dbPTM

RAVR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RAVR1_HUMAN
UniProt AC	Q8IY67
Protein Name	Ribonucleoprotein PTB-binding 1
Gene Name	RAVER1
Organism	Homo sapiens (Human).
Sequence Length	606
Subcellular Localization	Nucleus. Cytoplasm. Nuclear, in perinucleolar structures. Shuttles between nucleus and cytoplasm. Cytoplasm, at focal contacts and cell-cell contacts. Associated with myotubes during muscle differentiation (By similarity)..
Protein Description	Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity)..
Protein Sequence	MAADVSVTHRPPLSPKSGAEVEAGDAAERRAPEEELPPLDPEEIRKRLEHTERQFRNRRKILIRGLPGDVTNQEVHDLLSDYELKYCFVDKYKGTAFVTLLNGEQAEAAINAFHQSRLRERELSVQLQPTDALLCVANLPPSLTQQQFEELVRPFGSLERCFLVYSERTGQSKGYGFAEYMKKDSAARAKSDLLGKPLGPRTLYVHWTDAGQLTPALLHSRCLCVDRLPPGFNDVDALCRALSAVHSPTFCQLACGQDGQLKGFAVLEYETAEMAEEAQQQADGLSLGGSHLRVSFCAPGPPGRSMLAALIAAQATALNRGKGLLPEPNILQLLNNLGPSASLQLLLNPLLHGSAGGKQGLLGAPPAMPLLNGPALSTALLQLALQTQGQKKPGILGDSPLGALQPGAQPANPLLGELPAGGGLPPELPPRRGKPPPLLPSVLGPAGGDREALGLGPPAAQLTPPPAPVGLRGSGLRGPLSHFYSGSPTSYFTSGLQAGLKQSHLSKAIGSSPLGSGEGLLGLSPGPNGHSHLLKVRAGGGDMQGWEAPAPQRPLTRPALPSVSRPHWAARNAALPTCCPRPSPAQKAAMWASTPRASAATTRTPT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAADVSVTH ------CCCCCEECC	16.63	20068231
6	Phosphorylation	--MAADVSVTHRPPL --CCCCCEECCCCCC	23.11	25159151
8	Phosphorylation	MAADVSVTHRPPLSP CCCCCEECCCCCCCC	12.50	21955146
14	Phosphorylation	VTHRPPLSPKSGAEV ECCCCCCCCCCCCEE	35.74	29255136
16 (in isoform 3)	Ubiquitination	-	59.14	21890473
17	Phosphorylation	RPPLSPKSGAEVEAG CCCCCCCCCCEEECC	46.77	29255136
17 (in isoform 2)	Phosphorylation	-	46.77	18669648
23	Phosphorylation	KSGAEVEAGDAAERR CCCCEEECCCHHHHC	26.75	17081983
25	Phosphorylation	GAEVEAGDAAERRAP CCEEECCCHHHHCCC	50.05	17081983
30	Methylation	AGDAAERRAPEEELP CCCHHHHCCCHHHCC	46.10	115490363
31	Phosphorylation	GDAAERRAPEEELPP CCHHHHCCCHHHCCC	23.29	18691976
33	Sumoylation	AAERRAPEEELPPLD HHHHCCCHHHCCCCC	64.22	-
34	Phosphorylation	AERRAPEEELPPLDP HHHCCCHHHCCCCCH	64.87	18669648
47	Methylation	DPEEIRKRLEHTERQ CHHHHHHHHHHHHHH	35.14	-
80	Phosphorylation	QEVHDLLSDYELKYC HHHHHHHHCCEEEEE	45.50	-
82	Phosphorylation	VHDLLSDYELKYCFV HHHHHHCCEEEEEEE	21.56	-
86	Phosphorylation	LSDYELKYCFVDKYK HHCCEEEEEEEECCC	12.07	28152594
91	2-Hydroxyisobutyrylation	LKYCFVDKYKGTAFV EEEEEEECCCCEEEE	43.49	-
91	Acetylation	LKYCFVDKYKGTAFV EEEEEEECCCCEEEE	43.49	26822725
92	Phosphorylation	KYCFVDKYKGTAFVT EEEEEECCCCEEEEE	15.36	-
97	Phosphorylation	DKYKGTAFVTLLNGE ECCCCEEEEEEECHH	4.30	-
99	Phosphorylation	YKGTAFVTLLNGEQA CCCEEEEEEECHHHH	21.05	-
102	Ubiquitination	TAFVTLLNGEQAEAA EEEEEEECHHHHHHH	55.88	-
103	Phosphorylation	AFVTLLNGEQAEAAI EEEEEECHHHHHHHH	28.50	-
108	Ubiquitination	LNGEQAEAAINAFHQ ECHHHHHHHHHHHHH	19.36	-
109	Phosphorylation	NGEQAEAAINAFHQS CHHHHHHHHHHHHHH	6.25	-
157	Phosphorylation	ELVRPFGSLERCFLV HHHHHCCCCCEEEEE	27.69	26091039
175	Phosphorylation	RTGQSKGYGFAEYMK CCCCCCCCCHHHHHH	16.89	18083107
185	Phosphorylation	AEYMKKDSAARAKSD HHHHHHCHHHHHHHH	32.48	28634120
190	Sumoylation	KDSAARAKSDLLGKP HCHHHHHHHHHCCCC	38.66	-
190	Ubiquitination	KDSAARAKSDLLGKP HCHHHHHHHHHCCCC	38.66	-
191	Phosphorylation	DSAARAKSDLLGKPL CHHHHHHHHHCCCCC	32.29	20873877
196	Ubiquitination	AKSDLLGKPLGPRTL HHHHHCCCCCCCCEE	36.72	-
196 (in isoform 1)	Ubiquitination	-	36.72	21890473
207	Sumoylation	PRTLYVHWTDAGQLT CCEEEEEECCHHHCC	5.97	-
207	Ubiquitination	PRTLYVHWTDAGQLT CCEEEEEECCHHHCC	5.97	-
213	Ubiquitination	HWTDAGQLTPALLHS EECCHHHCCHHHHHC	6.40	-
213 (in isoform 2)	Ubiquitination	-	6.40	21890473
214	Phosphorylation	WTDAGQLTPALLHSR ECCHHHCCHHHHHCC	9.91	-
231	Phosphorylation	CVDRLPPGFNDVDAL ECCCCCCCCCHHHHH	31.86	-
243	Phosphorylation	DALCRALSAVHSPTF HHHHHHHHHHCCCCE	27.53	27067055
297	Glutathionylation	SHLRVSFCAPGPPGR CEEEEEEECCCCCCH	3.30	22555962
399	Phosphorylation	KPGILGDSPLGALQP CCCCCCCCCCCCCCC	21.89	29496963
416	Phosphorylation	QPANPLLGELPAGGG CCCCCCCCCCCCCCC	41.92	-
441	Phosphorylation	KPPPLLPSVLGPAGG CCCCCCHHHCCCCCC	29.91	24732914
451	Ubiquitination	GPAGGDREALGLGPP CCCCCCHHHCCCCCC	53.65	-
458	Phosphorylation	EALGLGPPAAQLTPP HHCCCCCCHHHCCCC	38.13	20068231
463	Phosphorylation	GPPAAQLTPPPAPVG CCCHHHCCCCCCCCC	22.97	29255136
463 (in isoform 2)	Phosphorylation	-	22.97	18669648
472	Methylation	PPAPVGLRGSGLRGP CCCCCCCCCCCCCCC	31.16	54558519
474	Phosphorylation	APVGLRGSGLRGPLS CCCCCCCCCCCCCCH	28.37	29496963
474 (in isoform 2)	Phosphorylation	-	28.37	20068231
477	Methylation	GLRGSGLRGPLSHFY CCCCCCCCCCCHHHC	48.48	81452779
480	Phosphorylation	GSGLRGPLSHFYSGS CCCCCCCCHHHCCCC	7.47	19664995
483 (in isoform 2)	Phosphorylation	-	4.70	30266825
485	Phosphorylation	GPLSHFYSGSPTSYF CCCHHHCCCCCCHHH	31.67	20068231
487	Phosphorylation	LSHFYSGSPTSYFTS CHHHCCCCCCHHHHH	21.04	22496350
488 (in isoform 2)	Phosphorylation	-	28.96	30266825
489	Phosphorylation	HFYSGSPTSYFTSGL HHCCCCCCHHHHHHH	37.44	25627689
491	Phosphorylation	YSGSPTSYFTSGLQA CCCCCCHHHHHHHHH	17.22	20068231
493 (in isoform 2)	Phosphorylation	-	17.41	30266825
501	Methylation	SGLQAGLKQSHLSKA HHHHHHHCHHHHHHH	49.16	115985349
502 (in isoform 2)	Phosphorylation	-	40.92	28111955
505	Phosphorylation	AGLKQSHLSKAIGSS HHHCHHHHHHHHCCC	7.32	20068231
507	Acetylation	LKQSHLSKAIGSSPL HCHHHHHHHHCCCCC	50.84	30591765
509 (in isoform 2)	Phosphorylation	-	6.72	25884760
510	Phosphorylation	SHLSKAIGSSPLGSG HHHHHHHCCCCCCCC	27.25	20068231
511	Phosphorylation	HLSKAIGSSPLGSGE HHHHHHCCCCCCCCC	23.75	25159151
512	Phosphorylation	LSKAIGSSPLGSGEG HHHHHCCCCCCCCCC	20.94	25159151
514 (in isoform 2)	Phosphorylation	-	10.35	28442448
516	Phosphorylation	IGSSPLGSGEGLLGL HCCCCCCCCCCCCCC	41.16	25159151
524	Phosphorylation	GEGLLGLSPGPNGHS CCCCCCCCCCCCCCC	26.47	29255136
531	Phosphorylation	SPGPNGHSHLLKVRA CCCCCCCCEEEEEEE	19.75	29255136
544 (in isoform 2)	Phosphorylation	-	59.60	-
553 (in isoform 2)	Phosphorylation	-	27.43	28985074
554 (in isoform 2)	Phosphorylation	-	32.60	25262027
556 (in isoform 2)	Phosphorylation	-	36.97	25627689
562	Phosphorylation	LTRPALPSVSRPHWA CCCCCCCCCCCCCHH	33.31	-
563 (in isoform 2)	Phosphorylation	-	5.48	22199227
567 (in isoform 2)	Phosphorylation	-	26.20	19664994
570 (in isoform 2)	Phosphorylation	-	10.48	30266825
571 (in isoform 2)	Phosphorylation	-	26.10	25159151
574 (in isoform 2)	Ubiquitination	-	20.02	21890473
577	Phosphorylation	ARNAALPTCCPRPSP HHCCCCCCCCCCCCH	27.82	28555341
580	Phosphorylation	AALPTCCPRPSPAQK CCCCCCCCCCCHHHH	54.05	20068231
581	Methylation	ALPTCCPRPSPAQKA CCCCCCCCCCHHHHH	30.34	115490355
581 (in isoform 2)	Phosphorylation	-	30.34	27251275
583	Phosphorylation	PTCCPRPSPAQKAAM CCCCCCCCHHHHHHH	33.86	21712546
583 (in isoform 2)	Phosphorylation	-	33.86	29116813
584	Phosphorylation	TCCPRPSPAQKAAMW CCCCCCCHHHHHHHH	41.20	19664994
584 (in isoform 2)	Phosphorylation	-	41.20	27251275
585 (in isoform 2)	Phosphorylation	-	28.04	29116813
587	Methylation	PRPSPAQKAAMWAST CCCCHHHHHHHHHCC	39.97	115976315
588 (in isoform 2)	Phosphorylation	-	7.17	21552520
590 (in isoform 2)	Phosphorylation	-	3.52	29116813
594	Phosphorylation	KAAMWASTPRASAAT HHHHHHCCCCCCCCC	14.73	-
596	Methylation	AMWASTPRASAATTR HHHHCCCCCCCCCCC	41.06	115490351
601	Phosphorylation	TPRASAATTRTPT-- CCCCCCCCCCCCC--	19.27	29396449
602	Phosphorylation	PRASAATTRTPT--- CCCCCCCCCCCC---	28.02	29396449
604	Phosphorylation	ASAATTRTPT----- CCCCCCCCCC-----	29.23	29396449
634	Phosphorylation	----------------------------------- -----------------------------------		20166139
638	Phosphorylation	--------------------------------------- ---------------------------------------		19651622
648	Phosphorylation	------------------------------------------------- -------------------------------------------------		20068231
658	Phosphorylation	----------------------------------------------------------- -----------------------------------------------------------		20068231
660	Phosphorylation	------------------------------------------------------------- -------------------------------------------------------------		20068231
674	Methylation	--------------------------------------------------------------------------- ---------------------------------------------------------------------------		-
684	Phosphorylation	------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------		20068231
685	Phosphorylation	-------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------		20068231
689	Phosphorylation	------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------		20068231
697	Phosphorylation	-------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------		20068231
704	Phosphorylation	--------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------		20068231
724	Phosphorylation	----------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------		20068231
728	Phosphorylation	--------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------		20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
700	S	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RAVR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RAVR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PUR4_HUMAN	PFAS	physical	26344197
GORS2_HUMAN	GORASP2	physical	27173435
UBAP2_HUMAN	UBAP2	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RAVR1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-14 AND THR-463, AND MASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-14 AND THR-463, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17; THR-463; SER-474;SER-512 AND SER-524, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-567(ISOFORM 2), AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; THR-463; SER-512 ANDSER-524, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-567; SER-617;SER-707 AND SER-711 (ISOFORM 2), AND MASS SPECTROMETRY.	18691976 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, AND MASSSPECTROMETRY.	17081983 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-463, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-463, AND MASSSPECTROMETRY.	15302935 [Abstract]