YTHD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YTHD3_HUMAN
• UniProt AC: Q7Z739
• Protein Name: YTH domain-containing family protein 3 {ECO:0000305}
• Gene Name: YTHDF3 {ECO:0000312|HGNC:HGNC:26465}
• Organism: Homo sapiens (Human).
• Sequence Length: 585
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs and promotes RNA translation efficiency. [PubMed: 28106072]
• Protein Sequence: MSATSVDQRPKGQGNKVSVQNGSIHQKDAVNDDDFEPYLSSQTNQSNSYPPMSDPYMPSYYAPSIGFPYSLGEAAWSTAGDQPMPYLTTYGQMSNGEHHYIPDGVFSQPGALGNTPPFLGQHGFNFFPGNADFSTWGTSGSQGQSTQSSAYSSSYGYPPSSLGRAITDGQAGFGNDTLSKVPGISSIEQGMTGLKIGGDLTAAVTKTVGTALSSSGMTSIATNSVPPVSSAAPKPTSWAAIARKPAKPQPKLKPKGNVGIGGSAVPPPPIKHNMNIGTWDEKGSVVKAPPTQPVLPPQTIIQQPQPLIQPPPLVQSQLPQQQPQPPQPQQQQGPQPQAQPHQVQPQQQQLQNRWVAPRNRGAGFNQNNGAGSENFGLGVVPVSASPSSVEVHPVLEKLKAINNYNPKDFDWNLKNGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDAAYRSLNGKGPLYLLFSVNGSGHFCGVAEMKSVVDYNAYAGVWSQDKWKGKFEVKWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIATFKHTTSIFDDFAHYEKRQEEEEAMRRERNRNKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSATSVDQR ------CCCCCCCCC	40.01	29255136
2	Acetylation	------MSATSVDQR ------CCCCCCCCC	40.01	22814378
4	Phosphorylation	----MSATSVDQRPK ----CCCCCCCCCCC	23.21	29255136
5	Phosphorylation	---MSATSVDQRPKG ---CCCCCCCCCCCC	24.34	22199227
16	Ubiquitination	RPKGQGNKVSVQNGS CCCCCCCCEEEECCC	42.59	-
18	Phosphorylation	KGQGNKVSVQNGSIH CCCCCCEEEECCCEE	21.42	27251275
23	Phosphorylation	KVSVQNGSIHQKDAV CEEEECCCEECCCCC	25.17	25159151
107	Phosphorylation	YIPDGVFSQPGALGN CCCCCCCCCCCCCCC	32.81	26074081
115	Phosphorylation	QPGALGNTPPFLGQH CCCCCCCCCCCCCCC	30.46	26074081
149	O-linked_Glycosylation	QGQSTQSSAYSSSYG CCCCCCCHHCCCCCC	22.78	20068230
151	Phosphorylation	QSTQSSAYSSSYGYP CCCCCHHCCCCCCCC	15.84	-
155	Phosphorylation	SSAYSSSYGYPPSSL CHHCCCCCCCCHHHH	23.72	-
160	O-linked_Glycosylation	SSYGYPPSSLGRAIT CCCCCCHHHHCCCCC	33.42	20068230
161	O-linked_Glycosylation	SYGYPPSSLGRAITD CCCCCHHHHCCCCCC	40.39	20068230
167	O-linked_Glycosylation	SSLGRAITDGQAGFG HHHCCCCCCCCCCCC	32.85	20068230
177	Phosphorylation	QAGFGNDTLSKVPGI CCCCCCCHHHCCCCC	36.61	25850435
179	Phosphorylation	GFGNDTLSKVPGISS CCCCCHHHCCCCCCH	33.43	25850435
185	Phosphorylation	LSKVPGISSIEQGMT HHCCCCCCHHHCCCC	31.04	23186163
186	Phosphorylation	SKVPGISSIEQGMTG HCCCCCCHHHCCCCC	28.37	25159151
191	Sulfoxidation	ISSIEQGMTGLKIGG CCHHHCCCCCCEECC	2.41	21406390
192	Phosphorylation	SSIEQGMTGLKIGGD CHHHCCCCCCEECCC	46.30	23186163
201	Phosphorylation	LKIGGDLTAAVTKTV CEECCCHHHEEEHHH	19.81	20068231
201	O-linked_Glycosylation	LKIGGDLTAAVTKTV CEECCCHHHEEEHHH	19.81	20068230
205	Phosphorylation	GDLTAAVTKTVGTAL CCHHHEEEHHHHHHH	19.10	20068231
205	O-linked_Glycosylation	GDLTAAVTKTVGTAL CCHHHEEEHHHHHHH	19.10	20068230
207	Phosphorylation	LTAAVTKTVGTALSS HHHEEEHHHHHHHHC	18.14	24300666
207	O-linked_Glycosylation	LTAAVTKTVGTALSS HHHEEEHHHHHHHHC	18.14	20068230
210	Phosphorylation	AVTKTVGTALSSSGM EEEHHHHHHHHCCCC	21.79	24300666
210	O-linked_Glycosylation	AVTKTVGTALSSSGM EEEHHHHHHHHCCCC	21.79	20068230
213	Phosphorylation	KTVGTALSSSGMTSI HHHHHHHHCCCCCEE	21.72	24300666
214	Phosphorylation	TVGTALSSSGMTSIA HHHHHHHCCCCCEEC	31.59	24300666
214	O-linked_Glycosylation	TVGTALSSSGMTSIA HHHHHHHCCCCCEEC	31.59	20068230
215	Phosphorylation	VGTALSSSGMTSIAT HHHHHHCCCCCEECC	29.25	24300666
216	Phosphorylation	GTALSSSGMTSIATN HHHHHCCCCCEECCC	25.90	27251275
218	Phosphorylation	ALSSSGMTSIATNSV HHHCCCCCEECCCCC	22.10	24300666
219	Phosphorylation	LSSSGMTSIATNSVP HHCCCCCEECCCCCC	11.01	24300666
222	Phosphorylation	SGMTSIATNSVPPVS CCCCEECCCCCCCCC	26.76	24300666
222	O-linked_Glycosylation	SGMTSIATNSVPPVS CCCCEECCCCCCCCC	26.76	20068230
224	O-linked_Glycosylation	MTSIATNSVPPVSSA CCEECCCCCCCCCCC	31.48	20068230
224	Phosphorylation	MTSIATNSVPPVSSA CCEECCCCCCCCCCC	31.48	24300666
229	O-linked_Glycosylation	TNSVPPVSSAAPKPT CCCCCCCCCCCCCCC	21.74	20068230
229	Phosphorylation	TNSVPPVSSAAPKPT CCCCCCCCCCCCCCC	21.74	24300666
230	Phosphorylation	NSVPPVSSAAPKPTS CCCCCCCCCCCCCCC	28.78	24300666
236	Phosphorylation	SSAAPKPTSWAAIAR CCCCCCCCCHHHHCC	42.92	24300666
236	O-linked_Glycosylation	SSAAPKPTSWAAIAR CCCCCCCCCHHHHCC	42.92	20068230
237	Phosphorylation	SAAPKPTSWAAIARK CCCCCCCCHHHHCCC	24.20	24300666
244	Ubiquitination	SWAAIARKPAKPQPK CHHHHCCCCCCCCCC	40.06	-
271	Acetylation	AVPPPPIKHNMNIGT CCCCCCCCCCCCCCC	34.40	26051181
284	Phosphorylation	GTWDEKGSVVKAPPT CCCCCCCCEEECCCC	34.50	28857561
372	Phosphorylation	NQNNGAGSENFGLGV CCCCCCCCCCCEEEE	28.91	24732914
375	Phosphorylation	NGAGSENFGLGVVPV CCCCCCCCEEEEEEC	8.20	27251275
383	Phosphorylation	GLGVVPVSASPSSVE EEEEEECCCCCCCCC	19.57	25159151
385	Phosphorylation	GVVPVSASPSSVEVH EEEECCCCCCCCCCH	20.15	21712546
387	Phosphorylation	VPVSASPSSVEVHPV EECCCCCCCCCCHHH	44.51	23663014
388	Phosphorylation	PVSASPSSVEVHPVL ECCCCCCCCCCHHHH	26.19	30278072
407	Acetylation	AINNYNPKDFDWNLK HHCCCCCCCCCEECC	68.35	26051181
422	Acetylation	NGRVFIIKSYSEDDI CCEEEEEEECCHHHH	38.23	26822725
422	2-Hydroxyisobutyrylation	NGRVFIIKSYSEDDI CCEEEEEEECCHHHH	38.23	-
423	Phosphorylation	GRVFIIKSYSEDDIH CEEEEEEECCHHHHH	24.39	28152594
424	Phosphorylation	RVFIIKSYSEDDIHR EEEEEEECCHHHHHH	15.86	28152594
425	Phosphorylation	VFIIKSYSEDDIHRS EEEEEECCHHHHHHH	41.46	25159151
428	Phosphorylation	IKSYSEDDIHRSIKY EEECCHHHHHHHHEE	34.24	27251275
434	Acetylation	DDIHRSIKYSIWCST HHHHHHHEEEEEEEC	33.90	26051181
436	Phosphorylation	IHRSIKYSIWCSTEH HHHHHEEEEEEECCC	12.47	-
440	Phosphorylation	IKYSIWCSTEHGNKR HEEEEEEECCCCCHH	23.10	-
446	Acetylation	CSTEHGNKRLDAAYR EECCCCCHHHHHHHH	59.95	25953088
452	Phosphorylation	NKRLDAAYRSLNGKG CHHHHHHHHHHCCCC	11.49	-
520	Methylation	NNQLRHIRLENNDNK CCCEEEEEEECCCCC	29.80	-
527	Ubiquitination	RLENNDNKPVTNSRD EEECCCCCCCCCCCC	43.67	-
530	Phosphorylation	NNDNKPVTNSRDTQE CCCCCCCCCCCCCCC	35.68	24732914
532	Phosphorylation	DNKPVTNSRDTQEVP CCCCCCCCCCCCCCC	23.36	24732914
542	Acetylation	TQEVPLEKAKQVLKI CCCCCHHHHHHHHHH	69.44	25953088
556	Phosphorylation	IIATFKHTTSIFDDF HHHHHCCHHHHHHHH	23.87	24247654
558	Phosphorylation	ATFKHTTSIFDDFAH HHHCCHHHHHHHHHH	23.55	28857561
566	Phosphorylation	IFDDFAHYEKRQEEE HHHHHHHHHHHHHHH	21.51	28796482

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YTHD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YTHD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YTHD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YTHD1_HUMAN	YTHDF1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.