TNR6C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNR6C_HUMAN
• UniProt AC: Q9HCJ0
• Protein Name: Trinucleotide repeat-containing gene 6C protein
• Gene Name: TNRC6C
• Organism: Homo sapiens (Human).
• Sequence Length: 1690
• Protein Description: Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes..
• Protein Sequence: MATGSAQGNFTGHTKKTNGNNGTNGALVQSPSNQSALGAGGANSNGSAARVWGVATGSSSGLAHCSVSGGDGKMDTMIGDGRSQNCWGASNSNAGINLNLNPNANPAAWPVLGHEGTVATGNPSSICSPVSAIGQNMGNQNGNPTGTLGAWGNLLPQESTEPQTSTSQNVSFSAQPQNLNTDGPNNTNPMNSSPNPINAMQTNGLPNWGMAVGMGAIIPPHLQGLPGANGSSVSQVSGGSAEGISNSVWGLSPGNPATGNSNSGFSQGNGDTVNSALSAKQNGSSSAVQKEGSGGNAWDSGPPAGPGILAWGRGSGNNGVGNIHSGAWGHPSRSTSNGVNGEWGKPPNQHSNSDINGKGSTGWESPSVTSQNPTVQPGGEHMNSWAKAASSGTTASEGSSDGSGNHNEGSTGREGTGEGRRRDKGIIDQGHIQLPRNDLDPRVLSNTGWGQTPVKQNTAWEFEESPRSERKNDNGTEAWGCAATQASNSGGKNDGSIMNSTNTSSVSGWVNAPPAAVPANTGWGDSNNKAPSGPGVWGDSISSTAVSTAAAAKSGHAWSGAANQEDKSPTWGEPPKPKSQHWGDGQRSNPAWSAGGGDWADSSSVLGHLGDGKKNGSGWDADSNRSGSGWNDTTRSGNSGWGNSTNTKANPGTNWGETLKPGPQQNWASKPQDNNVSNWGGAASVKQTGTGWIGGPVPVKQKDSSEATGWEEPSPPSIRRKMEIDDGTSAWGDPSNYNNKTVNMWDRNNPVIQSSTTTNTTTTTTTTTSNTTHRVETPPPHQAGTQLNRSPLLGPGRKVSSGWGEMPNVHSKTENSWGEPSSPSTLVDNGTAAWGKPPSSGSGWGDHPAEPPVAFGRAGAPVAASALCKPASKSMQEGWGSGGDEMNLSTSQWEDEEGDVWNNAASQESTSSCSSWGNAPKKGLQKGMKTSGKQDEAWIMSRLIKQLTDMGFPREPAEEALKSNNMNLDQAMSALLEKKVDVDKRGLGVTDHNGMAAKPLGCRPPISKESSVDRPTFLDKDGGLVEEPTPSPFLPSPSLKLPLSHSALPSQALGGIASGLGMQNLNSSRQIPSGNLGMFGNSGAAQARTMQQPPQPPVQPLNSSQPSLRAQVPQFLSPQVQAQLLQFAAKNIGLNPALLTSPINPQHMTMLNQLYQLQLAYQRLQIQQQMLQAQRNVSGSMRQQEQQVARTITNLQQQIQQHQRQLAQALLVKQPPPPPPPPHLSLHPSAGKSAMDSFPSHPQTPGLPDLQTKEQQSSPNTFAPYPLAGLNPNMNVNSMDMTGGLSVKDPSQSQSRLPQWTHPNSMDNLPSAASPLEQNPSKHGAIPGGLSIGPPGKSSIDDSYGRYDLIQNSESPASPPVAVPHSWSRAKSDSDKISNGSSINWPPEFHPGVPWKGLQNIDPENDPDVTPGSVPTGPTINTTIQDVNRYLLKSGGKLSDIKSTWSSGPTSHTQASLSHELWKVPRNSTAPTRPPPGLTNPKPSSTWGASPLGWTSSYSSGSAWSTDTSGRTSSWLVLRNLTPQIDGSTLRTLCLQHGPLITFHLNLTQGNAVVRYSSKEEAAKAQKSLHMCVLGNTTILAEFAGEEEVNRFLAQGQALPPTSSWQSSSASSQPRLSAAGSSHGLVRSDAGHWNAPCLGGKGSSELLWGGVPQYSSSLWGPPSADDSRVIGSPTPLTTLLPGDLLSGESL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	GSAQGNFTGHTKKTN CCCCCCCCCCCCCCC	31.86	23403867
14	Phosphorylation	QGNFTGHTKKTNGNN CCCCCCCCCCCCCCC	35.26	23403867
313	Methylation	PGILAWGRGSGNNGV CCEEEECCCCCCCCC	25.96	24129315
315	Phosphorylation	ILAWGRGSGNNGVGN EEEECCCCCCCCCCC	36.67	-
360	Phosphorylation	SDINGKGSTGWESPS CCCCCCCCCCCCCCC	27.51	27732954
361	Phosphorylation	DINGKGSTGWESPSV CCCCCCCCCCCCCCC	55.79	27732954
365	Phosphorylation	KGSTGWESPSVTSQN CCCCCCCCCCCCCCC	18.90	27732954
367	Phosphorylation	STGWESPSVTSQNPT CCCCCCCCCCCCCCC	47.51	27732954
369	Phosphorylation	GWESPSVTSQNPTVQ CCCCCCCCCCCCCCC	29.00	27732954
370	Phosphorylation	WESPSVTSQNPTVQP CCCCCCCCCCCCCCC	26.29	27732954
374	Phosphorylation	SVTSQNPTVQPGGEH CCCCCCCCCCCCCCC	39.04	27732954
390	Phosphorylation	NSWAKAASSGTTASE HHHHHHHHCCCCCCC	33.87	20068231
391	Phosphorylation	SWAKAASSGTTASEG HHHHHHHCCCCCCCC	35.12	20068231
393	Phosphorylation	AKAASSGTTASEGSS HHHHHCCCCCCCCCC	22.57	28450419
394	Phosphorylation	KAASSGTTASEGSSD HHHHCCCCCCCCCCC	31.54	28450419
396	Phosphorylation	ASSGTTASEGSSDGS HHCCCCCCCCCCCCC	40.16	28450419
399	Phosphorylation	GTTASEGSSDGSGNH CCCCCCCCCCCCCCC	22.62	28450419
400	Phosphorylation	TTASEGSSDGSGNHN CCCCCCCCCCCCCCC	57.77	28450419
403	Phosphorylation	SEGSSDGSGNHNEGS CCCCCCCCCCCCCCC	41.22	28450419
410	Phosphorylation	SGNHNEGSTGREGTG CCCCCCCCCCCCCCC	22.85	28450419
411	Phosphorylation	GNHNEGSTGREGTGE CCCCCCCCCCCCCCC	51.63	28450419
452	Phosphorylation	SNTGWGQTPVKQNTA HCCCCCCCCCCCCCC	26.55	28985074
455	Acetylation	GWGQTPVKQNTAWEF CCCCCCCCCCCCEEE	38.75	7693241
458	Phosphorylation	QTPVKQNTAWEFEES CCCCCCCCCEEECCC	30.56	28634120
465	Phosphorylation	TAWEFEESPRSERKN CCEEECCCCCHHCCC	20.58	30266825
468	Phosphorylation	EFEESPRSERKNDNG EECCCCCHHCCCCCC	45.17	23403867
532	O-linked_Glycosylation	DSNNKAPSGPGVWGD CCCCCCCCCCCCCCC	63.58	28411811
554	Phosphorylation	STAAAAKSGHAWSGA HHHHHHHCCCCCCCC	30.96	24117733
559	Phosphorylation	AKSGHAWSGAANQED HHCCCCCCCCCCCCC	21.24	24117733
568	Phosphorylation	AANQEDKSPTWGEPP CCCCCCCCCCCCCCC	39.62	25159151
570	Phosphorylation	NQEDKSPTWGEPPKP CCCCCCCCCCCCCCC	53.87	28464451
579	Phosphorylation	GEPPKPKSQHWGDGQ CCCCCCCCCCCCCCC	35.49	-
588	Phosphorylation	HWGDGQRSNPAWSAG CCCCCCCCCCCCCCC	39.00	-
593	Phosphorylation	QRSNPAWSAGGGDWA CCCCCCCCCCCCCCC	21.10	-
626	Phosphorylation	WDADSNRSGSGWNDT CCCCCCCCCCCCCCC	41.37	20068231
628	Phosphorylation	ADSNRSGSGWNDTTR CCCCCCCCCCCCCCC	41.71	20068231
633	Phosphorylation	SGSGWNDTTRSGNSG CCCCCCCCCCCCCCC	22.39	20068231
634	Phosphorylation	GSGWNDTTRSGNSGW CCCCCCCCCCCCCCC	26.21	20068231
644	Phosphorylation	GNSGWGNSTNTKANP CCCCCCCCCCCCCCC	21.06	-
645	Phosphorylation	NSGWGNSTNTKANPG CCCCCCCCCCCCCCC	51.40	-
647	Phosphorylation	GWGNSTNTKANPGTN CCCCCCCCCCCCCCC	31.46	-
704	Phosphorylation	VPVKQKDSSEATGWE EECCCCCCCCCCCCC	36.79	23403867
705	Phosphorylation	PVKQKDSSEATGWEE ECCCCCCCCCCCCCC	41.19	23403867
708	Phosphorylation	QKDSSEATGWEEPSP CCCCCCCCCCCCCCC	38.48	23403867
714	Phosphorylation	ATGWEEPSPPSIRRK CCCCCCCCCHHHCCC	53.36	23401153
717	Phosphorylation	WEEPSPPSIRRKMEI CCCCCCHHHCCCEEE	31.92	30266825
737	Phosphorylation	AWGDPSNYNNKTVNM CCCCCCCCCCCCCCC	25.17	24245541
741	Phosphorylation	PSNYNNKTVNMWDRN CCCCCCCCCCCCCCC	21.16	25394399
777	Phosphorylation	NTTHRVETPPPHQAG CCEEEECCCCCCCCC	37.93	26657352
777 (in isoform 2)	Phosphorylation	-	37.93	28348404
785 (in isoform 2)	Phosphorylation	-	32.66	28348404
790	Phosphorylation	AGTQLNRSPLLGPGR CCCCCCCCCCCCCCC	20.87	28348404
790 (in isoform 2)	Phosphorylation	-	20.87	28188228
798	Acetylation	PLLGPGRKVSSGWGE CCCCCCCCCCCCCCC	53.00	7926141
800	Phosphorylation	LGPGRKVSSGWGEMP CCCCCCCCCCCCCCC	26.60	28348404
801	Phosphorylation	GPGRKVSSGWGEMPN CCCCCCCCCCCCCCC	41.37	28348404
812	Acetylation	EMPNVHSKTENSWGE CCCCCCCCCCCCCCC	45.00	7926149
818	Phosphorylation	SKTENSWGEPSSPST CCCCCCCCCCCCCCE	36.44	27251275
821	Phosphorylation	ENSWGEPSSPSTLVD CCCCCCCCCCCEEEE	51.05	27251275
822	Phosphorylation	NSWGEPSSPSTLVDN CCCCCCCCCCEEEEC	33.32	27251275
824	Phosphorylation	WGEPSSPSTLVDNGT CCCCCCCCEEEECCC	36.00	27251275
872	Phosphorylation	SALCKPASKSMQEGW HHHHCCCCHHHHCCC	33.52	-
941	Phosphorylation	QDEAWIMSRLIKQLT HHHHHHHHHHHHHHH	18.14	23403867
978	Acetylation	AMSALLEKKVDVDKR HHHHHHHHCCCCCCC	59.05	7685239
1008	Phosphorylation	GCRPPISKESSVDRP CCCCCCCCCCCCCCC	63.44	24719451
1010	Phosphorylation	RPPISKESSVDRPTF CCCCCCCCCCCCCCE	39.12	26657352
1011	Phosphorylation	PPISKESSVDRPTFL CCCCCCCCCCCCCEE	29.18	25159151
1016	Phosphorylation	ESSVDRPTFLDKDGG CCCCCCCCEECCCCC	37.41	29496963
1029	Phosphorylation	GGLVEEPTPSPFLPS CCCCCCCCCCCCCCC	39.41	29255136
1031	Phosphorylation	LVEEPTPSPFLPSPS CCCCCCCCCCCCCCC	30.66	26074081
1033	Phosphorylation	EEPTPSPFLPSPSLK CCCCCCCCCCCCCCC	21.51	27251275
1036	Phosphorylation	TPSPFLPSPSLKLPL CCCCCCCCCCCCCCC	29.30	29255136
1038	Phosphorylation	SPFLPSPSLKLPLSH CCCCCCCCCCCCCCC	42.34	29255136
1088	Methylation	NSGAAQARTMQQPPQ CCHHHHHCCCCCCCC	20.74	115918713
1107	Phosphorylation	PLNSSQPSLRAQVPQ CCCCCCCCHHHCCCH	23.89	21955146
1109	Dimethylation	NSSQPSLRAQVPQFL CCCCCCHHHCCCHHH	27.58	-
1109	Methylation	NSSQPSLRAQVPQFL CCCCCCHHHCCCHHH	27.58	30763329
1240	Phosphorylation	SAMDSFPSHPQTPGL CHHHHCCCCCCCCCC	45.87	28555341
1241	Phosphorylation	AMDSFPSHPQTPGLP HHHHCCCCCCCCCCC	20.80	24719451
1244	Phosphorylation	SFPSHPQTPGLPDLQ HCCCCCCCCCCCCCC	24.63	27251275
1302	Phosphorylation	SRLPQWTHPNSMDNL CCCCCCCCCCCCCCC	19.31	27251275
1305	Phosphorylation	PQWTHPNSMDNLPSA CCCCCCCCCCCCCCC	31.78	28348404
1308	Phosphorylation	THPNSMDNLPSAASP CCCCCCCCCCCCCCC	45.25	24719451
1311	Phosphorylation	NSMDNLPSAASPLEQ CCCCCCCCCCCCCCC	39.37	24719451
1314	Phosphorylation	DNLPSAASPLEQNPS CCCCCCCCCCCCCCC	29.72	25159151
1321	Phosphorylation	SPLEQNPSKHGAIPG CCCCCCCCCCCCCCC	44.85	27732954
1347	Phosphorylation	IDDSYGRYDLIQNSE CCCCCCCCHHHCCCC	15.67	26074081
1353	Phosphorylation	RYDLIQNSESPASPP CCHHHCCCCCCCCCC	24.07	30266825
1355	Phosphorylation	DLIQNSESPASPPVA HHHCCCCCCCCCCCC	26.11	28464451
1358	Phosphorylation	QNSESPASPPVAVPH CCCCCCCCCCCCCCC	32.87	30266825
1366	Phosphorylation	PPVAVPHSWSRAKSD CCCCCCCCCCCCCCC	22.22	27080861
1368	Phosphorylation	VAVPHSWSRAKSDSD CCCCCCCCCCCCCCC	25.94	26074081
1413	Phosphorylation	DPDVTPGSVPTGPTI CCCCCCCCCCCCCCC	26.57	22210691
1419	Phosphorylation	GSVPTGPTINTTIQD CCCCCCCCCCCCHHH	28.36	22210691
1430	Phosphorylation	TIQDVNRYLLKSGGK CHHHHHHHHHHCCCC	15.93	29083192
1431	Phosphorylation	IQDVNRYLLKSGGKL HHHHHHHHHHCCCCH	4.36	27251275
1431 (in isoform 2)	Phosphorylation	-	4.36	28348404
1434	Phosphorylation	VNRYLLKSGGKLSDI HHHHHHHCCCCHHHC	53.39	29083192
1434 (in isoform 2)	Phosphorylation	-	53.39	28348404
1435 (in isoform 2)	Phosphorylation	-	35.35	28348404
1437	Acetylation	YLLKSGGKLSDIKST HHHHCCCCHHHCHHH	48.63	25953088
1438 (in isoform 2)	Phosphorylation	-	6.68	28348404
1439	Phosphorylation	LKSGGKLSDIKSTWS HHCCCCHHHCHHHCC	40.55	29083192
1439 (in isoform 2)	Phosphorylation	-	40.55	28348404
1444	Phosphorylation	KLSDIKSTWSSGPTS CHHHCHHHCCCCCCC	25.10	30576142
1447	O-linked_Glycosylation	DIKSTWSSGPTSHTQ HCHHHCCCCCCCCCC	40.11	28411811
1451	O-linked_Glycosylation	TWSSGPTSHTQASLS HCCCCCCCCCCCHHH	27.89	28411811
1453	O-linked_Glycosylation	SSGPTSHTQASLSHE CCCCCCCCCCHHHHH	26.12	28411811
1453	Phosphorylation	SSGPTSHTQASLSHE CCCCCCCCCCHHHHH	26.12	30576142
1456	O-linked_Glycosylation	PTSHTQASLSHELWK CCCCCCCHHHHHHHC	22.16	28411811
1458	Phosphorylation	SHTQASLSHELWKVP CCCCCHHHHHHHCCC	16.66	30576142
1528	Phosphorylation	LTPQIDGSTLRTLCL CCCCCCHHHHHHHHH	22.11	-
1529	Phosphorylation	TPQIDGSTLRTLCLQ CCCCCHHHHHHHHHH	26.28	-
1532	Phosphorylation	IDGSTLRTLCLQHGP CCHHHHHHHHHHCCC	25.57	-
1602	O-linked_Glycosylation	QGQALPPTSSWQSSS CCCCCCCCCCCCCCC	33.19	28411811
1603	O-linked_Glycosylation	GQALPPTSSWQSSSA CCCCCCCCCCCCCCC	35.04	28411811
1604	O-linked_Glycosylation	QALPPTSSWQSSSAS CCCCCCCCCCCCCCC	31.45	28411811
1607	O-linked_Glycosylation	PPTSSWQSSSASSQP CCCCCCCCCCCCCCC	21.72	28411811
1617	Phosphorylation	ASSQPRLSAAGSSHG CCCCCCHHHCCCCCC	19.83	28555341
1621	Phosphorylation	PRLSAAGSSHGLVRS CCHHHCCCCCCCCCC	17.90	29759185
1622	Phosphorylation	RLSAAGSSHGLVRSD CHHHCCCCCCCCCCC	22.21	29759185
1628	Phosphorylation	SSHGLVRSDAGHWNA CCCCCCCCCCCCCCC	25.08	20068231
1658	Phosphorylation	VPQYSSSLWGPPSAD CCCCCCCCCCCCCCC	7.09	27251275
1672	Phosphorylation	DDSRVIGSPTPLTTL CCCCCCCCCCCCCCC	17.93	25627689
1674	Phosphorylation	SRVIGSPTPLTTLLP CCCCCCCCCCCCCCC	32.40	29496963
1677	O-linked_Glycosylation	IGSPTPLTTLLPGDL CCCCCCCCCCCCCCC	19.32	28411811
1677	Phosphorylation	IGSPTPLTTLLPGDL CCCCCCCCCCCCCCC	19.32	28985074
1678	O-linked_Glycosylation	GSPTPLTTLLPGDLL CCCCCCCCCCCCCCC	33.70	28411811
1678	Phosphorylation	GSPTPLTTLLPGDLL CCCCCCCCCCCCCCC	33.70	26074081
1686	Phosphorylation	LLPGDLLSGESL--- CCCCCCCCCCCC---	48.05	27251275
1689	Phosphorylation	GDLLSGESL------ CCCCCCCCC------	42.79	24719451
1710	Phosphorylation	--------------------------- ---------------------------		24719451
1725	Phosphorylation	------------------------------------------ ------------------------------------------		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNR6C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNR6C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNR6C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PABP1_HUMAN	PABPC1	physical	21063388
PABP1_HUMAN	PABPC1	physical	20098421
PABP1_HUMAN	PABPC1	physical	19716330
AGO2_HUMAN	AGO2	physical	24778252
HNRL2_HUMAN	HNRNPUL2	physical	24778252
AGO3_HUMAN	AGO3	physical	24778252
AGO1_HUMAN	AGO1	physical	24778252
PABP1_HUMAN	PABPC1	physical	21984184
PABP4_HUMAN	PABPC4	physical	21984184
CNOT1_HUMAN	CNOT1	physical	21984184
CNO10_HUMAN	CNOT10	physical	21984184
CNOT3_HUMAN	CNOT3	physical	21984184
CNOT8_HUMAN	CNOT8	physical	21984184
CNOT6_HUMAN	CNOT6	physical	21984184
PAN2_HUMAN	PAN2	physical	21984184
PAN3_HUMAN	PAN3	physical	21984184
PABP1_HUMAN	PABPC1	physical	23340509
CNOT1_HUMAN	CNOT1	physical	21981923
CNOT2_HUMAN	CNOT2	physical	21981923
CNOT6_HUMAN	CNOT6	physical	21981923
CNO6L_HUMAN	CNOT6L	physical	21981923
CNOT7_HUMAN	CNOT7	physical	21981923
CNOT8_HUMAN	CNOT8	physical	21981923
CNOT3_HUMAN	CNOT3	physical	21981923
PAN3_HUMAN	PAN3	physical	21981923
PAN2_HUMAN	PAN2	physical	21981923
PABP1_HUMAN	PABPC1	physical	21981923
AGO1_HUMAN	AGO1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-714, AND MASSSPECTROMETRY.
PubMed: 19690332