ZBT24_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZBT24_HUMAN
• UniProt AC: O43167
• Protein Name: Zinc finger and BTB domain-containing protein 24
• Gene Name: ZBTB24
• Organism: Homo sapiens (Human).
• Sequence Length: 697
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in BMP2-induced transcription..
• Protein Sequence: MAETSPEPSGQLVVHSDAHSDTVLASFEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMVADTFGILLEFIYTGYLHASEKSTEQILATAQFLKVYDLVKAYTDFQNNHSSPKPTTLNTAGAPVVVISNKKNDPPKRKRGRPKKVNTLQEEKSELAAEEEIQLRVNNSVQNRQNFVVKGDSGVLNEQIAAKEKEESEPTCEPSREEEMPVEKDENYDPKTEDGQASQSRYSKRRIWRSVKLKDYKLVGDQEDHGSAKRICGRRKRPGGPEARCKDCGKVFKYNHFLAIHQRSHTGERPFKCNECGKGFAQKHSLQVHTRMHTGERPYTCTVCSKALTTKHSLLEHMSLHSGQKSFTCDQCGKYFSQNRQLKSHYRVHTGHSLPECKDCHRKFMDVSQLKKHLRTHTGEKPFTCEICGKSFTAKSSLQTHIRIHRGEKPYSCGICGKSFSDSSAKRRHCILHTGKKPFSCPECNLQFARLDNLKAHLKIHSKEKHASDASSISGSSNTEEVRNILQLQPYQLSTSGEQEIQLLVTDSVHNINFMPGPSQGISIVTAESSQNMTADQAANLTLLTQQPEQLQNLILSAQQEQTEHIQSLNMIESQMGPSQTEPVHVITLSKETLEHLHAHQEQTEELHLATSTSDPAQHLQLTQEPGPPPPTHHVPQPTPLGQEQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAETSPEPSGQ ----CCCCCCCCCCC	39.79	25627689
5	Phosphorylation	---MAETSPEPSGQL ---CCCCCCCCCCCE	20.83	25627689
125	Phosphorylation	VYDLVKAYTDFQNNH HHHHHHHHHHHCCCC	10.92	20873877
126	Phosphorylation	YDLVKAYTDFQNNHS HHHHHHHHHHCCCCC	34.89	28464451
133	Phosphorylation	TDFQNNHSSPKPTTL HHHCCCCCCCCCCCC	50.92	25849741
134	Phosphorylation	DFQNNHSSPKPTTLN HHCCCCCCCCCCCCC	29.41	25159151
136	Ubiquitination	QNNHSSPKPTTLNTA CCCCCCCCCCCCCCC	57.87	29967540
138	Phosphorylation	NHSSPKPTTLNTAGA CCCCCCCCCCCCCCC	50.47	20873877
139	Phosphorylation	HSSPKPTTLNTAGAP CCCCCCCCCCCCCCC	26.91	28464451
142	Phosphorylation	PKPTTLNTAGAPVVV CCCCCCCCCCCCEEE	29.58	28464451
151	Phosphorylation	GAPVVVISNKKNDPP CCCEEEEECCCCCCC	30.87	25159151
214	Ubiquitination	LNEQIAAKEKEESEP HHHHHHHHHHHHCCC	61.37	29967540
278	Phosphorylation	GDQEDHGSAKRICGR CCCCCCCCCHHHCCC	27.48	25159151
280	Acetylation	QEDHGSAKRICGRRK CCCCCCCHHHCCCCC	43.95	25953088
317	Phosphorylation	AIHQRSHTGERPFKC EEECCCCCCCCCEEC	41.82	21857030
345	Phosphorylation	QVHTRMHTGERPYTC EEEEEEECCCCCEEE	31.25	25159151
370	Phosphorylation	HSLLEHMSLHSGQKS HHHHHHHCCCCCCCC	25.49	28555341
373	Phosphorylation	LEHMSLHSGQKSFTC HHHHCCCCCCCCEEH	48.49	29214152
401	Phosphorylation	KSHYRVHTGHSLPEC CCEEEECCCCCCCCC	33.46	25159151
419	Phosphorylation	HRKFMDVSQLKKHLR HHHHCCHHHHHHHHH	26.07	28555341
422	Ubiquitination	FMDVSQLKKHLRTHT HCCHHHHHHHHHHCC	30.43	29967540
427	Phosphorylation	QLKKHLRTHTGEKPF HHHHHHHHCCCCCCE	30.10	-
429	Phosphorylation	KKHLRTHTGEKPFTC HHHHHHCCCCCCEEE	46.56	21712546
477	Acetylation	SFSDSSAKRRHCILH CCCCCCHHHCCEEEE	52.49	25953088
523	Phosphorylation	KHASDASSISGSSNT CCCCCCCCCCCCCCH	23.61	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZBT24_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZBT24_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZBT24_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDFI_HUMAN	MDFI	physical	19060904
KDM1A_HUMAN	KDM1A	physical	23455924
ANM7_HUMAN	PRMT7	physical	23455924
SUV91_HUMAN	SUV39H1	physical	23455924
BAX_HUMAN	BAX	physical	19074440
TRIM1_HUMAN	MID2	physical	25416956
ZBT43_HUMAN	ZBTB43	physical	25416956
POGZ_HUMAN	POGZ	physical	25416956
CCDB1_HUMAN	CCNDBP1	physical	25416956
LDOC1_HUMAN	LDOC1	physical	25416956
KLF15_HUMAN	KLF15	physical	25416956
BC11A_HUMAN	BCL11A	physical	25416956
HMBX1_HUMAN	HMBOX1	physical	25416956
CEP76_HUMAN	CEP76	physical	25416956
CEP70_HUMAN	CEP70	physical	25416956
TSG10_HUMAN	TSGA10	physical	25416956
T22D4_HUMAN	TSC22D4	physical	25416956
KRA42_HUMAN	KRTAP4-2	physical	25416956
TRI41_HUMAN	TRIM41	physical	25416956
ADIP_HUMAN	SSX2IP	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
KR101_HUMAN	KRTAP10-1	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
ZBT8A_HUMAN	ZBTB8A	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614069: Immunodeficiency-centromeric instability-facial anomalies syndrome 2 (ICF2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.