dbPTM

ATAD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ATAD2_HUMAN
UniProt AC	Q6PL18
Protein Name	ATPase family AAA domain-containing protein 2
Gene Name	ATAD2
Organism	Homo sapiens (Human).
Sequence Length	1390
Subcellular Localization	Nucleus .
Protein Description	May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells..
Protein Sequence	MVVLRSSLELHNHSAASATGSLDLSSDFLSLEHIGRRRLRSAGAAQKKPAATTAKAGDGSSVKEVETYHRTRALRSLRKDAQNSSDSSFEKNVEITEQLANGRHFTRQLARQQADKKKEEHREDKVIPVTRSLRARNIVQSTEHLHEDNGDVEVRRSCRIRSRYSGVNQSMLFDKLITNTAEAVLQKMDDMKKMRRQRMRELEDLGVFNETEESNLNMYTRGKQKDIQRTDEETTDNQEGSVESSEEGEDQEHEDDGEDEDDEDDDDDDDDDDDDDDEDDEDEEDGEEENQKRYYLRQRKATVYYQAPLEKPRHQRKPNIFYSGPASPARPRYRLSSAGPRSPYCKRMNRRRHAIHSSDSTSSSSSEDEQHFERRRKRSRNRAINRCLPLNFRKDELKGIYKDRMKIGASLADVDPMQLDSSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSINISAKDFEVAMQKMIPASQRAVTSPGQALSTVVKPLLQNTVDKILEALQRVFPHAEFRTNKTLDSDISCPLLESDLAYSDDDVPSVYENGLSQKSSHKAKDNFNFLHLNRNACYQPMSFRPRILIVGEPGFGQGSHLAPAVIHALEKFTVYTLDIPVLFGVSTTSPEETCAQVIREAKRTAPSIVYVPHIHVWWEIVGPTLKATFTTLLQNIPSFAPVLLLATSDKPHSALPEEVQELFIRDYGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKKAVLQALEVLPVAPPPEPRSLTAEEVKRLEEQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQPMDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRACALRDTAYAIIKEELDEDFEQLCEEIQESRKKRGCSSSKYAPSYYHVMPKQNSTLVGDKRSDPEQNEKLKTPSTPVACSTPAQLKRKIRKKSNWYLGTIKKRRKISQAKDDSQNAIDHKIESDTEETQDTSVDHNETGNTGESSVEENEKQQNASESKLELRNNSNTCNIENELEDSRKTTACTELRDKIACNGDASSSQIIHISDENEGKEMCVLRMTRARRSQVEQQQLITVEKALAILSQPTPSLVVDHERLKNLLKTVVKKSQNYNIFQLENLYAVISQCIYRHRKDHDKTSLIQKMEQEVENFSCSR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MVVLRSSLELHNH --CEEECCCEEECCC	34.80	28122231
7	Phosphorylation	-MVVLRSSLELHNHS -CEEECCCEEECCCC	21.30	28122231
14	Phosphorylation	SLELHNHSAASATGS CEEECCCCCCCCCCC	30.74	28122231
17	Phosphorylation	LHNHSAASATGSLDL ECCCCCCCCCCCCCC	26.53	22468782
19	Phosphorylation	NHSAASATGSLDLSS CCCCCCCCCCCCCCC	25.47	22468782
21	Phosphorylation	SAASATGSLDLSSDF CCCCCCCCCCCCCCC	17.85	22468782
26	Phosphorylation	TGSLDLSSDFLSLEH CCCCCCCCCCCCHHH	39.41	28122231
41	Phosphorylation	IGRRRLRSAGAAQKK HHHHHHHHCCCCCCC	35.33	30266825
47	Acetylation	RSAGAAQKKPAATTA HHCCCCCCCCCCCEE	56.87	25953088
48	Ubiquitination	SAGAAQKKPAATTAK HCCCCCCCCCCCEEE	28.01	-
55	Acetylation	KPAATTAKAGDGSSV CCCCCEEECCCCCCH	51.30	25953088
55	Ubiquitination	KPAATTAKAGDGSSV CCCCCEEECCCCCCH	51.30	21906983
55 (in isoform 1)	Ubiquitination	-	51.30	21890473
60	Phosphorylation	TAKAGDGSSVKEVET EEECCCCCCHHHHHH	36.38	30266825
61	Phosphorylation	AKAGDGSSVKEVETY EECCCCCCHHHHHHH	42.62	23401153
63	Acetylation	AGDGSSVKEVETYHR CCCCCCHHHHHHHHH	58.97	26051181
63	Ubiquitination	AGDGSSVKEVETYHR CCCCCCHHHHHHHHH	58.97	21906983
63 (in isoform 1)	Ubiquitination	-	58.97	21890473
67	Phosphorylation	SSVKEVETYHRTRAL CCHHHHHHHHHHHHH	29.78	23312004
68	Phosphorylation	SVKEVETYHRTRALR CHHHHHHHHHHHHHH	3.93	23312004
76	Phosphorylation	HRTRALRSLRKDAQN HHHHHHHHHHHHHHC	33.12	26670566
79	Ubiquitination	RALRSLRKDAQNSSD HHHHHHHHHHHCCCC	63.81	21906983
79 (in isoform 1)	Ubiquitination	-	63.81	21890473
84	Phosphorylation	LRKDAQNSSDSSFEK HHHHHHCCCCCCHHH	24.36	23663014
85	Phosphorylation	RKDAQNSSDSSFEKN HHHHHCCCCCCHHHH	49.41	25159151
87	Phosphorylation	DAQNSSDSSFEKNVE HHHCCCCCCHHHHHH	38.58	29255136
88	Phosphorylation	AQNSSDSSFEKNVEI HHCCCCCCHHHHHHH	42.27	29255136
91	Ubiquitination	SSDSSFEKNVEITEQ CCCCCHHHHHHHHHH	65.37	21906983
91 (in isoform 1)	Ubiquitination	-	65.37	21890473
96	Phosphorylation	FEKNVEITEQLANGR HHHHHHHHHHHHCCH	12.27	23663014
125	Sumoylation	KEEHREDKVIPVTRS HHHHHHCCCCCHHHH	36.99	28112733
130	Phosphorylation	EDKVIPVTRSLRARN HCCCCCHHHHHHHHC	14.80	23828894
132	Phosphorylation	KVIPVTRSLRARNIV CCCCHHHHHHHHCHH	16.91	17924679
141	Phosphorylation	RARNIVQSTEHLHED HHHCHHHHCCHHCCC	25.52	23401153
141 (in isoform 2)	Ubiquitination	-	25.52	21890473
142	Phosphorylation	ARNIVQSTEHLHEDN HHCHHHHCCHHCCCC	15.44	30266825
157	Phosphorylation	GDVEVRRSCRIRSRY CCCHHHHHCCCCCCC	9.36	17081983
162	Phosphorylation	RRSCRIRSRYSGVNQ HHHCCCCCCCCCCCH	32.95	23401153
164	Phosphorylation	SCRIRSRYSGVNQSM HCCCCCCCCCCCHHH	15.83	28450419
165	Phosphorylation	CRIRSRYSGVNQSML CCCCCCCCCCCHHHH	34.84	25159151
170	Acetylation	RYSGVNQSMLFDKLI CCCCCCHHHHHHHHH	16.55	19608861
170	Phosphorylation	RYSGVNQSMLFDKLI CCCCCCHHHHHHHHH	16.55	30266825
175	Acetylation	NQSMLFDKLITNTAE CHHHHHHHHHHHHHH	34.16	19608861
175	Ubiquitination	NQSMLFDKLITNTAE CHHHHHHHHHHHHHH	34.16	19608861
187	Acetylation	TAEAVLQKMDDMKKM HHHHHHHHHHHHHHH	39.89	19608861
187	Ubiquitination	TAEAVLQKMDDMKKM HHHHHHHHHHHHHHH	39.89	19608861
211	Phosphorylation	DLGVFNETEESNLNM HHCCCCCCCCCCCHH	46.27	30576142
214	Phosphorylation	VFNETEESNLNMYTR CCCCCCCCCCHHHCC	40.14	30576142
220	Phosphorylation	ESNLNMYTRGKQKDI CCCCHHHCCCCHHCC	23.37	28122231
236 (in isoform 2)	Ubiquitination	-	63.33	21890473
300	Ubiquitination	RYYLRQRKATVYYQA HHHHHHHCCEEEEEC	39.82	-
302	Phosphorylation	YLRQRKATVYYQAPL HHHHHCCEEEEECCC	16.45	20068231
304	Phosphorylation	RQRKATVYYQAPLEK HHHCCEEEEECCCCC	5.87	-
305	Phosphorylation	QRKATVYYQAPLEKP HHCCEEEEECCCCCC	8.21	25159151
311	Acetylation	YYQAPLEKPRHQRKP EEECCCCCCCCCCCC	55.84	26051181
311	Ubiquitination	YYQAPLEKPRHQRKP EEECCCCCCCCCCCC	55.84	21890473
311 (in isoform 1)	Ubiquitination	-	55.84	21890473
317	Sumoylation	EKPRHQRKPNIFYSG CCCCCCCCCCEEECC	35.53	28112733
322	Phosphorylation	QRKPNIFYSGPASPA CCCCCEEECCCCCCC	14.66	23927012
323	Phosphorylation	RKPNIFYSGPASPAR CCCCEEECCCCCCCC	27.79	29255136
327	Phosphorylation	IFYSGPASPARPRYR EEECCCCCCCCCCCC	23.40	29255136
333	Phosphorylation	ASPARPRYRLSSAGP CCCCCCCCCCCCCCC	20.70	23186163
336	Phosphorylation	ARPRYRLSSAGPRSP CCCCCCCCCCCCCCH	14.78	27273156
337	Phosphorylation	RPRYRLSSAGPRSPY CCCCCCCCCCCCCHH	41.66	23401153
342	Phosphorylation	LSSAGPRSPYCKRMN CCCCCCCCHHHHHHH	24.29	22167270
344	Phosphorylation	SAGPRSPYCKRMNRR CCCCCCHHHHHHHHC	16.32	23927012
360	Phosphorylation	HAIHSSDSTSSSSSE CCCCCCCCCCCCCCH	31.94	25814448
361	Phosphorylation	AIHSSDSTSSSSSED CCCCCCCCCCCCCHH	37.30	25814448
362	Phosphorylation	IHSSDSTSSSSSEDE CCCCCCCCCCCCHHH	31.98	25814448
372 (in isoform 2)	Phosphorylation	-	8.58	24260401
379	Phosphorylation	FERRRKRSRNRAINR HHHHHHHHHHHHHHH	36.62	22817900
398	Ubiquitination	NFRKDELKGIYKDRM CCCHHHHCCHHHCCC	41.01	-
406	Ubiquitination	GIYKDRMKIGASLAD CHHHCCCCCCCCCCC	38.59	21906983
406 (in isoform 1)	Ubiquitination	-	38.59	21890473
410	Phosphorylation	DRMKIGASLADVDPM CCCCCCCCCCCCCHH	20.91	23186163
421	Phosphorylation	VDPMQLDSSVRFDSV CCHHHCCCCCCCCCC	39.05	23186163
422	Phosphorylation	DPMQLDSSVRFDSVG CHHHCCCCCCCCCCC	19.58	23186163
456	Ubiquitination	PEVFEKFKIQPPRGC HHHHHHCCCCCCCCE	52.04	-
473	Ubiquitination	YGPPGTGKTLVARAL ECCCCCCHHHHHHHH	38.22	-
489	Acetylation	NECSQGDKRVAFFMR HHCCCCCHHHHHHHH	56.44	26051181
489	Ubiquitination	NECSQGDKRVAFFMR HHCCCCCHHHHHHHH	56.44	-
497	Ubiquitination	RVAFFMRKGADCLSK HHHHHHHHCHHHHHH	46.81	-
504	Acetylation	KGADCLSKWVGESER HCHHHHHHHCCCCHH	32.71	26051181
504	Ubiquitination	KGADCLSKWVGESER HCHHHHHHHCCCCHH	32.71	-
579	Phosphorylation	GATNRLDSIDPALRR ECCCCHHCCCHHHCC	33.22	23186163
601	Ubiquitination	FLFSLPDKEARKEIL HHHCCCCHHHHHHHH	51.86	21906983
601 (in isoform 1)	Ubiquitination	-	51.86	21890473
609	Ubiquitination	EARKEILKIHTRDWN HHHHHHHHHHHCCCC	37.80	-
670	Phosphorylation	EKLQLDLSSINISAK CCEECCHHHCCCCHH	28.92	25159151
671	Phosphorylation	KLQLDLSSINISAKD CEECCHHHCCCCHHH	27.27	23663014
677	Ubiquitination	SSINISAKDFEVAMQ HHCCCCHHHHHHHHH	57.04	-
685	Ubiquitination	DFEVAMQKMIPASQR HHHHHHHHHCCHHHC	26.22	21906983
685 (in isoform 1)	Ubiquitination	-	26.22	21890473
695	Phosphorylation	PASQRAVTSPGQALS CHHHCCCCCHHHHHH	28.37	20068231
696	Phosphorylation	ASQRAVTSPGQALST HHHCCCCCHHHHHHH	22.04	27067055
706	Ubiquitination	QALSTVVKPLLQNTV HHHHHHHHHHHHHHH	26.13	21906983
706 (in isoform 1)	Ubiquitination	-	26.13	21890473
734	Phosphorylation	AEFRTNKTLDSDISC CHHCCCCCCCCCCCC	37.56	20873877
737	Phosphorylation	RTNKTLDSDISCPLL CCCCCCCCCCCCCCC	39.70	20873877
740	Phosphorylation	KTLDSDISCPLLESD CCCCCCCCCCCCCCH	18.05	20873877
746	Phosphorylation	ISCPLLESDLAYSDD CCCCCCCCHHCCCCC	37.58	25159151
750	Phosphorylation	LLESDLAYSDDDVPS CCCCHHCCCCCCCCH	21.67	28102081
751	Phosphorylation	LESDLAYSDDDVPSV CCCHHCCCCCCCCHH	29.02	25159151
757	Phosphorylation	YSDDDVPSVYENGLS CCCCCCCHHHHCCCC	36.86	23663014
759	Phosphorylation	DDDVPSVYENGLSQK CCCCCHHHHCCCCCC	14.17	23663014
764	Phosphorylation	SVYENGLSQKSSHKA HHHHCCCCCCCCCCC	36.64	20068231
767	Phosphorylation	ENGLSQKSSHKAKDN HCCCCCCCCCCCCCC	30.00	26074081
768	Phosphorylation	NGLSQKSSHKAKDNF CCCCCCCCCCCCCCC	35.72	26074081
772	Acetylation	QKSSHKAKDNFNFLH CCCCCCCCCCCCEEE	58.99	23749302
772	Ubiquitination	QKSSHKAKDNFNFLH CCCCCCCCCCCCEEE	58.99	-
790	Phosphorylation	NACYQPMSFRPRILI CCCCCCCCCCCEEEE	25.45	24719451
852	Phosphorylation	VIREAKRTAPSIVYV HHHHHHHHCCCEEEE	42.06	-
855	Phosphorylation	EAKRTAPSIVYVPHI HHHHHCCCEEEECEE	23.40	-
858	Phosphorylation	RTAPSIVYVPHIHVW HHCCCEEEECEEEEH	13.44	-
926	Ubiquitination	FNVQLPDKEERTKFF HCEECCCHHHHHHHH	60.58	21906983
926 (in isoform 1)	Ubiquitination	-	60.58	21890473
931	Ubiquitination	PDKEERTKFFEDLIL CCHHHHHHHHHHHHH	55.03	21890473
931 (in isoform 1)	Ubiquitination	-	55.03	21890473
939	Ubiquitination	FFEDLILKQAAKPPI HHHHHHHHHHCCCCC	30.78	-
949	Ubiquitination	AKPPISKKKAVLQAL CCCCCCHHHHHHHHH	38.89	-
950	Ubiquitination	KPPISKKKAVLQALE CCCCCHHHHHHHHHH	47.68	-
969	Phosphorylation	APPPEPRSLTAEEVK CCCCCCCCCCHHHHH	40.56	25849741
971	Phosphorylation	PPEPRSLTAEEVKRL CCCCCCCCHHHHHHH	33.01	19691289
976	Ubiquitination	SLTAEEVKRLEEQEE CCCHHHHHHHHHHHH	55.32	21906983
976 (in isoform 1)	Ubiquitination	-	55.32	21890473
997	Phosphorylation	RIFLRNVTHRLAIDK HHHHHHHHHHHHHCC	12.58	24719451
1011	Ubiquitination	KRFRVFTKPVDPDEV CCEEEECCCCCCCCC	31.42	21906983
1011 (in isoform 1)	Ubiquitination	-	31.42	21890473
1021	Phosphorylation	DPDEVPDYVTVIKQP CCCCCCCCEEEECCC	7.61	28796482
1023	Phosphorylation	DEVPDYVTVIKQPMD CCCCCCEEEECCCCC	15.41	28796482
1026	Ubiquitination	PDYVTVIKQPMDLSS CCCEEEECCCCCHHH	43.97	21906983
1026 (in isoform 1)	Ubiquitination	-	43.97	21890473
1032	O-linked_Glycosylation	IKQPMDLSSVISKID ECCCCCHHHHHHHCC	20.49	OGP
1032	Phosphorylation	IKQPMDLSSVISKID ECCCCCHHHHHHHCC	20.49	26074081
1033	O-linked_Glycosylation	KQPMDLSSVISKIDL CCCCCHHHHHHHCCH	30.66	OGP
1033	Phosphorylation	KQPMDLSSVISKIDL CCCCCHHHHHHHCCH	30.66	26074081
1036	Phosphorylation	MDLSSVISKIDLHKY CCHHHHHHHCCHHHH	22.77	26074081
1037	Ubiquitination	DLSSVISKIDLHKYL CHHHHHHHCCHHHHC	29.17	-
1042	Ubiquitination	ISKIDLHKYLTVKDY HHHCCHHHHCCHHHH	49.61	21890473
1042 (in isoform 1)	Ubiquitination	-	49.61	21890473
1043	Phosphorylation	SKIDLHKYLTVKDYL HHCCHHHHCCHHHHH	9.25	26074081
1045	Phosphorylation	IDLHKYLTVKDYLRD CCHHHHCCHHHHHHH	23.55	24719451
1047	Ubiquitination	LHKYLTVKDYLRDID HHHHCCHHHHHHHHH	35.11	-
1049	Phosphorylation	KYLTVKDYLRDIDLI HHCCHHHHHHHHHHH	9.64	26074081
1058	Phosphorylation	RDIDLICSNALEYNP HHHHHHCCCCHHCCC	20.39	26074081
1063	Phosphorylation	ICSNALEYNPDRDPG HCCCCHHCCCCCCCC	32.61	-
1084	Phosphorylation	RACALRDTAYAIIKE HHHHHHHHHHHHHHH	18.35	20068231
1086	Phosphorylation	CALRDTAYAIIKEEL HHHHHHHHHHHHHHC	10.63	20068231
1090	Sumoylation	DTAYAIIKEELDEDF HHHHHHHHHHCHHHH	38.74	-
1117	Acetylation	KRGCSSSKYAPSYYH HCCCCCCCCCCCEEE	47.59	25953088
1117	Ubiquitination	KRGCSSSKYAPSYYH HCCCCCCCCCCCEEE	47.59	-
1118	Phosphorylation	RGCSSSKYAPSYYHV CCCCCCCCCCCEEEE	26.20	28555341
1121	Phosphorylation	SSSKYAPSYYHVMPK CCCCCCCCEEEECCC	30.10	28555341
1122	Phosphorylation	SSKYAPSYYHVMPKQ CCCCCCCEEEECCCC	9.13	27642862
1128	Sumoylation	SYYHVMPKQNSTLVG CEEEECCCCCCCCCC	43.97	28112733
1128	Ubiquitination	SYYHVMPKQNSTLVG CEEEECCCCCCCCCC	43.97	-
1131	Phosphorylation	HVMPKQNSTLVGDKR EECCCCCCCCCCCCC	22.18	30576142
1132	Phosphorylation	VMPKQNSTLVGDKRS ECCCCCCCCCCCCCC	32.77	30108239
1137	Ubiquitination	NSTLVGDKRSDPEQN CCCCCCCCCCCHHHH	48.12	-
1139	Phosphorylation	TLVGDKRSDPEQNEK CCCCCCCCCHHHHHC	64.36	25159151
1146	Ubiquitination	SDPEQNEKLKTPSTP CCHHHHHCCCCCCCC	63.93	21906983
1146 (in isoform 1)	Ubiquitination	-	63.93	21890473
1148	Sumoylation	PEQNEKLKTPSTPVA HHHHHCCCCCCCCCC	70.25	28112733
1148	Ubiquitination	PEQNEKLKTPSTPVA HHHHHCCCCCCCCCC	70.25	-
1149	Phosphorylation	EQNEKLKTPSTPVAC HHHHCCCCCCCCCCC	32.67	25159151
1151	Phosphorylation	NEKLKTPSTPVACST HHCCCCCCCCCCCCC	51.04	25159151
1152	Phosphorylation	EKLKTPSTPVACSTP HCCCCCCCCCCCCCH	24.00	25159151
1157	Phosphorylation	PSTPVACSTPAQLKR CCCCCCCCCHHHHHH	27.91	25159151
1158	Phosphorylation	STPVACSTPAQLKRK CCCCCCCCHHHHHHH	23.64	25159151
1163	Ubiquitination	CSTPAQLKRKIRKKS CCCHHHHHHHHHHCC	39.30	-
1170	Phosphorylation	KRKIRKKSNWYLGTI HHHHHHCCCCCHHHH	35.31	20873877
1173	Phosphorylation	IRKKSNWYLGTIKKR HHHCCCCCHHHHHHH	10.25	27642862
1176	Phosphorylation	KSNWYLGTIKKRRKI CCCCCHHHHHHHHCH	27.33	20873877
1184	Phosphorylation	IKKRRKISQAKDDSQ HHHHHCHHHCCCCCC	27.41	20873877
1190	Phosphorylation	ISQAKDDSQNAIDHK HHHCCCCCCHHHCCC	35.15	29255136
1200	Phosphorylation	AIDHKIESDTEETQD HHCCCCCCCCCCCCC	53.99	22167270
1202	Phosphorylation	DHKIESDTEETQDTS CCCCCCCCCCCCCCC	45.03	22167270
1205	Phosphorylation	IESDTEETQDTSVDH CCCCCCCCCCCCCCC	26.05	28450419
1208	Phosphorylation	DTEETQDTSVDHNET CCCCCCCCCCCCCCC	22.34	28450419
1209	Phosphorylation	TEETQDTSVDHNETG CCCCCCCCCCCCCCC	33.56	30576142
1215	Phosphorylation	TSVDHNETGNTGESS CCCCCCCCCCCCCCC	40.84	30576142
1218	Phosphorylation	DHNETGNTGESSVEE CCCCCCCCCCCCHHH	43.61	30576142
1221	Phosphorylation	ETGNTGESSVEENEK CCCCCCCCCHHHHHH	40.82	20363803
1222	Phosphorylation	TGNTGESSVEENEKQ CCCCCCCCHHHHHHH	29.28	20363803
1233	Phosphorylation	NEKQQNASESKLELR HHHHHCCCHHHHHHH	50.37	30266825
1235	Phosphorylation	KQQNASESKLELRNN HHHCCCHHHHHHHCC	39.79	30266825
1236	Sumoylation	QQNASESKLELRNNS HHCCCHHHHHHHCCC	41.76	28112733
1236	Ubiquitination	QQNASESKLELRNNS HHCCCHHHHHHHCCC	41.76	21906983
1236 (in isoform 1)	Ubiquitination	-	41.76	21890473
1243	Phosphorylation	KLELRNNSNTCNIEN HHHHHCCCCCCCCCH	36.74	25159151
1245	Phosphorylation	ELRNNSNTCNIENEL HHHCCCCCCCCCHHH	13.52	30266825
1255	Phosphorylation	IENELEDSRKTTACT CCHHHHHHHCCHHCH	26.71	25159151
1257	Ubiquitination	NELEDSRKTTACTEL HHHHHHHCCHHCHHH	54.93	-
1258	Phosphorylation	ELEDSRKTTACTELR HHHHHHCCHHCHHHH	20.65	30108239
1259	Phosphorylation	LEDSRKTTACTELRD HHHHHCCHHCHHHHH	23.83	30108239
1262	Phosphorylation	SRKTTACTELRDKIA HHCCHHCHHHHHHHC	35.27	30108239
1267	Ubiquitination	ACTELRDKIACNGDA HCHHHHHHHCCCCCC	26.26	-
1275	Phosphorylation	IACNGDASSSQIIHI HCCCCCCCCCCEEEE	34.95	30576142
1276	Phosphorylation	ACNGDASSSQIIHIS CCCCCCCCCCEEEEE	28.16	30576142
1277	Phosphorylation	CNGDASSSQIIHISD CCCCCCCCCEEEEEC	23.93	25850435
1283	Phosphorylation	SSQIIHISDENEGKE CCCEEEEECCCCCCE	25.39	30266825
1289	Acetylation	ISDENEGKEMCVLRM EECCCCCCEEEHHHH	35.78	26051181
1302	Phosphorylation	RMTRARRSQVEQQQL HHHHHHHHHHHHHHC	32.78	25159151
1311	Phosphorylation	VEQQQLITVEKALAI HHHHHCHHHHHHHHH	31.07	28111955
1314	Ubiquitination	QQLITVEKALAILSQ HHCHHHHHHHHHHHC	44.35	2190698
1314 (in isoform 1)	Ubiquitination	-	44.35	21890473
1323	Phosphorylation	LAILSQPTPSLVVDH HHHHHCCCCCEEECH	20.20	28112733
1372	Ubiquitination	RHRKDHDKTSLIQKM HCCCCCCCCHHHHHH	36.27	-
1378	Ubiquitination	DKTSLIQKMEQEVEN CCCHHHHHHHHHHHH	37.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ATAD2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ATAD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ATAD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYC_HUMAN	MYC	physical	19843847
NCOA3_HUMAN	NCOA3	physical	17998543
ESR1_HUMAN	ESR1	physical	17998543
H31T_HUMAN	HIST3H3	physical	20855524
SPTN2_HUMAN	SPTBN2	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ATAD2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-170 AND SER-1302, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1158 AND SER-1243, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-746; SER-751; THR-1149;THR-1152; THR-1158 AND SER-1302, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1302, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132, AND MASSSPECTROMETRY.	17924679 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 AND SER-1243, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-751, AND MASSSPECTROMETRY.	15302935 [Abstract]