CNOT6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNOT6_HUMAN
• UniProt AC: Q9ULM6
• Protein Name: CCR4-NOT transcription complex subunit 6
• Gene Name: CNOT6
• Organism: Homo sapiens (Human).
• Sequence Length: 557
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence..
• Protein Sequence: MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEPDRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQEVETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANAHMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSGVVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYTNYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLELLLPFLPQVNGIHLPGRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	PPDPRRMYTIMSSEE CCCHHHCEEEECHHH	7.42	23663014
16	Phosphorylation	PDPRRMYTIMSSEEA CCHHHCEEEECHHHH	10.81	23663014
19	Phosphorylation	RRMYTIMSSEEAANG HHCEEEECHHHHHCC	30.65	23663014
20	Phosphorylation	RMYTIMSSEEAANGK HCEEEECHHHHHCCC	23.29	23663014
37	Phosphorylation	HWAELEISGKVRSLS CEEEEEECHHHHHHH	24.16	28787133
42	Phosphorylation	EISGKVRSLSASLWS EECHHHHHHHHHHHH	29.66	-
49	Phosphorylation	SLSASLWSLTHLTAL HHHHHHHHHHHHHHH	28.78	-
54	Phosphorylation	LWSLTHLTALHLSDN HHHHHHHHHHHCCCC	21.40	-
118	Ubiquitination	VLPFELGKLFQLQTL HHCHHHHHHHCHHHC	59.77	-
128	Ubiquitination	QLQTLGLKGNPLTQD CHHHCCCCCCCCHHH	55.64	-
146	Phosphorylation	LYQEPDGTRRLLNYL HHCCCCHHHHHHHHH	21.72	21082442
152	Phosphorylation	GTRRLLNYLLDNLSG HHHHHHHHHHHHCCC	14.49	23403867
158	Phosphorylation	NYLLDNLSGTAKRIT HHHHHHCCCCCCCCC	40.11	23403867
160	Phosphorylation	LLDNLSGTAKRITTE HHHHCCCCCCCCCCC	26.15	23403867
162	Ubiquitination	DNLSGTAKRITTEQP HHCCCCCCCCCCCCC	44.14	21906983
173	Phosphorylation	TEQPPPRSWIMLQEP CCCCCCCCEEEECCC	27.08	-
201	Phosphorylation	YNVLCDKYATRQLYG HHHHHHHHHHHHHHC	10.43	-
212	Phosphorylation	QLYGYCPSWALNWDY HHHCCCCHHHHCCHH	22.78	-
264	Phosphorylation	RGYNGFFSPKSRART CCCCCCCCHHHHCCC	29.20	24719451
266	Ubiquitination	YNGFFSPKSRARTMS CCCCCCHHHHCCCCC	51.91	-
278	Ubiquitination	TMSEQERKHVDGCAI CCCHHHHHCCCCEEE	47.42	-
289	Phosphorylation	GCAIFFKTEKFTLVQ CEEEEEECCEEEEEE	38.97	-
291	Ubiquitination	AIFFKTEKFTLVQKH EEEEECCEEEEEEEE	49.21	-
343	Phosphorylation	KESIEMPSGKPHLGT HHHCCCCCCCCCCCC	59.13	27251275
345	Ubiquitination	SIEMPSGKPHLGTEK HCCCCCCCCCCCCCH	33.33	-
389	Ubiquitination	EVKNIIDKASRNLKS HHHHHHHHHHHHHHH	37.54	-
391	Phosphorylation	KNIIDKASRNLKSSV HHHHHHHHHHHHHHH	27.69	23612710
442	Phosphorylation	KDFKELRYNESLTNF HHHHHHHCCCCCCCE	35.59	29496907
445	Phosphorylation	KELRYNESLTNFSCH HHHHCCCCCCCEEEE	36.53	20873877
447	Phosphorylation	LRYNESLTNFSCHGK HHCCCCCCCEEEECC	43.42	20873877
454	Ubiquitination	TNFSCHGKNGTTNGR CCEEEECCCCCCCCC	28.65	-
533	Phosphorylation	LIPSDHFSLFAQLEL CCCCCHHHHHHHHHH	21.11	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CNOT6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNOT6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNOT6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CNOT1_HUMAN	CNOT1	physical	17452450
CNOT2_HUMAN	CNOT2	physical	17452450
CNOT3_HUMAN	CNOT3	physical	17452450
CAF1A_HUMAN	CHAF1A	physical	17452450
CNOT9_HUMAN	RQCD1	physical	17452450
TB182_HUMAN	TNKS1BP1	physical	17452450
CNO10_HUMAN	CNOT10	physical	17452450
CNO11_HUMAN	CNOT11	physical	27173435
CNO10_HUMAN	CNOT10	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.