PAN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAN3_HUMAN
• UniProt AC: Q58A45
• Protein Name: PAN2-PAN3 deadenylation complex subunit PAN3 {ECO:0000255|HAMAP-Rule:MF_03181}
• Gene Name: PAN3 {ECO:0000255|HAMAP-Rule:MF_03181}
• Organism: Homo sapiens (Human).
• Sequence Length: 887
• Subcellular Localization: Cytoplasm, P-body .
• Protein Description: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins..
• Protein Sequence: MNSGGGLPPPSAAASPSSSSLAAAVAVVAPPGVGGVPGGAAVGVKLKYCRYYAKDKTCFYGEECQFLHEDPAAGAAPGLGLHSNSVPLALAGAPVAGFPPGAVAGGGAGPPPGPKKPDLGDPGTGAAAGGGGSSGGLDGPRLAIPGMDGGALTDTSLTDSYFSTSFIGVNGFGSPVETKYPLMQRMTNSSSSPSLLNDSAKPYSAHDPLTSPASSLFNDFGALNISQRRKPRKYRLGMLEERLVPMGSKARKAKNPIGCLADRCKSGVPINMVWWNRVTENNLQTPNPTASEFIPKGGSTSRLSNVSQSNMSAFSQVFSHPSMGSPATAGLAPGMSLSAGSSPLHSPKITPHTSPAPRRRSHTPNPASYMVPSSASTSVNNPVSQTPSSGQVIQKETVGGTTYFYTDTTPAPLTGMVFPNYHIYPPTAPHVAYMQPKANAPSFFMADELRQELINRHLITMAQIDQADMPAVPTEVDSYHSLFPLEPLPPPNRIQKSSNFGYITSCYKAVNSKDDLPYCLRRIHGFRLVNTKCMVLVDMWKKIQHSNIVTLREVFTTKAFAEPSLVFAYDFHAGGETMMSRHFNDPNADAYFTKRKWGQHEGPLPRQHAGLLPESLIWAYIVQLSSALRTIHTAGLACRVMDPTKILITGKTRLRVNCVGVFDVLTFDNSQNNNPLALMAQYQQADLISLGKVVLALACNSLAGIQRENLQKAMELVTINYSSDLKNLILYLLTDQNRMRSVNDIMPMIGARFYTQLDAAQMRNDVIEEDLAKEVQNGRLFRLLAKLGTINERPEFQKDPTWSETGDRYLLKLFRDHLFHQVTEAGAPWIDLSHIISCLNKLDAGVPEKISLISRDEKSVLVVTYSDLKRCFENTFQELIAAANGQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Ubiquitination	YAKDKTCFYGEECQF ECCCCCEECCCCCHH	12.13	22817900
70	Ubiquitination	ECQFLHEDPAAGAAP CCHHHCCCCCCCCCC	27.65	22817900
116	Ubiquitination	GPPPGPKKPDLGDPG CCCCCCCCCCCCCCC	47.07	29967540
133	Phosphorylation	AAAGGGGSSGGLDGP CCCCCCCCCCCCCCC	29.14	30624053
134	Phosphorylation	AAGGGGSSGGLDGPR CCCCCCCCCCCCCCC	39.91	30624053
150	Ubiquitination	AIPGMDGGALTDTSL CCCCCCCCCCCCCCC	17.10	22817900
150 (in isoform 1)	Ubiquitination	-	17.10	21906983
164	Phosphorylation	LTDSYFSTSFIGVNG CCCCCCCCCEECCCC	20.11	-
174	Phosphorylation	IGVNGFGSPVETKYP ECCCCCCCCCCCCHH	24.42	26074081
178	Phosphorylation	GFGSPVETKYPLMQR CCCCCCCCCHHHHHH	35.79	26074081
187	Phosphorylation	YPLMQRMTNSSSSPS HHHHHHHCCCCCCHH	33.85	22199227
189	Phosphorylation	LMQRMTNSSSSPSLL HHHHHCCCCCCHHHH	23.56	28450419
190	Phosphorylation	MQRMTNSSSSPSLLN HHHHCCCCCCHHHHC	36.58	28450419
191	Phosphorylation	QRMTNSSSSPSLLND HHHCCCCCCHHHHCC	46.20	30576142
192	Phosphorylation	RMTNSSSSPSLLNDS HHCCCCCCHHHHCCC	22.06	28450419
194	Phosphorylation	TNSSSSPSLLNDSAK CCCCCCHHHHCCCCC	47.65	28450419
199	Phosphorylation	SPSLLNDSAKPYSAH CHHHHCCCCCCCCCC	36.80	26074081
204	Phosphorylation	NDSAKPYSAHDPLTS CCCCCCCCCCCCCCC	27.88	28464451
208	Phosphorylation	KPYSAHDPLTSPASS CCCCCCCCCCCHHHH	27.89	18669648
210	Phosphorylation	YSAHDPLTSPASSLF CCCCCCCCCHHHHHH	37.74	26074081
211	Phosphorylation	SAHDPLTSPASSLFN CCCCCCCCHHHHHHC	26.59	26074081
214	Phosphorylation	DPLTSPASSLFNDFG CCCCCHHHHHHCCCC	30.84	26074081
215	Phosphorylation	PLTSPASSLFNDFGA CCCCHHHHHHCCCCC	38.80	28464451
226	Phosphorylation	DFGALNISQRRKPRK CCCCCCHHHCCCCCC	19.30	29507054
231 (in isoform 3)	Phosphorylation	-	35.86	25159151
242	Ubiquitination	RLGMLEERLVPMGSK CCCCHHHHHCCCCHH	31.45	22817900
249	Ubiquitination	RLVPMGSKARKAKNP HHCCCCHHHHHCCCC	46.62	29967540
252	Methylation	PMGSKARKAKNPIGC CCCHHHHHCCCCHHH	69.44	115974585
260	Ubiquitination	AKNPIGCLADRCKSG CCCCHHHHHHHHCCC	4.72	22817900
262	Ubiquitination	NPIGCLADRCKSGVP CCHHHHHHHHCCCCC	43.49	22817900
282	Ubiquitination	WNRVTENNLQTPNPT ECCCCCCCCCCCCCC	27.56	22817900
282 (in isoform 2)	Ubiquitination	-	27.56	21906983
284	Ubiquitination	RVTENNLQTPNPTAS CCCCCCCCCCCCCHH	57.97	22817900
285	Phosphorylation	VTENNLQTPNPTASE CCCCCCCCCCCCHHH	28.35	28674419
296	Ubiquitination	TASEFIPKGGSTSRL CHHHCCCCCCCCHHH	71.71	21906983
299	Phosphorylation	EFIPKGGSTSRLSNV HCCCCCCCCHHHCCC	31.70	24275569
311	Ubiquitination	SNVSQSNMSAFSQVF CCCCCCCHHHHHHHH	3.56	22817900
317	Ubiquitination	NMSAFSQVFSHPSMG CHHHHHHHHCCCCCC	5.28	23503661
333	Ubiquitination	PATAGLAPGMSLSAG CCCCCCCCCCCCCCC	44.02	22817900
333 (in isoform 2)	Ubiquitination	-	44.02	21906983
338	Phosphorylation	LAPGMSLSAGSSPLH CCCCCCCCCCCCCCC	24.23	28348404
339	Ubiquitination	APGMSLSAGSSPLHS CCCCCCCCCCCCCCC	27.47	23503661
341	Phosphorylation	GMSLSAGSSPLHSPK CCCCCCCCCCCCCCC	28.62	28348404
342	Phosphorylation	MSLSAGSSPLHSPKI CCCCCCCCCCCCCCC	30.48	28348404
346	Phosphorylation	AGSSPLHSPKITPHT CCCCCCCCCCCCCCC	35.26	-
350	Phosphorylation	PLHSPKITPHTSPAP CCCCCCCCCCCCCCC	18.36	30266825
353	Phosphorylation	SPKITPHTSPAPRRR CCCCCCCCCCCCCCC	37.29	25849741
354	Phosphorylation	PKITPHTSPAPRRRS CCCCCCCCCCCCCCC	18.94	23401153
357	Ubiquitination	TPHTSPAPRRRSHTP CCCCCCCCCCCCCCC	33.42	22817900
359	Ubiquitination	HTSPAPRRRSHTPNP CCCCCCCCCCCCCCC	43.31	22817900
361	Phosphorylation	SPAPRRRSHTPNPAS CCCCCCCCCCCCCHH	29.87	26657352
363	Phosphorylation	APRRRSHTPNPASYM CCCCCCCCCCCHHHC	26.47	26657352
368	Phosphorylation	SHTPNPASYMVPSSA CCCCCCHHHCCCCCC	18.28	28450419
368	Ubiquitination	SHTPNPASYMVPSSA CCCCCCHHHCCCCCC	18.28	22817900
369	Phosphorylation	HTPNPASYMVPSSAS CCCCCHHHCCCCCCC	12.30	28450419
370	Ubiquitination	TPNPASYMVPSSAST CCCCHHHCCCCCCCC	3.11	22817900
373	Phosphorylation	PASYMVPSSASTSVN CHHHCCCCCCCCCCC	27.42	28450419
374	Phosphorylation	ASYMVPSSASTSVNN HHHCCCCCCCCCCCC	21.84	28450419
376	Phosphorylation	YMVPSSASTSVNNPV HCCCCCCCCCCCCCC	24.14	28450419
377	Phosphorylation	MVPSSASTSVNNPVS CCCCCCCCCCCCCCC	36.09	28450419
378	Phosphorylation	VPSSASTSVNNPVSQ CCCCCCCCCCCCCCC	21.98	28450419
384	Phosphorylation	TSVNNPVSQTPSSGQ CCCCCCCCCCCCCCC	29.59	25002506
386	Phosphorylation	VNNPVSQTPSSGQVI CCCCCCCCCCCCCEE	20.03	25002506
389	Phosphorylation	PVSQTPSSGQVIQKE CCCCCCCCCCEEEEE	34.15	25002506
394 (in isoform 3)	Ubiquitination	-	38.38	21906983
408	Ubiquitination	TTYFYTDTTPAPLTG EEEEEECCCCCCCCC	27.21	22817900
414	Ubiquitination	DTTPAPLTGMVFPNY CCCCCCCCCCCCCCC	23.36	23503661
419	Ubiquitination	PLTGMVFPNYHIYPP CCCCCCCCCCCCCCC	29.12	22817900
425	Ubiquitination	FPNYHIYPPTAPHVA CCCCCCCCCCCCCCE	21.11	23503661
439	Ubiquitination	AYMQPKANAPSFFMA EECCCCCCCCCCCCC	59.52	22817900
445 (in isoform 3)	Ubiquitination	-	4.29	21906983
448	Ubiquitination	PSFFMADELRQELIN CCCCCCHHHHHHHHH	35.99	22817900
448 (in isoform 1)	Ubiquitination	-	35.99	21906983
450	Ubiquitination	FFMADELRQELINRH CCCCHHHHHHHHHHH	26.36	22817900
461	Ubiquitination	INRHLITMAQIDQAD HHHHCHHHHHCCCCC	1.73	22817900
461 (in isoform 2)	Ubiquitination	-	1.73	21906983
464	Ubiquitination	HLITMAQIDQADMPA HCHHHHHCCCCCCCC	2.84	22817900
486	Ubiquitination	YHSLFPLEPLPPPNR CCCCCCCCCCCCCCC	45.06	22817900
486 (in isoform 2)	Ubiquitination	-	45.06	21906983
496	Methylation	PPPNRIQKSSNFGYI CCCCCCCCCCCCCEE	54.18	30788607
496	Ubiquitination	PPPNRIQKSSNFGYI CCCCCCCCCCCCCEE	54.18	29967540
499	Ubiquitination	NRIQKSSNFGYITSC CCCCCCCCCCEEHHH	41.26	22817900
499 (in isoform 1)	Ubiquitination	-	41.26	21906983
505	Ubiquitination	SNFGYITSCYKAVNS CCCCEEHHHHHHHCC	13.09	23503661
513	Ubiquitination	CYKAVNSKDDLPYCL HHHHHCCCCCHHHHH	50.48	29967540
536	Ubiquitination	VNTKCMVLVDMWKKI ECCEEEEHHHHHHHH	0.78	22817900
540	Ubiquitination	CMVLVDMWKKIQHSN EEEHHHHHHHHCCCC	8.37	22817900
540 (in isoform 3)	Ubiquitination	-	8.37	-
542	Ubiquitination	VLVDMWKKIQHSNIV EHHHHHHHHCCCCCE	31.89	22817900
547	Ubiquitination	WKKIQHSNIVTLREV HHHHCCCCCEEHHHH	30.53	22817900
558	Ubiquitination	LREVFTTKAFAEPSL HHHHHCCCCCCCCEE	38.15	-
561	Ubiquitination	VFTTKAFAEPSLVFA HHCCCCCCCCEEEEE	32.42	22817900
572	Ubiquitination	LVFAYDFHAGGETMM EEEEEEECCCCCCHH	22.14	22817900
573 (in isoform 3)	Ubiquitination	-	27.90	21906983
591	Ubiquitination	NDPNADAYFTKRKWG CCCCHHHHEECCCCC	16.60	22817900
593	Ubiquitination	PNADAYFTKRKWGQH CCHHHHEECCCCCCC	19.77	22817900
594	Ubiquitination	NADAYFTKRKWGQHE CHHHHEECCCCCCCC	41.92	21906983
595	Ubiquitination	ADAYFTKRKWGQHEG HHHHEECCCCCCCCC	36.58	22817900
596	Ubiquitination	DAYFTKRKWGQHEGP HHHEECCCCCCCCCC	58.18	22817900
597	Ubiquitination	AYFTKRKWGQHEGPL HHEECCCCCCCCCCC	18.73	23503661
598 (in isoform 3)	Ubiquitination	-	23.23	21906983
627	Ubiquitination	YIVQLSSALRTIHTA HHHHHHHHHHHHHHC	9.55	22817900
627 (in isoform 1)	Ubiquitination	-	9.55	21906983
644	Phosphorylation	ACRVMDPTKILITGK HHEECCCCEEEEECC	26.84	21857030
644	Ubiquitination	ACRVMDPTKILITGK HHEECCCCEEEEECC	26.84	22817900
645	Ubiquitination	CRVMDPTKILITGKT HEECCCCEEEEECCC	40.69	21906983
650	Ubiquitination	PTKILITGKTRLRVN CCEEEEECCCEEEEC	23.50	23503661
651	Ubiquitination	TKILITGKTRLRVNC CEEEEECCCEEEECE	23.09	23503661
652	Phosphorylation	KILITGKTRLRVNCV EEEEECCCEEEECEE	35.96	21857030
652	Ubiquitination	KILITGKTRLRVNCV EEEEECCCEEEECEE	35.96	22817900
652 (in isoform 1)	Ubiquitination	-	35.96	21906983
718	Phosphorylation	QKAMELVTINYSSDL HHHHHHHEEECCHHH	19.01	25072903
719	Ubiquitination	KAMELVTINYSSDLK HHHHHHEEECCHHHH	3.38	22817900
721	Phosphorylation	MELVTINYSSDLKNL HHHHEEECCHHHHHH	13.00	25072903
722	Phosphorylation	ELVTINYSSDLKNLI HHHEEECCHHHHHHH	16.94	25072903
723	Phosphorylation	LVTINYSSDLKNLIL HHEEECCHHHHHHHH	36.28	25072903
731	Phosphorylation	DLKNLILYLLTDQNR HHHHHHHHHHCCCCC	7.83	25072903
734	Phosphorylation	NLILYLLTDQNRMRS HHHHHHHCCCCCCCC	32.70	25072903
744	Ubiquitination	NRMRSVNDIMPMIGA CCCCCHHHHHHHHHH	36.09	22817900
772	Ubiquitination	DVIEEDLAKEVQNGR CCCHHHHHHHHHCCH	20.48	22817900
773	Ubiquitination	VIEEDLAKEVQNGRL CCHHHHHHHHHCCHH	66.76	21906983
786	Ubiquitination	RLFRLLAKLGTINER HHHHHHHHHCCCCCC	47.63	29967540
797	Ubiquitination	INERPEFQKDPTWSE CCCCCHHHCCCCCCH	47.80	22817900
798	Ubiquitination	NERPEFQKDPTWSET CCCCHHHCCCCCCHH	71.62	22817900
849	Ubiquitination	LDAGVPEKISLISRD CCCCCCHHEEEEECC	31.37	29967540
851	Phosphorylation	AGVPEKISLISRDEK CCCCHHEEEEECCCC	30.62	24719451
854	Phosphorylation	PEKISLISRDEKSVL CHHEEEEECCCCEEE	38.68	24719451
859	Phosphorylation	LISRDEKSVLVVTYS EEECCCCEEEEEEHH	20.73	-
864	Phosphorylation	EKSVLVVTYSDLKRC CCEEEEEEHHHHHHH	15.16	29759185
865	Phosphorylation	KSVLVVTYSDLKRCF CEEEEEEHHHHHHHH	6.65	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAN3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PABP1_HUMAN	PABPC1	physical	18056425
PABP1_HUMAN	PABPC1	physical	23340509
TNR6C_HUMAN	TNRC6C	physical	21981923
MARF1_HUMAN	KIAA0430	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.