RL22_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RL22_HUMAN
• UniProt AC: P35268
• Protein Name: 60S ribosomal protein L22
• Gene Name: RPL22
• Organism: Homo sapiens (Human).
• Sequence Length: 128
• Protein Sequence: MAPVKKLVVKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVTIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANSKESYELRYFQINQDEEEEEDED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Acetylation	PVKKLVVKGGKKKKQ CCEEEEEECCCHHCE	55.24	25953088
13	Acetylation	KLVVKGGKKKKQVLK EEEEECCCHHCEEEE	70.82	11924071
20	Acetylation	KKKKQVLKFTLDCTH CHHCEEEEEEECCCC	37.13	26051181
22	Phosphorylation	KKQVLKFTLDCTHPV HCEEEEEEECCCCCC	21.79	26126808
26	Phosphorylation	LKFTLDCTHPVEDGI EEEEECCCCCCCCCC	28.96	26126808
48	Ubiquitination	QFLQERIKVNGKAGN HHHHHHHHHCCCCCC	35.55	23000965
52	Acetylation	ERIKVNGKAGNLGGG HHHHHCCCCCCCCCC	48.17	25953088
52	Ubiquitination	ERIKVNGKAGNLGGG HHHHHCCCCCCCCCC	48.17	23000965
62	Phosphorylation	NLGGGVVTIERSKSK CCCCCEEEEECCCCE	18.08	29255136
66	Phosphorylation	GVVTIERSKSKITVT CEEEEECCCCEEEEE	28.61	23403867
67	Ubiquitination	VVTIERSKSKITVTS EEEEECCCCEEEEEE	63.09	23000965
68	Phosphorylation	VTIERSKSKITVTSE EEEECCCCEEEEEEE	30.45	23927012
69	Succinylation	TIERSKSKITVTSEV EEECCCCEEEEEEEC	46.24	-
69	Malonylation	TIERSKSKITVTSEV EEECCCCEEEEEEEC	46.24	26320211
69	Acetylation	TIERSKSKITVTSEV EEECCCCEEEEEEEC	46.24	25953088
69	2-Hydroxyisobutyrylation	TIERSKSKITVTSEV EEECCCCEEEEEEEC	46.24	-
69	Succinylation	TIERSKSKITVTSEV EEECCCCEEEEEEEC	46.24	-
69	Ubiquitination	TIERSKSKITVTSEV EEECCCCEEEEEEEC	46.24	23000965
71	Phosphorylation	ERSKSKITVTSEVPF ECCCCEEEEEEECCC	22.82	28464451
73	Phosphorylation	SKSKITVTSEVPFSK CCCEEEEEEECCCCH	15.54	23927012
74	Phosphorylation	KSKITVTSEVPFSKR CCEEEEEEECCCCHH	32.06	23927012
79	Phosphorylation	VTSEVPFSKRYLKYL EEEECCCCHHHHHHH	15.34	22199227
80	Ubiquitination	TSEVPFSKRYLKYLT EEECCCCHHHHHHHH	45.50	23000965
80	Methylation	TSEVPFSKRYLKYLT EEECCCCHHHHHHHH	45.50	24588265
80	Acetylation	TSEVPFSKRYLKYLT EEECCCCHHHHHHHH	45.50	25953088
80	2-Hydroxyisobutyrylation	TSEVPFSKRYLKYLT EEECCCCHHHHHHHH	45.50	-
84	Ubiquitination	PFSKRYLKYLTKKYL CCCHHHHHHHHHHHH	29.31	23000965
84	Acetylation	PFSKRYLKYLTKKYL CCCHHHHHHHHHHHH	29.31	25825284
84	2-Hydroxyisobutyrylation	PFSKRYLKYLTKKYL CCCHHHHHHHHHHHH	29.31	-
88	Ubiquitination	RYLKYLTKKYLKKNN HHHHHHHHHHHHHCC	36.50	23000965
89	Ubiquitination	YLKYLTKKYLKKNNL HHHHHHHHHHHHCCH	51.05	23000965
101	Methylation	NNLRDWLRVVANSKE CCHHHHHHHHHCCCC	19.33	115491887
106	Phosphorylation	WLRVVANSKESYELR HHHHHHCCCCEEEEE	28.23	30624053
107	Acetylation	LRVVANSKESYELRY HHHHHCCCCEEEEEE	50.95	26051181
107	Succinylation	LRVVANSKESYELRY HHHHHCCCCEEEEEE	50.95	23954790
107	2-Hydroxyisobutyrylation	LRVVANSKESYELRY HHHHHCCCCEEEEEE	50.95	-
107	Ubiquitination	LRVVANSKESYELRY HHHHHCCCCEEEEEE	50.95	23000965
109	Phosphorylation	VVANSKESYELRYFQ HHHCCCCEEEEEEEE	27.87	23312004
114	Phosphorylation	KESYELRYFQINQDE CCEEEEEEEEECCCH	16.68	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RL22_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RL22_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RL22_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
XPO2_HUMAN	CSE1L	physical	16169070
RL24_HUMAN	RPL24	physical	22939629
RL37A_HUMAN	RPL37A	physical	22939629
RS23_HUMAN	RPS23	physical	22939629
RL4_HUMAN	RPL4	physical	22939629
RS11_HUMAN	RPS11	physical	22939629
RS13_HUMAN	RPS13	physical	22939629
RS8_HUMAN	RPS8	physical	22939629
RL6_HUMAN	RPL6	physical	22939629
RL27A_HUMAN	RPL27A	physical	22939629
RL5_HUMAN	RPL5	physical	22939629
RL23A_HUMAN	RPL23A	physical	22939629
RS16_HUMAN	RPS16	physical	22939629
RL7_HUMAN	RPL7	physical	22939629
RS3A_HUMAN	RPS3A	physical	22939629
RL30_HUMAN	RPL30	physical	22939629
RS26_HUMAN	RPS26	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
RS3_HUMAN	RPS3	physical	22939629
RL7A_HUMAN	RPL7A	physical	22939629
RS6_HUMAN	RPS6	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
RLA0_HUMAN	RPLP0	physical	22939629
RSSA_HUMAN	RPSA	physical	22939629
RS17_HUMAN	RPS17	physical	22939629
RS24_HUMAN	RPS24	physical	22939629
RS19_HUMAN	RPS19	physical	22939629
RL23_HUMAN	RPL23	physical	22939629
RL31_HUMAN	RPL31	physical	22939629
RS27A_HUMAN	RPS27A	physical	22939629
RS21_HUMAN	RPS21	physical	22939629
RS27L_HUMAN	RPS27L	physical	22939629
STRAP_HUMAN	STRAP	physical	22939629
IL7RA_HUMAN	IL7R	physical	23151878
ARFG1_HUMAN	ARFGAP1	physical	22863883
HNRPU_HUMAN	HNRNPU	physical	26344197
LC7L2_HUMAN	LUC7L2	physical	26344197
RL10_HUMAN	RPL10	physical	26344197
RL10A_HUMAN	RPL10A	physical	26344197
RL11_HUMAN	RPL11	physical	26344197
RL12_HUMAN	RPL12	physical	26344197
RL13_HUMAN	RPL13	physical	26344197
RL13A_HUMAN	RPL13A	physical	26344197
RL14_HUMAN	RPL14	physical	26344197
RL15_HUMAN	RPL15	physical	26344197
RL18_HUMAN	RPL18	physical	26344197
RL21_HUMAN	RPL21	physical	26344197
RL23A_HUMAN	RPL23A	physical	26344197
RL26_HUMAN	RPL26	physical	26344197
RL26L_HUMAN	RPL26L1	physical	26344197
RL27_HUMAN	RPL27	physical	26344197
RL27A_HUMAN	RPL27A	physical	26344197
RL3_HUMAN	RPL3	physical	26344197
RL30_HUMAN	RPL30	physical	26344197
RL31_HUMAN	RPL31	physical	26344197
RL34_HUMAN	RPL34	physical	26344197
RL35_HUMAN	RPL35	physical	26344197
RL35A_HUMAN	RPL35A	physical	26344197
RL36_HUMAN	RPL36	physical	26344197
RL37A_HUMAN	RPL37A	physical	26344197
RL4_HUMAN	RPL4	physical	26344197
RL5_HUMAN	RPL5	physical	26344197
RL7_HUMAN	RPL7	physical	26344197
RL7A_HUMAN	RPL7A	physical	26344197
RL9_HUMAN	RPL9	physical	26344197
RLA2_HUMAN	RPLP2	physical	26344197
RS10_HUMAN	RPS10	physical	26344197
RS11_HUMAN	RPS11	physical	26344197
RS14_HUMAN	RPS14	physical	26344197
RS15_HUMAN	RPS15	physical	26344197
RS15A_HUMAN	RPS15A	physical	26344197
RS16_HUMAN	RPS16	physical	26344197
RS18_HUMAN	RPS18	physical	26344197
RS2_HUMAN	RPS2	physical	26344197
RS23_HUMAN	RPS23	physical	26344197
RS25_HUMAN	RPS25	physical	26344197
RS26_HUMAN	RPS26	physical	26344197
RS27_HUMAN	RPS27	physical	26344197
RS3_HUMAN	RPS3	physical	26344197
RS3A_HUMAN	RPS3A	physical	26344197
RS4X_HUMAN	RPS4X	physical	26344197
RS6_HUMAN	RPS6	physical	26344197
RS7_HUMAN	RPS7	physical	26344197
RS8_HUMAN	RPS8	physical	26344197
RS9_HUMAN	RPS9	physical	26344197
RSSA_HUMAN	RPSA	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.