G3BP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: G3BP1_HUMAN
• UniProt AC: Q13283
• Protein Name: Ras GTPase-activating protein-binding protein 1
• Gene Name: G3BP1
• Organism: Homo sapiens (Human).
• Sequence Length: 466
• Subcellular Localization: Cytoplasm, cytosol . Perikaryon . Cytoplasm, Stress granule . Nucleus . Cytoplasmic in proliferating cells (PubMed:11604510). Cytosolic and partially nuclear in resting cells (PubMed:11604510). Recruited to stress granules in response to arsenite tre
• Protein Description: ATP- and magnesium-dependent helicase. [PubMed: 9889278 Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends]
• Protein Sequence: MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKEIHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSVANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAVVSNDMEEHLEEPVAEPEPDPEPEPEQEPVSEIQEEKPEPVLEETAPEDAQKSSSPAPADIAQTVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPPQRPQRDQRVREQRINIPPQRGPRPIREAGEQGDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFFQSYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAAREGDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRGLAPRQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Sulfoxidation	-----MVMEKPSPLL -----CCCCCCCCCE	5.45	21406390
5	Ubiquitination	---MVMEKPSPLLVG ---CCCCCCCCCEEC	32.47	21890473
5	Ubiquitination	---MVMEKPSPLLVG ---CCCCCCCCCEEC	32.47	-
5	Methylation	---MVMEKPSPLLVG ---CCCCCCCCCEEC	32.47	23644510
5	Malonylation	---MVMEKPSPLLVG ---CCCCCCCCCEEC	32.47	26320211
7	Phosphorylation	-MVMEKPSPLLVGRE -CCCCCCCCCEECHH	38.97	29255136
19	Phosphorylation	GREFVRQYYTLLNQA CHHHHHHHHHHHHHC	6.45	28152594
20	Phosphorylation	REFVRQYYTLLNQAP HHHHHHHHHHHHHCH	5.20	28152594
21	Phosphorylation	EFVRQYYTLLNQAPD HHHHHHHHHHHHCHH	21.60	28857561
36	Ubiquitination	MLHRFYGKNSSYVHG HHHHHHCCCCCCCCC	42.13	21890473
36	Ubiquitination	MLHRFYGKNSSYVHG HHHHHHCCCCCCCCC	42.13	21890473
36	Acetylation	MLHRFYGKNSSYVHG HHHHHHCCCCCCCCC	42.13	26051181
38	Phosphorylation	HRFYGKNSSYVHGGL HHHHCCCCCCCCCCC	26.91	28152594
39	Phosphorylation	RFYGKNSSYVHGGLD HHHCCCCCCCCCCCC	40.34	28152594
40	Phosphorylation	FYGKNSSYVHGGLDS HHCCCCCCCCCCCCC	9.04	28152594
47	Phosphorylation	YVHGGLDSNGKPADA CCCCCCCCCCCCCHH	53.15	25849741
50	Acetylation	GGLDSNGKPADAVYG CCCCCCCCCCHHHCC	41.08	26051181
50	Ubiquitination	GGLDSNGKPADAVYG CCCCCCCCCCHHHCC	41.08	21890473
50	Ubiquitination	GGLDSNGKPADAVYG CCCCCCCCCCHHHCC	41.08	21890473
56	Phosphorylation	GKPADAVYGQKEIHR CCCCHHHCCHHHHHH	18.63	27155012
59	Ubiquitination	ADAVYGQKEIHRKVM CHHHCCHHHHHHHHH	55.03	21890473
59	Ubiquitination	ADAVYGQKEIHRKVM CHHHCCHHHHHHHHH	55.03	21890473
59	Acetylation	ADAVYGQKEIHRKVM CHHHCCHHHHHHHHH	55.03	23236377
64	Ubiquitination	GQKEIHRKVMSQNFT CHHHHHHHHHHCCCC	28.29	-
67	Phosphorylation	EIHRKVMSQNFTNCH HHHHHHHHCCCCCCC	25.59	28857561
71	Phosphorylation	KVMSQNFTNCHTKIR HHHHCCCCCCCCEEE	44.48	-
75	Phosphorylation	QNFTNCHTKIRHVDA CCCCCCCCEEEEEEC	30.30	28857561
76	Ubiquitination	NFTNCHTKIRHVDAH CCCCCCCEEEEEECC	17.68	-
76	Acetylation	NFTNCHTKIRHVDAH CCCCCCCEEEEEECC	17.68	23749302
76	Malonylation	NFTNCHTKIRHVDAH CCCCCCCEEEEEECC	17.68	26320211
111	Phosphorylation	ALRRFMQTFVLAPEG HHHHHHHHHHHCCCC	12.15	28857561
119	Phosphorylation	FVLAPEGSVANKFYV HHHCCCCCHHCEEEE	19.18	28857561
123	Acetylation	PEGSVANKFYVHNDI CCCCHHCEEEEECCH	28.47	26051181
123	Ubiquitination	PEGSVANKFYVHNDI CCCCHHCEEEEECCH	28.47	-
125	Phosphorylation	GSVANKFYVHNDIFR CCHHCEEEEECCHHH	11.47	28152594
133	Phosphorylation	VHNDIFRYQDEVFGG EECCHHHCCCCCCCC	15.01	22167270
143	Phosphorylation	EVFGGFVTEPQEESE CCCCCCCCCCCCCCH	39.42	22167270
149	Phosphorylation	VTEPQEESEEEVEEP CCCCCCCCHHHCCCH	49.94	19664994
162	Phosphorylation	EPEERQQTPEVVPDD CHHHHHCCCCCCCCC	17.06	29496963
170	Phosphorylation	PEVVPDDSGTFYDQA CCCCCCCCCCCCCEE	47.30	26074081
172	Phosphorylation	VVPDDSGTFYDQAVV CCCCCCCCCCCEECC	23.99	26074081
174	Phosphorylation	PDDSGTFYDQAVVSN CCCCCCCCCEECCCC	13.64	20068231
180	Phosphorylation	FYDQAVVSNDMEEHL CCCEECCCCCHHHHH	22.10	20068231
214	Sumoylation	VSEIQEEKPEPVLEE HHHHHHHCCCCCCCC	54.66	-
222	Phosphorylation	PEPVLEETAPEDAQK CCCCCCCCCCHHHHH	37.83	26074081
230	Phosphorylation	APEDAQKSSSPAPAD CCHHHHHCCCCCCHH	24.78	29255136
231	Phosphorylation	PEDAQKSSSPAPADI CHHHHHCCCCCCHHH	47.58	29255136
232	Phosphorylation	EDAQKSSSPAPADIA HHHHHCCCCCCHHHH	31.97	29255136
241	O-linked_Glycosylation	APADIAQTVQEDLRT CCHHHHHHHHHHHHH	18.35	30059200
241	Phosphorylation	APADIAQTVQEDLRT CCHHHHHHHHHHHHH	18.35	30266825
247	Methylation	QTVQEDLRTFSWASV HHHHHHHHHCCCCCC	46.15	-
248	Phosphorylation	TVQEDLRTFSWASVT HHHHHHHHCCCCCCC	29.35	20873877
250	O-linked_Glycosylation	QEDLRTFSWASVTSK HHHHHHCCCCCCCCC	22.56	30059200
250	Phosphorylation	QEDLRTFSWASVTSK HHHHHHCCCCCCCCC	22.56	25159151
253	Phosphorylation	LRTFSWASVTSKNLP HHHCCCCCCCCCCCC	21.48	23401153
255	Phosphorylation	TFSWASVTSKNLPPS HCCCCCCCCCCCCCC	31.33	23898821
256	O-linked_Glycosylation	FSWASVTSKNLPPSG CCCCCCCCCCCCCCC	19.86	30059200
256	Phosphorylation	FSWASVTSKNLPPSG CCCCCCCCCCCCCCC	19.86	23898821
257	Acetylation	SWASVTSKNLPPSGA CCCCCCCCCCCCCCC	53.81	26051181
262	Phosphorylation	TSKNLPPSGAVPVTG CCCCCCCCCCCCCCC	37.13	28555341
268	Phosphorylation	PSGAVPVTGIPPHVV CCCCCCCCCCCCCEE	24.27	21082442
268	O-linked_Glycosylation	PSGAVPVTGIPPHVV CCCCCCCCCCCCCEE	24.27	30059200
280	Phosphorylation	HVVKVPASQPRPESK CEEEECCCCCCCCCC	34.35	28555341
280	O-linked_Glycosylation	HVVKVPASQPRPESK CEEEECCCCCCCCCC	34.35	30059200
286	Phosphorylation	ASQPRPESKPESQIP CCCCCCCCCCHHHCC	57.08	28555341
287	Ubiquitination	SQPRPESKPESQIPP CCCCCCCCCHHHCCC	51.66	-
287	Acetylation	SQPRPESKPESQIPP CCCCCCCCCHHHCCC	51.66	26051181
339	Phosphorylation	RMVRHPDSHQLFIGN CCCCCCCCCCEEECC	19.99	20873877
353	Ubiquitination	NLPHEVDKSELKDFF CCCCCCCHHHHHHHH	51.51	19608861
353	Acetylation	NLPHEVDKSELKDFF CCCCCCCHHHHHHHH	51.51	23236377
354	Phosphorylation	LPHEVDKSELKDFFQ CCCCCCHHHHHHHHH	43.63	28555341
357	Ubiquitination	EVDKSELKDFFQSYG CCCHHHHHHHHHHHC	48.73	-
362	Phosphorylation	ELKDFFQSYGNVVEL HHHHHHHHHCCEEEE	29.83	28796482
363	Phosphorylation	LKDFFQSYGNVVELR HHHHHHHHCCEEEEE	11.26	28796482
373	Phosphorylation	VVELRINSGGKLPNF EEEEEECCCCCCCCE	46.69	22617229
376	Acetylation	LRINSGGKLPNFGFV EEECCCCCCCCEEEE	65.38	19608861
376	Sumoylation	LRINSGGKLPNFGFV EEECCCCCCCCEEEE	65.38	28112733
376	Ubiquitination	LRINSGGKLPNFGFV EEECCCCCCCCEEEE	65.38	19608861
388	Phosphorylation	GFVVFDDSEPVQKVL EEEEECCCHHHHHHH	45.72	21406692
393	Ubiquitination	DDSEPVQKVLSNRPI CCCHHHHHHHHCCCE	45.43	-
403	Methylation	SNRPIMFRGEVRLNV HCCCEEEEEEEEECH	24.00	-
413	Acetylation	VRLNVEEKKTRAARE EEECHHHHHHHHHHH	46.03	25953088
427	Methylation	EGDRRDNRLRGPGGP HCCCCCCCCCCCCCC	30.01	-
429	Asymmetric dimethylarginine	DRRDNRLRGPGGPRG CCCCCCCCCCCCCCC	46.12	-
429	Methylation	DRRDNRLRGPGGPRG CCCCCCCCCCCCCCC	46.12	24129315
435	Methylation	LRGPGGPRGGLGGGM CCCCCCCCCCCCCCC	55.90	24129315
435	Asymmetric dimethylarginine	LRGPGGPRGGLGGGM CCCCCCCCCCCCCCC	55.90	-
443	Methylation	GGLGGGMRGPPRGGM CCCCCCCCCCCCCCC	58.71	-
447	Methylation	GGMRGPPRGGMVQKP CCCCCCCCCCCCCCC	58.39	24129315
447	Dimethylation	GGMRGPPRGGMVQKP CCCCCCCCCCCCCCC	58.39	-
453	Methylation	PRGGMVQKPGFGVGR CCCCCCCCCCCCCCC	35.38	-
460	Methylation	KPGFGVGRGLAPRQ- CCCCCCCCCCCCCC-	34.25	24129315
460	Dimethylation	KPGFGVGRGLAPRQ- CCCCCCCCCCCCCC-	34.25	-
465	Methylation	VGRGLAPRQ------ CCCCCCCCC------	49.59	24129315
465	Dimethylation	VGRGLAPRQ------ CCCCCCCCC------	49.59	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
56	Y	Phosphorylation	Kinase	LCK	P06239	PSP
133	Y	Phosphorylation	Kinase	SRC	P12931	PSP
149	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
149	S	Phosphorylation	RASA1-dependent phosphorylation of Ser-149 induces a conformational change that prevents self-association.	11604510
149	S	Phosphorylation	Ser-149 phosphorylation induces partial nuclear localization.	11604510
435	R	Methylation	Arg-435 is dimethylated, probably to asymmetric dimethylarginine.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of G3BP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBP10_HUMAN	USP10	physical	11439350
ICLN_HUMAN	CLNS1A	physical	19615732
IF4G1_HUMAN	EIF4G1	physical	19615732
FLNA_HUMAN	FLNA	physical	19615732
FLNB_HUMAN	FLNB	physical	19615732
IFRD2_HUMAN	IFRD2	physical	19615732
NU214_HUMAN	NUP214	physical	19615732
H2A2A_HUMAN	HIST2H2AA3	physical	19615732
HAT1_HUMAN	HAT1	physical	19615732
UBP10_HUMAN	USP10	physical	19615732
ASCC3_HUMAN	ASCC3	physical	19615732
FAF1_HUMAN	FAF1	physical	19615732
ATX2L_HUMAN	ATXN2L	physical	19615732
NU188_HUMAN	NUP188	physical	19615732
NUP62_HUMAN	NUP62	physical	19615732
NOG2_HUMAN	GNL2	physical	19615732
UTP18_HUMAN	UTP18	physical	19615732
UIMC1_HUMAN	UIMC1	physical	19615732
YTHD1_HUMAN	YTHDF1	physical	19615732
TMA16_HUMAN	TMA16	physical	19615732
NUFP2_HUMAN	NUFIP2	physical	19615732
NOL6_HUMAN	NOL6	physical	19615732
KRI1_HUMAN	KRI1	physical	19615732
DHX40_HUMAN	DHX40	physical	19615732
RPAP2_HUMAN	RPAP2	physical	19615732
WDR36_HUMAN	WDR36	physical	19615732
CAPR1_HUMAN	CAPRIN1	physical	17210633
G3BP1_HUMAN	G3BP1	physical	12642610
HDAC6_HUMAN	HDAC6	physical	18079183
P53_HUMAN	TP53	physical	17297477
A4_HUMAN	APP	physical	21832049
TPM4_HUMAN	TPM4	physical	22939629
NOLC1_HUMAN	NOLC1	physical	22939629
UBP10_HUMAN	USP10	physical	23230274
PABP1_HUMAN	PABPC1	physical	23230274
IL7RA_HUMAN	IL7R	physical	23151878
SND1_HUMAN	SND1	physical	20643132
EDC4_HUMAN	EDC4	physical	22863883
EI2BG_HUMAN	EIF2B3	physical	22863883
EIF3C_HUMAN	EIF3C	physical	22863883
PA2G4_HUMAN	PA2G4	physical	22863883
PTBP1_HUMAN	PTBP1	physical	22863883
RL35_HUMAN	RPL35	physical	22863883
YBOX1_HUMAN	YBX1	physical	22863883
UBP10_HUMAN	USP10	physical	24998844
ADDG_HUMAN	ADD3	physical	26344197
PUR8_HUMAN	ADSL	physical	26344197
BLMH_HUMAN	BLMH	physical	26496610
CENPF_HUMAN	CENPF	physical	26496610
CATC_HUMAN	CTSC	physical	26496610
KC1G2_HUMAN	CSNK1G2	physical	26496610
EM55_HUMAN	MPP1	physical	26496610
STX3_HUMAN	STX3	physical	26496610
BCL7C_HUMAN	BCL7C	physical	26496610
COX5A_HUMAN	COX5A	physical	26496610
CROCC_HUMAN	CROCC	physical	26496610
RBM22_HUMAN	RBM22	physical	26496610
CTBL1_HUMAN	CTNNBL1	physical	26496610
IFIH1_HUMAN	IFIH1	physical	26496610
CCD84_HUMAN	CCDC84	physical	26496610
ACTBL_HUMAN	ACTBL2	physical	26777405
ACTZ_HUMAN	ACTR1A	physical	26777405
ACTY_HUMAN	ACTR1B	physical	26777405
DSRAD_HUMAN	ADAR	physical	26777405
AGO2_HUMAN	AGO2	physical	26777405
P5CS_HUMAN	ALDH18A1	physical	26777405
AN32E_HUMAN	ANP32E	physical	26777405
ANXA1_HUMAN	ANXA1	physical	26777405
ANXA6_HUMAN	ANXA6	physical	26777405
ANXA7_HUMAN	ANXA7	physical	26777405
APEX1_HUMAN	APEX1	physical	26777405
ARC1B_HUMAN	ARPC1B	physical	26777405
ATAD2_HUMAN	ATAD2	physical	26777405
ATD3A_HUMAN	ATAD3A	physical	26777405
ATPA_HUMAN	ATP5A1	physical	26777405
ATX2_HUMAN	ATXN2	physical	26777405
ATX2L_HUMAN	ATXN2L	physical	26777405
BAG3_HUMAN	BAG3	physical	26777405
BAF_HUMAN	BANF1	physical	26777405
BRAT1_HUMAN	BRAT1	physical	26777405
CN166_HUMAN	C14orf166	physical	26777405
CO052_HUMAN	C15orf52	physical	26777405
RTCB_HUMAN	RTCB	physical	26777405
CALL5_HUMAN	CALML5	physical	26777405
CAP1_HUMAN	CAP1	physical	26777405
CAPR1_HUMAN	CAPRIN1	physical	26777405
CAZA2_HUMAN	CAPZA2	physical	26777405
CHSP1_HUMAN	CARHSP1	physical	26777405
PEBB_HUMAN	CBFB	physical	26777405
CBX1_HUMAN	CBX1	physical	26777405
TCPG_HUMAN	CCT3	physical	26777405
TCPZ_HUMAN	CCT6A	physical	26777405
CDC5L_HUMAN	CDC5L	physical	26777405
CDC73_HUMAN	CDC73	physical	26777405
CDK1_HUMAN	CDK1	physical	26777405
CELF1_HUMAN	CELF1	physical	26777405
CENPB_HUMAN	CENPB	physical	26777405
COF1_HUMAN	CFL1	physical	26777405
MIC19_HUMAN	CHCHD3	physical	26777405
CHRD1_HUMAN	CHORDC1	physical	26777405
CTRO_HUMAN	CIT	physical	26777405
CLIC4_HUMAN	CLIC4	physical	26777405
CNN3_HUMAN	CNN3	physical	26777405
CNOT1_HUMAN	CNOT1	physical	26777405
COR1B_HUMAN	CORO1B	physical	26777405
CPSF3_HUMAN	CPSF3	physical	26777405
CPSF6_HUMAN	CPSF6	physical	26777405
CPSF7_HUMAN	CPSF7	physical	26777405
CRYAB_HUMAN	CRYAB	physical	26777405
CSDE1_HUMAN	CSDE1	physical	26777405
XPO2_HUMAN	CSE1L	physical	26777405
CSTF1_HUMAN	CSTF1	physical	26777405
CTNA2_HUMAN	CTNNA2	physical	26777405
CTND1_HUMAN	CTNND1	physical	26777405
CT2NL_HUMAN	CTTNBP2NL	physical	26777405
CWC22_HUMAN	CWC22	physical	26777405
DAZP1_HUMAN	DAZAP1	physical	26777405
DCD_HUMAN	DCD	physical	26777405
DDX1_HUMAN	DDX1	physical	26777405
DD19A_HUMAN	DDX19A	physical	26777405
DDX21_HUMAN	DDX21	physical	26777405
DDX3X_HUMAN	DDX3X	physical	26777405
DDX47_HUMAN	DDX47	physical	26777405
DDX50_HUMAN	DDX50	physical	26777405
DDX6_HUMAN	DDX6	physical	26777405
DHX30_HUMAN	DHX30	physical	26777405
DKC1_HUMAN	DKC1	physical	26777405
DNJA1_HUMAN	DNAJA1	physical	26777405
DNJC8_HUMAN	DNAJC8	physical	26777405
DPYL2_HUMAN	DPYSL2	physical	26777405
DPYL3_HUMAN	DPYSL3	physical	26777405
DESP_HUMAN	DSP	physical	26777405
DYST_HUMAN	DST	physical	26777405
DEST_HUMAN	DSTN	physical	26777405
DTX3L_HUMAN	DTX3L	physical	26777405
DYL2_HUMAN	DYNLL2	physical	26777405
EDC4_HUMAN	EDC4	physical	26777405
EIF2A_HUMAN	EIF2A	physical	26777405
IF2B_HUMAN	EIF2S2	physical	26777405
EIF3A_HUMAN	EIF3A	physical	26777405
EIF3B_HUMAN	EIF3B	physical	26777405
EIF3D_HUMAN	EIF3D	physical	26777405
EIF3E_HUMAN	EIF3E	physical	26777405
EIF3F_HUMAN	EIF3F	physical	26777405
EIF3G_HUMAN	EIF3G	physical	26777405
EIF3H_HUMAN	EIF3H	physical	26777405
EIF3I_HUMAN	EIF3I	physical	26777405
EIF3J_HUMAN	EIF3J	physical	26777405
EIF3K_HUMAN	EIF3K	physical	26777405
EIF3L_HUMAN	EIF3L	physical	26777405
EIF3M_HUMAN	EIF3M	physical	26777405
IF4A1_HUMAN	EIF4A1	physical	26777405
IF4B_HUMAN	EIF4B	physical	26777405
IF4G1_HUMAN	EIF4G1	physical	26777405
IF4G2_HUMAN	EIF4G2	physical	26777405
IF4H_HUMAN	EIF4H	physical	26777405
ELAV1_HUMAN	ELAVL1	physical	26777405
ELAV2_HUMAN	ELAVL2	physical	26777405
EPIPL_HUMAN	EPPK1	physical	26777405
ERF1_HUMAN	ETF1	physical	26777405
F120A_HUMAN	FAM120A	physical	26777405
FA98A_HUMAN	FAM98A	physical	26777405
FBRL_HUMAN	FBL	physical	26777405
FHL1_HUMAN	FHL1	physical	26777405
FLNB_HUMAN	FLNB	physical	26777405
FMR1_HUMAN	FMR1	physical	26777405
FND3B_HUMAN	FNDC3B	physical	26777405
FSCN1_HUMAN	FSCN1	physical	26777405
SPB1_HUMAN	FTSJ3	physical	26777405
FUBP3_HUMAN	FUBP3	physical	26777405
FXR1_HUMAN	FXR1	physical	26777405
FXR2_HUMAN	FXR2	physical	26777405
G3BP2_HUMAN	G3BP2	physical	26777405
GFPT1_HUMAN	GFPT1	physical	26777405
GBB2_HUMAN	GNB2	physical	26777405
H10_HUMAN	H1F0	physical	26777405
H1X_HUMAN	H1FX	physical	26777405
H2AV_HUMAN	H2AFV	physical	26777405
HNRL1_HUMAN	HNRNPUL1	physical	26777405
HELZ2_HUMAN	HELZ2	physical	26777405
HMGA1_HUMAN	HMGA1	physical	26777405
HMGB3_HUMAN	HMGB3	physical	26777405
HMGN1_HUMAN	HMGN1	physical	26777405
ROA3_HUMAN	HNRNPA3	physical	26777405
ROAA_HUMAN	HNRNPAB	physical	26777405
HNRH2_HUMAN	HNRNPH2	physical	26777405
HS90A_HUMAN	HSP90AA1	physical	26777405
HSP74_HUMAN	HSPA4	physical	26777405
GRP75_HUMAN	HSPA9	physical	26777405
CH60_HUMAN	HSPD1	physical	26777405
IF2B1_HUMAN	IGF2BP1	physical	26777405
IF2B2_HUMAN	IGF2BP2	physical	26777405
IF2B3_HUMAN	IGF2BP3	physical	26777405
RED_HUMAN	IK	physical	26777405
IPO7_HUMAN	IPO7	physical	26777405
ITB1_HUMAN	ITGB1	physical	26777405
KANK2_HUMAN	KANK2	physical	26777405
KHDR3_HUMAN	KHDRBS3	physical	26777405
CIP2A_HUMAN	KIAA1524	physical	26777405
KIF23_HUMAN	KIF23	physical	26777405
IMA5_HUMAN	KPNA1	physical	26777405
IMA1_HUMAN	KPNA2	physical	26777405
IMA7_HUMAN	KPNA6	physical	26777405
IMB1_HUMAN	KPNB1	physical	26777405
LARP1_HUMAN	LARP1	physical	26777405
LARP4_HUMAN	LARP4	physical	26777405
LBR_HUMAN	LBR	physical	26777405
MAN1_HUMAN	LEMD3	physical	26777405
LMNA_HUMAN	LMNA	physical	26777405
LPP_HUMAN	LPP	physical	26777405
LS14A_HUMAN	LSM14A	physical	26777405
LS14B_HUMAN	LSM14B	physical	26777405
LSM3_HUMAN	LSM3	physical	26777405
LUC7L_HUMAN	LUC7L	physical	26777405
LUZP1_HUMAN	LUZP1	physical	26777405
MACF1_HUMAN	MACF1	physical	26777405
MAGA4_HUMAN	MAGEA4	physical	26777405
MAGD1_HUMAN	MAGED1	physical	26777405
MAGD2_HUMAN	MAGED2	physical	26777405
MGN2_HUMAN	MAGOHB	physical	26777405
MAP4_HUMAN	MAP4	physical	26777405
M4K4_HUMAN	MAP4K4	physical	26777405
MARE1_HUMAN	MAPRE1	physical	26777405
SYMC_HUMAN	MARS	physical	26777405
MCM4_HUMAN	MCM4	physical	26777405
MCM5_HUMAN	MCM5	physical	26777405
MCM7_HUMAN	MCM7	physical	26777405
MAP11_HUMAN	METAP1	physical	26777405
MEX3A_HUMAN	MEX3A	physical	26777405
MFAP1_HUMAN	MFAP1	physical	26777405
KI67_HUMAN	MKI67	physical	26777405
MOV10_HUMAN	MOV10	physical	26777405
MSH6_HUMAN	MSH6	physical	26777405
MSI2H_HUMAN	MSI2	physical	26777405
C1TC_HUMAN	MTHFD1	physical	26777405
MYO6_HUMAN	MYO6	physical	26777405
NEXN_HUMAN	NEXN	physical	26777405
NOP58_HUMAN	NOP58	physical	26777405
NOSIP_HUMAN	NOSIP	physical	26777405
NSUN2_HUMAN	NSUN2	physical	26777405
NTM1A_HUMAN	NTMT1	physical	26777405
NUDC_HUMAN	NUDC	physical	26777405
NUFP2_HUMAN	NUFIP2	physical	26777405
NU205_HUMAN	NUP205	physical	26777405
NUP98_HUMAN	NUP98	physical	26777405
PABP4_HUMAN	PABPC4	physical	26777405
PAK4_HUMAN	PAK4	physical	26777405
PALLD_HUMAN	PALLD	physical	26777405
PAWR_HUMAN	PAWR	physical	26777405
PCNA_HUMAN	PCNA	physical	26777405
PDC6I_HUMAN	PDCD6IP	physical	26777405
PDLI1_HUMAN	PDLIM1	physical	26777405
PDLI4_HUMAN	PDLIM4	physical	26777405
PDLI5_HUMAN	PDLIM5	physical	26777405
PDS5B_HUMAN	PDS5B	physical	26777405
PELO_HUMAN	PELO	physical	26777405
PFD4_HUMAN	PFDN4	physical	26777405
PROF2_HUMAN	PFN2	physical	26777405
PGAM5_HUMAN	PGAM5	physical	26777405
PHLB2_HUMAN	PHLDB2	physical	26777405
PKP2_HUMAN	PKP2	physical	26777405
RPB2_HUMAN	POLR2B	physical	26777405
PPME1_HUMAN	PPME1	physical	26777405
PP1RA_HUMAN	PPP1R10	physical	26777405
PPR18_HUMAN	PPP1R18	physical	26777405
2AAA_HUMAN	PPP2R1A	physical	26777405
PRDX1_HUMAN	PRDX1	physical	26777405
PRDX6_HUMAN	PRDX6	physical	26777405
PRKRA_HUMAN	PRKRA	physical	26777405
ANM1_HUMAN	PRMT1	physical	26777405
ANM5_HUMAN	PRMT5	physical	26777405
PRC2A_HUMAN	PRRC2A	physical	26777405
PRC2C_HUMAN	PRRC2C	physical	26777405
PSMD2_HUMAN	PSMD2	physical	26777405
PTBP3_HUMAN	PTBP3	physical	26777405
TEBP_HUMAN	PTGES3	physical	26777405
PUM1_HUMAN	PUM1	physical	26777405
PUM2_HUMAN	PUM2	physical	26777405
PURA_HUMAN	PURA	physical	26777405
PURB_HUMAN	PURB	physical	26777405
P5CR1_HUMAN	PYCR1	physical	26777405
RAB1A_HUMAN	RAB1A	physical	26777405
RGAP1_HUMAN	RACGAP1	physical	26777405
RAD21_HUMAN	RAD21	physical	26777405
RANG_HUMAN	RANBP1	physical	26777405
RBBP4_HUMAN	RBBP4	physical	26777405
RFOX1_HUMAN	RBFOX1	physical	26777405
RB12B_HUMAN	RBM12B	physical	26777405
RBM26_HUMAN	RBM26	physical	26777405
RBMS1_HUMAN	RBMS1	physical	26777405
RBMS2_HUMAN	RBMS2	physical	26777405
RCC1_HUMAN	RCC1	physical	26777405
RCC2_HUMAN	RCC2	physical	26777405
RFC3_HUMAN	RFC3	physical	26777405
RFC4_HUMAN	RFC4	physical	26777405
RGPD3_HUMAN	RGPD3	physical	26777405
RN214_HUMAN	RNF214	physical	26777405
RINI_HUMAN	RNH1	physical	26777405
RL1D1_HUMAN	RSL1D1	physical	26777405
S1A7A_HUMAN	S100A7A	physical	26777405
S10A9_HUMAN	S100A9	physical	26777405
SAFB2_HUMAN	SAFB2	physical	26777405
SC24C_HUMAN	SEC24C	physical	26777405
1433S_HUMAN	SFN	physical	26777405
SI1L1_HUMAN	SIPA1L1	physical	26777405
SMCA1_HUMAN	SMARCA1	physical	26777405
SMC4_HUMAN	SMC4	physical	26777405
SMU1_HUMAN	SMU1	physical	26777405
RUXF_HUMAN	SNRPF	physical	26777405
SNTB2_HUMAN	SNTB2	physical	26777405
SRBS1_HUMAN	SORBS1	physical	26777405
SPS2L_HUMAN	SPATS2L	physical	26777405
CYTSA_HUMAN	SPECC1L	physical	26777405
SORCN_HUMAN	SRI	physical	26777405
SRRT_HUMAN	SRRT	physical	26777405
SRSF4_HUMAN	SRSF4	physical	26777405
STAT1_HUMAN	STAT1	physical	26777405
STAU1_HUMAN	STAU1	physical	26777405
STAU2_HUMAN	STAU2	physical	26777405
STIP1_HUMAN	STIP1	physical	26777405
STRAP_HUMAN	STRAP	physical	26777405
SUGP2_HUMAN	SUGP2	physical	26777405
SUN1_HUMAN	SUN1	physical	26777405
SYCP3_HUMAN	SYCP3	physical	26777405
HNRPQ_HUMAN	SYNCRIP	physical	26777405
TADBP_HUMAN	TARDBP	physical	26777405
TCEA1_HUMAN	TCEA1	physical	26777405
TCPA_HUMAN	TCP1	physical	26777405
TIA1_HUMAN	TIA1	physical	26777405
TIAR_HUMAN	TIAL1	physical	26777405
TMOD3_HUMAN	TMOD3	physical	26777405
TB182_HUMAN	TNKS1BP1	physical	26777405
TNPO1_HUMAN	TNPO1	physical	26777405
TNPO2_HUMAN	TNPO2	physical	26777405
TNR6B_HUMAN	TNRC6B	physical	26777405
TOM34_HUMAN	TOMM34	physical	26777405
TPM1_HUMAN	TPM1	physical	26777405
TPM2_HUMAN	TPM2	physical	26777405
RO52_HUMAN	TRIM21	physical	26777405
TRI25_HUMAN	TRIM25	physical	26777405
TRI56_HUMAN	TRIM56	physical	26777405
TRIP6_HUMAN	TRIP6	physical	26777405
TBA1C_HUMAN	TUBA1C	physical	26777405
TBA3C_HUMAN	TUBA3C	physical	26777405
TBA4A_HUMAN	TUBA4A	physical	26777405
TBB3_HUMAN	TUBB3	physical	26777405
TBB8_HUMAN	TUBB8	physical	26777405
EFTU_HUMAN	TUFM	physical	26777405
THIO_HUMAN	TXN	physical	26777405
U2AF1_HUMAN	U2AF1	physical	26777405
UBA1_HUMAN	UBA1	physical	26777405
UBAP2_HUMAN	UBAP2	physical	26777405
UBP2L_HUMAN	UBAP2L	physical	26777405
RENT1_HUMAN	UPF1	physical	26777405
UBP10_HUMAN	USP10	physical	26777405
UBP5_HUMAN	USP5	physical	26777405
VASP_HUMAN	VASP	physical	26777405
TERA_HUMAN	VCP	physical	26777405
SYYC_HUMAN	YARS	physical	26777405
YBOX3_HUMAN	YBX3	physical	26777405
YES_HUMAN	YES1	physical	26777405
YTHD1_HUMAN	YTHDF1	physical	26777405
YTHD2_HUMAN	YTHDF2	physical	26777405
YTHD3_HUMAN	YTHDF3	physical	26777405
1433B_HUMAN	YWHAB	physical	26777405
1433F_HUMAN	YWHAH	physical	26777405
1433T_HUMAN	YWHAQ	physical	26777405
ZC3HE_HUMAN	ZC3H14	physical	26777405
Z3H7A_HUMAN	ZC3H7A	physical	26777405
Z3H7B_HUMAN	ZC3H7B	physical	26777405
ZCCHV_HUMAN	ZC3HAV1	physical	26777405
ZN638_HUMAN	ZNF638	physical	26777405
SRSF3_HUMAN	SRSF3	physical	26777405
UBP10_HUMAN	USP10	physical	27022092
CAPR1_HUMAN	CAPRIN1	physical	27022092
RS6_HUMAN	RPS6	physical	27022092
RS23_HUMAN	RPS23	physical	27022092
PPIA_HUMAN	PPIA	physical	28394340

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-376, AND MASS SPECTROMETRY.
PubMed: 19608861

Methylation

"Identifying and quantifying in vivo methylation sites by heavy methylSILAC.";
Ong S.E., Mittler G., Mann M.;
Nat. Methods 1:119-126(2004).
Cited for: METHYLATION [LARGE SCALE ANALYSIS] AT ARG-435; ARG-447; ARG-460 ANDARG-465, AND MASS SPECTROMETRY.
PubMed: 15782174

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149 AND SER-232, ANDMASS SPECTROMETRY.
PubMed: 19690332

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230 AND SER-232, ANDMASS SPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149; SER-231 ANDSER-232, AND MASS SPECTROMETRY.
PubMed: 19413330

"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography.";
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.;
Proteomics 8:1346-1361(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149, AND MASSSPECTROMETRY.
PubMed: 18318008

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-143; SER-149; SER-232AND SER-373, AND MASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149 AND SER-232, ANDMASS SPECTROMETRY.
PubMed: 18691976

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149 AND SER-232, ANDMASS SPECTROMETRY.
PubMed: 18220336

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231 AND SER-232, ANDMASS SPECTROMETRY.
PubMed: 18187866

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230; SER-231 ANDSER-232, AND MASS SPECTROMETRY.
PubMed: 17287340

"Quantitative phosphoproteome profiling of Wnt3a-mediated signalingnetwork: indicating the involvement of ribonucleoside-diphosphatereductase M2 subunit phosphorylation at residue serine 20 in canonicalWnt signal transduction.";
Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S.,Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.;
Mol. Cell. Proteomics 6:1952-1967(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149, AND MASSSPECTROMETRY.
PubMed: 17693683

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, AND MASSSPECTROMETRY.
PubMed: 17924679

"Toward a global characterization of the phosphoproteome in prostatecancer cells: identification of phosphoproteins in the LNCaP cellline.";
Giorgianni F., Zhao Y., Desiderio D.M., Beranova-Giorgianni S.;
Electrophoresis 28:2027-2034(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, AND MASSSPECTROMETRY.
PubMed: 17487921

"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149, AND MASSSPECTROMETRY.
PubMed: 16565220

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149, AND MASSSPECTROMETRY.
PubMed: 17081983

"Quantitative phosphoproteome analysis using a dendrimer conjugationchemistry and tandem mass spectrometry.";
Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J.,Bodenmiller B., Watts J.D., Hood L., Aebersold R.;
Nat. Methods 2:591-598(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, AND MASSSPECTROMETRY.
PubMed: 16094384

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, AND MASSSPECTROMETRY.
PubMed: 15302935

"RasGAP-associated endoribonuclease G3Bp: selective RNA degradationand phosphorylation-dependent localization.";
Tourriere H., Gallouzi I.-E., Chebli K., Capony J.-P., Mouaikel J.,van der Geer P., Tazi J.;
Mol. Cell. Biol. 21:7747-7760(2001).
Cited for: FUNCTION AS AN ENDORIBONUCLEASE, PHOSPHORYLATION AT SER-149 ANDSER-232, AND MUTAGENESIS OF SER-149 AND SER-232.
PubMed: 11604510