dbPTM

PABP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PABP4_HUMAN
UniProt AC	Q13310
Protein Name	Polyadenylate-binding protein 4
Gene Name	PABPC4
Organism	Homo sapiens (Human).
Sequence Length	644
Subcellular Localization	Cytoplasm . Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein Description	Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity)..
Protein Sequence	MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAADKAIEKMNGMLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDESLKELFSQFGKTLSVKVMRDPNGKSKGFGFVSYEKHEDANKAVEEMNGKEISGKIIFVGRAQKKVERQAELKRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKGFGFVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRALPANAILNQFQPAAGGYFVPAVPQAQGRPPYYTPNQLAQMRPNPRWQQGGRPQGFQGMPSAIRQSGPRPTLRHLAPTGSECPDRLAMDFGGAGAAQQGLTDSCQSGGVPTAVQNLAPRAAVAAAAPRAVAPYKYASSVRSPHPAIQPLQAPQPAVHVQGQEPLTASMLAAAPPQEQKQMLGERLFPLIQTMHSNLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHHAKKEAAQKVGAVAAATS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MNAAASSYPMASL --CCCCHHCCCCCEE	26.19	25404012
7	Phosphorylation	-MNAAASSYPMASLY -CCCCHHCCCCCEEE	28.64	25404012
8	Phosphorylation	MNAAASSYPMASLYV CCCCHHCCCCCEEEC	8.43	25404012
12	Phosphorylation	ASSYPMASLYVGDLH HHCCCCCEEECCCCC	17.62	25404012
14	Phosphorylation	SYPMASLYVGDLHSD CCCCCEEECCCCCCC	10.41	25404012
20	Phosphorylation	LYVGDLHSDVTEAML EECCCCCCCCHHHHH	40.86	25404012
23	Phosphorylation	GDLHSDVTEAMLYEK CCCCCCCHHHHHHHH	24.02	25404012
28	Phosphorylation	DVTEAMLYEKFSPAG CCHHHHHHHHCCCCC	12.18	25404012
32	Phosphorylation	AMLYEKFSPAGPVLS HHHHHHCCCCCCEEE	25.55	22199227
39	Phosphorylation	SPAGPVLSIRVCRDM CCCCCEEEEEEEHHH	14.48	28555341
51	Phosphorylation	RDMITRRSLGYAYVN HHHHHHCCCEEEEEE	23.90	25159151
54	Phosphorylation	ITRRSLGYAYVNFQQ HHHCCCEEEEEEECC	10.47	20090780
56	Phosphorylation	RRSLGYAYVNFQQPA HCCCEEEEEEECCCC	6.35	28152594
71	Phosphorylation	DAERALDTMNFDVIK HHHHHHHHCCCEEEC	18.18	20860994
72	Sulfoxidation	AERALDTMNFDVIKG HHHHHHHCCCEEECC	4.73	28183972
78	Succinylation	TMNFDVIKGKPIRIM HCCCEEECCEEEEEE	61.81	23954790
78	Ubiquitination	TMNFDVIKGKPIRIM HCCCEEECCEEEEEE	61.81	23000965
78 (in isoform 1)	Ubiquitination	-	61.81	21890473
78 (in isoform 2)	Ubiquitination	-	61.81	21890473
78 (in isoform 3)	Ubiquitination	-	61.81	-
80	Ubiquitination	NFDVIKGKPIRIMWS CCEEECCEEEEEEEE	32.06	23000965
80 (in isoform 3)	Ubiquitination	-	32.06	-
87	Phosphorylation	KPIRIMWSQRDPSLR EEEEEEEECCCHHHH	9.65	23186163
92	Phosphorylation	MWSQRDPSLRKSGVG EEECCCHHHHHCCCC	45.13	23403867
95	Ubiquitination	QRDPSLRKSGVGNVF CCCHHHHHCCCCCEE	57.78	21906983
95 (in isoform 1)	Ubiquitination	-	57.78	21890473
95 (in isoform 2)	Ubiquitination	-	57.78	21890473
95 (in isoform 3)	Ubiquitination	-	57.78	-
96	Phosphorylation	RDPSLRKSGVGNVFI CCHHHHHCCCCCEEE	32.07	25159151
104	Acetylation	GVGNVFIKNLDKSID CCCCEEECCCCHHCC	39.74	19608861
104	Ubiquitination	GVGNVFIKNLDKSID CCCCEEECCCCHHCC	39.74	27667366
104 (in isoform 1)	Ubiquitination	-	39.74	21890473
104 (in isoform 2)	Ubiquitination	-	39.74	21890473
104 (in isoform 3)	Ubiquitination	-	39.74	-
108	Acetylation	VFIKNLDKSIDNKAL EEECCCCHHCCCHHH	53.10	23749302
108	Ubiquitination	VFIKNLDKSIDNKAL EEECCCCHHCCCHHH	53.10	27667366
108 (in isoform 1)	Ubiquitination	-	53.10	21890473
108 (in isoform 2)	Ubiquitination	-	53.10	21890473
108 (in isoform 3)	Malonylation	-	53.10	26320211
108 (in isoform 3)	Ubiquitination	-	53.10	-
113	Neddylation	LDKSIDNKALYDTFS CCHHCCCHHHHHHHH	35.70	32015554
113	Ubiquitination	LDKSIDNKALYDTFS CCHHCCCHHHHHHHH	35.70	21906983
113 (in isoform 1)	Ubiquitination	-	35.70	21890473
113 (in isoform 2)	Ubiquitination	-	35.70	21890473
116	Phosphorylation	SIDNKALYDTFSAFG HCCCHHHHHHHHHHC	20.14	17360941
120	Phosphorylation	KALYDTFSAFGNILS HHHHHHHHHHCCCCE	25.44	21712546
127	Phosphorylation	SAFGNILSCKVVCDE HHHCCCCEEEEEECC	14.22	21712546
128	Glutathionylation	AFGNILSCKVVCDEN HHCCCCEEEEEECCC	3.30	22555962
128	S-palmitoylation	AFGNILSCKVVCDEN HHCCCCEEEEEECCC	3.30	29575903
129	Ubiquitination	FGNILSCKVVCDENG HCCCCEEEEEECCCC	34.03	21906983
129 (in isoform 1)	Ubiquitination	-	34.03	21890473
129 (in isoform 2)	Ubiquitination	-	34.03	21890473
138	Acetylation	VCDENGSKGYAFVHF EECCCCCEEEEEEEE	58.29	26051181
138	Ubiquitination	VCDENGSKGYAFVHF EECCCCCEEEEEEEE	58.29	-
140	Phosphorylation	DENGSKGYAFVHFET CCCCCEEEEEEEEEC	10.70	28152594
153	Acetylation	ETQEAADKAIEKMNG ECHHHHHHHHHHHCC	46.68	26051181
157	Ubiquitination	AADKAIEKMNGMLLN HHHHHHHHHCCCCCC	31.39	27667366
157 (in isoform 1)	Ubiquitination	-	31.39	21890473
157 (in isoform 2)	Ubiquitination	-	31.39	21890473
157	Ubiquitination	AADKAIEKMNGMLLN HHHHHHHHHCCCCCC	31.39	21890473
166	Methylation	NGMLLNDRKVFVGRF CCCCCCCCEEEEECC	35.64	-
167	Sumoylation	GMLLNDRKVFVGRFK CCCCCCCEEEEECCC	42.77	-
167	Sumoylation	GMLLNDRKVFVGRFK CCCCCCCEEEEECCC	42.77	-
167	Ubiquitination	GMLLNDRKVFVGRFK CCCCCCCEEEEECCC	42.77	27667366
167 (in isoform 1)	Ubiquitination	-	42.77	21890473
167 (in isoform 2)	Ubiquitination	-	42.77	21890473
177	Ubiquitination	VGRFKSRKEREAELG EECCCCHHHHHHHHH	69.11	29967540
179	Methylation	RFKSRKEREAELGAK CCCCHHHHHHHHHHH	52.00	24387935
186	Ubiquitination	REAELGAKAKEFTNV HHHHHHHHHHHHHCE	59.18	21906983
186 (in isoform 1)	Ubiquitination	-	59.18	21890473
186 (in isoform 2)	Ubiquitination	-	59.18	21890473
186 (in isoform 3)	Ubiquitination	-	59.18	-
188	Methylation	AELGAKAKEFTNVYI HHHHHHHHHHHCEEE	53.29	24501153
188	Ubiquitination	AELGAKAKEFTNVYI HHHHHHHHHHHCEEE	53.29	27667366
188 (in isoform 1)	Ubiquitination	-	53.29	21890473
188 (in isoform 2)	Ubiquitination	-	53.29	21890473
188 (in isoform 3)	Malonylation	-	53.29	26320211
188 (in isoform 3)	Ubiquitination	-	53.29	-
188	Ubiquitination	AELGAKAKEFTNVYI HHHHHHHHHHHCEEE	53.29	21890473
191	Phosphorylation	GAKAKEFTNVYIKNF HHHHHHHHCEEECCC	25.51	28152594
194	Phosphorylation	AKEFTNVYIKNFGEE HHHHHCEEECCCCCC	14.30	28152594
196	Ubiquitination	EFTNVYIKNFGEEVD HHHCEEECCCCCCCC	28.65	22817900
196 (in isoform 1)	Ubiquitination	-	28.65	21890473
196 (in isoform 2)	Ubiquitination	-	28.65	21890473
196	Ubiquitination	EFTNVYIKNFGEEVD HHHCEEECCCCCCCC	28.65	21890473
206	Phosphorylation	GEEVDDESLKELFSQ CCCCCHHHHHHHHHH	52.30	20873877
208	Acetylation	EVDDESLKELFSQFG CCCHHHHHHHHHHHC	62.74	26051181
208	Ubiquitination	EVDDESLKELFSQFG CCCHHHHHHHHHHHC	62.74	21906983
208 (in isoform 1)	Ubiquitination	-	62.74	21890473
208 (in isoform 2)	Ubiquitination	-	62.74	21890473
212	Phosphorylation	ESLKELFSQFGKTLS HHHHHHHHHHCCEEE	36.91	20873877
216	Acetylation	ELFSQFGKTLSVKVM HHHHHHCCEEEEEEE	47.80	26051181
216	Ubiquitination	ELFSQFGKTLSVKVM HHHHHHCCEEEEEEE	47.80	23000965
216 (in isoform 1)	Ubiquitination	-	47.80	21890473
216 (in isoform 2)	Ubiquitination	-	47.80	21890473
216 (in isoform 3)	Ubiquitination	-	47.80	-
216	Ubiquitination	ELFSQFGKTLSVKVM HHHHHHCCEEEEEEE	47.80	21890473
221	Malonylation	FGKTLSVKVMRDPNG HCCEEEEEEEECCCC	27.26	26320211
221	Ubiquitination	FGKTLSVKVMRDPNG HCCEEEEEEEECCCC	27.26	23000965
221 (in isoform 3)	Malonylation	-	27.26	26320211
231 (in isoform 3)	Malonylation	-	62.84	32601280
237	Phosphorylation	SKGFGFVSYEKHEDA CCCEEEEEEECCHHH	25.88	28152594
238	Phosphorylation	KGFGFVSYEKHEDAN CCEEEEEEECCHHHH	24.56	28152594
240	Acetylation	FGFVSYEKHEDANKA EEEEEEECCHHHHHH	44.02	26051181
240	Ubiquitination	FGFVSYEKHEDANKA EEEEEEECCHHHHHH	44.02	32015554
246	Acetylation	EKHEDANKAVEEMNG ECCHHHHHHHHHHCC	56.37	26051181
246	Ubiquitination	EKHEDANKAVEEMNG ECCHHHHHHHHHHCC	56.37	32015554
254	Acetylation	AVEEMNGKEISGKII HHHHHCCCCCCCEEE	47.04	26051181
254	Ubiquitination	AVEEMNGKEISGKII HHHHHCCCCCCCEEE	47.04	21906983
254 (in isoform 1)	Ubiquitination	-	47.04	21890473
254 (in isoform 2)	Ubiquitination	-	47.04	21890473
257	Phosphorylation	EMNGKEISGKIIFVG HHCCCCCCCEEEEEC	34.82	24719451
259	Ubiquitination	NGKEISGKIIFVGRA CCCCCCCEEEEECCH	26.32	-
269	Ubiquitination	FVGRAQKKVERQAEL EECCHHHHHHHHHHH	36.93	24816145
279	Acetylation	RQAELKRKFEQLKQE HHHHHHHHHHHHHHH	52.22	26051181
279	Ubiquitination	RQAELKRKFEQLKQE HHHHHHHHHHHHHHH	52.22	21906983
279 (in isoform 1)	Ubiquitination	-	52.22	21890473
279 (in isoform 2)	Ubiquitination	-	52.22	21890473
279 (in isoform 3)	Ubiquitination	-	52.22	-
284	Acetylation	KRKFEQLKQERISRY HHHHHHHHHHHHHHH	50.21	26051181
284	Ubiquitination	KRKFEQLKQERISRY HHHHHHHHHHHHHHH	50.21	21906983
284 (in isoform 1)	Ubiquitination	-	50.21	21890473
284 (in isoform 2)	Ubiquitination	-	50.21	21890473
284 (in isoform 3)	Ubiquitination	-	50.21	-
291	Phosphorylation	KQERISRYQGVNLYI HHHHHHHHHCCEEEE	11.65	28152594
297	Phosphorylation	RYQGVNLYIKNLDDT HHHCCEEEEECCCCC	12.49	28152594
299	Acetylation	QGVNLYIKNLDDTID HCCEEEEECCCCCCC	37.59	26051181
299	Ubiquitination	QGVNLYIKNLDDTID HCCEEEEECCCCCCC	37.59	22817900
299 (in isoform 1)	Ubiquitination	-	37.59	21890473
299 (in isoform 2)	Ubiquitination	-	37.59	21890473
299	Ubiquitination	QGVNLYIKNLDDTID HCCEEEEECCCCCCC	37.59	21890473
304	Phosphorylation	YIKNLDDTIDDEKLR EEECCCCCCCHHHHH	26.44	21815630
309	Acetylation	DDTIDDEKLRKEFSP CCCCCHHHHHHHCCC	61.66	25953088
309	Ubiquitination	DDTIDDEKLRKEFSP CCCCCHHHHHHHCCC	61.66	23000965
309 (in isoform 1)	Ubiquitination	-	61.66	21890473
309 (in isoform 2)	Ubiquitination	-	61.66	21890473
309 (in isoform 3)	Ubiquitination	-	61.66	-
312	Acetylation	IDDEKLRKEFSPFGS CCHHHHHHHCCCCCC	73.82	26051181
312	Malonylation	IDDEKLRKEFSPFGS CCHHHHHHHCCCCCC	73.82	26320211
312	Ubiquitination	IDDEKLRKEFSPFGS CCHHHHHHHCCCCCC	73.82	23000965
312 (in isoform 1)	Ubiquitination	-	73.82	21890473
312 (in isoform 2)	Ubiquitination	-	73.82	21890473
312 (in isoform 3)	Malonylation	-	73.82	26320211
312 (in isoform 3)	Ubiquitination	-	73.82	-
312	Ubiquitination	IDDEKLRKEFSPFGS CCHHHHHHHCCCCCC	73.82	21890473
315	Phosphorylation	EKLRKEFSPFGSITS HHHHHHCCCCCCCCE	22.02	25159151
319	Phosphorylation	KEFSPFGSITSAKVM HHCCCCCCCCEEEEE	24.07	25159151
321	Phosphorylation	FSPFGSITSAKVMLE CCCCCCCCEEEEEEC	25.08	28450419
322	Phosphorylation	SPFGSITSAKVMLED CCCCCCCEEEEEECC	25.15	28450419
324	Acetylation	FGSITSAKVMLEDGR CCCCCEEEEEECCCC	28.13	26051181
324	Ubiquitination	FGSITSAKVMLEDGR CCCCCEEEEEECCCC	28.13	32015554
333	Ubiquitination	MLEDGRSKGFGFVCF EECCCCCCCCEEEEE	57.82	32015554
333 (in isoform 1)	Ubiquitination	-	57.82	21890473
333 (in isoform 2)	Ubiquitination	-	57.82	21890473
333 (in isoform 3)	Malonylation	-	57.82	26320211
333	Ubiquitination	MLEDGRSKGFGFVCF EECCCCCCCCEEEEE	57.82	21890473
339	Glutathionylation	SKGFGFVCFSSPEEA CCCCEEEEECCHHHH	2.27	22555962
339	S-palmitoylation	SKGFGFVCFSSPEEA CCCCEEEEECCHHHH	2.27	29575903
341	Phosphorylation	GFGFVCFSSPEEATK CCEEEEECCHHHHHH	39.60	25159151
342	Phosphorylation	FGFVCFSSPEEATKA CEEEEECCHHHHHHH	18.97	25159151
347	Phosphorylation	FSSPEEATKAVTEMN ECCHHHHHHHHHHHC	23.86	24732914
348	Ubiquitination	SSPEEATKAVTEMNG CCHHHHHHHHHHHCC	48.16	21906983
348 (in isoform 1)	Ubiquitination	-	48.16	21890473
348 (in isoform 2)	Ubiquitination	-	48.16	21890473
360	Phosphorylation	MNGRIVGSKPLYVAL HCCEECCCHHHHHHH	21.87	28152594
361	"N6,N6-dimethyllysine"	NGRIVGSKPLYVALA CCEECCCHHHHHHHH	32.87	-
361	Acetylation	NGRIVGSKPLYVALA CCEECCCHHHHHHHH	32.87	26051181
361	Methylation	NGRIVGSKPLYVALA CCEECCCHHHHHHHH	32.87	23161681
361	Sumoylation	NGRIVGSKPLYVALA CCEECCCHHHHHHHH	32.87	28112733
361	Ubiquitination	NGRIVGSKPLYVALA CCEECCCHHHHHHHH	32.87	23000965
361 (in isoform 1)	Ubiquitination	-	32.87	21890473
361 (in isoform 2)	Ubiquitination	-	32.87	21890473
361 (in isoform 3)	Ubiquitination	-	32.87	-
361	Ubiquitination	NGRIVGSKPLYVALA CCEECCCHHHHHHHH	32.87	21890473
364	Phosphorylation	IVGSKPLYVALAQRK ECCCHHHHHHHHHCH	7.69	27273156
371	Ubiquitination	YVALAQRKEERKAHL HHHHHHCHHHHHHHH	52.42	23000965
375	Methylation	AQRKEERKAHLTNQY HHCHHHHHHHHHHHH	43.36	100290643
375	Sumoylation	AQRKEERKAHLTNQY HHCHHHHHHHHHHHH	43.36	28112733
375	Ubiquitination	AQRKEERKAHLTNQY HHCHHHHHHHHHHHH	43.36	23000965
375 (in isoform 1)	Ubiquitination	-	43.36	21890473
375 (in isoform 2)	Ubiquitination	-	43.36	21890473
375 (in isoform 3)	Ubiquitination	-	43.36	-
375	Ubiquitination	AQRKEERKAHLTNQY HHCHHHHHHHHHHHH	43.36	21890473
379	Phosphorylation	EERKAHLTNQYMQRV HHHHHHHHHHHHHHH	15.48	-
382	Phosphorylation	KAHLTNQYMQRVAGM HHHHHHHHHHHHHHC	9.40	25839225
383	Sulfoxidation	AHLTNQYMQRVAGMR HHHHHHHHHHHHHCC	1.16	30846556
385	Methylation	LTNQYMQRVAGMRAL HHHHHHHHHHHCCCC	12.06	54557819
419	Dimethylation	AVPQAQGRPPYYTPN CCCCCCCCCCCCCHH	19.55	-
419	Methylation	AVPQAQGRPPYYTPN CCCCCCCCCCCCCHH	19.55	24129315
432	Methylation	PNQLAQMRPNPRWQQ HHHHHHCCCCCHHHC	18.76	24129315
436	Dimethylation	AQMRPNPRWQQGGRP HHCCCCCHHHCCCCC	50.94	-
436	Methylation	AQMRPNPRWQQGGRP HHCCCCCHHHCCCCC	50.94	24129315
442	Dimethylation	PRWQQGGRPQGFQGM CHHHCCCCCCCCCCC	27.48	-
442	Methylation	PRWQQGGRPQGFQGM CHHHCCCCCCCCCCC	27.48	30988779
454	Dimethylation	QGMPSAIRQSGPRPT CCCCHHHHHCCCCCC	25.08	-
454	Methylation	QGMPSAIRQSGPRPT CCCCHHHHHCCCCCC	25.08	24129315
459	Dimethylation	AIRQSGPRPTLRHLA HHHHCCCCCCHHHCC	40.12	-
459	Methylation	AIRQSGPRPTLRHLA HHHHCCCCCCHHHCC	40.12	30762793
463	Dimethylation	SGPRPTLRHLAPTGS CCCCCCHHHCCCCCC	25.83	-
463	Methylation	SGPRPTLRHLAPTGS CCCCCCHHHCCCCCC	25.83	18966649
486 (in isoform 3)	Phosphorylation	-	11.00	28348404
493	Phosphorylation	AQQGLTDSCQSGGVP HHCCCCHHHHCCCCC	14.60	30175587
496 (in isoform 2)	Methylation	-	41.67	24129315
505	Methylation	GVPTAVQNLAPRAAV CCCHHHHHHHHHHHH	31.41	15782174
509	Dimethylation	AVQNLAPRAAVAAAA HHHHHHHHHHHHHHC	29.57	-
509	Methylation	AVQNLAPRAAVAAAA HHHHHHHHHHHHHHC	29.57	30988773
518	Dimethylation	AVAAAAPRAVAPYKY HHHHHCCCCCCCCHH	36.65	-
518	Methylation	AVAAAAPRAVAPYKY HHHHHCCCCCCCCHH	36.65	20680597
524	Acetylation	PRAVAPYKYASSVRS CCCCCCCHHHCCCCC	33.03	25953088
524	Methylation	PRAVAPYKYASSVRS CCCCCCCHHHCCCCC	33.03	23748837
527	Phosphorylation	VAPYKYASSVRSPHP CCCCHHHCCCCCCCC	26.69	26074081
528	Phosphorylation	APYKYASSVRSPHPA CCCHHHCCCCCCCCC	17.24	26074081
530	Dimethylation	YKYASSVRSPHPAIQ CHHHCCCCCCCCCCC	46.55	-
530	Methylation	YKYASSVRSPHPAIQ CHHHCCCCCCCCCCC	46.55	24129315
531	Phosphorylation	KYASSVRSPHPAIQP HHHCCCCCCCCCCCC	25.96	25159151
534	Methylation	SSVRSPHPAIQPLQA CCCCCCCCCCCCCCC	34.15	15782174
555	Phosphorylation	VQGQEPLTASMLAAA ECCCCCCCHHHHHCC	27.66	27080861
557	Phosphorylation	GQEPLTASMLAAAPP CCCCCCHHHHHCCCH	14.75	27080861
584	Phosphorylation	PLIQTMHSNLAGKIT HHHHHHHHHHHHHHH	23.79	28112733
600	Phosphorylation	MLLEIDNSELLHMLE EEEEECHHHHHHHHC	26.35	24732914
608	Phosphorylation	ELLHMLESPESLRSK HHHHHHCCHHHHHHH	29.97	25159151
611	Phosphorylation	HMLESPESLRSKVDE HHHCCHHHHHHHHHH	32.25	24732914
616	Ubiquitination	PESLRSKVDEAVAVL HHHHHHHHHHHHHHH	9.42	33845483
622	Ubiquitination	KVDEAVAVLQAHHAK HHHHHHHHHHHHHHH	3.06	33845483
622 (in isoform 2)	Ubiquitination	-	3.06	21890473
629	Acetylation	VLQAHHAKKEAAQKV HHHHHHHHHHHHHHH	46.95	25953088
629	Malonylation	VLQAHHAKKEAAQKV HHHHHHHHHHHHHHH	46.95	26320211
629	Ubiquitination	VLQAHHAKKEAAQKV HHHHHHHHHHHHHHH	46.95	33845483
630	Acetylation	LQAHHAKKEAAQKVG HHHHHHHHHHHHHHC	54.06	25953088
635	Acetylation	AKKEAAQKVGAVAAA HHHHHHHHHCHHHHH	37.60	26051181
635	Ubiquitination	AKKEAAQKVGAVAAA HHHHHHHHHCHHHHH	37.60	33845483
635 (in isoform 1)	Ubiquitination	-	37.60	21890473
643	O-linked_Glycosylation	VGAVAAATS------ HCHHHHHCC------	30.18	30059200
643	Phosphorylation	VGAVAAATS------ HCHHHHHCC------	30.18	28985074
644	O-linked_Glycosylation	GAVAAATS------- CHHHHHCC-------	33.23	30059200
644	Phosphorylation	GAVAAATS------- CHHHHHCC-------	33.23	25159151
645	Ubiquitination	AVAAATS-------- HHHHHCC--------		33845483
645 (in isoform 3)	Malonylation	-		26320211
651	Ubiquitination	S-------------- C--------------		33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PABP4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
518	R	Methylation
Arg-518 is dimethylated, probably to asymmetric dimethylarginine.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PABP4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IL7RA_HUMAN	IL7R	physical	23151878
APT_HUMAN	APRT	physical	26344197
XPO2_HUMAN	CSE1L	physical	26344197
ECH1_HUMAN	ECH1	physical	26344197
FBRL_HUMAN	FBL	physical	26344197
G3BP1_HUMAN	G3BP1	physical	26344197
G3BP2_HUMAN	G3BP2	physical	26344197
GNL1_HUMAN	GNL1	physical	26344197
LC7L2_HUMAN	LUC7L2	physical	26344197
MSI2H_HUMAN	MSI2	physical	26344197
NH2L1_HUMAN	NHP2L1	physical	26344197
PCF11_HUMAN	PCF11	physical	26344197
PDCD6_HUMAN	PDCD6	physical	26344197
PLRG1_HUMAN	PLRG1	physical	26344197
IPYR_HUMAN	PPA1	physical	26344197
PPT1_HUMAN	PPT1	physical	26344197
AMPB_HUMAN	RNPEP	physical	26344197
RL15_HUMAN	RPL15	physical	26344197
RL18A_HUMAN	RPL18A	physical	26344197
RL27_HUMAN	RPL27	physical	26344197
RL39_HUMAN	RPL39	physical	26344197
RL3L_HUMAN	RPL3L	physical	26344197
RL8_HUMAN	RPL8	physical	26344197
RS3A_HUMAN	RPS3A	physical	26344197
RS9_HUMAN	RPS9	physical	26344197
SF3A2_HUMAN	SF3A2	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PABP4_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-104 AND LYS-108, AND MASSSPECTROMETRY.	19608861 [Abstract]
Methylation
Reference	PubMed
"Identifying and quantifying in vivo methylation sites by heavy methylSILAC."; Ong S.E., Mittler G., Mann M.; Nat. Methods 1:119-126(2004). Cited for: METHYLATION [LARGE SCALE ANALYSIS] AT ARG-518, AND MASS SPECTROMETRY.	15782174 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96 AND SER-531, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-54 AND TYR-140, AND MASSSPECTROMETRY.	15592455 [Abstract]

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