dbPTM

RL8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RL8_HUMAN
UniProt AC	P62917
Protein Name	60S ribosomal protein L8
Gene Name	RPL8
Organism	Homo sapiens (Human).
Sequence Length	257
Subcellular Localization	Cytoplasm .
Protein Description	Component of the large ribosomal subunit..
Protein Sequence	MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKVVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPILKAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAARRTGRLRGTKTVQEKEN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Sumoylation	RVIRGQRKGAGSVFR CEECCCCCCCCHHHH	45.27	-
10	Ubiquitination	RVIRGQRKGAGSVFR CEECCCCCCCCHHHH	45.27	24816145
10	Sumoylation	RVIRGQRKGAGSVFR CEECCCCCCCCHHHH	45.27	-
14	Phosphorylation	GQRKGAGSVFRAHVK CCCCCCCHHHHHHHC	19.97	23911959
37	Methylation	RAVDFAERHGYIKGI HHHHHHHHHCCCHHH	25.71	115492307
40	Phosphorylation	DFAERHGYIKGIVKD HHHHHHCCCHHHHHH	8.04	28152594
42	2-Hydroxyisobutyrylation	AERHGYIKGIVKDII HHHHCCCHHHHHHHH	33.82	-
42	Succinylation	AERHGYIKGIVKDII HHHHCCCHHHHHHHH	33.82	23954790
42	Ubiquitination	AERHGYIKGIVKDII HHHHCCCHHHHHHHH	33.82	23000965
42	Sumoylation	AERHGYIKGIVKDII HHHHCCCHHHHHHHH	33.82	28112733
42	Acetylation	AERHGYIKGIVKDII HHHHCCCHHHHHHHH	33.82	26051181
46	Ubiquitination	GYIKGIVKDIIHDPG CCCHHHHHHHHCCCC	41.09	23000965
46	Succinylation	GYIKGIVKDIIHDPG CCCHHHHHHHHCCCC	41.09	23954790
46	2-Hydroxyisobutyrylation	GYIKGIVKDIIHDPG CCCHHHHHHHHCCCC	41.09	-
46	Acetylation	GYIKGIVKDIIHDPG CCCHHHHHHHHCCCC	41.09	23749302
54	Methylation	DIIHDPGRGAPLAKV HHHCCCCCCCCCHHE	43.41	115492315
60	2-Hydroxyisobutyrylation	GRGAPLAKVVFRDPY CCCCCCHHEEECCCC	46.76	-
60	Ubiquitination	GRGAPLAKVVFRDPY CCCCCCHHEEECCCC	46.76	23000965
60	Neddylation	GRGAPLAKVVFRDPY CCCCCCHHEEECCCC	46.76	32015554
67	Phosphorylation	KVVFRDPYRFKKRTE HEEECCCCCCCCCEE	32.73	28152594
73	Phosphorylation	PYRFKKRTELFIAAE CCCCCCCEEEEEEEE	46.01	20068231
84	Phosphorylation	IAAEGIHTGQFVYCG EEEECCCCCCEEECC	30.66	28152594
89	Phosphorylation	IHTGQFVYCGKKAQL CCCCCEEECCCCEEE	9.21	28152594
92	Acetylation	GQFVYCGKKAQLNIG CCEEECCCCEEEECC	41.18	25953088
92	2-Hydroxyisobutyrylation	GQFVYCGKKAQLNIG CCEEECCCCEEEECC	41.18	-
92	Ubiquitination	GQFVYCGKKAQLNIG CCEEECCCCEEEECC	41.18	21963094
93	2-Hydroxyisobutyrylation	QFVYCGKKAQLNIGN CEEECCCCEEEECCC	27.01	-
93	Ubiquitination	QFVYCGKKAQLNIGN CEEECCCCEEEECCC	27.01	22817900
106	Phosphorylation	GNVLPVGTMPEGTIV CCEECCEECCCCEEE	29.77	-
107	Sulfoxidation	NVLPVGTMPEGTIVC CEECCEECCCCEEEE	2.04	30846556
111	Phosphorylation	VGTMPEGTIVCCLEE CEECCCCEEEEECCC	14.47	-
114	S-palmitoylation	MPEGTIVCCLEEKPG CCCCEEEEECCCCCC	1.61	19801377
119	Acetylation	IVCCLEEKPGDRGKL EEEECCCCCCCCCHH	44.95	25953088
119	Ubiquitination	IVCCLEEKPGDRGKL EEEECCCCCCCCCHH	44.95	21906983
125	Ubiquitination	EKPGDRGKLARASGN CCCCCCCHHHHHCCC	39.61	23503661
130	Phosphorylation	RGKLARASGNYATVI CCHHHHHCCCEEEEE	23.24	28152594
133	Phosphorylation	LARASGNYATVISHN HHHHCCCEEEEEECC	13.74	25159151
133	Nitration	LARASGNYATVISHN HHHHCCCEEEEEECC	13.74	-
135	Phosphorylation	RASGNYATVISHNPE HHCCCEEEEEECCCC	14.17	28442448
138	Phosphorylation	GNYATVISHNPETKK CCEEEEEECCCCCCC	16.93	28442448
143	Phosphorylation	VISHNPETKKTRVKL EEECCCCCCCEEEEC	38.81	24117733
144	Ubiquitination	ISHNPETKKTRVKLP EECCCCCCCEEEECC	50.95	21906983
144	Sumoylation	ISHNPETKKTRVKLP EECCCCCCCEEEECC	50.95	-
144	2-Hydroxyisobutyrylation	ISHNPETKKTRVKLP EECCCCCCCEEEECC	50.95	-
144	Acetylation	ISHNPETKKTRVKLP EECCCCCCCEEEECC	50.95	23236377
145	Ubiquitination	SHNPETKKTRVKLPS ECCCCCCCEEEECCC	49.32	21963094
149	Sumoylation	ETKKTRVKLPSGSKK CCCCEEEECCCCCCE	51.92	28112733
149	2-Hydroxyisobutyrylation	ETKKTRVKLPSGSKK CCCCEEEECCCCCCE	51.92	-
149	Acetylation	ETKKTRVKLPSGSKK CCCCEEEECCCCCCE	51.92	26051181
149	Ubiquitination	ETKKTRVKLPSGSKK CCCCEEEECCCCCCE	51.92	27667366
152	Phosphorylation	KTRVKLPSGSKKVIS CEEEECCCCCCEEHH	67.16	20860994
154	O-linked_Glycosylation	RVKLPSGSKKVISSA EEECCCCCCEEHHCC	33.37	31492838
154	Phosphorylation	RVKLPSGSKKVISSA EEECCCCCCEEHHCC	33.37	23312004
155	Acetylation	VKLPSGSKKVISSAN EECCCCCCEEHHCCC	55.36	25953088
155	Ubiquitination	VKLPSGSKKVISSAN EECCCCCCEEHHCCC	55.36	24816145
156	Ubiquitination	KLPSGSKKVISSANR ECCCCCCEEHHCCCC	46.64	27667366
156	2-Hydroxyisobutyrylation	KLPSGSKKVISSANR ECCCCCCEEHHCCCC	46.64	-
159	Phosphorylation	SGSKKVISSANRAVV CCCCEEHHCCCCEEE	26.78	21406692
160	Phosphorylation	GSKKVISSANRAVVG CCCEEHHCCCCEEEE	20.59	21406692
177	Ubiquitination	AGGGRIDKPILKAGR ECCCCCCHHHHHCHH	31.42	23000965
177	Sumoylation	AGGGRIDKPILKAGR ECCCCCCHHHHHCHH	31.42	-
177	Sumoylation	AGGGRIDKPILKAGR ECCCCCCHHHHHCHH	31.42	-
177	Acetylation	AGGGRIDKPILKAGR ECCCCCCHHHHHCHH	31.42	26822725
181	Ubiquitination	RIDKPILKAGRAYHK CCCHHHHHCHHHHHH	49.90	23000965
181	Acetylation	RIDKPILKAGRAYHK CCCHHHHHCHHHHHH	49.90	26051181
188	Ubiquitination	KAGRAYHKYKAKRNC HCHHHHHHHHCCCCC	35.45	21906983
190	Ubiquitination	GRAYHKYKAKRNCWP HHHHHHHHCCCCCCC	52.84	22817900
192	Ubiquitination	AYHKYKAKRNCWPRV HHHHHHCCCCCCCCC	39.74	22817900
192	Methylation	AYHKYKAKRNCWPRV HHHHHHCCCCCCCCC	39.74	116252491
216	Hydroxylation	HPFGGGNHQHIGKPS CCCCCCCCCCCCCCC	24.70	23103944
234	2-Hydroxyisobutyrylation	RDAPAGRKVGLIAAR CCCCCCCCEEEEEEH	39.47	-
234	Sumoylation	RDAPAGRKVGLIAAR CCCCCCCCEEEEEEH	39.47	28112733
234	Ubiquitination	RDAPAGRKVGLIAAR CCCCCCCCEEEEEEH	39.47	27667366
234	Sumoylation	RDAPAGRKVGLIAAR CCCCCCCCEEEEEEH	39.47	-
242	Methylation	VGLIAARRTGRLRGT EEEEEEHHCCCCCCC	36.48	24376817
242	Dimethylation	VGLIAARRTGRLRGT EEEEEEHHCCCCCCC	36.48	-
250	Ubiquitination	TGRLRGTKTVQEKEN CCCCCCCCCHHHCCC	49.91	24816145
250	Sumoylation	TGRLRGTKTVQEKEN CCCCCCCCCHHHCCC	49.91	28112733
255	Ubiquitination	GTKTVQEKEN----- CCCCHHHCCC-----	45.53	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
130	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
216	H	Hydroxylation		23103944
Hydroxylated on His-216 by RIOX1.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RL8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RS13_HUMAN	RPS13	physical	22939629
RL9_HUMAN	RPL9	physical	22939629
RS16_HUMAN	RPS16	physical	22939629
RS23_HUMAN	RPS23	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
RS3A_HUMAN	RPS3A	physical	22939629
RS3_HUMAN	RPS3	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
RS6_HUMAN	RPS6	physical	22939629
RS8_HUMAN	RPS8	physical	22939629
RSSA_HUMAN	RPSA	physical	22939629
RS26_HUMAN	RPS26	physical	22939629
RS20_HUMAN	RPS20	physical	22939629
RS9_HUMAN	RPS9	physical	22939629
RS17_HUMAN	RPS17	physical	22939629
RLA0_HUMAN	RPLP0	physical	22939629
RM23_HUMAN	MRPL23	physical	22939629
THIOM_HUMAN	TXN2	physical	22939629
TBA1C_HUMAN	TUBA1C	physical	22939629
IL7RA_HUMAN	IL7R	physical	23151878
RL28_HUMAN	RPL28	physical	22863883
RS25_HUMAN	RPS25	physical	22863883
RL26L_HUMAN	RPL26L1	physical	26186194
RLA2_HUMAN	RPLP2	physical	26186194
RL4_HUMAN	RPL4	physical	26186194
CC137_HUMAN	CCDC137	physical	26186194
RBM28_HUMAN	RBM28	physical	26186194
POP1_HUMAN	POP1	physical	26186194
DDX24_HUMAN	DDX24	physical	26186194
SPB1_HUMAN	FTSJ3	physical	26186194
RLA0_HUMAN	RPLP0	physical	26186194
ZN668_HUMAN	ZNF668	physical	26186194
DKC1_HUMAN	DKC1	physical	26186194
STAU2_HUMAN	STAU2	physical	26186194
STAU1_HUMAN	STAU1	physical	26186194
RL6_HUMAN	RPL6	physical	26186194
DDX27_HUMAN	DDX27	physical	26186194
RL15_HUMAN	RPL15	physical	26186194
GLYR1_HUMAN	GLYR1	physical	26186194
REXO4_HUMAN	REXO4	physical	26186194
RS3A_HUMAN	RPS3A	physical	26186194
RL18_HUMAN	RPL18	physical	26186194
NSD2_HUMAN	WHSC1	physical	26186194
CG050_HUMAN	C7orf50	physical	26186194
RRP8_HUMAN	RRP8	physical	26186194
PAPD5_HUMAN	PAPD5	physical	26186194
ZCCHV_HUMAN	ZC3HAV1	physical	26186194
NOP2_HUMAN	NOP2	physical	26186194
NOG2_HUMAN	GNL2	physical	26186194
CCD86_HUMAN	CCDC86	physical	26186194
RBM34_HUMAN	RBM34	physical	26186194
RIOX2_HUMAN	MINA	physical	26186194
LN28B_HUMAN	LIN28B	physical	26186194
RS8_HUMAN	RPS8	physical	26186194
PUM3_HUMAN	KIAA0020	physical	26186194
RL13A_HUMAN	RPL13A	physical	26186194
RL37A_HUMAN	RPL37A	physical	26186194
RSBNL_HUMAN	RSBN1L	physical	26186194
RPF2_HUMAN	RPF2	physical	26186194
RS24_HUMAN	RPS24	physical	26186194
ZN770_HUMAN	ZNF770	physical	26186194
IF6_HUMAN	EIF6	physical	26344197
PESC_HUMAN	PES1	physical	26344197
RL10A_HUMAN	RPL10A	physical	26344197
RL11_HUMAN	RPL11	physical	26344197
RL12_HUMAN	RPL12	physical	26344197
RL13_HUMAN	RPL13	physical	26344197
RL14_HUMAN	RPL14	physical	26344197
RL15_HUMAN	RPL15	physical	26344197
RL17_HUMAN	RPL17	physical	26344197
RL18_HUMAN	RPL18	physical	26344197
RL22_HUMAN	RPL22	physical	26344197
RL23_HUMAN	RPL23	physical	26344197
RL23A_HUMAN	RPL23A	physical	26344197
RL24_HUMAN	RPL24	physical	26344197
RL26_HUMAN	RPL26	physical	26344197
RL26L_HUMAN	RPL26L1	physical	26344197
RL27A_HUMAN	RPL27A	physical	26344197
RL3_HUMAN	RPL3	physical	26344197
RL31_HUMAN	RPL31	physical	26344197
RL32_HUMAN	RPL32	physical	26344197
RL34_HUMAN	RPL34	physical	26344197
RL35A_HUMAN	RPL35A	physical	26344197
RL37A_HUMAN	RPL37A	physical	26344197
RL38_HUMAN	RPL38	physical	26344197
RL3L_HUMAN	RPL3L	physical	26344197
RL5_HUMAN	RPL5	physical	26344197
RL9_HUMAN	RPL9	physical	26344197
RLA2_HUMAN	RPLP2	physical	26344197
RS11_HUMAN	RPS11	physical	26344197
RS14_HUMAN	RPS14	physical	26344197
RS15_HUMAN	RPS15	physical	26344197
RS15A_HUMAN	RPS15A	physical	26344197
RS16_HUMAN	RPS16	physical	26344197
RS18_HUMAN	RPS18	physical	26344197
RS19_HUMAN	RPS19	physical	26344197
RS20_HUMAN	RPS20	physical	26344197
RS23_HUMAN	RPS23	physical	26344197
RS25_HUMAN	RPS25	physical	26344197
RS26_HUMAN	RPS26	physical	26344197
RS29_HUMAN	RPS29	physical	26344197
RS3A_HUMAN	RPS3A	physical	26344197
RS6_HUMAN	RPS6	physical	26344197
RS7_HUMAN	RPS7	physical	26344197
RS8_HUMAN	RPS8	physical	26344197
RS9_HUMAN	RPS9	physical	26344197
RSSA_HUMAN	RPSA	physical	26344197
TBB4B_HUMAN	TUBB4B	physical	26344197
PUM3_HUMAN	KIAA0020	physical	28514442
ZCCHV_HUMAN	ZC3HAV1	physical	28514442
RBM34_HUMAN	RBM34	physical	28514442
RRP8_HUMAN	RRP8	physical	28514442
GLYR1_HUMAN	GLYR1	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
NOG2_HUMAN	GNL2	physical	28514442
STAU1_HUMAN	STAU1	physical	28514442
RLA0_HUMAN	RPLP0	physical	28514442
NSD2_HUMAN	WHSC1	physical	28514442
RL18A_HUMAN	RPL18A	physical	28514442
RLA2_HUMAN	RPLP2	physical	28514442
REXO4_HUMAN	REXO4	physical	28514442
RS24_HUMAN	RPS24	physical	28514442
ZN512_HUMAN	ZNF512	physical	28514442
NOP2_HUMAN	NOP2	physical	28514442
RS8_HUMAN	RPS8	physical	28514442
CC137_HUMAN	CCDC137	physical	28514442
NPM_HUMAN	NPM1	physical	28514442
ZBT24_HUMAN	ZBTB24	physical	28514442
RL4_HUMAN	RPL4	physical	28514442
SPB1_HUMAN	FTSJ3	physical	28514442
PAPD5_HUMAN	PAPD5	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RL8_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-46, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-133, AND MASSSPECTROMETRY.	15592455 [Abstract]

show