MEX3A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MEX3A_HUMAN
• UniProt AC: A1L020
• Protein Name: RNA-binding protein MEX3A
• Gene Name: MEX3A
• Organism: Homo sapiens (Human).
• Sequence Length: 520
• Subcellular Localization: Cytoplasm . Nucleus . Cytoplasm, P-body . Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway.
• Protein Description: RNA binding protein, may be involved in post-transcriptional regulatory mechanisms..
• Protein Sequence: MPSLVVSGIMERNGGFGELGCFGGSAKDRGLLEDERALQLALDQLCLLGLGEPPAPTAGEDGGGGGGGAPAQPAAPPQPAPPPPPAAPPAAPTAAPAAQTPQPPTAPKGASDAKLCALYKEAELRLKGSSNTTECVPVPTSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFMVTGRREDVATARREIISAAEHFSMIRASRNKSGAAFGVAPALPGQVTIRVRVPYRVVGLVVGPKGATIKRIQQQTNTYIITPSRDRDPVFEITGAPGNVERAREEIETHIAVRTGKILEYNNENDFLAGSPDAAIDSRYSDAWRVHQPGCKPLSTFRQNSLGCIGECGVDSGFEAPRLGEQGGDFGYGGYLFPGYGVGKQDVYYGVAETSPPLWAGQENATPTSVLFSSASSSSSSSAKARAGPPGAHRSPATSAGPELAGLPRRPPGEPLQGFSKLGGGGLRSPGGGRDCMVCFESEVTAALVPCGHNLFCMECAVRICERTDPECPVCHITATQAIRIFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MPSLVVSGIM -----CCCEEEEECC	32.28	21406692
7	Phosphorylation	-MPSLVVSGIMERNG -CCCEEEEECCHHCC	18.34	21406692
27	Ubiquitination	GCFGGSAKDRGLLED CCCCCCHHHCCCCCC	50.05	29967540
114	Acetylation	PKGASDAKLCALYKE CCCCCHHHHHHHHHH	49.44	25953088
114	Ubiquitination	PKGASDAKLCALYKE CCCCCHHHHHHHHHH	49.44	29967540
119	Phosphorylation	DAKLCALYKEAELRL HHHHHHHHHHEEEEE	6.56	27642862
120	Ubiquitination	AKLCALYKEAELRLK HHHHHHHHHEEEEEC	51.83	29967540
127	Ubiquitination	KEAELRLKGSSNTTE HHEEEEECCCCCCCC	50.76	29967540
133	Phosphorylation	LKGSSNTTECVPVPT ECCCCCCCCEEECCC	31.47	-
161	Ubiquitination	KIKALRAKTNTYIKT EEEEEEECCCEEEEC	35.55	27667366
162	Phosphorylation	IKALRAKTNTYIKTP EEEEEECCCEEEECC	31.63	28152594
164	Phosphorylation	ALRAKTNTYIKTPVR EEEECCCEEEECCCC	31.68	28152594
165	Phosphorylation	LRAKTNTYIKTPVRG EEECCCEEEECCCCC	11.51	28152594
167	Ubiquitination	AKTNTYIKTPVRGEE ECCCEEEECCCCCCC	36.04	-
168	Phosphorylation	KTNTYIKTPVRGEEP CCCEEEECCCCCCCC	19.91	28555341
209	Ubiquitination	MIRASRNKSGAAFGV HHHHHCCCCCCCCCC	49.51	-
210	Phosphorylation	IRASRNKSGAAFGVA HHHHCCCCCCCCCCC	36.89	27251275
242	Ubiquitination	VGLVVGPKGATIKRI EEEEECCCCHHHHHH	56.07	33845483
245	Phosphorylation	VVGPKGATIKRIQQQ EECCCCHHHHHHHHC	35.38	-
247	Ubiquitination	GPKGATIKRIQQQTN CCCCHHHHHHHHCCC	38.81	-
294	Ubiquitination	HIAVRTGKILEYNNE HEEEECCCEEEECCC	43.43	-
298	Phosphorylation	RTGKILEYNNENDFL ECCCEEEECCCCCCC	21.60	26074081
308	Phosphorylation	ENDFLAGSPDAAIDS CCCCCCCCCCHHHCC	17.63	25159151
315	Phosphorylation	SPDAAIDSRYSDAWR CCCHHHCCCCCCCEE	27.31	26074081
329	Ubiquitination	RVHQPGCKPLSTFRQ ECCCCCCCCCHHHCC	55.71	29967540
338	Phosphorylation	LSTFRQNSLGCIGEC CHHHCCCCCCCEECC	20.14	22617229
349	Phosphorylation	IGECGVDSGFEAPRL EECCCCCCCCCCCCC	42.87	26074081
387	Phosphorylation	VYYGVAETSPPLWAG EEEEEECCCCCCCCC	36.47	28348404
388	Phosphorylation	YYGVAETSPPLWAGQ EEEEECCCCCCCCCC	18.94	28348404
399	Phosphorylation	WAGQENATPTSVLFS CCCCCCCCCCEEEEE	38.39	28348404
419	Methylation	SSSSAKARAGPPGAH CCCCCHHHCCCCCCC	39.09	115491305
428	Phosphorylation	GPPGAHRSPATSAGP CCCCCCCCCCCCCCH	14.71	19664994
431	Phosphorylation	GAHRSPATSAGPELA CCCCCCCCCCCHHHC	23.61	30266825
432	Phosphorylation	AHRSPATSAGPELAG CCCCCCCCCCHHHCC	33.08	30266825
453	Phosphorylation	GEPLQGFSKLGGGGL CCCCCCCCCCCCCCC	33.52	-
454	Ubiquitination	EPLQGFSKLGGGGLR CCCCCCCCCCCCCCC	49.22	-
462	Phosphorylation	LGGGGLRSPGGGRDC CCCCCCCCCCCCCCC	32.70	21712546
501	Phosphorylation	AVRICERTDPECPVC HHHHHHCCCCCCCCC	33.34	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MEX3A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MEX3A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MEX3A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PABP1_HUMAN	PABPC1	physical	18779327

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.