dbPTM

RL21_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RL21_HUMAN
UniProt AC	P46778
Protein Name	60S ribosomal protein L21
Gene Name	RPL21
Organism	Homo sapiens (Human).
Sequence Length	160
Subcellular Localization	Cytoplasm, cytosol . Cytoplasm . Endoplasmic reticulum . Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Protein Description	Component of the large ribosomal subunit..
Protein Sequence	MTNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKGMPHKCYHGKTGRVYNVTQHAVGIVVNKQVKGKILAKRINVRIEHIKHSKSRDSFLKRVKENDQKKKEAKEKGTWVQLKRQPAPPREAHFVRTNGKEPELLEPIPYEFMA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	GKRRGTRYMFSRPFR CCCCCCCCCCCCCCH	11.44	30576142
14	Sulfoxidation	KRRGTRYMFSRPFRK CCCCCCCCCCCCCHH	1.90	28183972
16	Phosphorylation	RGTRYMFSRPFRKHG CCCCCCCCCCCHHCC	23.63	30576142
21	Ubiquitination	MFSRPFRKHGVVPLA CCCCCCHHCCCEEHH	45.12	21890473
29	Phosphorylation	HGVVPLATYMRIYKK CCCEEHHHEEEEEEC	26.07	28152594
30	Phosphorylation	GVVPLATYMRIYKKG CCEEHHHEEEEEECC	4.45	28152594
31	Sulfoxidation	VVPLATYMRIYKKGD CEEHHHEEEEEECCC	1.50	28183972
32	Methylation	VPLATYMRIYKKGDI EEHHHEEEEEECCCE	20.76	115491871
35	Ubiquitination	ATYMRIYKKGDIVDI HHEEEEEECCCEEEC	48.16	-
36	Ubiquitination	TYMRIYKKGDIVDIK HEEEEEECCCEEECC	44.86	-
36	Acetylation	TYMRIYKKGDIVDIK HEEEEEECCCEEECC	44.86	26051181
43	Sumoylation	KGDIVDIKGMGTVQK CCCEEECCCCEEEEC	38.08	-
43	Acetylation	KGDIVDIKGMGTVQK CCCEEECCCCEEEEC	38.08	27452117
43	2-Hydroxyisobutyrylation	KGDIVDIKGMGTVQK CCCEEECCCCEEEEC	38.08	-
43	Ubiquitination	KGDIVDIKGMGTVQK CCCEEECCCCEEEEC	38.08	21890473
45	Sulfoxidation	DIVDIKGMGTVQKGM CEEECCCCEEEECCC	3.27	28183972
47	Phosphorylation	VDIKGMGTVQKGMPH EECCCCEEEECCCCC	15.75	22817900
50	Acetylation	KGMGTVQKGMPHKCY CCCEEEECCCCCCEE	53.49	25953088
50	2-Hydroxyisobutyrylation	KGMGTVQKGMPHKCY CCCEEEECCCCCCEE	53.49	-
50	Ubiquitination	KGMGTVQKGMPHKCY CCCEEEECCCCCCEE	53.49	-
55	2-Hydroxyisobutyrylation	VQKGMPHKCYHGKTG EECCCCCCEECCCCC	30.53	-
55	Ubiquitination	VQKGMPHKCYHGKTG EECCCCCCEECCCCC	30.53	-
57	Phosphorylation	KGMPHKCYHGKTGRV CCCCCCEECCCCCCE	20.57	22817900
60	Acetylation	PHKCYHGKTGRVYNV CCCEECCCCCCEEEE	34.20	26051181
61	Phosphorylation	HKCYHGKTGRVYNVT CCEECCCCCCEEEEC	34.51	23882029
65	Phosphorylation	HGKTGRVYNVTQHAV CCCCCCEEEECCCEE	11.53	28152594
68	Phosphorylation	TGRVYNVTQHAVGIV CCCEEEECCCEEEEE	15.82	28152594
78	Acetylation	AVGIVVNKQVKGKIL EEEEEECCHHCCCEE	44.87	23749302
78	Malonylation	AVGIVVNKQVKGKIL EEEEEECCHHCCCEE	44.87	26320211
78	Ubiquitination	AVGIVVNKQVKGKIL EEEEEECCHHCCCEE	44.87	21890473
81	Ubiquitination	IVVNKQVKGKILAKR EEECCHHCCCEEEEE	52.58	-
97	2-Hydroxyisobutyrylation	NVRIEHIKHSKSRDS CEEEEEECCCCCHHH	43.67	-
97	Acetylation	NVRIEHIKHSKSRDS CEEEEEECCCCCHHH	43.67	25825284
101	Phosphorylation	EHIKHSKSRDSFLKR EEECCCCCHHHHHHH	44.31	30266825
104	Phosphorylation	KHSKSRDSFLKRVKE CCCCCHHHHHHHHHH	31.22	23401153
107	Ubiquitination	KSRDSFLKRVKENDQ CCHHHHHHHHHHHHH	53.81	-
107	Acetylation	KSRDSFLKRVKENDQ CCHHHHHHHHHHHHH	53.81	26051181
107	Methylation	KSRDSFLKRVKENDQ CCHHHHHHHHHHHHH	53.81	2380247
122	Ubiquitination	KKKEAKEKGTWVQLK HHHHHHHHCCEEEEE	62.02	-
122	Acetylation	KKKEAKEKGTWVQLK HHHHHHHHCCEEEEE	62.02	25953088
122	2-Hydroxyisobutyrylation	KKKEAKEKGTWVQLK HHHHHHHHCCEEEEE	62.02	-
122	Malonylation	KKKEAKEKGTWVQLK HHHHHHHHCCEEEEE	62.02	26320211
124	Phosphorylation	KEAKEKGTWVQLKRQ HHHHHHCCEEEEECC	33.27	23403867
129	Sumoylation	KGTWVQLKRQPAPPR HCCEEEEECCCCCCC	31.71	-
129	Succinylation	KGTWVQLKRQPAPPR HCCEEEEECCCCCCC	31.71	23954790
129	Acetylation	KGTWVQLKRQPAPPR HCCEEEEECCCCCCC	31.71	26051181
129	Sumoylation	KGTWVQLKRQPAPPR HCCEEEEECCCCCCC	31.71	-
129	Ubiquitination	KGTWVQLKRQPAPPR HCCEEEEECCCCCCC	31.71	21890473
129	2-Hydroxyisobutyrylation	KGTWVQLKRQPAPPR HCCEEEEECCCCCCC	31.71	-
136	Methylation	KRQPAPPREAHFVRT ECCCCCCCCEEEEEC	53.31	115491879
143	Phosphorylation	REAHFVRTNGKEPEL CCEEEEECCCCCCHH	42.92	21712546
146	Ubiquitination	HFVRTNGKEPELLEP EEEECCCCCCHHCCC	72.64	2190698
146	Acetylation	HFVRTNGKEPELLEP EEEECCCCCCHHCCC	72.64	26051181
156	Phosphorylation	ELLEPIPYEFMA--- HHCCCCCCCCCC---	23.63	27642862
159	Sulfoxidation	EPIPYEFMA------ CCCCCCCCC------	2.64	21406390

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
104	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RL21_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RL21_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RL4_HUMAN	RPL4	physical	22939629
RL6_HUMAN	RPL6	physical	22939629
RL7A_HUMAN	RPL7A	physical	22939629
RL7_HUMAN	RPL7	physical	22939629
RS3A_HUMAN	RPS3A	physical	22939629
RS3_HUMAN	RPS3	physical	22939629
RLA0_HUMAN	RPLP0	physical	22939629
RS9_HUMAN	RPS9	physical	22939629
RL23A_HUMAN	RPL23A	physical	22939629
RL24_HUMAN	RPL24	physical	22939629
RL31_HUMAN	RPL31	physical	22939629
RL37A_HUMAN	RPL37A	physical	22939629
RL5_HUMAN	RPL5	physical	22939629
RL8_HUMAN	RPL8	physical	22939629
RL9_HUMAN	RPL9	physical	22939629
RS11_HUMAN	RPS11	physical	22939629
RS13_HUMAN	RPS13	physical	22939629
RS15A_HUMAN	RPS15A	physical	22939629
RS16_HUMAN	RPS16	physical	22939629
RS17_HUMAN	RPS17	physical	22939629
RS19_HUMAN	RPS19	physical	22939629
RS20_HUMAN	RPS20	physical	22939629
RS23_HUMAN	RPS23	physical	22939629
RS25_HUMAN	RPS25	physical	22939629
RS28_HUMAN	RPS28	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
RS5_HUMAN	RPS5	physical	22939629
RS6_HUMAN	RPS6	physical	22939629
RS8_HUMAN	RPS8	physical	22939629
RSSA_HUMAN	RPSA	physical	22939629
RS26_HUMAN	RPS26	physical	22939629
RL23_HUMAN	RPL23	physical	22939629
RL3_HUMAN	RPL3	physical	22939629
RS12_HUMAN	RPS12	physical	22939629
RS24_HUMAN	RPS24	physical	22939629
RL22_HUMAN	RPL22	physical	22939629
RL30_HUMAN	RPL30	physical	22939629
RS15_HUMAN	RPS15	physical	22939629
RL36_HUMAN	RPL36	physical	22939629
RL38_HUMAN	RPL38	physical	22939629
RL32_HUMAN	RPL32	physical	22939629
RS21_HUMAN	RPS21	physical	22939629
RS27A_HUMAN	RPS27A	physical	22939629
RL29_HUMAN	RPL29	physical	22939629
RS27L_HUMAN	RPS27L	physical	22939629
TEBP_HUMAN	PTGES3	physical	22939629
AIMP1_HUMAN	AIMP1	physical	22863883
SYDC_HUMAN	DARS	physical	22863883
SYK_HUMAN	KARS	physical	22863883
RL17_HUMAN	RPL17	physical	22863883
RL23A_HUMAN	RPL23A	physical	22863883
RL26_HUMAN	RPL26	physical	22863883
RL36_HUMAN	RPL36	physical	22863883
RLA0_HUMAN	RPLP0	physical	22863883
RL10_HUMAN	RPL10	physical	26344197
RL10A_HUMAN	RPL10A	physical	26344197
RL11_HUMAN	RPL11	physical	26344197
RL12_HUMAN	RPL12	physical	26344197
RL13_HUMAN	RPL13	physical	26344197
RL13A_HUMAN	RPL13A	physical	26344197
RL15_HUMAN	RPL15	physical	26344197
RL18_HUMAN	RPL18	physical	26344197
RL18A_HUMAN	RPL18A	physical	26344197
RL23A_HUMAN	RPL23A	physical	26344197
RL24_HUMAN	RPL24	physical	26344197
RL26_HUMAN	RPL26	physical	26344197
RL26L_HUMAN	RPL26L1	physical	26344197
RL27_HUMAN	RPL27	physical	26344197
RL27A_HUMAN	RPL27A	physical	26344197
RL28_HUMAN	RPL28	physical	26344197
RL30_HUMAN	RPL30	physical	26344197
RL32_HUMAN	RPL32	physical	26344197
RL35_HUMAN	RPL35	physical	26344197
RL35A_HUMAN	RPL35A	physical	26344197
RL36_HUMAN	RPL36	physical	26344197
RL37A_HUMAN	RPL37A	physical	26344197
RL38_HUMAN	RPL38	physical	26344197
RL3L_HUMAN	RPL3L	physical	26344197
RL5_HUMAN	RPL5	physical	26344197
RL6_HUMAN	RPL6	physical	26344197
RL7_HUMAN	RPL7	physical	26344197
RL7A_HUMAN	RPL7A	physical	26344197
RL8_HUMAN	RPL8	physical	26344197
RL9_HUMAN	RPL9	physical	26344197
RLA1_HUMAN	RPLP1	physical	26344197
RLA2_HUMAN	RPLP2	physical	26344197
RS10_HUMAN	RPS10	physical	26344197
RS11_HUMAN	RPS11	physical	26344197
RS13_HUMAN	RPS13	physical	26344197
RS14_HUMAN	RPS14	physical	26344197
RS15_HUMAN	RPS15	physical	26344197
RS15A_HUMAN	RPS15A	physical	26344197
RS18_HUMAN	RPS18	physical	26344197
RS19_HUMAN	RPS19	physical	26344197
RS2_HUMAN	RPS2	physical	26344197
RS23_HUMAN	RPS23	physical	26344197
RS26_HUMAN	RPS26	physical	26344197
RS27_HUMAN	RPS27	physical	26344197
RS3_HUMAN	RPS3	physical	26344197
RS3A_HUMAN	RPS3A	physical	26344197
RS4X_HUMAN	RPS4X	physical	26344197
RS5_HUMAN	RPS5	physical	26344197
RS6_HUMAN	RPS6	physical	26344197
RS7_HUMAN	RPS7	physical	26344197
RS8_HUMAN	RPS8	physical	26344197
RS9_HUMAN	RPS9	physical	26344197
RSSA_HUMAN	RPSA	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615885	Hypotrichosis 12 (HYPT12)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RL21_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-47, AND MASSSPECTROMETRY.	18187866 [Abstract]