dbPTM

TADBP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TADBP_HUMAN
UniProt AC	Q13148
Protein Name	TAR DNA-binding protein 43
Gene Name	TARDBP
Organism	Homo sapiens (Human).
Sequence Length	414
Subcellular Localization	Nucleus . In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies.
Protein Description	DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR..
Protein Sequence	MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSEYIRVTE ------CCCCEEEEC	38.82	19285963
4	Phosphorylation	----MSEYIRVTEDE ----CCCCEEEECCC	6.16	19285963
8	Phosphorylation	MSEYIRVTEDENDEP CCCCEEEECCCCCCC	28.06	20873877
20	Phosphorylation	DEPIEIPSEDDGTVL CCCCCCCCCCCCEEE	60.36	25338102
25	Phosphorylation	IPSEDDGTVLLSTVT CCCCCCCEEEEEEEE	18.25	20873877
29	Phosphorylation	DDGTVLLSTVTAQFP CCCEEEEEEEEECCC	19.37	20873877
30	Phosphorylation	DGTVLLSTVTAQFPG CCEEEEEEEEECCCC	23.11	20873877
32	Phosphorylation	TVLLSTVTAQFPGAC EEEEEEEEECCCCCC	18.15	20873877
44	Ubiquitination	GACGLRYRNPVSQCM CCCCCEECCHHHHHH	34.24	21890473
48	Phosphorylation	LRYRNPVSQCMRGVR CEECCHHHHHHHHHE	20.94	21406692
73	Phosphorylation	AGWGNLVYVVNYPKD CCCCCEEEEEECCCC	11.22	27642862
79	Sumoylation	VYVVNYPKDNKRKMD EEEEECCCCCCCCCC	64.67	28112733
79	Ubiquitination	VYVVNYPKDNKRKMD EEEEECCCCCCCCCC	64.67	-
82	Ubiquitination	VNYPKDNKRKMDETD EECCCCCCCCCCCCC	64.63	-
84	Sumoylation	YPKDNKRKMDETDAS CCCCCCCCCCCCCHH	52.92	-
84	Ubiquitination	YPKDNKRKMDETDAS CCCCCCCCCCCCCHH	52.92	-
84	Sumoylation	YPKDNKRKMDETDAS CCCCCCCCCCCCCHH	52.92	28112733
84 (in isoform 2)	Ubiquitination	-	52.92	-
85	Sulfoxidation	PKDNKRKMDETDASS CCCCCCCCCCCCHHH	6.99	30846556
88	Phosphorylation	NKRKMDETDASSAVK CCCCCCCCCHHHHHH	32.38	19285963
91	Phosphorylation	KMDETDASSAVKVKR CCCCCCHHHHHHHHH	22.95	29255136
92	Phosphorylation	MDETDASSAVKVKRA CCCCCHHHHHHHHHH	38.51	29255136
95	Acetylation	TDASSAVKVKRAVQK CCHHHHHHHHHHHHH	41.58	25953088
95	Sumoylation	TDASSAVKVKRAVQK CCHHHHHHHHHHHHH	41.58	-
95	Ubiquitination	TDASSAVKVKRAVQK CCHHHHHHHHHHHHH	41.58	21890473
95	Sumoylation	TDASSAVKVKRAVQK CCHHHHHHHHHHHHH	41.58	28112733
95 (in isoform 2)	Ubiquitination	-	41.58	-
97	Ubiquitination	ASSAVKVKRAVQKTS HHHHHHHHHHHHHCC	28.99	-
102	Sumoylation	KVKRAVQKTSDLIVL HHHHHHHHCCCEEEE	43.32	-
102	Ubiquitination	KVKRAVQKTSDLIVL HHHHHHHHCCCEEEE	43.32	21890473
102	Sumoylation	KVKRAVQKTSDLIVL HHHHHHHHCCCEEEE	43.32	25772364
102 (in isoform 2)	Ubiquitination	-	43.32	-
102	Ubiquitination	KVKRAVQKTSDLIVL HHHHHHHHCCCEEEE	43.32	21890473
102	Ubiquitination	KVKRAVQKTSDLIVL HHHHHHHHCCCEEEE	43.32	21890473
102	Ubiquitination	KVKRAVQKTSDLIVL HHHHHHHHCCCEEEE	43.32	21890473
102	Acetylation	KVKRAVQKTSDLIVL HHHHHHHHCCCEEEE	43.32	25953088
102	Ubiquitination	KVKRAVQKTSDLIVL HHHHHHHHCCCEEEE	43.32	21890473
103	Phosphorylation	VKRAVQKTSDLIVLG HHHHHHHCCCEEEEC	15.47	24719451
104	Phosphorylation	KRAVQKTSDLIVLGL HHHHHHCCCEEEECC	37.14	24719451
114	Ubiquitination	IVLGLPWKTTEQDLK EEECCCCCCCHHHHH	43.56	21890473
114	Sumoylation	IVLGLPWKTTEQDLK EEECCCCCCCHHHHH	43.56	-
114 (in isoform 2)	Ubiquitination	-	43.56	-
114	Ubiquitination	IVLGLPWKTTEQDLK EEECCCCCCCHHHHH	43.56	21890473
114	Ubiquitination	IVLGLPWKTTEQDLK EEECCCCCCCHHHHH	43.56	21890473
114	Ubiquitination	IVLGLPWKTTEQDLK EEECCCCCCCHHHHH	43.56	21890473
114	Ubiquitination	IVLGLPWKTTEQDLK EEECCCCCCCHHHHH	43.56	21890473
115	Phosphorylation	VLGLPWKTTEQDLKE EECCCCCCCHHHHHH	31.53	30622161
116	Phosphorylation	LGLPWKTTEQDLKEY ECCCCCCCHHHHHHH	28.11	28450419
121	Ubiquitination	KTTEQDLKEYFSTFG CCCHHHHHHHHHHHH	59.67	21890473
121	Sumoylation	KTTEQDLKEYFSTFG CCCHHHHHHHHHHHH	59.67	-
136	Acetylation	EVLMVQVKKDLKTGH HEEEEEEECCCCCCC	24.39	19824233
140	Acetylation	VQVKKDLKTGHSKGF EEEECCCCCCCCCCC	63.70	19824243
140	Ubiquitination	VQVKKDLKTGHSKGF EEEECCCCCCCCCCC	63.70	21890473
140	2-Hydroxyisobutyrylation	VQVKKDLKTGHSKGF EEEECCCCCCCCCCC	63.70	-
145	Acetylation	DLKTGHSKGFGFVRF CCCCCCCCCCCEEEE	53.21	77040215
145	Sumoylation	DLKTGHSKGFGFVRF CCCCCCCCCCCEEEE	53.21	-
145	Ubiquitination	DLKTGHSKGFGFVRF CCCCCCCCCCCEEEE	53.21	21890473
145	Sumoylation	DLKTGHSKGFGFVRF CCCCCCCCCCCEEEE	53.21	-
145 (in isoform 2)	Ubiquitination	-	53.21	-
147	Ubiquitination	KTGHSKGFGFVRFTE CCCCCCCCCEEEEEE	8.68	21890473
153	Phosphorylation	GFGFVRFTEYETQVK CCCEEEEEEEEEHHH	27.39	20068231
155	Phosphorylation	GFVRFTEYETQVKVM CEEEEEEEEEHHHEE	22.63	28796482
155	Nitration	GFVRFTEYETQVKVM CEEEEEEEEEHHHEE	22.63	-
157	Phosphorylation	VRFTEYETQVKVMSQ EEEEEEEEHHHEEEC	37.45	28152594
160	Sumoylation	TEYETQVKVMSQRHM EEEEEHHHEEECCCC	23.54	-
160	Ubiquitination	TEYETQVKVMSQRHM EEEEEHHHEEECCCC	23.54	21890473
160	Sumoylation	TEYETQVKVMSQRHM EEEEEHHHEEECCCC	23.54	-
160 (in isoform 2)	Ubiquitination	-	23.54	-
160	Ubiquitination	TEYETQVKVMSQRHM EEEEEHHHEEECCCC	23.54	21890473
160	Ubiquitination	TEYETQVKVMSQRHM EEEEEHHHEEECCCC	23.54	21890473
160	Ubiquitination	TEYETQVKVMSQRHM EEEEEHHHEEECCCC	23.54	21890473
160	Acetylation	TEYETQVKVMSQRHM EEEEEHHHEEECCCC	23.54	26051181
160	Ubiquitination	TEYETQVKVMSQRHM EEEEEHHHEEECCCC	23.54	21890473
162	Oxidation	YETQVKVMSQRHMID EEEHHHEEECCCCCC	2.04	17322306
176	Sumoylation	DGRWCDCKLPNSKQS CCCEECCCCCCCCCC	54.45	-
176	Ubiquitination	DGRWCDCKLPNSKQS CCCEECCCCCCCCCC	54.45	21890473
176	Sumoylation	DGRWCDCKLPNSKQS CCCEECCCCCCCCCC	54.45	-
176 (in isoform 2)	Ubiquitination	-	54.45	-
176	Acetylation	DGRWCDCKLPNSKQS CCCEECCCCCCCCCC	54.45	25953088
180	Phosphorylation	CDCKLPNSKQSQDEP ECCCCCCCCCCCCCC	30.08	28450419
181	Methylation	DCKLPNSKQSQDEPL CCCCCCCCCCCCCCH	61.68	184427
181	Sumoylation	DCKLPNSKQSQDEPL CCCCCCCCCCCCCCH	61.68	-
181	Ubiquitination	DCKLPNSKQSQDEPL CCCCCCCCCCCCCCH	61.68	21890473
181	Sumoylation	DCKLPNSKQSQDEPL CCCCCCCCCCCCCCH	61.68	28112733
181 (in isoform 2)	Ubiquitination	-	61.68	-
181	2-Hydroxyisobutyrylation	DCKLPNSKQSQDEPL CCCCCCCCCCCCCCH	61.68	-
183	Phosphorylation	KLPNSKQSQDEPLRS CCCCCCCCCCCCHHH	43.25	25159151
192	Acetylation	DEPLRSRKVFVGRCT CCCHHHCCEEEEECC	41.07	77040213
192	Sumoylation	DEPLRSRKVFVGRCT CCCHHHCCEEEEECC	41.07	-
192	Ubiquitination	DEPLRSRKVFVGRCT CCCHHHCCEEEEECC	41.07	21890473
192	Sumoylation	DEPLRSRKVFVGRCT CCCHHHCCEEEEECC	41.07	-
192 (in isoform 2)	Ubiquitination	-	41.07	-
214	Phosphorylation	LREFFSQYGDVMDVF HHHHHHHHCCEEEEE	17.69	27642862
224	Ubiquitination	VMDVFIPKPFRAFAF EEEEECCCCEEEEEE	52.55	-
242	Phosphorylation	ADDQIAQSLCGEDLI CCHHHHHHHHCCCEE	19.33	30624053
244	Glutathionylation	DQIAQSLCGEDLIIK HHHHHHHHCCCEEEE	7.31	22555962
254	Phosphorylation	DLIIKGISVHISNAE CEEEEEEEEEECCCC	19.13	30108239
258	Phosphorylation	KGISVHISNAEPKHN EEEEEEECCCCCCCC	18.34	28348404
263	Sumoylation	HISNAEPKHNSNRQL EECCCCCCCCCCCCH	47.09	-
263	Ubiquitination	HISNAEPKHNSNRQL EECCCCCCCCCCCCH	47.09	21890473
263	Sumoylation	HISNAEPKHNSNRQL EECCCCCCCCCCCCH	47.09	28112733
263 (in isoform 2)	Ubiquitination	-	47.09	-
273	Phosphorylation	SNRQLERSGRFGGNP CCCCHHHCCCCCCCC	25.58	22115753
275	Methylation	RQLERSGRFGGNPGG CCHHHCCCCCCCCCC	28.43	115918217
292	Phosphorylation	NQGGFGNSRGGGAGL CCCCCCCCCCCCCCC	32.45	23401153
293	Methylation	QGGFGNSRGGGAGLG CCCCCCCCCCCCCCC	52.34	24129315
305	Phosphorylation	GLGNNQGSNMGGGMN CCCCCCCCCCCCCCC	17.55	22817900
307	Sulfoxidation	GNNQGSNMGGGMNFG CCCCCCCCCCCCCCC	5.89	33144500
311	Sulfoxidation	GSNMGGGMNFGAFSI CCCCCCCCCCCCCCC	4.20	33144500
317	Phosphorylation	GMNFGAFSINPAMMA CCCCCCCCCCHHHHH	22.41	-
322	Sulfoxidation	AFSINPAMMAAAQAA CCCCCHHHHHHHHHH	1.66	33144500
323	Sulfoxidation	FSINPAMMAAAQAAL CCCCHHHHHHHHHHH	2.20	33144500
333	Phosphorylation	AQAALQSSWGMMGML HHHHHHHHHHHHHHH	18.06	-
336	Sulfoxidation	ALQSSWGMMGMLASQ HHHHHHHHHHHHHHH	1.38	33144500
337	Sulfoxidation	LQSSWGMMGMLASQQ HHHHHHHHHHHHHHC	2.22	33144500
339	Sulfoxidation	SSWGMMGMLASQQNQ HHHHHHHHHHHHCCC	1.21	33144500
342	Phosphorylation	GMMGMLASQQNQSGP HHHHHHHHHCCCCCC	28.47	22817900
347	Phosphorylation	LASQQNQSGPSGNNQ HHHHCCCCCCCCCCC	61.29	22817900
350	Phosphorylation	QQNQSGPSGNNQNQG HCCCCCCCCCCCCCC	58.65	22817900
359	Sulfoxidation	NNQNQGNMQREPNQA CCCCCCCCCCCCCCC	5.20	33144500
369	Phosphorylation	EPNQAFGSGNNSYSG CCCCCCCCCCCCCCC	31.71	22817900
375	Phosphorylation	GSGNNSYSGSNSGAA CCCCCCCCCCCCCCE	35.25	22817900
377	Phosphorylation	GNNSYSGSNSGAAIG CCCCCCCCCCCCEEE	23.14	22817900
379	Phosphorylation	NSYSGSNSGAAIGWG CCCCCCCCCCEEECC	31.35	18546284
387	Phosphorylation	GAAIGWGSASNAGSG CCEEECCCCCCCCCC	23.24	22817900
389	Phosphorylation	AIGWGSASNAGSGSG EEECCCCCCCCCCCC	28.98	22817900
393	Phosphorylation	GSASNAGSGSGFNGG CCCCCCCCCCCCCCC	27.63	22817900
395	Phosphorylation	ASNAGSGSGFNGGFG CCCCCCCCCCCCCCC	41.74	22817900
403	Phosphorylation	GFNGGFGSSMDSKSS CCCCCCCCCCCCCCC	21.89	18546284
404	Phosphorylation	FNGGFGSSMDSKSSG CCCCCCCCCCCCCCC	27.30	18546284
405	Sulfoxidation	NGGFGSSMDSKSSGW CCCCCCCCCCCCCCC	7.85	33144500
407	Phosphorylation	GFGSSMDSKSSGWGM CCCCCCCCCCCCCCC	26.29	22817900
408	Sumoylation	FGSSMDSKSSGWGM- CCCCCCCCCCCCCC-	44.36	-
409	Phosphorylation	GSSMDSKSSGWGM-- CCCCCCCCCCCCC--	37.73	19235466
410	Phosphorylation	SSMDSKSSGWGM--- CCCCCCCCCCCC---	42.15	19235466
414	Sulfoxidation	SKSSGWGM------- CCCCCCCC-------	3.91	33144500

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
2	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
4	Y	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
25	T	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
88	T	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
91	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
92	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
92	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
116	T	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
153	T	Phosphorylation	Kinase	MEK1	Q02750	PSP
155	Y	Phosphorylation	Kinase	MEK1	Q02750	PSP
183	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
242	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
254	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
273	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
292	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
292	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
305	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
305	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
317	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
333	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
342	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
347	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
350	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
369	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
375	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
377	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
379	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
379	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
387	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
389	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
389	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
393	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
393	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
395	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
395	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
403	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
403	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
404	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
404	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
407	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
409	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
409	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
409	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
409	S	Phosphorylation	Kinase	CSNK1E	P49674	GPS
410	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
410	S	Phosphorylation	Kinase	CSNK1E	P49674	GPS
410	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
410	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	PRKN	O60260	PMID:23258539

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TADBP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TADBP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SETB1_HUMAN	SETDB1	physical	16169070
ZHX1_HUMAN	ZHX1	physical	16169070
HDAC6_HUMAN	HDAC6	physical	19910924
THP2_YEAST	THP2	genetic	21508314
MFT1_YEAST	MFT1	genetic	21508314
TEX1_YEAST	TEX1	genetic	21508314
THO2_YEAST	THO2	genetic	21508314
RPB2_YEAST	RPB2	genetic	21508314
FUS_HUMAN	FUS	physical	20720006
PABP2_HUMAN	PABPN1	physical	20720006
TERA_HUMAN	VCP	physical	19237541
SQSTM_HUMAN	SQSTM1	physical	22674379
SQSTM_HUMAN	SQSTM1	physical	18584184
ARG28_HUMAN	ARHGEF28	physical	22941224
HSP74_HUMAN	HSPA4	physical	20804554
HS90A_HUMAN	HSP90AA1	physical	20804554
NACC1_HUMAN	NACC1	physical	23022214
A4_HUMAN	APP	physical	21832049
U2AF2_HUMAN	U2AF2	physical	22939629
PRKN_MOUSE	Park2	physical	23258539
HDAC6_MOUSE	Hdac6	physical	23258539
HNRH1_HUMAN	HNRNPH1	physical	20020773
PABP1_HUMAN	PABPC1	physical	20020773
TADBP_HUMAN	TARDBP	physical	20020773
DDX21_HUMAN	DDX21	physical	20020773
MSI2H_HUMAN	MSI2	physical	20020773
XRCC6_HUMAN	XRCC6	physical	20020773
ZCCHV_HUMAN	ZC3HAV1	physical	20020773
PRC2C_HUMAN	PRRC2C	physical	20020773
IF4G1_HUMAN	EIF4G1	physical	20020773
TOP1_HUMAN	TOP1	physical	20020773
LARP4_HUMAN	LARP4	physical	20020773
RS11_HUMAN	RPS11	physical	20020773
MATR3_HUMAN	MATR3	physical	20020773
YTDC2_HUMAN	YTHDC2	physical	20020773
DCD_HUMAN	DCD	physical	20020773
ROAA_HUMAN	HNRNPAB	physical	20020773
HS105_HUMAN	HSPH1	physical	20020773
HNRL2_HUMAN	HNRNPUL2	physical	20020773
LA_HUMAN	SSB	physical	20020773
DIM1_HUMAN	DIMT1	physical	20020773
RL5_HUMAN	RPL5	physical	20020773
MSI1H_HUMAN	MSI1	physical	20020773
1433S_HUMAN	SFN	physical	20020773
STAU1_HUMAN	STAU1	physical	20020773
XRCC5_HUMAN	XRCC5	physical	20020773
H1X_HUMAN	H1FX	physical	20020773
DHX57_HUMAN	DHX57	physical	20020773
RS7_HUMAN	RPS7	physical	20020773
FUBP3_HUMAN	FUBP3	physical	20020773
GNL3_HUMAN	GNL3	physical	20020773
HNRPR_HUMAN	HNRNPR	physical	20020773
RRBP1_HUMAN	RRBP1	physical	20020773
SRPK1_HUMAN	SRPK1	physical	20020773
SRSF6_HUMAN	SRSF6	physical	20020773
TIF1B_HUMAN	TRIM28	physical	20020773
DDX50_HUMAN	DDX50	physical	20020773
PRC2A_HUMAN	PRRC2A	physical	20020773
NUFP2_HUMAN	NUFIP2	physical	20020773
PKP1_HUMAN	PKP1	physical	20020773
PAIRB_HUMAN	SERBP1	physical	20020773
LYRIC_HUMAN	MTDH	physical	20020773
SRRT_HUMAN	SRRT	physical	20020773
U520_HUMAN	SNRNP200	physical	20020773
ZFR_HUMAN	ZFR	physical	20020773
RS23_HUMAN	RPS23	physical	20020773
RL17_HUMAN	RPL17	physical	20020773
RL28_HUMAN	RPL28	physical	20020773
RL9_HUMAN	RPL9	physical	20020773
NKRF_HUMAN	NKRF	physical	20020773
NXF1_HUMAN	NXF1	physical	20020773
NOP56_HUMAN	NOP56	physical	20020773
PCBP1_HUMAN	PCBP1	physical	20020773
LC7L2_HUMAN	LUC7L2	physical	20020773
RALY_HUMAN	RALY	physical	20020773
FBRL_HUMAN	FBL	physical	20020773
YTHD2_HUMAN	YTHDF2	physical	20020773
RT29_HUMAN	DAP3	physical	20020773
ATX2L_HUMAN	ATXN2L	physical	20020773
CDC5L_HUMAN	CDC5L	physical	20020773
DSC1_HUMAN	DSC1	physical	20020773
RPOM_HUMAN	POLRMT	physical	20020773
DSRAD_HUMAN	ADAR	physical	20020773
GRSF1_HUMAN	GRSF1	physical	20020773
NCBP1_HUMAN	NCBP1	physical	20020773
NOP58_HUMAN	NOP58	physical	20020773
TSR1_HUMAN	TSR1	physical	20020773
NOP2_HUMAN	NOP2	physical	20020773
TRM1L_HUMAN	TRMT1L	physical	20020773
UBP10_HUMAN	USP10	physical	20020773
RT27_HUMAN	MRPS27	physical	20020773
RM12_HUMAN	MRPL12	physical	20020773
RM22_HUMAN	MRPL22	physical	20020773
RM44_HUMAN	MRPL44	physical	20020773
RS17_HUMAN	RPS17	physical	20020773
XRN1_HUMAN	XRN1	physical	20020773
RL18A_HUMAN	RPL18A	physical	20020773
ASPH_HUMAN	ASPH	physical	20020773
BAG2_HUMAN	BAG2	physical	20020773
C1QBP_HUMAN	C1QBP	physical	20020773
CELF1_HUMAN	CELF1	physical	20020773
ELAV2_HUMAN	ELAVL2	physical	20020773
EIF3I_HUMAN	EIF3I	physical	20020773
IF4G3_HUMAN	EIF4G3	physical	20020773
RACK1_HUMAN	GNB2L1	physical	20020773
IMA1_HUMAN	KPNA2	physical	20020773
MAP4_HUMAN	MAP4	physical	20020773
MBB1A_HUMAN	MYBBP1A	physical	20020773
PYM1_HUMAN	WIBG	physical	20020773
FA98A_HUMAN	FAM98A	physical	20020773
LSM12_HUMAN	LSM12	physical	20020773
PATL1_HUMAN	PATL1	physical	20020773
RFC4_HUMAN	RFC4	physical	20020773
RBM39_HUMAN	RBM39	physical	20020773
RUVB2_HUMAN	RUVBL2	physical	20020773
PURB_HUMAN	PURB	physical	20020773
TERA_HUMAN	VCP	physical	20020773
SR140_HUMAN	U2SURP	physical	20020773
PRPF3_HUMAN	PRPF3	physical	20020773
BCLF1_HUMAN	BCLAF1	physical	20020773
ZC11A_HUMAN	ZC3H11A	physical	20020773
ZN346_HUMAN	ZNF346	physical	20020773
RT34_HUMAN	MRPS34	physical	20020773
RM48_HUMAN	MRPL48	physical	20020773
RS24_HUMAN	RPS24	physical	20020773
XRN2_HUMAN	XRN2	physical	20020773
RL13A_HUMAN	RPL13A	physical	20020773
RL21_HUMAN	RPL21	physical	20020773
ATPA_HUMAN	ATP5A1	physical	20020773
SCMC3_HUMAN	SLC25A23	physical	20020773
CDK4_HUMAN	CDK4	physical	20020773
CPSF1_HUMAN	CPSF1	physical	20020773
DNJB6_HUMAN	DNAJB6	physical	20020773
IF2G_HUMAN	EIF2S3	physical	20020773
EIF3A_HUMAN	EIF3A	physical	20020773
EIF3H_HUMAN	EIF3H	physical	20020773
QPCTL_HUMAN	QPCTL	physical	20020773
NACAM_HUMAN	NACA	physical	20020773
NACA_HUMAN	NACA	physical	20020773
AHNK_HUMAN	AHNAK	physical	20020773
NOP14_HUMAN	NOP14	physical	20020773
NOP16_HUMAN	NOP16	physical	20020773
PWP2_HUMAN	PWP2	physical	20020773
RNF10_HUMAN	RNF10	physical	20020773
SRBD1_HUMAN	SRBD1	physical	20020773
SK2L2_HUMAN	SKIV2L2	physical	20020773
PURA_HUMAN	PURA	physical	20020773
SNUT1_HUMAN	SART1	physical	20020773
DDX17_HUMAN	DDX17	physical	20020773
HNRL1_HUMAN	HNRNPUL1	physical	20020773
DHX30_HUMAN	DHX30	physical	20020773
DHX36_HUMAN	DHX36	physical	20020773
RENT1_HUMAN	UPF1	physical	20020773
IF2B2_HUMAN	IGF2BP2	physical	20020773
RS2_HUMAN	RPS2	physical	20020773
ROA3_HUMAN	HNRNPA3	physical	20020773
PTBP1_HUMAN	PTBP1	physical	20020773
RS6_HUMAN	RPS6	physical	20020773
RL6_HUMAN	RPL6	physical	20020773
RL26_HUMAN	RPL26	physical	20020773
H13_HUMAN	HIST1H1D	physical	20020773
PABP4_HUMAN	PABPC4	physical	20020773
RS20_HUMAN	RPS20	physical	20020773
NPM_HUMAN	NPM1	physical	20020773
RL4_HUMAN	RPL4	physical	20020773
HSP74_HUMAN	HSPA4	physical	20020773
RS14_HUMAN	RPS14	physical	20020773
HNRPM_HUMAN	HNRNPM	physical	20020773
DESP_HUMAN	DSP	physical	20020773
LARP1_HUMAN	LARP1	physical	20020773
RL8_HUMAN	RPL8	physical	20020773
FUBP2_HUMAN	KHSRP	physical	20020773
RS18_HUMAN	RPS18	physical	20020773
RS3A_HUMAN	RPS3A	physical	20020773
G3BP1_HUMAN	G3BP1	physical	20020773
GRP78_HUMAN	HSPA5	physical	20020773
ROA0_HUMAN	HNRNPA0	physical	20020773
RS16_HUMAN	RPS16	physical	20020773
HNRPC_HUMAN	HNRNPC	physical	20020773
RLA0_HUMAN	RPLP0	physical	20020773
EIF3B_HUMAN	EIF3B	physical	20020773
RL7_HUMAN	RPL7	physical	20020773
RL12_HUMAN	RPL12	physical	20020773
DDX3X_HUMAN	DDX3X	physical	20020773
SRSF7_HUMAN	SRSF7	physical	20020773
ADT2_HUMAN	SLC25A5	physical	20020773
RS9_HUMAN	RPS9	physical	20020773
RSSA_HUMAN	RPSA	physical	20020773
ILF3_HUMAN	ILF3	physical	20020773
DDX5_HUMAN	DDX5	physical	20020773
F120A_HUMAN	FAM120A	physical	20020773
RL14_HUMAN	RPL14	physical	20020773
RL11_HUMAN	RPL11	physical	20020773
EIF3C_HUMAN	EIF3C	physical	20020773
DDX6_HUMAN	DDX6	physical	20020773
SND1_HUMAN	SND1	physical	20020773
HSP7C_HUMAN	HSPA8	physical	20020773
MOV10_HUMAN	MOV10	physical	20020773
RL3_HUMAN	RPL3	physical	20020773
YBOX3_HUMAN	YBX3	physical	20020773
DHX9_HUMAN	DHX9	physical	20020773
RL7A_HUMAN	RPL7A	physical	20020773
ROA1_HUMAN	HNRNPA1	physical	20020773
ELAV1_HUMAN	ELAVL1	physical	20020773
TBA1B_HUMAN	TUBA1B	physical	20020773
RS3_HUMAN	RPS3	physical	20020773
NUCL_HUMAN	NCL	physical	20020773
ILF2_HUMAN	ILF2	physical	20020773
RL19_HUMAN	RPL19	physical	20020773
RL10A_HUMAN	RPL10A	physical	20020773
RL23_HUMAN	RPL23	physical	20020773
G3BP2_HUMAN	G3BP2	physical	20020773
RT22_HUMAN	MRPS22	physical	20020773
RL15_HUMAN	RPL15	physical	20020773
RL32_HUMAN	RPL32	physical	20020773
LRC15_HUMAN	LRRC15	physical	20020773
GGYF2_HUMAN	GIGYF2	physical	20020773
HNRPU_HUMAN	HNRNPU	physical	20020773
ROA2_HUMAN	HNRNPA2B1	physical	20020773
HNRPQ_HUMAN	SYNCRIP	physical	20020773
RS4X_HUMAN	RPS4X	physical	20020773
RL31_HUMAN	RPL31	physical	20020773
EF2_HUMAN	EEF2	physical	20020773
RBMX_HUMAN	RBMX	physical	20020773
RL10_HUMAN	RPL10	physical	20020773
HNRDL_HUMAN	HNRNPDL	physical	20020773
CAPR1_HUMAN	CAPRIN1	physical	20020773
RL13_HUMAN	RPL13	physical	20020773
RS25_HUMAN	RPS25	physical	20020773
RL23A_HUMAN	RPL23A	physical	20020773
PLAK_HUMAN	JUP	physical	20020773
TBB5_HUMAN	TUBB	physical	20020773
PCBP2_HUMAN	PCBP2	physical	20020773
RL35_HUMAN	RPL35	physical	20020773
RU2A_HUMAN	SNRPA1	physical	20020773
RL22_HUMAN	RPL22	physical	20020773
PRP19_HUMAN	PRPF19	physical	20020773
MYH9_HUMAN	MYH9	physical	20020773
SERA_HUMAN	PHGDH	physical	20020773
EF1G_HUMAN	EEF1G	physical	20020773
AGO2_HUMAN	AGO2	physical	20020773
CCAR2_HUMAN	CCAR2	physical	20020773
SDA1_HUMAN	SDAD1	physical	20020773
TPIS_HUMAN	TPI1	physical	20020773
LSM6_HUMAN	LSM6	physical	24825905
MED6_HUMAN	MED6	physical	24825905
RACK1_HUMAN	GNB2L1	physical	24825905
RBM45_HUMAN	RBM45	physical	24825905
RING2_HUMAN	RNF2	physical	24825905
UB2E3_HUMAN	UBE2E3	physical	24825905
UBP8_HUMAN	USP8	physical	24825905
STAU1_HUMAN	STAU1	physical	23125841
TADBP_HUMAN	TARDBP	physical	19465477
ZFN2B_HUMAN	ZFAND2B	physical	25416956
SEI1_YEAST	FLD1	genetic	23104007
RM39_YEAST	MRPL39	genetic	23104007
MSN2_YEAST	MSN2	genetic	23104007
NHX1_YEAST	NHX1	genetic	23104007
RL16B_YEAST	RPL16B	genetic	23104007
IF4F1_YEAST	TIF4631	genetic	23104007
CCE1_YEAST	CCE1	genetic	23104007
DBR1_YEAST	DBR1	genetic	23104007
DOM34_YEAST	DOM34	genetic	23104007
PBP1_YEAST	PBP1	genetic	23104007
RL16A_YEAST	RPL16A	genetic	23104007
SET3_YEAST	SET3	genetic	23104007
SIW14_YEAST	SIW14	genetic	23104007
OCA6_YEAST	OCA6	genetic	23104007
HS104_YEAST	HSP104	genetic	25062688
ATX2_HUMAN	ATXN2	physical	26344197
FLNB_HUMAN	FLNB	physical	26344197
GMFB_HUMAN	GMFB	physical	26344197
KIF4B_HUMAN	KIF4B	physical	26344197
TYW4_HUMAN	LCMT2	physical	26344197
PDCD6_HUMAN	PDCD6	physical	26344197
PDIA3_HUMAN	PDIA3	physical	26344197
CUL2_HUMAN	CUL2	physical	26751167
VHL_HUMAN	VHL	physical	26751167
NCF2_HUMAN	NCF2	physical	28514442
NCAM1_HUMAN	NCAM1	physical	28514442
EPHA2_HUMAN	EPHA2	physical	28514442
SIS1_YEAST	SIS1	genetic	28531192
DNJB1_HUMAN	DNAJB1	genetic	28531192

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
612069	Amyotrophic lateral sclerosis 10 (ALS10)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TADBP_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91 AND SER-92, AND MASSSPECTROMETRY.	17081983 [Abstract]