPCPAVTPSAPSAA CCCCCCCCCCCCCCC	17.40	23663014
337	Phosphorylation	PCPAVTPSAPSAALP CCCCCCCCCCCCCCC	43.37	23663014
348	Phosphorylation	AALPDEGSRHTPSPG CCCCCCCCCCCCCCC	20.88	26074081
351	Phosphorylation	PDEGSRHTPSPGLPA CCCCCCCCCCCCCCC	25.09	29255136
353	Phosphorylation	EGSRHTPSPGLPAEG CCCCCCCCCCCCCCC	32.52	29255136
368	Phosphorylation	APEAPRPSSPPPEVL CCCCCCCCCCCCCCC	57.67	29255136
369	Phosphorylation	PEAPRPSSPPPEVLE CCCCCCCCCCCCCCC	44.07	29255136
379	Phosphorylation	PEVLEPHSLDQPPAT CCCCCCCCCCCCCCC	44.34	22167270
386	Phosphorylation	SLDQPPATSPRPLIE CCCCCCCCCCCCCEE	45.07	23663014
387	Phosphorylation	LDQPPATSPRPLIEV CCCCCCCCCCCCEEH	22.48	22167270
401	Phosphorylation	VGELLDLTRTFPSGG HHHHHHHCEECCCCC	27.59	20068231
406	Phosphorylation	DLTRTFPSGGEEEAK HHCEECCCCCCCHHC	56.06	21815630
421	Phosphorylation	GDAHLRPTSLVQRRF CCCCCCCCHHHHHHH	28.41	25159151
422	O-linked_Glycosylation	DAHLRPTSLVQRRFS CCCCCCCHHHHHHHC	29.26	23301498
422	Phosphorylation	DAHLRPTSLVQRRFS CCCCCCCHHHHHHHC	29.26	25159151
429	Phosphorylation	SLVQRRFSEGVLQSP HHHHHHHCCCCCCCC	31.46	29255136
435	Phosphorylation	FSEGVLQSPSQDQEK HCCCCCCCCCCCHHH	23.51	19664994
437	Phosphorylation	EGVLQSPSQDQEKLG CCCCCCCCCCHHHHC	52.19	29255136
446	Phosphorylation	DQEKLGGSLAALPQG CHHHHCCCCCCCCCC	17.03	26657352
456	Phosphorylation	ALPQGQGSQLALDRP CCCCCCCCCEEECCC	17.71	29255136
479	Phosphorylation	LSQSFEWTFPTRPSG CCCEEEEECCCCCCC	16.73	26074081
482	Phosphorylation	SFEWTFPTRPSGLGV EEEEECCCCCCCCCE	51.53	26074081
485	Phosphorylation	WTFPTRPSGLGVWRL EECCCCCCCCCEEEC	43.27	26657352
494	Phosphorylation	LGVWRLDSPPPSPIT CCEEECCCCCCCCCC	43.85	29255136
498	Phosphorylation	RLDSPPPSPITEASE ECCCCCCCCCCCHHH	34.41	29255136
501	Phosphorylation	SPPPSPITEASEAAE CCCCCCCCCHHHHHH	28.96	29255136
504	Phosphorylation	PSPITEASEAAEAAE CCCCCCHHHHHHHHH	22.87	29255136
518	Phosphorylation	EAGNLAVSSREEGVS HHCCEEEEECCCCCC	20.33	28355574
519	Phosphorylation	AGNLAVSSREEGVSQ HCCEEEEECCCCCCC	36.79	23927012
541	Phosphorylation	APSGSGSSWVQGDDP CCCCCCCCCCCCCCC	34.49	22067460
551	Phosphorylation	QGDDPSMSLTQKGDG CCCCCCCCCEECCCC	32.38	27251275
560	Phosphorylation	TQKGDGESQPQFPAV EECCCCCCCCCCCCC	53.33	24043423
574	Phosphorylation	VPLEPLPTTEGTPGL CCCCCCCCCCCCCCC	45.20	24719451
575	Phosphorylation	PLEPLPTTEGTPGLP CCCCCCCCCCCCCCC	30.40	28348404
578	Phosphorylation	PLPTTEGTPGLPLQQ CCCCCCCCCCCCHHH	14.14	18669648
590	Phosphorylation	LQQAEERYESQEPLA HHHHHHHHHCCCCCC	24.18	30266825
592	Phosphorylation	QAEERYESQEPLAGQ HHHHHHHCCCCCCCC	30.80	30266825
601	Phosphorylation	EPLAGQESPLPLATR CCCCCCCCCCCHHHH	24.69	19664994
607	Phosphorylation	ESPLPLATREAALPI CCCCCHHHHHHHCHH	36.40	23927012
659	Phosphorylation	TLARAETTQARTEAQ HHHHHHHHHHHHHHH	16.25	-
663	Phosphorylation	AETTQARTEAQDLCR HHHHHHHHHHHHHHH	38.39	23927012
672	Phosphorylation	AQDLCRASPEPPGPE HHHHHHCCCCCCCCC	15.50	29255136
680	Phosphorylation	PEPPGPESSSRWLDD CCCCCCCCHHHHHHH	36.43	23927012
681	Phosphorylation	EPPGPESSSRWLDDL CCCCCCCHHHHHHHH	23.43	23927012
682	Phosphorylation	PPGPESSSRWLDDLL CCCCCCHHHHHHHHH	36.43	23927012
691	Phosphorylation	WLDDLLASPPPSGGG HHHHHHHCCCCCCCC	37.60	19664994
695	Phosphorylation	LLASPPPSGGGARRG HHHCCCCCCCCCCCC	56.71	20201521
710	Phosphorylation	AGAELKDTQSPSTCS CCCCCCCCCCCCCCC	29.38	22167270
712	Phosphorylation	AELKDTQSPSTCSEG CCCCCCCCCCCCCCC	23.94	19664994
714	Phosphorylation	LKDTQSPSTCSEGLL CCCCCCCCCCCCCCC	47.49	22167270
715	Phosphorylation	KDTQSPSTCSEGLLG CCCCCCCCCCCCCCC	24.36	22167270
717	Phosphorylation	TQSPSTCSEGLLGWS CCCCCCCCCCCCCCC	34.48	30278072
724	Phosphorylation	SEGLLGWSQKDLQSE CCCCCCCCHHHHHHH	26.08	23403867
730	Phosphorylation	WSQKDLQSEFGITGD CCHHHHHHHHCCCCC	42.04	27080861
735	Phosphorylation	LQSEFGITGDPQPSS HHHHHCCCCCCCCCC	35.59	27080861
741	Phosphorylation	ITGDPQPSSFSPSSW CCCCCCCCCCCCCHH	38.47	20068231
742	Phosphorylation	TGDPQPSSFSPSSWC CCCCCCCCCCCCHHC	36.10	25159151
744	Phosphorylation	DPQPSSFSPSSWCQG CCCCCCCCCCHHCCC	26.31	25159151
746	Phosphorylation	QPSSFSPSSWCQGAS CCCCCCCCHHCCCCC	34.96	23663014
747	Phosphorylation	PSSFSPSSWCQGASQ CCCCCCCHHCCCCCC	34.94	23663014
753	Phosphorylation	SSWCQGASQDYGLGG CHHCCCCCCCCCCCC	30.34	23663014
756	Phosphorylation	CQGASQDYGLGGASP CCCCCCCCCCCCCCC	13.45	23663014
762	Phosphorylation	DYGLGGASPRGDPGL CCCCCCCCCCCCCCC	20.57	25159151
778	Phosphorylation	ERDWTSKYGQGAGEG CCCCHHCCCCCCCCC	17.91	-
786	Phosphorylation	GQGAGEGSTREWASR CCCCCCCCHHHHHHH	21.71	24719451
792	Phosphorylation	GSTREWASRCGIGQE CCHHHHHHHCCCCHH	29.22	21601212
804	Phosphorylation	GQEEMEASSSQDQSK CHHHHHHCCCCCCHH	19.74	27174698
805	Phosphorylation	QEEMEASSSQDQSKV HHHHHHCCCCCCHHC	38.78	27174698
806	Phosphorylation	EEMEASSSQDQSKVS HHHHHCCCCCCHHCC	34.97	17525332
810	Phosphorylation	ASSSQDQSKVSAPGV HCCCCCCHHCCCCCE	43.23	24719451
813	Phosphorylation	SQDQSKVSAPGVLTA CCCCHHCCCCCEECH	32.27	27174698
819	O-linked_Glycosylation	VSAPGVLTAQDRVVG CCCCCEECHHHHCCC	21.62	23301498
819	Phosphorylation	VSAPGVLTAQDRVVG CCCCCEECHHHHCCC	21.62	27174698
827	Malonylation	AQDRVVGKPAQLGTQ HHHHCCCCHHHCCCC	26.10	32601280
827	Ubiquitination	AQDRVVGKPAQLGTQ HHHHCCCCHHHCCCC	26.10	-
833	Phosphorylation	GKPAQLGTQRSQEAD CCHHHCCCCCCCCCC	29.42	23401153
836	Phosphorylation	AQLGTQRSQEADVQD HHCCCCCCCCCCCCC	23.66	19664994
851	Phosphorylation	WEFRKRDSQGTYSSR CCEEHHCCCCCCCCC	34.25	21945579
854	Phosphorylation	RKRDSQGTYSSRDAE EHHCCCCCCCCCCHH	16.76	21945579
855	Phosphorylation	KRDSQGTYSSRDAEL HHCCCCCCCCCCHHH	16.09	21945579
856	Phosphorylation	RDSQGTYSSRDAELQ HCCCCCCCCCCHHHC	20.80	21945579
857	Phosphorylation	DSQGTYSSRDAELQD CCCCCCCCCCHHHCC	24.62	21945579
869	2-Hydroxyisobutyrylation	LQDQEFGKRDSLGTY HCCCCCCCCCCCCCC	59.35	-
872	Phosphorylation	QEFGKRDSLGTYSSR CCCCCCCCCCCCCCC	32.50	25159151
875	Phosphorylation	GKRDSLGTYSSRDVS CCCCCCCCCCCCCCC	26.06	22167270
876	Phosphorylation	KRDSLGTYSSRDVSL CCCCCCCCCCCCCCC	11.66	27273156
877	Phosphorylation	RDSLGTYSSRDVSLG CCCCCCCCCCCCCCC	20.80	25159151
878	Phosphorylation	DSLGTYSSRDVSLGD CCCCCCCCCCCCCCC	23.30	30278072
882	Phosphorylation	TYSSRDVSLGDWEFG CCCCCCCCCCCCCCC	30.81	30266825
890	Ubiquitination	LGDWEFGKRDSLGAY CCCCCCCCCCCCCCC	59.35	-
893	Phosphorylation	WEFGKRDSLGAYASQ CCCCCCCCCCCCCCC	32.51	19664994
897	Phosphorylation	KRDSLGAYASQDANE CCCCCCCCCCCCHHH	12.65	30266825
899	Phosphorylation	DSLGAYASQDANEQG CCCCCCCCCCHHHHC	18.86	30266825
911	Acetylation	EQGQDLGKRDHHGRY HHCCCCCCCCCCCCC	63.05	26051181
911	Ubiquitination	EQGQDLGKRDHHGRY HHCCCCCCCCCCCCC	63.05	-
918	Phosphorylation	KRDHHGRYSSQDADE CCCCCCCCCCCCCCC	19.78	23927012
919	Phosphorylation	RDHHGRYSSQDADEQ CCCCCCCCCCCCCCC	21.84	25159151
920	Phosphorylation	DHHGRYSSQDADEQD CCCCCCCCCCCCCCC	24.12	23927012
932	Ubiquitination	EQDWEFQKRDVSLGT CCCCHHHHHCCCCCC	56.75	-
936	Phosphorylation	EFQKRDVSLGTYGSR HHHHHCCCCCCCCCC	25.93	21945579
939	Phosphorylation	KRDVSLGTYGSRAAE HHCCCCCCCCCCCCC	29.97	21945579
940	Phosphorylation	RDVSLGTYGSRAAEP HCCCCCCCCCCCCCH	16.00	21945579
942	Phosphorylation	VSLGTYGSRAAEPQE CCCCCCCCCCCCHHH	14.34	21945579
954	Methylation	PQEQEFGKSAWIRDY HHHHHHCCCEEEECC	42.18	115979813
954	Ubiquitination	PQEQEFGKSAWIRDY HHHHHHCCCEEEECC	42.18	-
955	Phosphorylation	QEQEFGKSAWIRDYS HHHHHCCCEEEECCC	29.25	21601212
961	Phosphorylation	KSAWIRDYSSGGSSR CCEEEECCCCCCCCC	8.55	21945579
962	Phosphorylation	SAWIRDYSSGGSSRT CEEEECCCCCCCCCC	27.13	21945579
963	Phosphorylation	AWIRDYSSGGSSRTL EEEECCCCCCCCCCC	40.73	23403867
966	Phosphorylation	RDYSSGGSSRTLDAQ ECCCCCCCCCCCCCC	21.85	21945579
967	Phosphorylation	DYSSGGSSRTLDAQD CCCCCCCCCCCCCCC	32.34	21945579
969	Phosphorylation	SSGGSSRTLDAQDRS CCCCCCCCCCCCCCC	30.82	23403867
976	Phosphorylation	TLDAQDRSFGTRPLS CCCCCCCCCCCCCCC	36.00	22167270
979	Phosphorylation	AQDRSFGTRPLSSGF CCCCCCCCCCCCCCC	27.40	22167270
983	Phosphorylation	SFGTRPLSSGFSPEE CCCCCCCCCCCCHHH	30.97	22167270
984	Phosphorylation	FGTRPLSSGFSPEEA CCCCCCCCCCCHHHH	52.09	22167270
987	Phosphorylation	RPLSSGFSPEEAQQQ CCCCCCCCHHHHHHH	34.62	22167270
1004	Phosphorylation	EFEKKIPSVEDSLGE HHHHHCCCHHHHCCC	41.43	30266825
1008	Phosphorylation	KIPSVEDSLGEGSRD HCCCHHHHCCCCCCC	25.43	30266825
1013	Phosphorylation	EDSLGEGSRDAGRPG HHHCCCCCCCCCCCC	23.76	30266825
1024	Phosphorylation	GRPGERGSGGLFSPS CCCCCCCCCCCCCCC	35.59	29255136
1029	Phosphorylation	RGSGGLFSPSTAHVP CCCCCCCCCCCCCCC	24.00	29255136
1031	Phosphorylation	SGGLFSPSTAHVPDG CCCCCCCCCCCCCCC	36.71	30266825
1032	Phosphorylation	GGLFSPSTAHVPDGA CCCCCCCCCCCCCCC	24.94	29255136
1043	Methylation	PDGALGQRDQSSWQN CCCCCCCCCCCCCCC	41.98	115388515
1046	Phosphorylation	ALGQRDQSSWQNSDA CCCCCCCCCCCCCCH	37.52	28450419
1047	Phosphorylation	LGQRDQSSWQNSDAS CCCCCCCCCCCCCHH	27.35	28192239
1051	Phosphorylation	DQSSWQNSDASQEVG CCCCCCCCCHHHHCC	21.32	28450419
1054	Phosphorylation	SWQNSDASQEVGGHQ CCCCCCHHHHCCCHH	31.68	21406692
1073	Phosphorylation	AGAQGPGSADLEDGE HCCCCCCCCCCCCCC	23.03	30278072
1091	Phosphorylation	RGWVGEFSLSVGPQR CCEEEEEEEEECCCC	18.55	27251275
1093	Phosphorylation	WVGEFSLSVGPQREA EEEEEEEEECCCCCC	24.67	21082442
1103	Phosphorylation	PQREAAFSPGQQDWS CCCCCCCCCCCCCCC	24.32	19664994
1110	Phosphorylation	SPGQQDWSRDFCIEA CCCCCCCCCCCEEHH	30.20	30266825
1118	Phosphorylation	RDFCIEASERSYQFG CCCEEHHHHCEEEEE	22.28	28857561
1121	Phosphorylation	CIEASERSYQFGIIG EEHHHHCEEEEEEEC	21.16	28796482
1122	Phosphorylation	IEASERSYQFGIIGN EHHHHCEEEEEEECC	17.68	28796482
1131	Methylation	FGIIGNDRVSGAGFS EEEECCCCCCCCCCC	28.62	115918681
1133	Phosphorylation	IIGNDRVSGAGFSPS EECCCCCCCCCCCCC	24.66	23927012
1138	Phosphorylation	RVSGAGFSPSSKMEG CCCCCCCCCCCCCCC	23.97	19664994
1140	Phosphorylation	SGAGFSPSSKMEGGH CCCCCCCCCCCCCCE	41.20	30266825
1141	Phosphorylation	GAGFSPSSKMEGGHF CCCCCCCCCCCCCEE	39.13	30266825
1154	O-linked_Glycosylation	HFVPPGKTTAGSVDW EECCCCCCCCCCCCC	28.00	23301498
1154	Phosphorylation	HFVPPGKTTAGSVDW EECCCCCCCCCCCCC	28.00	30266825
1155	Phosphorylation	FVPPGKTTAGSVDWT ECCCCCCCCCCCCCH	32.29	30266825
1158	Phosphorylation	PGKTTAGSVDWTDQL CCCCCCCCCCCHHHC	17.90	19664994
1162	Phosphorylation	TAGSVDWTDQLGLRN CCCCCCCHHHCCCCC	14.92	30266825
1173	Phosphorylation	GLRNLEVSSCVGSGG CCCCEEEEECCCCCC	14.51	21815630
1174	Phosphorylation	LRNLEVSSCVGSGGS CCCEEEEECCCCCCC	20.28	29396449
1178	Phosphorylation	EVSSCVGSGGSSEAR EEEECCCCCCCHHHH	21.42	25159151
1181	Phosphorylation	SCVGSGGSSEARESA ECCCCCCCHHHHHHH	28.64	25159151
1182	Phosphorylation	CVGSGGSSEARESAV CCCCCCCHHHHHHHH	38.25	18669648
1192	Sulfoxidation	RESAVGQMGWSGGLS HHHHHHHCCCCCCCC	4.96	30846556
1195	Phosphorylation	AVGQMGWSGGLSLRD HHHHCCCCCCCCCCC	19.77	27251275
1199	Phosphorylation	MGWSGGLSLRDMNLT CCCCCCCCCCCCCCC	25.32	28348404
1206	Phosphorylation	SLRDMNLTGCLESGG CCCCCCCCCCCCCCC	22.35	25159151
1211	Phosphorylation	NLTGCLESGGSEEPG CCCCCCCCCCCCCCC	35.19	28348404
1214	Phosphorylation	GCLESGGSEEPGGIG CCCCCCCCCCCCCCC	42.17	28348404
1228	Phosphorylation	GVGEKDWTSDVNVKS CCCCCCCCCCCCCCC	25.78	24719451
1229	Phosphorylation	VGEKDWTSDVNVKSK CCCCCCCCCCCCCCH	34.99	25056879
1234	Ubiquitination	WTSDVNVKSKDLAEV CCCCCCCCCHHHHHC	46.73	-
1248	Phosphorylation	VGEGGGHSQARESGV CCCCCCCHHHHHCCC	28.89	17525332
1253	Phosphorylation	GHSQARESGVGQTDW CCHHHHHCCCCCCCC	32.97	25159151
1258	Phosphorylation	RESGVGQTDWSGVEA HHCCCCCCCCCCCHH	33.24	29396449
1261	Phosphorylation	GVGQTDWSGVEAGEF CCCCCCCCCCHHHHH	35.45	22199227
1282	Phosphorylation	GVGQADWTPDLGLRN CCCCCCCCCCCCCCC	13.89	19664994
1297	Phosphorylation	MAPGAVCSPGESKEL CCCCCEECCCCCCCC	29.37	19664994
1301	Phosphorylation	AVCSPGESKELGVGQ CEECCCCCCCCCCCC	37.03	29255136
1309	Sulfoxidation	KELGVGQMDWGNNLG CCCCCCCCCCCCCCC	3.73	30846556
1323	Phosphorylation	GLRDLEVTCDPDSGG CCCCEEEEECCCCCC	11.21	23403867
1328	Phosphorylation	EVTCDPDSGGSQGLR EEEECCCCCCCCCCC	50.90	25159151
1331	Phosphorylation	CDPDSGGSQGLRGCG ECCCCCCCCCCCCCC	25.30	17525332
1337	Glutathionylation	GSQGLRGCGVGQMDW CCCCCCCCCCCCCCC	3.01	22555962
1342	Sulfoxidation	RGCGVGQMDWTQDLA CCCCCCCCCCCHHCC	3.69	30846556
1345	Phosphorylation	GVGQMDWTQDLAPQN CCCCCCCCHHCCCCC	14.13	-
1371	Phosphorylation	EHGVGGVSQCPEPGL HHCCCCCCCCCCCCC	29.37	23312004
1373	Glutathionylation	GVGGVSQCPEPGLRH CCCCCCCCCCCCCCC	2.99	22555962
1383	Phosphorylation	PGLRHNGSLSPGLEA CCCCCCCCCCCCCCC	30.87	29255136
1385	Phosphorylation	LRHNGSLSPGLEARD CCCCCCCCCCCCCCC	20.72	29255136
1405	Phosphorylation	ELGVGETSGPETQGE HCCCCCCCCCCCCCC	48.31	30576142
1409	Phosphorylation	GETSGPETQGEDYSS CCCCCCCCCCCCCCC	45.03	28176443
1414	Phosphorylation	PETQGEDYSSSSLEP CCCCCCCCCCCCCCC	13.22	28176443
1415	Phosphorylation	ETQGEDYSSSSLEPH CCCCCCCCCCCCCCC	35.75	30576142
1416	Phosphorylation	TQGEDYSSSSLEPHP CCCCCCCCCCCCCCC	20.09	18669648
1417	Phosphorylation	QGEDYSSSSLEPHPA CCCCCCCCCCCCCCC	32.76	28176443
1418	Phosphorylation	GEDYSSSSLEPHPAD CCCCCCCCCCCCCCC	38.40	28176443
1430	Phosphorylation	PADPGMETGEALSFG CCCCCCCCCCCCCCC	31.28	28176443
1435	Phosphorylation	METGEALSFGASPGR CCCCCCCCCCCCCCC	28.78	28176443
1439	Phosphorylation	EALSFGASPGRCPAR CCCCCCCCCCCCCCC	28.41	25159151
1450	Phosphorylation	CPARPPPSGSQGLLE CCCCCCCCCCHHHHH	57.77	23663014
1452	Phosphorylation	ARPPPSGSQGLLEEM CCCCCCCCHHHHHHH	25.97	17525332
1463	Phosphorylation	LEEMLAASSSKAVAR HHHHHHHHCCHHHHH	29.54	25159151
1464	Phosphorylation	EEMLAASSSKAVARR HHHHHHHCCHHHHHH	31.00	26074081
1465	Phosphorylation	EMLAASSSKAVARRE HHHHHHCCHHHHHHH	23.34	26074081
1473	Phosphorylation	KAVARRESAASGLGG HHHHHHHHHHHCHHH	27.59	30266825
1476	Phosphorylation	ARRESAASGLGGLLE HHHHHHHHCHHHHHH	33.98	30266825
1503	Phosphorylation	VLEPGRDSPPSWRPQ HCCCCCCCCCCCCCC	37.03	23322592
1506	Phosphorylation	PGRDSPPSWRPQPDG CCCCCCCCCCCCCCC	38.82	26471730
1516	Phosphorylation	PQPDGEASQTEDVDG CCCCCCCCCEECCCC	33.08	30576142
1518	Phosphorylation	PDGEASQTEDVDGTW CCCCCCCEECCCCCC	31.49	24275569
1533	Phosphorylation	GSSAARWSDQGPAQT CCCCCHHHCCCCCCC	17.95	22167270
1540	Phosphorylation	SDQGPAQTSRRPSQG HCCCCCCCCCCCCCC	26.72	23403867
1541	Phosphorylation	DQGPAQTSRRPSQGP CCCCCCCCCCCCCCC	17.76	23403867
1545	Phosphorylation	AQTSRRPSQGPPARS CCCCCCCCCCCCCCC	46.05	29255136
1552	Phosphorylation	SQGPPARSPSQDFSF CCCCCCCCCCCCCCC	30.89	27273156
1554	Phosphorylation	GPPARSPSQDFSFIE CCCCCCCCCCCCCCC	43.56	23927012
1558	Phosphorylation	RSPSQDFSFIEDTEI CCCCCCCCCCCCHHH	33.34	30278072
1563	Phosphorylation	DFSFIEDTEILDSAM CCCCCCCHHHHHHHH	16.49	23927012
1568	Phosphorylation	EDTEILDSAMYRSRA CCHHHHHHHHHHHHH	16.10	23663014
1570	Sulfoxidation	TEILDSAMYRSRANL HHHHHHHHHHHHHHC	3.11	30846556
1571	Phosphorylation	EILDSAMYRSRANLG HHHHHHHHHHHHHCC	12.73	27080861
1602	Phosphorylation	GLSEAADSDAHLFQD CCCHHCCCCCHHCCC	31.78	27251275
1610	Phosphorylation	DAHLFQDSTEPRASR CCHHCCCCCCCCHHC	24.72	28555341
1611	Phosphorylation	AHLFQDSTEPRASRV CHHCCCCCCCCHHCC	59.29	22817900
1616	Phosphorylation	DSTEPRASRVPSSDE CCCCCCHHCCCCCCH	34.78	23927012
1620	Phosphorylation	PRASRVPSSDEEVVE CCHHCCCCCCHHHHH	47.79	29255136
1621	Phosphorylation	RASRVPSSDEEVVEE CHHCCCCCCHHHHHC	42.86	29255136
1631	Phosphorylation	EVVEEPQSRRTRMSL HHHHCCHHHHCHHHH	34.15	23927012
1634	Phosphorylation	EEPQSRRTRMSLGTK HCCHHHHCHHHHCCC	29.61	28102081
1637	Phosphorylation	QSRRTRMSLGTKGLK HHHHCHHHHCCCCCE	21.98	21815630
1640	Phosphorylation	RTRMSLGTKGLKVNL HCHHHHCCCCCEEEC	27.51	28102081
1641	Acetylation	TRMSLGTKGLKVNLF CHHHHCCCCCEEECC	61.52	25953088
1641	Methylation	TRMSLGTKGLKVNLF CHHHHCCCCCEEECC	61.52	115979789
1644	Methylation	SLGTKGLKVNLFPGL HHCCCCCEEECCCCC	37.43	24129315
1644	Ubiquitination	SLGTKGLKVNLFPGL HHCCCCCEEECCCCC	37.43	-
1652	Phosphorylation	VNLFPGLSPSALKAK EECCCCCCHHHHHHH	23.79	29255136
1654	Phosphorylation	LFPGLSPSALKAKLR CCCCCCHHHHHHHHC	42.74	29255136
1657	Methylation	GLSPSALKAKLRPRN CCCHHHHHHHHCCCC	43.10	115979797
1657	Ubiquitination	GLSPSALKAKLRPRN CCCHHHHHHHHCCCC	43.10	-
1666	Phosphorylation	KLRPRNRSAEEGELA HHCCCCCCHHHHHHH	43.51	29255136
1675	Phosphorylation	EEGELAESKSSQKES HHHHHHCCHHHHHHH	32.03	28258704
1677	Phosphorylation	GELAESKSSQKESAV HHHHCCHHHHHHHHH	47.48	29496963
1678	Phosphorylation	ELAESKSSQKESAVQ HHHCCHHHHHHHHHH	49.35	26434776
1687	Phosphorylation	KESAVQRSKSCKVPG HHHHHHHHHCCCCCC	16.30	23927012
1689	Phosphorylation	SAVQRSKSCKVPGLG HHHHHHHCCCCCCCC	22.03	30576142
1697	Acetylation	CKVPGLGKPLTLPPK CCCCCCCCCCCCCCC	41.73	26051181
1700	Phosphorylation	PGLGKPLTLPPKPEK CCCCCCCCCCCCCCC	45.83	21406692
1708	Phosphorylation	LPPKPEKSSGSEGSS CCCCCCCCCCCCCCC	37.97	30266825
1709	Phosphorylation	PPKPEKSSGSEGSSP CCCCCCCCCCCCCCC	58.36	30266825
1711	Phosphorylation	KPEKSSGSEGSSPNW CCCCCCCCCCCCCHH	40.51	30266825
1714	Phosphorylation	KSSGSEGSSPNWLQA CCCCCCCCCCHHHHH	38.27	30266825
1715	Phosphorylation	SSGSEGSSPNWLQAL CCCCCCCCCHHHHHH	32.86	19664994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
691	S	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TB182_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TB182_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNKS1_HUMAN	TNKS	physical	11854288
TNKS1_HUMAN	TNKS	physical	12080061
RABX5_HUMAN	RABGEF1	physical	22863883
CNOT2_HUMAN	CNOT2	physical	27173435
CNOT6_HUMAN	CNOT6	physical	27173435
CNO11_HUMAN	CNOT11	physical	27173435
CNOT7_HUMAN	CNOT7	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TB182_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-429; SER-494; SER-601;SER-691; SER-836; SER-1138; SER-1620; SER-1621 AND SER-1666, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-504; SER-518; SER-601;SER-691 AND SER-1666, AND MASS SPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-435; SER-601; SER-672;SER-712; SER-714; SER-836; SER-1138; SER-1141; THR-1282; SER-1616;SER-1620; SER-1621; SER-1652 AND SER-1715, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1620 AND SER-1621, ANDMASS SPECTROMETRY.	18318008 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178; SER-221; SER-228;THR-239; SER-287; SER-301; SER-429; SER-435; SER-494; SER-498;SER-601; SER-672; SER-691; SER-695; SER-712; SER-744; SER-762;SER-836; SER-872; SER-893; SER-920; SER-936; SER-976; THR-979;SER-983; SER-987; SER-1008; SER-1029; SER-1103; SER-1133; SER-1138;SER-1178; SER-1181; THR-1282; SER-1297; SER-1328; SER-1331; SER-1383;SER-1385; SER-1405; SER-1439; SER-1473; SER-1476; SER-1533; SER-1545;SER-1552; SER-1558; THR-1563; SER-1620; SER-1621; SER-1652 ANDSER-1666, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-437; SER-601; SER-672;SER-691; SER-836; SER-1103; SER-1141 AND SER-1652, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1024 AND SER-1029, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-601; SER-672 ANDSER-691, AND MASS SPECTROMETRY.	18187866 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221; SER-806; SER-836;SER-1248; SER-1331; SER-1452 AND SER-1554, AND MASS SPECTROMETRY.	17525332 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1654, AND MASSSPECTROMETRY.	17924679 [Abstract]
"Toward a global characterization of the phosphoproteome in prostatecancer cells: identification of phosphoproteins in the LNCaP cellline."; Giorgianni F., Zhao Y., Desiderio D.M., Beranova-Giorgianni S.; Electrophoresis 28:2027-2034(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1620 AND SER-1621, ANDMASS SPECTROMETRY.	17487921 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-672; SER-691; SER-695;SER-836; SER-1103; SER-1138; SER-1620; SER-1621 AND SER-1666, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-228; SER-672; THR-833;SER-836; SER-872; SER-936; SER-1093; SER-1383; SER-1385; SER-1620;SER-1621 AND SER-1666, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Global phosphoproteome of HT-29 human colon adenocarcinoma cells."; Kim J.-E., Tannenbaum S.R., White F.M.; J. Proteome Res. 4:1339-1346(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1666, AND MASSSPECTROMETRY.	16083285 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-601; SER-672; SER-691;SER-1138; SER-1383; SER-1385 AND SER-1621, AND MASS SPECTROMETRY.	15302935 [Abstract]